ES2196900T3 - Procedimiento para la preparacion de alfa-aminonitrilos opticamente activos. - Google Patents

Procedimiento para la preparacion de alfa-aminonitrilos opticamente activos.

Info

Publication number
ES2196900T3
ES2196900T3 ES99962574T ES99962574T ES2196900T3 ES 2196900 T3 ES2196900 T3 ES 2196900T3 ES 99962574 T ES99962574 T ES 99962574T ES 99962574 T ES99962574 T ES 99962574T ES 2196900 T3 ES2196900 T3 ES 2196900T3
Authority
ES
Spain
Prior art keywords
aminonitrile
alpha
enantiomers
preparation
acylase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99962574T
Other languages
English (en)
Inventor
Peter Jan Leonard M Quaedflieg
Theodorus Sonke
Adolf Fritz Volker Wagner
Quirinus Bernardus Broxterman
Wilhelmus Hubertus Jos Boesten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of ES2196900T3 publication Critical patent/ES2196900T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Procedimiento para la preparación de un a-aminonitrilo con pureza óptica mejorada, en el que una mezcla de los enantiómeros de un N-formil-a-aminonitrilo quiral se pone en contacto con una acilasa, mediante lo cual uno de los enantiómeros del N-formil-aminonitrilo se desformila selectivamente en el correspondiente a-aminonitrilo desprotegido.
ES99962574T 1998-12-22 1999-12-17 Procedimiento para la preparacion de alfa-aminonitrilos opticamente activos. Expired - Lifetime ES2196900T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98204370A EP1013773A1 (en) 1998-12-22 1998-12-22 Process for the preparation of optically active alpha-aminonitriles

Publications (1)

Publication Number Publication Date
ES2196900T3 true ES2196900T3 (es) 2003-12-16

Family

ID=8234515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99962574T Expired - Lifetime ES2196900T3 (es) 1998-12-22 1999-12-17 Procedimiento para la preparacion de alfa-aminonitrilos opticamente activos.

Country Status (9)

Country Link
EP (2) EP1013773A1 (es)
JP (1) JP2002533091A (es)
AT (1) ATE236990T1 (es)
AU (1) AU1898000A (es)
DE (1) DE69906802T2 (es)
DK (1) DK1141369T3 (es)
ES (1) ES2196900T3 (es)
PT (1) PT1141369E (es)
WO (1) WO2000037668A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1352894A1 (en) 2002-04-09 2003-10-15 DSM IP Assets B.V. Process for the preparation of enantiomerically enriched compounds
US7067291B2 (en) 2002-12-20 2006-06-27 Pfizer Inc. Biocatalytic preparation of enantiomerically enriched aminopentanenitrile

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929570A1 (de) * 1989-09-06 1991-03-07 Degussa Mikrobiologisch hergestellte n-acyl-l-prolin-acylase, verfahren zu ihrer gewinnung und ihre verwendung

Also Published As

Publication number Publication date
PT1141369E (pt) 2003-08-29
DE69906802T2 (de) 2003-12-24
EP1141369B1 (en) 2003-04-09
ATE236990T1 (de) 2003-04-15
JP2002533091A (ja) 2002-10-08
EP1141369A1 (en) 2001-10-10
AU1898000A (en) 2000-07-12
DE69906802D1 (de) 2003-05-15
EP1013773A1 (en) 2000-06-28
WO2000037668A1 (en) 2000-06-29
DK1141369T3 (da) 2003-08-04

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