ES2196531T3 - Sintesis de terfenadina y sus derivados. - Google Patents

Sintesis de terfenadina y sus derivados.

Info

Publication number
ES2196531T3
ES2196531T3 ES98901831T ES98901831T ES2196531T3 ES 2196531 T3 ES2196531 T3 ES 2196531T3 ES 98901831 T ES98901831 T ES 98901831T ES 98901831 T ES98901831 T ES 98901831T ES 2196531 T3 ES2196531 T3 ES 2196531T3
Authority
ES
Spain
Prior art keywords
terfenadine
synthesis
derivatives
processes
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98901831T
Other languages
English (en)
Inventor
Chris Hugh Senanayake
Qun Kevin Fang
Scott Harold Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2196531T3 publication Critical patent/ES2196531T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UNOS PROCEDIMIENTOS PARA LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (1), EN LA CUAL R 1A A ES UN CARBOXILO PROTEGIDO, CARBOXILO, HIDROXIMETILO, HIDROXIMETILO PROTEGIDO O METILO. LOS PROCEDIMIENTOS DE LA PRESENTE INVENCION EMPIEZAN POR UN MATERIAL DE SALIDA DE FORMULA GENERAL (II) Y ELABORAN EL PRODUCTO MEDIANTE UNA AMINACION REDUCTORA DE UN ALDEHIDO DE FORMULA (IVA) CON UN AL, AL DIFENIL - 4 - PIPERIDINEMETANOL.
ES98901831T 1997-02-04 1998-01-20 Sintesis de terfenadina y sus derivados. Expired - Lifetime ES2196531T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/803,895 US5925761A (en) 1997-02-04 1997-02-04 Synthesis of terfenadine and derivatives

Publications (1)

Publication Number Publication Date
ES2196531T3 true ES2196531T3 (es) 2003-12-16

Family

ID=25187720

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98901831T Expired - Lifetime ES2196531T3 (es) 1997-02-04 1998-01-20 Sintesis de terfenadina y sus derivados.

Country Status (11)

Country Link
US (2) US5925761A (es)
EP (1) EP0956286B1 (es)
JP (1) JP4330179B2 (es)
AT (1) ATE236148T1 (es)
AU (1) AU724665B2 (es)
CA (1) CA2279960C (es)
DE (1) DE69812895T2 (es)
DK (1) DK0956286T3 (es)
ES (1) ES2196531T3 (es)
PT (1) PT956286E (es)
WO (1) WO1998033789A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
IN191492B (es) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
MXPA03009259A (es) * 2001-04-09 2004-06-03 Teva Pharma Polimorfos de clorhidrato de fexofenadina.
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
WO2003104197A1 (en) * 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
SK285548B6 (sk) * 2002-11-13 2007-03-01 Zentiva, A. S. Spôsob prípravy terfenadinu a jeho derivátov
WO2005102999A2 (en) * 2004-04-26 2005-11-03 Teva Pharmaceutical Industries Ltd. Crystalline forms of fexofenadine hydrochloride and processes for their preparation
EP1685106A2 (en) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadine crystal form and processes for its preparation thereof
WO2007135693A2 (en) * 2006-05-18 2007-11-29 Ind-Swift Laboratories Limited Intermediates useful for the preparation of antihistaminic piperidine derivative
CA2663401C (en) 2006-09-15 2011-07-12 Pfizer Products Inc. Pyrido (2, 3-d) pyrimidinone compounds and their use as pi3 inhibitors
US7868200B2 (en) * 2008-12-30 2011-01-11 Lyondellbasell Flavors & Fragrances, Llc Process for preparing alicyclic carboxylic acid compounds
KR102233327B1 (ko) * 2013-12-26 2021-03-26 스미또모 가가꾸 가부시끼가이샤 할로겐 치환 프탈리드의 제조 방법
CN104876853B (zh) * 2015-06-17 2017-06-16 苏州卫生职业技术学院 盐酸非索非那定的合成方法
US10092087B2 (en) 2016-06-03 2018-10-09 Israel Harry Zimmerman Self-righting toothbrush
US10485330B2 (en) 2017-02-20 2019-11-26 Israel Harry Zimmerman Self-righting toothbrush
US10517386B2 (en) 2017-03-30 2019-12-31 Israel Harry Zimmerman Self-righting toothbrush
USD874832S1 (en) 2018-03-23 2020-02-11 Israel Harry Zimmerman Toothbrush handle
USD876097S1 (en) 2018-03-23 2020-02-25 Israel Harry Zimmerman Toothbrush handle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141024A (en) * 1964-07-14 S-trimethoxy benzoyl amino
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
EP0479601B1 (en) * 1990-10-05 1999-12-15 Ajinomoto Co., Inc. Piperidine derivatives and their use as antiarrhythmic agents
RU2167657C2 (ru) * 1992-08-03 2001-05-27 Сепракор, Инк. Фармацевтическая композиция для лечения аллергических заболеваний, способ антигистаминного лечения, применение композиции для получения лекарственного препарата
DK1026147T3 (da) * 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater
CA2362337C (en) * 1993-06-25 2005-08-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
PT759904E (pt) * 1994-05-16 2000-10-31 Merrell Pharma Inc Processo e sais diastereomericos uteis para a resolucao optica de alfa-¬4-(1,1-dimetiletil)-fenil|-4-(hidroxidifenilmetil)-1-piperidinobutanol racemico e compostos derivados

Also Published As

Publication number Publication date
AU5826298A (en) 1998-08-25
WO1998033789A1 (en) 1998-08-06
DE69812895D1 (de) 2003-05-08
CA2279960A1 (en) 1998-08-06
US5925761A (en) 1999-07-20
CA2279960C (en) 2007-07-17
EP0956286B1 (en) 2003-04-02
DK0956286T3 (da) 2003-07-14
EP0956286A1 (en) 1999-11-17
JP4330179B2 (ja) 2009-09-16
AU724665B2 (en) 2000-09-28
ATE236148T1 (de) 2003-04-15
JP2001511144A (ja) 2001-08-07
DE69812895T2 (de) 2004-04-22
PT956286E (pt) 2003-08-29
US6147217A (en) 2000-11-14

Similar Documents

Publication Publication Date Title
PT956286E (pt) Sintese de terfenadina e derivados
DK1054860T3 (da) Proces for syntesen af 1,3-dioler
NO995846D0 (no) Oksazolidinon-antibakterielle midler med en tiokarbonylfunksjonalitet
AU1676200A (en) Polyhydroxylated heterocyclic derivatives as anti-coagulants
BR9804214A (pt) Compostos.
BR0208338A (pt) Derivados de piridina
AR038427A2 (es) Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
NO20025186D0 (no) FremgangsmÕte for syntese av en ecteinascidinforbindelse
IT1313663B1 (it) Alcossiammine eterocicliche come regolatori in procedimenti dipolimerizzazione a radicali controllati.
HN1998000036A (es) Compuesto de pirazina
SE9702773D0 (sv) Novel compounds
MY122453A (en) Derivatives of benzoxadiazoles, benzothiadiazoles, benzotriazoles and quinoxalines
TR199800182T1 (xx) 2-oksazolidinon t�revlerinin bir kapta sentezi.
BR0209901A (pt) Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina
BR0115996A (pt) Sulfamidotienopirimidinas
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
NO20002600D0 (no) Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
DE60017374D1 (de) Antibakterielle mittel
MX9708510A (es) Tetralinas.
EP1536821A4 (en) INHIBITION OF T CELL ACTIVATION BY BUTYROPHILIN A AND B7-L1
DE69703115D1 (de) Zwischenprodukte um 2-imidazolin-5onederivate herzustellen.
NO20001896D0 (no) Fremgangsmõte for syntese av klorpurinmellomprodukter
TR200003203T2 (tr) Karboksaldehitin saflaştırılması
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona