ES2196081T3 - Racemizacion de precursores para levobupivacaina y analogos de la mismos. - Google Patents

Racemizacion de precursores para levobupivacaina y analogos de la mismos.

Info

Publication number
ES2196081T3
ES2196081T3 ES95933510T ES95933510T ES2196081T3 ES 2196081 T3 ES2196081 T3 ES 2196081T3 ES 95933510 T ES95933510 T ES 95933510T ES 95933510 T ES95933510 T ES 95933510T ES 2196081 T3 ES2196081 T3 ES 2196081T3
Authority
ES
Spain
Prior art keywords
levobupivacaine
racemization
analogs
practice
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95933510T
Other languages
English (en)
Inventor
Ulrich Conrad Dyer
Raymond Mccague
Martin Woods
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9420245A external-priority patent/GB9420245D0/en
Priority claimed from GBGB9504924.3A external-priority patent/GB9504924D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ES2196081T3 publication Critical patent/ES2196081T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE ACIDO PIPECOLICO OPTICAMENTE ENRIQUECIDO COMO UNA SAL CON UN ACIDO OPTICAMENTE ACTIVO, COMPRENDE LA TRANSFORMACION ASIMETRICA DE ACIDO PIPECOLICO, COMO UNA MEZCLA RACEMICA O UNA MEZCLA ENRIQUECIDA EN EL ENANTIOMERO OPUESTO DEL DESEADO, CON EL ACIDO OPTICAMENTE ACTIVO EN UN SOLVENTE QUE COMPRENDE UN ACIDO QUE CAUSA RACEMIZACION, EN LA AUSENCIA DE ALDEHIDO.
ES95933510T 1994-10-07 1995-10-09 Racemizacion de precursores para levobupivacaina y analogos de la mismos. Expired - Lifetime ES2196081T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9420245A GB9420245D0 (en) 1994-10-07 1994-10-07 Racemisation
GBGB9504924.3A GB9504924D0 (en) 1995-03-10 1995-03-10 Racemisation

Publications (1)

Publication Number Publication Date
ES2196081T3 true ES2196081T3 (es) 2003-12-16

Family

ID=26305756

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95933510T Expired - Lifetime ES2196081T3 (es) 1994-10-07 1995-10-09 Racemizacion de precursores para levobupivacaina y analogos de la mismos.

Country Status (11)

Country Link
EP (1) EP0784603B1 (es)
JP (1) JPH11510471A (es)
AT (1) ATE238256T1 (es)
AU (1) AU695740B2 (es)
CA (1) CA2201780C (es)
DE (1) DE69530499T2 (es)
DK (1) DK0784603T3 (es)
ES (1) ES2196081T3 (es)
MX (1) MX9702483A (es)
PT (1) PT784603E (es)
WO (1) WO1996011173A2 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963991C3 (de) * 1969-12-20 1975-05-15 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Gewinnung eines Derivates von L-3,4-dihydroxyphenylalanin
DE3334849A1 (de) * 1983-09-27 1985-04-04 Hoechst Ag, 6230 Frankfurt Verfahren zur racemisierung optisch aktiver aminosaeuren
GB8421964D0 (en) * 1984-08-30 1984-10-03 Beecham Group Plc Chemical process
DE3435095C2 (de) * 1984-09-25 1986-07-24 Degussa Ag, 6000 Frankfurt Verfahren zur Racemisierung von N-Acetyl-D(L)-α-aminocarbonsäuren

Also Published As

Publication number Publication date
CA2201780C (en) 2007-01-09
EP0784603B1 (en) 2003-04-23
EP0784603A2 (en) 1997-07-23
AU3614095A (en) 1996-05-02
WO1996011173A3 (en) 1996-07-04
DK0784603T3 (da) 2003-08-18
WO1996011173A2 (en) 1996-04-18
MX9702483A (es) 1998-04-30
JPH11510471A (ja) 1999-09-14
PT784603E (pt) 2003-08-29
ATE238256T1 (de) 2003-05-15
AU695740B2 (en) 1998-08-20
DE69530499T2 (de) 2004-01-08
CA2201780A1 (en) 1996-04-18
DE69530499D1 (de) 2003-05-28

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