ES2196393T3 - Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos. - Google Patents

Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos.

Info

Publication number
ES2196393T3
ES2196393T3 ES97954636T ES97954636T ES2196393T3 ES 2196393 T3 ES2196393 T3 ES 2196393T3 ES 97954636 T ES97954636 T ES 97954636T ES 97954636 T ES97954636 T ES 97954636T ES 2196393 T3 ES2196393 T3 ES 2196393T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
cancer
resistance
pharmacos
taxoid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97954636T
Other languages
English (en)
Inventor
Iwao Ojima
Ralph J Bernacki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Research Foundation of the State University of New York
Original Assignee
Health Research Inc
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc, Research Foundation of the State University of New York filed Critical Health Research Inc
Application granted granted Critical
Publication of ES2196393T3 publication Critical patent/ES2196393T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS TAXOIDES QUE POSEEN UNA FUERTE ACTIVIDAD DE ANULACION DE LA RESISTENCIA A LOS FARMACOS ASOCIADA A LOS AGENTES ANTICANCEROSOS, A LA PREPARACION DE ESTOS AGENTES DE ANULACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. LOS NUEVOS TAXOIDES DE LA PRESENTE INVENCION TIENEN LA FORMULA (I).
ES97954636T 1997-01-08 1997-12-29 Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos. Expired - Lifetime ES2196393T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/780,633 US5811452A (en) 1997-01-08 1997-01-08 Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ES2196393T3 true ES2196393T3 (es) 2003-12-16

Family

ID=25120175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97954636T Expired - Lifetime ES2196393T3 (es) 1997-01-08 1997-12-29 Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos.

Country Status (12)

Country Link
US (1) US5811452A (es)
EP (1) EP0966456B1 (es)
JP (1) JP2001509150A (es)
KR (1) KR20000069887A (es)
AT (1) ATE236143T1 (es)
AU (1) AU738536B2 (es)
BR (1) BR9714272A (es)
CA (1) CA2276483A1 (es)
DE (1) DE69720535T2 (es)
ES (1) ES2196393T3 (es)
IL (1) IL130669A0 (es)
WO (1) WO1998030553A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6020507A (en) * 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
CA2388063C (en) * 1999-11-24 2010-06-08 Immunogen, Inc. Cytotoxic agents comprising taxanes and their therapeutic use
NZ514406A (en) 2000-02-02 2005-01-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US6596737B2 (en) 2000-02-02 2003-07-22 Fsu Research Foundation, Inc. C10 carbamoyloxy substituted taxanes
WO2001057029A1 (en) * 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
HK1047937A1 (zh) * 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 C7氨基甲酰氧基取代的紫衫烷抗肿瘤剂
TR200102857T1 (tr) 2000-02-02 2002-06-21 Florida State University Research Foundation Inc. Antitümör ajanları olarak C7 karbonat ikameli taksanlar
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
AU2000275771B2 (en) 2000-09-11 2006-06-29 Therapro Technologies, Inc. Thionin as an antineoplastic and immunostimulant
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
ITMI20012186A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
WO2004010937A2 (en) * 2002-07-26 2004-02-05 Advanced Research & Technology Institute At Indiana University Method of treating cancer
BR0313197A (pt) 2002-08-02 2005-08-09 Immunogen Inc Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
US20040132991A1 (en) * 2002-10-09 2004-07-08 Phytogen Life Sciences Inc. Novel taxanes and methods related to use and preparation thereof
CA2501610C (en) * 2002-10-11 2012-01-03 Dana-Farber Cancer Institute Inc Epothilone derivatives for the treatment of multiple myeloma
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
EP1737444A4 (en) 2004-03-05 2008-05-21 Univ Florida State Res Found C7-LACTYLOXA-SUBSTITUTED TAXANE
JP2008530122A (ja) * 2005-02-14 2008-08-07 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ１０シクロプロピルエステル置換タキサン組成物
RS52438B (sr) * 2005-03-31 2013-02-28 Accord Healthcare Inc. Priprema taksana od 9-dihidro-13-acetilbakcatina iii
EP2080764B1 (en) 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
NZ610239A (en) 2008-04-30 2014-11-28 Immunogen Inc Cross-linkers and their uses
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5350866A (en) * 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
EP0966456B1 (en) 2003-04-02
EP0966456A4 (en) 2000-07-26
IL130669A0 (en) 2000-06-01
KR20000069887A (ko) 2000-11-25
AU738536B2 (en) 2001-09-20
AU5903798A (en) 1998-08-03
WO1998030553A1 (en) 1998-07-16
BR9714272A (pt) 2000-04-18
JP2001509150A (ja) 2001-07-10
US5811452A (en) 1998-09-22
ATE236143T1 (de) 2003-04-15
CA2276483A1 (en) 1998-07-16
DE69720535T2 (de) 2004-03-04
DE69720535D1 (de) 2003-05-08
EP0966456A1 (en) 1999-12-29

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