ATE234605T1 - Fusogene liposomen und verfahren zu deren herstellung und verwendung - Google Patents
Fusogene liposomen und verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE234605T1 ATE234605T1 AT94919976T AT94919976T ATE234605T1 AT E234605 T1 ATE234605 T1 AT E234605T1 AT 94919976 T AT94919976 T AT 94919976T AT 94919976 T AT94919976 T AT 94919976T AT E234605 T1 ATE234605 T1 AT E234605T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- outermost
- lipid bilayer
- liposome
- bilayer
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 6
- 230000000799 fusogenic effect Effects 0.000 title abstract 2
- 239000000232 Lipid Bilayer Substances 0.000 abstract 8
- 150000002632 lipids Chemical class 0.000 abstract 6
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1994/003996 WO1995027478A1 (en) | 1994-04-12 | 1994-04-12 | Fusogenic liposomes and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234605T1 true ATE234605T1 (de) | 2003-04-15 |
Family
ID=22242444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94919976T ATE234605T1 (de) | 1994-04-12 | 1994-04-12 | Fusogene liposomen und verfahren zu deren herstellung und verwendung |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0758883B1 (de) |
| JP (1) | JP3804025B2 (de) |
| KR (1) | KR100315132B1 (de) |
| AT (1) | ATE234605T1 (de) |
| AU (1) | AU689479B2 (de) |
| CA (1) | CA2187748C (de) |
| DE (1) | DE69432320T2 (de) |
| DK (1) | DK0758883T3 (de) |
| ES (1) | ES2196028T3 (de) |
| FI (1) | FI964083A0 (de) |
| NO (1) | NO318814B1 (de) |
| NZ (1) | NZ268146A (de) |
| WO (1) | WO1995027478A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6339069B1 (en) | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| WO1998016240A1 (en) * | 1996-10-15 | 1998-04-23 | The Liposome Company, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| US6835395B1 (en) | 1997-05-14 | 2004-12-28 | The University Of British Columbia | Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles |
| CA2289702C (en) * | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| AU780535B2 (en) * | 1999-08-27 | 2005-03-24 | Inex Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
| JP2007524604A (ja) * | 2003-03-31 | 2007-08-30 | アルザ・コーポレーシヨン | 非対称の脂質被膜を有する脂質粒子およびその製造方法 |
| EP1852177B1 (de) * | 2005-01-28 | 2014-02-26 | Japan Science and Technology Agency | Molekulares aggregat, das dazu befähigt ist, eine phasenumwandlung durch dehydratisierende kondensation zu durchlaufen, und verfahren zur phasenumwandlung davon |
| EP2153820A4 (de) * | 2007-05-14 | 2013-12-25 | Konica Minolta Holdings Inc | Liposom und verfahren zur herstellung des liposoms |
| EP3699172A3 (de) | 2008-11-10 | 2020-11-18 | Arbutus Biopharma Corporation | Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika |
| WO2011017297A2 (en) | 2009-08-03 | 2011-02-10 | The University Of North Carolina At Chapel Hill | Biodegradable delivery system complexes for the delivery of bioactive compounds |
| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| EP3536787A1 (de) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nukleaseresistente polynukleotide und verwendungen davon |
| EA201591229A1 (ru) | 2013-03-14 | 2016-01-29 | Шир Хьюман Дженетик Терапис, Инк. | Способы очистки матричной рнк |
| KR102311614B1 (ko) | 2013-03-14 | 2021-10-08 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| EP3574923A1 (de) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna-therapie für phenylketonurie |
| ES2707966T3 (es) | 2013-10-22 | 2019-04-08 | Translate Bio Inc | Terapia de ARNm para la deficiencia en síntesis de argininosuccinato |
| EP4729528A3 (de) | 2014-04-25 | 2026-06-24 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
| MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
| IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
| CA3155003A1 (en) | 2019-09-20 | 2021-03-25 | Translate Bio, Inc. | Mrna encoding engineered cftr |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE3776763D1 (de) * | 1986-06-16 | 1992-03-26 | The Liposome Co.,Inc., Princeton, N.J., Us | |
| JPH0395118A (ja) * | 1989-09-07 | 1991-04-19 | Green Cross Corp:The | プロスタグランジン含有脂肪小体製剤 |
| DE4013632A1 (de) * | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
-
1994
- 1994-04-12 WO PCT/US1994/003996 patent/WO1995027478A1/en not_active Ceased
- 1994-04-12 CA CA002187748A patent/CA2187748C/en not_active Expired - Fee Related
- 1994-04-12 KR KR1019960705605A patent/KR100315132B1/ko not_active Expired - Fee Related
- 1994-04-12 NZ NZ268146A patent/NZ268146A/en not_active IP Right Cessation
- 1994-04-12 DE DE69432320T patent/DE69432320T2/de not_active Expired - Fee Related
- 1994-04-12 ES ES94919976T patent/ES2196028T3/es not_active Expired - Lifetime
- 1994-04-12 AU AU70915/94A patent/AU689479B2/en not_active Ceased
- 1994-04-12 JP JP52630695A patent/JP3804025B2/ja not_active Expired - Fee Related
- 1994-04-12 EP EP94919976A patent/EP0758883B1/de not_active Expired - Lifetime
- 1994-04-12 AT AT94919976T patent/ATE234605T1/de not_active IP Right Cessation
- 1994-04-12 DK DK94919976T patent/DK0758883T3/da active
-
1996
- 1996-10-09 NO NO19964284A patent/NO318814B1/no unknown
- 1996-10-11 FI FI964083A patent/FI964083A0/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09511521A (ja) | 1997-11-18 |
| NO964284D0 (no) | 1996-10-09 |
| ES2196028T3 (es) | 2003-12-16 |
| NO964284L (no) | 1996-10-09 |
| CA2187748A1 (en) | 1995-10-19 |
| KR100315132B1 (ko) | 2002-06-26 |
| FI964083A7 (fi) | 1996-10-11 |
| WO1995027478A1 (en) | 1995-10-19 |
| EP0758883B1 (de) | 2003-03-19 |
| EP0758883A1 (de) | 1997-02-26 |
| FI964083A0 (fi) | 1996-10-11 |
| JP3804025B2 (ja) | 2006-08-02 |
| AU7091594A (en) | 1995-10-30 |
| NO318814B1 (no) | 2005-05-09 |
| AU689479B2 (en) | 1998-04-02 |
| DE69432320D1 (de) | 2003-04-24 |
| DK0758883T3 (da) | 2003-06-02 |
| CA2187748C (en) | 2007-04-10 |
| NZ268146A (en) | 1997-10-24 |
| DE69432320T2 (de) | 2003-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |