ATE253579T1 - Verfahren zur herstellung eines enantiomers von narwedin - Google Patents

Verfahren zur herstellung eines enantiomers von narwedin

Info

Publication number: ATE253579T1
Authority: AT; Austria
Prior art keywords: narwedine; enantiomer; producing; solvent; single enantiomer
Prior art date: 1997-04-11

Application number

AT98915005T

Other languages

English (en)

Inventor

Gerard Andrew De Montfo Potter

Peter David Tiffen

Road

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-11

Filing date

1998-04-08

Publication date

2003-11-15

1998-04-08 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253579T1 publication Critical patent/ATE253579T1/de

Links

QENVUHCAYXAROT-UHFFFAOYSA-N Galanthaminon Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(=O)C=C2 QENVUHCAYXAROT-UHFFFAOYSA-N 0.000 title abstract 4
QENVUHCAYXAROT-YOEHRIQHSA-N Narwedine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1CC(=O)C=C2 QENVUHCAYXAROT-YOEHRIQHSA-N 0.000 title abstract 4
WCRYNEMFWLZAAZ-WMLDXEAASA-N Narwedine Natural products COc1ccc2CCCC[C@@]34C=CC(=O)C[C@@H]3Oc1c24 WCRYNEMFWLZAAZ-WMLDXEAASA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000001412 amines Chemical class 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 1
238000010899 nucleation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)

AT98915005T 1997-04-11 1998-04-08 Verfahren zur herstellung eines enantiomers von narwedin ATE253579T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9707413.2A GB9707413D0 (en)	1997-04-11	1997-04-11	Process
PCT/GB1998/001029 WO1998046610A1 (en)	1997-04-11	1998-04-08	Process for preparing single enantiomer narwedine

Publications (1)

Publication Number	Publication Date
ATE253579T1 true ATE253579T1 (de)	2003-11-15

Family

ID=10810680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98915005T ATE253579T1 (de)	1997-04-11	1998-04-08	Verfahren zur herstellung eines enantiomers von narwedin

Country Status (15)

Country	Link
US (1)	US6392038B1 (de)
EP (1)	EP0971930B1 (de)
JP (1)	JP4322317B2 (de)
KR (1)	KR100523125B1 (de)
AT (1)	ATE253579T1 (de)
AU (1)	AU726812B2 (de)
CA (1)	CA2284976C (de)
DE (1)	DE69819479T2 (de)
DK (1)	DK0971930T3 (de)
ES (1)	ES2209125T3 (de)
GB (1)	GB9707413D0 (de)
NO (1)	NO325949B1 (de)
NZ (1)	NZ337962A (de)
PT (1)	PT971930E (de)
WO (1)	WO1998046610A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7307162B2 (en) *	2003-09-26	2007-12-11	Scinopharm Taiwan, Ltd.	Resolution of a narwedine amide derivative
WO2005065662A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Solid dosage formulations of galantamine
EP1763337A2 (de) *	2003-12-31	2007-03-21	Actavis Group HF	Galanthamin-formulierungen mit sofortiger, kontrollierter und gleichmässig hinhaltender wirkstofffreisetzung
WO2006046096A2 (en) *	2004-08-16	2006-05-04	Ranbaxy Laboratories Limited	A polymorphic form of narwedine and its use in the synthesis of galantamine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5428159A (en) *	1994-04-08	1995-06-27	Ciba-Geigy Corporation	Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
ES2106700T3 (es) *	1994-10-21	2000-05-16	Sanochemia Pharmazeutika Ag	Procedimiento para la preparacion de derivados de la 4a,5,9,10,11,12-hexahidro-6h-benzofuro(3a,3,2-ef)(2)benzacepinas.

1997
- 1997-04-11 GB GBGB9707413.2A patent/GB9707413D0/en active Pending
1998
- 1998-04-08 AT AT98915005T patent/ATE253579T1/de active
- 1998-04-08 JP JP54359598A patent/JP4322317B2/ja not_active Expired - Lifetime
- 1998-04-08 PT PT98915005T patent/PT971930E/pt unknown
- 1998-04-08 ES ES98915005T patent/ES2209125T3/es not_active Expired - Lifetime
- 1998-04-08 CA CA002284976A patent/CA2284976C/en not_active Expired - Lifetime
- 1998-04-08 WO PCT/GB1998/001029 patent/WO1998046610A1/en not_active Ceased
- 1998-04-08 NZ NZ337962A patent/NZ337962A/en not_active IP Right Cessation
- 1998-04-08 EP EP98915005A patent/EP0971930B1/de not_active Expired - Lifetime
- 1998-04-08 DK DK98915005T patent/DK0971930T3/da active
- 1998-04-08 US US09/402,722 patent/US6392038B1/en not_active Expired - Lifetime
- 1998-04-08 DE DE69819479T patent/DE69819479T2/de not_active Expired - Lifetime
- 1998-04-08 KR KR10-1999-7009195A patent/KR100523125B1/ko not_active Expired - Lifetime
- 1998-04-08 AU AU69296/98A patent/AU726812B2/en not_active Expired
1999
- 1999-10-08 NO NO19994928A patent/NO325949B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
US6392038B1 (en)	2002-05-21
NZ337962A (en)	2001-05-25
GB9707413D0 (en)	1997-05-28
AU6929698A (en)	1998-11-11
KR100523125B1 (ko)	2005-10-19
WO1998046610A1 (en)	1998-10-22
ES2209125T3 (es)	2004-06-16
EP0971930B1 (de)	2003-11-05
JP4322317B2 (ja)	2009-08-26
NO994928D0 (no)	1999-10-08
NO325949B1 (no)	2008-08-25
DK0971930T3 (da)	2004-01-26
PT971930E (pt)	2004-02-27
AU726812B2 (en)	2000-11-23
JP2001518911A (ja)	2001-10-16
EP0971930A1 (de)	2000-01-19
NO994928L (no)	1999-10-08
KR20010006117A (ko)	2001-01-26
CA2284976C (en)	2006-10-17
DE69819479D1 (de)	2003-12-11
CA2284976A1 (en)	1998-10-22
DE69819479T2 (de)	2004-08-26

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2004-07-15

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