ATE234605T1 - Fusogene liposomen und verfahren zu deren herstellung und verwendung - Google Patents

Fusogene liposomen und verfahren zu deren herstellung und verwendung

Info

Publication number
ATE234605T1
ATE234605T1 AT94919976T AT94919976T ATE234605T1 AT E234605 T1 ATE234605 T1 AT E234605T1 AT 94919976 T AT94919976 T AT 94919976T AT 94919976 T AT94919976 T AT 94919976T AT E234605 T1 ATE234605 T1 AT E234605T1
Authority
AT
Austria
Prior art keywords
lipid
outermost
lipid bilayer
liposome
bilayer
Prior art date
Application number
AT94919976T
Other languages
English (en)
Inventor
Austin Bailey
Pieter R Cullis
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Application granted granted Critical
Publication of ATE234605T1 publication Critical patent/ATE234605T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
AT94919976T 1994-04-12 1994-04-12 Fusogene liposomen und verfahren zu deren herstellung und verwendung ATE234605T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/003996 WO1995027478A1 (en) 1994-04-12 1994-04-12 Fusogenic liposomes and methods of making and using same

Publications (1)

Publication Number Publication Date
ATE234605T1 true ATE234605T1 (de) 2003-04-15

Family

ID=22242444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94919976T ATE234605T1 (de) 1994-04-12 1994-04-12 Fusogene liposomen und verfahren zu deren herstellung und verwendung

Country Status (13)

Country Link
EP (1) EP0758883B1 (de)
JP (1) JP3804025B2 (de)
KR (1) KR100315132B1 (de)
AT (1) ATE234605T1 (de)
AU (1) AU689479B2 (de)
CA (1) CA2187748C (de)
DE (1) DE69432320T2 (de)
DK (1) DK0758883T3 (de)
ES (1) ES2196028T3 (de)
FI (1) FI964083A7 (de)
NO (1) NO318814B1 (de)
NZ (1) NZ268146A (de)
WO (1) WO1995027478A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6339069B1 (en) 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
EP0964690B1 (de) * 1996-10-15 2003-07-09 The Liposome Company, Inc. Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung
US6835395B1 (en) 1997-05-14 2004-12-28 The University Of British Columbia Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
AU733310C (en) 1997-05-14 2001-11-29 University Of British Columbia, The High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
EP1212085B1 (de) * 1999-08-27 2007-10-31 INEX Pharmaceuticals Corp. Zusammensetzungen zur stimulation der zytokin sekretion und zur induktion einer immunantwort
MXPA05010499A (es) * 2003-03-31 2006-05-25 Johnson & Johnson Particulas lipidicas que tienen un revestimiento lipidico asimetrico y metodo de preparacion de las mismas.
US8449979B2 (en) 2005-01-28 2013-05-28 Japan Science And Technology Agency Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof
EP3494964B1 (de) * 2007-05-14 2021-04-07 Konica Minolta Holdings, Inc. Liposom und verfahren zur herstellung des liposoms
CN111808084A (zh) 2008-11-10 2020-10-23 阿布特斯生物制药公司 用于递送治疗剂的新型脂质和组合物
WO2011017297A2 (en) 2009-08-03 2011-02-10 The University Of North Carolina At Chapel Hill Biodegradable delivery system complexes for the delivery of bioactive compounds
EP3318248B1 (de) 2009-12-01 2019-04-10 Translate Bio, Inc. Ausgabe von mrna zur vermehrung von proteinen und enzymen bei humangenetischen erkrankungen
RU2013154295A (ru) 2011-06-08 2015-07-20 Шир Хьюман Дженетик Терапис, Инк. КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК
WO2013185067A1 (en) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
RS57739B1 (sr) 2013-03-14 2018-12-31 Translate Bio Inc Kompozicije cftr irnk i postupci i upotrebe u vezi sa njima
JP6586075B2 (ja) 2013-03-14 2019-10-02 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａの精製方法
CN106413811A (zh) 2013-10-22 2017-02-15 夏尔人类遗传性治疗公司 精氨基琥珀酸合成酶缺乏症的mrna疗法
JP6506749B2 (ja) 2013-10-22 2019-04-24 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド フェニルケトン尿症のためのｍＲＮＡ療法
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
EA201991747A1 (ru) 2017-02-27 2020-06-04 Транслейт Био, Инк. НОВАЯ КОДОН-ОПТИМИЗИРОВАННАЯ мРНК CFTR
MX2019013752A (es) 2017-05-16 2020-07-20 Translate Bio Inc Tratamiento de la fibrosis quística mediante el suministro de arnm que codifica cftr optimizado en codones.
KR102950141B1 (ko) 2018-08-24 2026-04-07 트랜슬레이트 바이오 인코포레이티드 전령 rna의 정제 방법
WO2020106946A1 (en) 2018-11-21 2020-05-28 Translate Bio, Inc. TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
EP4031662A1 (de) 2019-09-20 2022-07-27 Translate Bio, Inc. Mrna-codierendes technisches cftr

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946787A (en) * 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
DE3776763D1 (de) * 1986-06-16 1992-03-26 The Liposome Co.,Inc., Princeton, N.J., Us
JPH0395118A (ja) * 1989-09-07 1991-04-19 Green Cross Corp:The プロスタグランジン含有脂肪小体製剤
DE4013632A1 (de) * 1990-04-27 1991-10-31 Max Planck Gesellschaft Liposomen mit positiver ueberschussladung
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells

Also Published As

Publication number Publication date
JPH09511521A (ja) 1997-11-18
ES2196028T3 (es) 2003-12-16
NO318814B1 (no) 2005-05-09
NZ268146A (en) 1997-10-24
CA2187748C (en) 2007-04-10
JP3804025B2 (ja) 2006-08-02
EP0758883B1 (de) 2003-03-19
AU7091594A (en) 1995-10-30
NO964284L (no) 1996-10-09
EP0758883A1 (de) 1997-02-26
DE69432320D1 (de) 2003-04-24
FI964083A0 (fi) 1996-10-11
DE69432320T2 (de) 2003-12-04
FI964083A7 (fi) 1996-10-11
DK0758883T3 (da) 2003-06-02
AU689479B2 (en) 1998-04-02
WO1995027478A1 (en) 1995-10-19
CA2187748A1 (en) 1995-10-19
NO964284D0 (no) 1996-10-09
KR100315132B1 (ko) 2002-06-26

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