ES2235026T3 - Composicion de implante oseo a base de fosfato/sulfato calcico. - Google Patents

Composicion de implante oseo a base de fosfato/sulfato calcico.

Info

Publication number: ES2235026T3
Authority: ES; Spain
Prior art keywords: calcium; composition according; ions; composition; source
Prior art date: 2001-05-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES02720293T

Other languages

English (en)

Spanish (es)

Inventor

John Joseph Biocomposites Limited COOPER

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biocomposites Ltd

Original Assignee

Biocomposites Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-02

Filing date

2002-05-01

Publication date

2005-07-01

2002-05-01 Application filed by Biocomposites Ltd filed Critical Biocomposites Ltd

2005-07-01 Application granted granted Critical

2005-07-01 Publication of ES2235026T3 publication Critical patent/ES2235026T3/es

2022-05-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 54
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Inorganic materials [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 title claims abstract description 44
239000007943 implant Substances 0.000 title claims abstract description 8
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 16
239000001506 calcium phosphate Substances 0.000 title claims description 11
229910000389 calcium phosphate Inorganic materials 0.000 title claims description 4
235000011010 calcium phosphates Nutrition 0.000 title claims description 4
235000011132 calcium sulphate Nutrition 0.000 title description 10
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title 1
239000001175 calcium sulphate Substances 0.000 title 1
210000000988 bone and bone Anatomy 0.000 claims abstract description 27
-1 orthophosphate ions Chemical class 0.000 claims abstract description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 10
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 7
239000000292 calcium oxide Substances 0.000 claims abstract description 7
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 7
150000001875 compounds Chemical class 0.000 claims abstract description 7
150000002500 ions Chemical class 0.000 claims abstract description 7
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 6
229910001424 calcium ion Inorganic materials 0.000 claims abstract description 6
239000000395 magnesium oxide Substances 0.000 claims abstract description 6
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 6
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 6
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims abstract description 5
239000001095 magnesium carbonate Substances 0.000 claims abstract description 5
229910000021 magnesium carbonate Inorganic materials 0.000 claims abstract description 5
239000011787 zinc oxide Substances 0.000 claims abstract description 5
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 4
239000000920 calcium hydroxide Substances 0.000 claims abstract description 4
229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 4
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims abstract description 4
239000000347 magnesium hydroxide Substances 0.000 claims abstract description 4
229910001862 magnesium hydroxide Inorganic materials 0.000 claims abstract description 4
UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 claims abstract description 4
229940007718 zinc hydroxide Drugs 0.000 claims abstract description 4
229910021511 zinc hydroxide Inorganic materials 0.000 claims abstract description 4
239000000843 powder Substances 0.000 claims description 10
239000002245 particle Substances 0.000 claims description 9
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 9
239000008187 granular material Substances 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 6
239000007787 solid Substances 0.000 claims description 6
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 5
230000003115 biocidal effect Effects 0.000 claims description 4
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 4
239000008116 calcium stearate Substances 0.000 claims description 4
235000013539 calcium stearate Nutrition 0.000 claims description 4
230000000921 morphogenic effect Effects 0.000 claims description 4
102000004169 proteins and genes Human genes 0.000 claims description 4
108090000623 proteins and genes Proteins 0.000 claims description 4
239000003826 tablet Substances 0.000 claims description 4
235000019739 Dicalciumphosphate Nutrition 0.000 claims description 3
239000003242 anti bacterial agent Substances 0.000 claims description 3
230000000118 anti-neoplastic effect Effects 0.000 claims description 3
239000007864 aqueous solution Substances 0.000 claims description 3
FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 3
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 3
229910001634 calcium fluoride Inorganic materials 0.000 claims description 3
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 3
229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 3
229940038472 dicalcium phosphate Drugs 0.000 claims description 3
150000004683 dihydrates Chemical class 0.000 claims description 3
239000010459 dolomite Substances 0.000 claims description 3
229910000514 dolomite Inorganic materials 0.000 claims description 3
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 3
229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
239000001354 calcium citrate Substances 0.000 claims description 2
ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims description 2
235000013337 tricalcium citrate Nutrition 0.000 claims description 2
159000000007 calcium salts Chemical class 0.000 claims 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 1
229940095672 calcium sulfate Drugs 0.000 description 9
229910052588 hydroxylapatite Inorganic materials 0.000 description 8
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 8
229910000391 tricalcium phosphate Inorganic materials 0.000 description 4
235000019731 tricalcium phosphate Nutrition 0.000 description 4
229940078499 tricalcium phosphate Drugs 0.000 description 4
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
239000011777 magnesium Substances 0.000 description 3
229910052749 magnesium Inorganic materials 0.000 description 3
239000000463 material Substances 0.000 description 3
238000000034 method Methods 0.000 description 3
239000011505 plaster Substances 0.000 description 3
102000002265 Human Growth Hormone Human genes 0.000 description 2
108010000521 Human Growth Hormone Proteins 0.000 description 2
239000000854 Human Growth Hormone Substances 0.000 description 2
210000000601 blood cell Anatomy 0.000 description 2
239000000316 bone substitute Substances 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
239000004568 cement Substances 0.000 description 2
238000002513 implantation Methods 0.000 description 2
230000005541 medical transmission Effects 0.000 description 2
229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
229910052586 apatite Inorganic materials 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000002639 bone cement Substances 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229940043430 calcium compound Drugs 0.000 description 1
150000001674 calcium compounds Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000007547 defect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000004927 fusion Effects 0.000 description 1
229960002518 gentamicin Drugs 0.000 description 1
230000035876 healing Effects 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
230000028993 immune response Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
208000014674 injury Diseases 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000009545 invasion Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000000465 moulding Methods 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
230000001599 osteoclastic effect Effects 0.000 description 1
230000002188 osteogenic effect Effects 0.000 description 1
230000001009 osteoporotic effect Effects 0.000 description 1
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical class [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
230000003239 periodontal effect Effects 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000008733 trauma Effects 0.000 description 1

Classifications

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- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2310/00005—The prosthesis being constructed from a particular material
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Composite Materials (AREA)
Inorganic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Prostheses (AREA)

ES02720293T 2001-05-02 2002-05-01 Composicion de implante oseo a base de fosfato/sulfato calcico. Expired - Lifetime ES2235026T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB0110726		2001-05-02
GBGB0110726.7A GB0110726D0 (en)	2001-05-02	2001-05-02	Bone implant composition

Publications (1)

Publication Number	Publication Date
ES2235026T3 true ES2235026T3 (es)	2005-07-01

Family

ID=9913856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES02720293T Expired - Lifetime ES2235026T3 (es)	2001-05-02	2002-05-01	Composicion de implante oseo a base de fosfato/sulfato calcico.

Country Status (9)

Country	Link
US (2)	US20040151751A1 (de)
EP (1)	EP1390086B1 (de)
JP (1)	JP2004528904A (de)
CN (1)	CN1265846C (de)
AT (1)	ATE285801T1 (de)
DE (1)	DE60202461T2 (de)
ES (1)	ES2235026T3 (de)
GB (1)	GB0110726D0 (de)
WO (1)	WO2002087649A1 (de)

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US8496955B2 (en)	2001-05-02	2013-07-30	Biocomposites Limited	Calcium phosphate/sulfate-based bone implant composition
SE522098C2 (sv) *	2001-12-20	2004-01-13	Bone Support Ab	Ett nytt benmineralsubstitut
DE60305036T2 (de) *	2002-06-19	2006-10-12	Dr. H.C. Robert Mathys Stiftung	Hydraulischer zement auf basis von calciumphosphat für chirurgische anwendungen
SE0300620D0 (sv) *	2003-03-05	2003-03-05	Bone Support Ab	A new bone substitute composition
WO2005039537A1 (en)	2003-10-22	2005-05-06	Lidds Ab	Composition comprising biodegradable hydrating ceramics for controlled drug delivery
SE0302983D0 (sv) *	2003-11-11	2003-11-11	Bone Support Ab	Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv)	2004-06-22	2006-04-04	Bone Support Ab	Anordning för framställning av härdbar massa samt användning av anordningen
KR100759718B1 (ko)	2004-12-21	2007-10-04	요업기술원	수열 열간 가압법을 이용한 인산칼슘계 다공체 및 그 제조방법
EP1855732A1 (de) *	2005-02-24	2007-11-21	Roland Dricot	Knochenimplantat
CN103349793B (zh)	2005-09-09	2016-02-10	阿格诺沃斯健康关爱公司	复合骨移植替代物水泥以及由其制得的制品
WO2008109165A2 (en) *	2007-03-07	2008-09-12	New York University	Mineralized guided bone regeneration membranes and methods of making the same
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KR101909711B1 (ko) *	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
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ES2816576T3 (es) *	2009-07-16	2021-04-05	Univ Missouri	Andamios con oligoelementos para la regeneración de tejidos en mamíferos
JP5095034B2 (ja) *	2009-12-18	2012-12-12	ハウメディカ・オステオニクス・コーポレイション	照射後貯蔵安定性の直接注入可能なデュアルペースト型骨セメントを製造するシステムおよびリン酸カルシウム組成物
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US9180137B2 (en)	2010-02-09	2015-11-10	Bone Support Ab	Preparation of bone cement compositions
US20120028204A1 (en) *	2010-08-02	2012-02-02	Lazarou Spiros A	Correction of alveolar cleft with calcium-based bone graft materials
JP5894170B2 (ja) *	2010-10-19	2016-03-30	リン，ジン−フェイ，チャン	硬化硫酸カルシウム二水和物ブロックの調製方法とその使用方法
WO2012062360A1 (en)	2010-11-10	2012-05-18	Stryker Trauma Gmbh	Polymeric bone foam composition and method
EP2953581B1 (de)	2013-02-05	2020-09-16	University of Utah Research Foundation	Implantierbare vorrichtungen für knochen- oder gelenkdefekte
US20140234435A1 (en)	2013-02-20	2014-08-21	Bone Support Ab	Setting of hardenable bone substitute
ITMI20130636A1 (it) *	2013-04-18	2014-10-19	Novagenit S R L	Metodo per la preparazione di biomateriali biocompatibili e biodegradabili a base di collagene e granuli di idrossiapatite/¿-tricalcio fosfato per uso in chirurgia ortopedica e biomateriali così ottenuti
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2001
- 2001-05-02 GB GBGB0110726.7A patent/GB0110726D0/en not_active Ceased
2002
- 2002-05-01 CN CNB028091949A patent/CN1265846C/zh not_active Expired - Lifetime
- 2002-05-01 JP JP2002584991A patent/JP2004528904A/ja active Pending
- 2002-05-01 DE DE60202461T patent/DE60202461T2/de not_active Expired - Lifetime
- 2002-05-01 US US10/476,242 patent/US20040151751A1/en not_active Abandoned
- 2002-05-01 WO PCT/GB2002/001986 patent/WO2002087649A1/en not_active Ceased
- 2002-05-01 AT AT02720293T patent/ATE285801T1/de not_active IP Right Cessation
- 2002-05-01 ES ES02720293T patent/ES2235026T3/es not_active Expired - Lifetime
- 2002-05-01 EP EP02720293A patent/EP1390086B1/de not_active Expired - Lifetime
2009
- 2009-01-20 US US12/356,357 patent/US8632796B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE285801T1 (de)	2005-01-15
JP2004528904A (ja)	2004-09-24
EP1390086A1 (de)	2004-02-25
US20090124536A1 (en)	2009-05-14
DE60202461D1 (de)	2005-02-03
GB0110726D0 (en)	2001-06-27
WO2002087649A1 (en)	2002-11-07
CN1265846C (zh)	2006-07-26
DE60202461T2 (de)	2005-12-29
US8632796B2 (en)	2014-01-21
US20040151751A1 (en)	2004-08-05
CN1535165A (zh)	2004-10-06
EP1390086B1 (de)	2004-12-29

Publication	Publication Date	Title
ES2235026T3 (es)	2005-07-01	Composicion de implante oseo a base de fosfato/sulfato calcico.
US5149368A (en)	1992-09-22	Resorbable bioactive calcium phosphate cement
US6224635B1 (en)	2001-05-01	Implantation of surgical implants with calcium sulfate
ES2266226T3 (es)	2007-03-01	Cementos de fosfato de amonio-magnesio, su produccion y utilizacion.
ES2260616T3 (es)	2006-11-01	Cemento hidraulico con base de fosfato de calcio destinado a uso quirurgico.
ES2252254T3 (es)	2006-05-16	Una composicion para un material sustituto de mineral oseo inyectable.
US8420127B2 (en)	2013-04-16	Bone substitute composition
Pietrzak et al.	2000	Calcium sulfate bone void filler: a review and a look ahead
JP3110762B2 (ja)	2000-11-20	吸収可能な生体活性リン酸塩含有セメント
US8496955B2 (en)	2013-07-30	Calcium phosphate/sulfate-based bone implant composition
Georgiade et al.	1993	The use of particulate hydroxyapatite and plaster of Paris in aesthetic and reconstructive surgery
ES2178556B1 (es)	2004-07-16	Cemento de sulfato de calcio con biodegradacion controlada.
Tofighi et al.	2009	New generation of synthetic, bioresorbable and injectable calcium phosphate bone substitute materials: Alpha-bsm®, Beta-bsmTM and Gamma-bsmTM
HK1079464B (en)	2009-12-04	A new bone substitute composition
HK1051676B (en)	2009-06-05	Magnesium-ammonium-phosphate cemente preparation, the production of the same and the use thereof, and the production on the cement