DK1054860T3 - Proces for syntesen af 1,3-dioler - Google Patents

Proces for syntesen af 1,3-dioler

Info

Publication number: DK1054860T3
Authority: DK; Denmark
Prior art keywords: diols; synthesis
Prior art date: 1997-12-19

Application number

DK98961855T

Other languages

English (en)

Inventor

Richard Joseph Mccabe

Robert Lee Bosch

Robert Joseph Stahl

Thomas Norman Nanninga

Original Assignee

Pfizer Ireland Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-19

Filing date

1998-12-02

Publication date

2007-07-02

1998-12-02 Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals

2007-07-02 Application granted granted Critical

2007-07-02 Publication of DK1054860T3 publication Critical patent/DK1054860T3/da

Links

150000000185 1,3-diols Chemical class 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)

DK98961855T 1997-12-19 1998-12-02 Proces for syntesen af 1,3-dioler DK1054860T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6819397P	1997-12-19	1997-12-19
PCT/US1998/025493 WO1999032434A1 (en)	1997-12-19	1998-12-02	Process for the synthesis of 1,3-diols

Publications (1)

Publication Number	Publication Date
DK1054860T3 true DK1054860T3 (da)	2007-07-02

Family

ID=22081016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98961855T DK1054860T3 (da)	1997-12-19	1998-12-02	Proces for syntesen af 1,3-dioler

Country Status (31)

Country	Link
US (4)	US6433213B1 (da)
EP (1)	EP1054860B1 (da)
JP (1)	JP2001526256A (da)
KR (2)	KR100668575B1 (da)
AR (1)	AR014943A1 (da)
AT (1)	ATE360608T1 (da)
AU (1)	AU755543B2 (da)
BR (1)	BR9813760A (da)
CA (1)	CA2305618C (da)
CO (1)	CO4990941A1 (da)
CU (1)	CU22939A3 (da)
CY (1)	CY1106612T1 (da)
DE (1)	DE69837681T2 (da)
DK (1)	DK1054860T3 (da)
ES (1)	ES2284219T3 (da)
GT (2)	GT199800197A (da)
HN (1)	HN1998000187A (da)
HU (1)	HUP0100252A3 (da)
IL (1)	IL135562A (da)
IS (1)	IS5447A (da)
MY (1)	MY118726A (da)
NO (1)	NO20003139D0 (da)
NZ (1)	NZ504346A (da)
PA (1)	PA8464901A1 (da)
PE (1)	PE20000136A1 (da)
PL (1)	PL193678B1 (da)
PT (1)	PT1054860E (da)
SV (1)	SV1998000153A (da)
TW (1)	TW444000B (da)
WO (1)	WO1999032434A1 (da)
ZA (1)	ZA9811586B (da)

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EP1584616A1 (en)	1999-12-17	2005-10-12	Pfizer Science and Technology Ireland Limited	Industrial process for the production of crystalline atorvastatin trihydrate hemi calcium salt
ES2258030T3 (es)	1999-12-17	2006-08-16	Pfizer Science And Technology Ireland Limited	Procedimiento para producir atorvastatina calcio cristalina.
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EP1404642B1 (en) *	2001-07-06	2010-02-17	Basf Se	Process for the preparatiom of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
MXPA03012045A (es)	2001-07-06	2004-03-29	Teva Pharma	Proceso para preparar derivados del acido 7-amino sin 3,5-dihidroxi heptanoico a traves de derivados del acido 6-ciano sin 3,5-dihidroxi hexanoico.
GB0211715D0 (en)	2002-05-22	2002-07-03	Phoenix Chemicals Ltd	Process
AU2003251523A1 (en)	2002-06-13	2003-12-31	Diversa Corporation	Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
US7132267B2 (en) *	2002-08-09	2006-11-07	Codexis, Inc.	Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
WO2004015132A2 (en) *	2002-08-09	2004-02-19	Codexis, Inc.	Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
ES2323366T3 (es) *	2003-04-22	2009-07-14	Biocon Limited	Procedimiento novedoso para la reduccion estereoselectiva de beta-cetoesteres.
US7790197B2 (en) *	2003-06-09	2010-09-07	Warner-Lambert Company Llc	Pharmaceutical compositions of atorvastatin
US7655692B2 (en) *	2003-06-12	2010-02-02	Pfizer Inc.	Process for forming amorphous atorvastatin
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JP2007502114A (ja) *	2003-08-11	2007-02-08	コデクシス，インコーポレイテッド	改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
CA2535255A1 (en) *	2003-08-11	2005-02-24	Codexis, Inc.	Improved halohydrin dehalogenases and related polynucleotides
JP2007502124A (ja) *	2003-08-11	2007-02-08	コデクシス，インコーポレイテッド	改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
US7588928B2 (en) *	2003-08-11	2009-09-15	Codexis, Inc.	Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) *	2003-08-11	2009-06-02	Codexis, Inc.	Halohydrin dehalogenases and related polynucleotides
CN101318923A (zh) *	2003-09-17	2008-12-10	沃尼尔·朗伯有限责任公司	[R－(R,R)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯基氨基)羰基]－1H－吡咯－1－庚酸的结晶形式
AU2003272080A1 (en) *	2003-09-18	2005-04-06	Biocon Limited	Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7851624B2 (en) *	2003-12-24	2010-12-14	Teva Pharamaceutical Industries Ltd.	Triol form of rosuvastatin and synthesis of rosuvastatin
CA2550742A1 (en) *	2003-12-24	2005-07-14	Teva Pharmaceutical Industries Ltd.	Process for preparation of statins with high syn to anti ratio
CN1960972A (zh) *	2004-04-16	2007-05-09	辉瑞产品公司	用于形成无定形阿托伐它汀钙的方法
CA2649054A1 (en)	2004-05-05	2005-11-10	Pfizer Products Inc.	Salt forms of [r-(r,r)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
CA2573969C (en) *	2004-07-16	2014-02-04	Lek Pharmaceuticals D.D.	Oxidative degradation products of atorvastatin calcium
JP2008506764A (ja)	2004-07-20	2008-03-06	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β、δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸カルシウム塩（２：１）の新規形態
WO2006046109A1 (en)	2004-10-28	2006-05-04	Warner-Lambert Company Llc	Process for forming amorphous atorvastatin
AP2007003979A0 (en)	2004-11-23	2007-06-30	Warner Lambert Co	7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
JP2008521878A (ja) *	2004-12-02	2008-06-26	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	非晶質アトルバスタチンの医薬組成物及びその製造のための方法
ATE432276T1 (de) *	2005-09-09	2009-06-15	Pfizer Science & Tech Ltd	Herstellung eines atorvastatin-zwischenprodukts
CA2621507A1 (en) *	2005-09-09	2007-03-15	Pfizer Science And Technology Ireland Limited	Preparation of an atorvastatin intermediate
CA2547216A1 (en) *	2005-09-21	2007-03-21	Renuka D. Reddy	Process for annealing amorphous atorvastatin
ATE466840T1 (de)	2005-11-21	2010-05-15	Warner Lambert Co	Neue formen von är-(r,r)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-( -methylethyl)-3-phenyl-4- ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure magnesium
WO2008042876A2 (en)	2006-10-02	2008-04-10	Codexis, Inc.	Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
DK2115153T3 (da)	2007-03-01	2013-09-08	Bp Corp North America Inc	Nitrilaser, nucleinsyrer som koder for dem og fremgangsmåder til at fremstille og anvende disse
WO2009137691A2 (en) *	2008-05-09	2009-11-12	The Scripps Research Institute	1,3-diol synthesis via controlled, radical-mediated c-h functionalization
WO2010080635A2 (en) *	2008-12-18	2010-07-15	Codexis, Inc.	Recombinant halohydrin dehalogenase polypeptides
EP2327682A1 (en)	2009-10-29	2011-06-01	KRKA, D.D., Novo Mesto	Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2373609B1 (en)	2008-12-19	2013-10-16	KRKA, D.D., Novo Mesto	Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
US9273158B2 (en)	2011-05-16	2016-03-01	The Regents Of The University Of California	Methods for production of hydrocarbons and oxygen-containing hyrdrocarbons
US20140335179A1 (en)	2011-07-01	2014-11-13	Dsm Sinochem Pharmaceuticals Netherlands B.V.	Micronized crystals of atorvastatin hemicalcium
CN108033899B (zh) *	2017-12-06	2020-04-10	浙江科技学院	一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN111978286A (zh) *	2020-08-21	2020-11-24	江苏万年长药业有限公司	一种制备ats-8的方法

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1998
- 1998-12-02 EP EP98961855A patent/EP1054860B1/en not_active Expired - Lifetime
- 1998-12-02 IL IL13556298A patent/IL135562A/xx not_active IP Right Cessation
- 1998-12-02 DE DE69837681T patent/DE69837681T2/de not_active Expired - Fee Related
- 1998-12-02 CA CA002305618A patent/CA2305618C/en not_active Expired - Fee Related
- 1998-12-02 PL PL98341294A patent/PL193678B1/pl not_active IP Right Cessation
- 1998-12-02 DK DK98961855T patent/DK1054860T3/da active
- 1998-12-02 BR BR9813760-3A patent/BR9813760A/pt not_active Application Discontinuation
- 1998-12-02 JP JP2000525371A patent/JP2001526256A/ja not_active Abandoned
- 1998-12-02 AU AU17074/99A patent/AU755543B2/en not_active Ceased
- 1998-12-02 KR KR1020007006762A patent/KR100668575B1/ko not_active Expired - Fee Related
- 1998-12-02 PT PT98961855T patent/PT1054860E/pt unknown
- 1998-12-02 US US09/581,798 patent/US6433213B1/en not_active Expired - Fee Related
- 1998-12-02 KR KR1020067012766A patent/KR100681366B1/ko not_active Expired - Fee Related
- 1998-12-02 HU HU0100252A patent/HUP0100252A3/hu unknown
- 1998-12-02 AT AT98961855T patent/ATE360608T1/de not_active IP Right Cessation
- 1998-12-02 WO PCT/US1998/025493 patent/WO1999032434A1/en not_active Ceased
- 1998-12-02 ES ES98961855T patent/ES2284219T3/es not_active Expired - Lifetime
- 1998-12-02 NZ NZ504346A patent/NZ504346A/en unknown
- 1998-12-09 HN HN1998000187A patent/HN1998000187A/es unknown
- 1998-12-14 GT GT199800197A patent/GT199800197A/es unknown
- 1998-12-14 GT GT199800197AK patent/GT199800197AA/es unknown
- 1998-12-17 ZA ZA9811586A patent/ZA9811586B/xx unknown
- 1998-12-17 MY MYPI98005721A patent/MY118726A/en unknown
- 1998-12-18 SV SV1998000153A patent/SV1998000153A/es not_active Application Discontinuation
- 1998-12-18 PA PA19988464901A patent/PA8464901A1/es unknown
- 1998-12-18 CO CO98075429A patent/CO4990941A1/es unknown
- 1998-12-18 AR ARP980106461A patent/AR014943A1/es active IP Right Grant
- 1998-12-18 TW TW087121215A patent/TW444000B/zh not_active IP Right Cessation
- 1998-12-18 PE PE1998001245A patent/PE20000136A1/es not_active Application Discontinuation
2000
- 2000-04-14 IS IS5447A patent/IS5447A/is unknown
- 2000-06-09 CU CU20000144A patent/CU22939A3/es not_active IP Right Cessation
- 2000-06-16 NO NO20003139A patent/NO20003139D0/no not_active Application Discontinuation
2002
- 2002-06-11 US US10/166,990 patent/US6596879B2/en not_active Expired - Fee Related
2003
- 2003-04-11 US US10/411,886 patent/US6962994B2/en not_active Expired - Fee Related
2005
- 2005-04-29 US US11/119,151 patent/US7232915B2/en not_active Expired - Fee Related
2007
- 2007-05-21 CY CY20071100687T patent/CY1106612T1/el unknown

Also Published As

Publication number	Publication date
MY118726A (en)	2005-01-31
KR100668575B1 (ko)	2007-01-17
CA2305618C (en)	2004-08-17
ZA9811586B (en)	1999-06-17
US20020161021A1 (en)	2002-10-31
JP2001526256A (ja)	2001-12-18
AR014943A1 (es)	2001-04-11
PT1054860E (pt)	2007-06-22
IL135562A0 (en)	2001-05-20
EP1054860B1 (en)	2007-04-25
PL341294A1 (en)	2001-04-09
KR20010033315A (ko)	2001-04-25
CY1106612T1 (el)	2012-01-25
CO4990941A1 (es)	2000-12-26
HUP0100252A3 (en)	2002-12-28
DE69837681D1 (de)	2007-06-06
GT199800197A (es)	2000-06-06
AU755543B2 (en)	2002-12-12
KR100681366B1 (ko)	2007-02-12
WO1999032434A1 (en)	1999-07-01
NO20003139L (no)	2000-06-16
PL193678B1 (pl)	2007-03-30
IL135562A (en)	2005-08-31
AU1707499A (en)	1999-07-12
US20050197500A1 (en)	2005-09-08
ATE360608T1 (de)	2007-05-15
IS5447A (is)	2000-04-14
EP1054860A1 (en)	2000-11-29
HN1998000187A (es)	1999-10-22
CA2305618A1 (en)	1999-07-01
SV1998000153A (es)	1999-09-30
PE20000136A1 (es)	2000-03-11
US7232915B2 (en)	2007-06-19
US6596879B2 (en)	2003-07-22
US20040006231A1 (en)	2004-01-08
KR20060080941A (ko)	2006-07-11
PA8464901A1 (es)	2000-05-24
CU22939A3 (es)	2004-04-13
US6962994B2 (en)	2005-11-08
DE69837681T2 (de)	2008-01-10
HUP0100252A1 (hu)	2001-07-30
US6433213B1 (en)	2002-08-13
GT199800197AA (es)	2000-06-06
ES2284219T3 (es)	2007-11-01
NO20003139D0 (no)	2000-06-16
NZ504346A (en)	2001-11-30
BR9813760A (pt)	2000-10-03
TW444000B (en)	2001-07-01

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