ES2196393T3 - Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos. - Google Patents

Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos.

Info

Publication number
ES2196393T3
ES2196393T3 ES97954636T ES97954636T ES2196393T3 ES 2196393 T3 ES2196393 T3 ES 2196393T3 ES 97954636 T ES97954636 T ES 97954636T ES 97954636 T ES97954636 T ES 97954636T ES 2196393 T3 ES2196393 T3 ES 2196393T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
cancer
resistance
pharmacos
taxoid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97954636T
Other languages
English (en)
Inventor
Iwao Ojima
Ralph J Bernacki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Research Foundation of the State University of New York
Original Assignee
Health Research Inc
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc, Research Foundation of the State University of New York filed Critical Health Research Inc
Application granted granted Critical
Publication of ES2196393T3 publication Critical patent/ES2196393T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS TAXOIDES QUE POSEEN UNA FUERTE ACTIVIDAD DE ANULACION DE LA RESISTENCIA A LOS FARMACOS ASOCIADA A LOS AGENTES ANTICANCEROSOS, A LA PREPARACION DE ESTOS AGENTES DE ANULACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. LOS NUEVOS TAXOIDES DE LA PRESENTE INVENCION TIENEN LA FORMULA (I).
ES97954636T 1997-01-08 1997-12-29 Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos. Expired - Lifetime ES2196393T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/780,633 US5811452A (en) 1997-01-08 1997-01-08 Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ES2196393T3 true ES2196393T3 (es) 2003-12-16

Family

ID=25120175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97954636T Expired - Lifetime ES2196393T3 (es) 1997-01-08 1997-12-29 Agentes taxoides de reversion para la resistencia a farmacos en la quimioterapia del cancer y composiciones farmaceuticas de los mismos.

Country Status (12)

Country Link
US (1) US5811452A (es)
EP (1) EP0966456B1 (es)
JP (1) JP2001509150A (es)
KR (1) KR20000069887A (es)
AT (1) ATE236143T1 (es)
AU (1) AU738536B2 (es)
BR (1) BR9714272A (es)
CA (1) CA2276483A1 (es)
DE (1) DE69720535T2 (es)
ES (1) ES2196393T3 (es)
IL (1) IL130669A0 (es)
WO (1) WO1998030553A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US6020507A (en) * 1998-03-02 2000-02-01 Bristol-Myers Squibb Company Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
ES2276708T3 (es) * 1999-11-24 2007-07-01 Immunogen, Inc. Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
PL350331A1 (en) 2000-02-02 2002-12-02 Univ Florida State Res Found C10 carbamoyloxy substituted taxanes as antitumor agents
HUP0200750A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
HK1047935A1 (zh) 2000-02-02 2003-03-14 佛罗里达州立大学研究基金有限公司 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷
SK13632001A3 (sk) 2000-02-02 2002-06-04 Florida State University Research Foundation, Inc. C10 karbonátom substituované taxány ako protinádorové činidlá
MXPA01009923A (es) 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.
KR20010112395A (ko) * 2000-02-02 2001-12-20 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ７ 카르보네이트 치환된 탁산
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
AU7577100A (en) 2000-09-11 2002-03-26 Therapro Technologies Inc Thionin as an antineoplastic and immunostimulant
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
US20040167139A1 (en) * 2002-07-26 2004-08-26 Potter David A. Methods of treating cancer
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
KR20050032110A (ko) 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
BR0314555A (pt) * 2002-10-11 2005-08-09 Dana Farber Cancer Inst Inc Derivados de epotilona para o tratamento de mieloma múltiplo
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
PA8625301A1 (es) 2004-03-05 2006-06-02 Univ Florida State Res Found Taxanos con sustituyente lactiloxilo en el c7
WO2006088767A2 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
CA2599888C (en) * 2005-03-31 2010-06-15 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
EP2276755A4 (en) * 2008-03-31 2011-05-04 Univ Florida State Res Found C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES
EP2281006B1 (en) 2008-04-30 2017-08-02 Immunogen, Inc. Cross-linkers and their uses
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
EP3319936B1 (en) 2015-07-12 2025-12-17 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
AU2016429272A1 (en) 2016-11-14 2019-05-02 Hangzhou Dac Biotech Co., Ltd. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350866A (en) * 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
EP0966456B1 (en) 2003-04-02
EP0966456A4 (en) 2000-07-26
DE69720535T2 (de) 2004-03-04
JP2001509150A (ja) 2001-07-10
EP0966456A1 (en) 1999-12-29
WO1998030553A1 (en) 1998-07-16
IL130669A0 (en) 2000-06-01
US5811452A (en) 1998-09-22
KR20000069887A (ko) 2000-11-25
AU5903798A (en) 1998-08-03
DE69720535D1 (de) 2003-05-08
ATE236143T1 (de) 2003-04-15
AU738536B2 (en) 2001-09-20
CA2276483A1 (en) 1998-07-16
BR9714272A (pt) 2000-04-18

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