ES2196614T3 - Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3. - Google Patents

Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3.

Info

Publication number
ES2196614T3
ES2196614T3 ES98952587T ES98952587T ES2196614T3 ES 2196614 T3 ES2196614 T3 ES 2196614T3 ES 98952587 T ES98952587 T ES 98952587T ES 98952587 T ES98952587 T ES 98952587T ES 2196614 T3 ES2196614 T3 ES 2196614T3
Authority
ES
Spain
Prior art keywords
carbon atoms
dihidroxi
dialquil
analogs
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98952587T
Other languages
English (en)
Inventor
Percy Sarwood Manchand
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2196614T3 publication Critical patent/ES2196614T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto seleccionado del grupo de compuestos representados por la fórmula (I)**fórmula** en donde: X es hidrógeno o =CH2; R1 y R2 juntamente con el carbono 20 forman un ciclo- alquilo de 3 a 6 átomos de carbono o un ciclofluoralquilo de 3 a 6 átomos de carbono; R3 y R4 son, independientemente entre sí, un alquilo de 1 a 4 átomos de carbono o un fluoralquilo de 1 a 4 átomos de carbono ó R3 y R4 juntamente con el carbono 25 forman un cicloalquilo de 3 a 9 átomos de carbono o un ciclofluor- alquilo de 3 a 9 átomos de carbono; A es un enlace sencillo, y B es un enlace triple.
ES98952587T 1997-09-08 1998-09-02 Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3. Expired - Lifetime ES2196614T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5813297P 1997-09-08 1997-09-08

Publications (1)

Publication Number Publication Date
ES2196614T3 true ES2196614T3 (es) 2003-12-16

Family

ID=22014900

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98952587T Expired - Lifetime ES2196614T3 (es) 1997-09-08 1998-09-02 Analogos de la 1-3-dihidroxi-20,20-dialquil-vitamina d3.

Country Status (9)

Country Link
US (3) US6492353B1 (es)
EP (1) EP1015423B1 (es)
JP (1) JP4219553B2 (es)
AT (1) ATE238986T1 (es)
AU (1) AU1022999A (es)
CA (1) CA2303248A1 (es)
DE (1) DE69814109T2 (es)
ES (1) ES2196614T3 (es)
WO (1) WO1999012894A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19916419B4 (de) * 1999-04-08 2005-06-16 Schering Ag Kombinationspräparat aus Vitamin-D-Metaboliten oder Vitamin-D-Analoga und einem Östrogenpartialagonisten zur Behandlung von Osteoporose
DK1267886T3 (da) * 2000-03-27 2006-07-10 Wisconsin Alumni Res Found D-vitaminforbindelser anvendt til at stabilisere nyretransplantater
ATE509014T1 (de) * 2001-01-26 2011-05-15 Chugai Pharmaceutical Co Ltd Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
EP1392323B1 (en) * 2001-05-22 2008-10-08 Bioxell S.p.a. Use of a vitamin d3 analogue for the treatment of autoimmune diabetes
RU2296121C2 (ru) * 2001-09-21 2007-03-27 Ф.Хоффманн-Ля Рош Аг Соединения, способ их получения, способы лечения
US20050107350A1 (en) * 2003-08-22 2005-05-19 Pharmacia Corporation Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
AU2004275815A1 (en) * 2003-09-24 2005-04-07 Bioxell S.P.A. 1,3-diaclyated,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof
CA2580962A1 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin d3 compounds and methods of use thereof
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
WO2006093291A1 (ja) * 2005-03-04 2006-09-08 Tokyo Medical And Dental University １９－ノルビタミンｄ誘導体
WO2007039322A1 (en) * 2005-09-19 2007-04-12 Bioxell Spa Use of vitamin d3 compounds for the treatment of uveitis
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8415390B2 (en) 2008-05-30 2013-04-09 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US20120077786A1 (en) * 2010-09-27 2012-03-29 Byron David A Methods and compositions for disease treatment using inhalation
US9018194B2 (en) * 2011-03-02 2015-04-28 Nibon University Vitamin D receptor modulators with partial agonist activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5206229A (en) * 1988-04-21 1993-04-27 Leo Pharmaceutical Products Ltd Vitamin d analogues
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
DE69213844T2 (de) 1991-07-05 1997-04-10 Duphar Int Res Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
DK0580968T3 (da) * 1992-05-20 1996-10-14 Hoffmann La Roche Fluorerede analoger af vitamin D3
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
IL107185A (en) 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
AU699200B2 (en) * 1993-07-09 1998-11-26 Roger Bouillon Novel structural analogues of vitamin D
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
NZ307549A (en) * 1995-06-14 1999-11-29 Schering Ag Novel vitamin d derivatives with c-25 substituents, process for their preparation, intermediate products and their use in preparing medicaments
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
DE69832699T2 (de) * 1997-05-16 2006-08-24 Woman & Infants Hospital Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen

Also Published As

Publication number Publication date
US20030083319A1 (en) 2003-05-01
WO1999012894A1 (en) 1999-03-18
EP1015423B1 (en) 2003-05-02
US20040167105A1 (en) 2004-08-26
AU1022999A (en) 1999-03-29
DE69814109D1 (de) 2003-06-05
DE69814109T2 (de) 2004-02-26
JP2001515881A (ja) 2001-09-25
US6492353B1 (en) 2002-12-10
CA2303248A1 (en) 1999-03-18
ATE238986T1 (de) 2003-05-15
JP4219553B2 (ja) 2009-02-04
EP1015423A1 (en) 2000-07-05

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