ES2332096T3 - Formulacion de monomero de cianoacrilato que contiene diyodometil-p-tolilsulfona. - Google Patents

Formulacion de monomero de cianoacrilato que contiene diyodometil-p-tolilsulfona. Download PDF

Info

Publication number: ES2332096T3
Authority: ES; Spain
Prior art keywords: cyanoacrylate; formulation; monomer; tolylsulfone; ppm
Prior art date: 2003-09-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES04786514T

Other languages

English (en)

Spanish (es)

Inventor

Binoy K. Bordoloi

Shubhangi R. Bhende

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ethicon Inc

Original Assignee

Ethicon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-08

Filing date

2004-08-16

Publication date

2010-01-26

2004-08-16 Application filed by Ethicon Inc filed Critical Ethicon Inc

2010-01-26 Application granted granted Critical

2010-01-26 Publication of ES2332096T3 publication Critical patent/ES2332096T3/es

2024-08-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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238000009472 formulation Methods 0.000 title claims abstract description 77
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239000000178 monomer Substances 0.000 claims abstract description 80
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229920002301 cellulose acetate Polymers 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
229940106681 chloroacetic acid Drugs 0.000 description 1
230000001332 colony forming effect Effects 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
238000006482 condensation reaction Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
125000004093 cyano group Chemical group *C#N 0.000 description 1
IFOANVWKEDPYCU-UHFFFAOYSA-N cyano penta-2,4-dienoate Chemical class C=CC=CC(=O)OC#N IFOANVWKEDPYCU-UHFFFAOYSA-N 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
RXJJVYBGRFLCOX-UHFFFAOYSA-N dioctyl pentanedioate Chemical compound CCCCCCCCOC(=O)CCCC(=O)OCCCCCCCC RXJJVYBGRFLCOX-UHFFFAOYSA-N 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
TXKMVPPZCYKFAC-UHFFFAOYSA-N disulfur monoxide Inorganic materials O=S=S TXKMVPPZCYKFAC-UHFFFAOYSA-N 0.000 description 1
LFJLAWZRNOKTDN-UHFFFAOYSA-N dodecyl 2-cyanoprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(=C)C#N LFJLAWZRNOKTDN-UHFFFAOYSA-N 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000012530 fluid Substances 0.000 description 1
230000004927 fusion Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
229960004068 hexachlorophene Drugs 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
229960004337 hydroquinone Drugs 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
125000006229 isopropoxyethyl group Chemical group [H]C([H])([H])C([H])(OC([H])([H])C([H])([H])*)C([H])([H])[H] 0.000 description 1
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
238000005259 measurement Methods 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
239000002184 metal Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
125000006178 methyl benzyl group Chemical group 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229960003085 meticillin Drugs 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000011356 non-aqueous organic solvent Substances 0.000 description 1
KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
238000013021 overheating Methods 0.000 description 1
125000005702 oxyalkylene group Chemical group 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
229920001485 poly(butyl acrylate) polymer Polymers 0.000 description 1
229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 1
229920001610 polycaprolactone Polymers 0.000 description 1
239000004632 polycaprolactone Substances 0.000 description 1
229920002721 polycyanoacrylate Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
229940079877 pyrogallol Drugs 0.000 description 1
238000000197 pyrolysis Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229940116351 sebacate Drugs 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical compound S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000010998 test method Methods 0.000 description 1
239000010409 thin film Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 1
JNXDCMUUZNIWPQ-UHFFFAOYSA-N trioctyl benzene-1,2,4-tricarboxylate Chemical compound CCCCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCCC)C(C(=O)OCCCCCCCC)=C1 JNXDCMUUZNIWPQ-UHFFFAOYSA-N 0.000 description 1
BOSMZFBHAYFUBJ-UHFFFAOYSA-N tris(4-methylphenyl) phosphate Chemical compound C1=CC(C)=CC=C1OP(=O)(OC=1C=CC(C)=CC=1)OC1=CC=C(C)C=C1 BOSMZFBHAYFUBJ-UHFFFAOYSA-N 0.000 description 1
231100000402 unacceptable toxicity Toxicity 0.000 description 1
KAKZBPTYRLMSJV-UHFFFAOYSA-N vinyl-ethylene Natural products C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Materials For Medical Uses (AREA)
Adhesives Or Adhesive Processes (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

ES04786514T 2003-09-08 2004-08-16 Formulacion de monomero de cianoacrilato que contiene diyodometil-p-tolilsulfona. Expired - Lifetime ES2332096T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50110003P	2003-09-08	2003-09-08
US501100P		2003-09-08

Publications (1)

Publication Number	Publication Date
ES2332096T3 true ES2332096T3 (es)	2010-01-26

Family

ID=34312246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES04786514T Expired - Lifetime ES2332096T3 (es)	2003-09-08	2004-08-16	Formulacion de monomero de cianoacrilato que contiene diyodometil-p-tolilsulfona.

Country Status (11)

Country	Link
US (1)	US8337881B2 (pt)
EP (1)	EP1667741B1 (pt)
JP (1)	JP2007504853A (pt)
KR (1)	KR20060079802A (pt)
AT (1)	ATE444767T1 (pt)
AU (1)	AU2004271940A1 (pt)
BR (1)	BRPI0414181B8 (pt)
CA (1)	CA2538255C (pt)
DE (1)	DE602004023526D1 (pt)
ES (1)	ES2332096T3 (pt)
WO (1)	WO2005025629A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060093572A1 (en) *	2004-11-03	2006-05-04	Bordoloi Binoy K	Cyanoacrylate monomer formulation containing diiodomethyl-p-tolylsulfone and 2,4,4'-trichloro-2' -hydroxydiphenyl ether
US8609128B2 (en) *	2008-10-31	2013-12-17	Adhezion Biomedical, Llc	Cyanoacrylate-based liquid microbial sealant drape
US9309019B2 (en) *	2010-05-21	2016-04-12	Adhezion Biomedical, Llc	Low dose gamma sterilization of liquid adhesives
WO2019226500A1 (en) *	2018-05-25	2019-11-28	Bergen Medical Products, Inc.	Methods and systems for stable adhesives

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US2721858A (en)	1954-03-10	1955-10-25	Eastman Kodak Co	Method of making alpha-cyanoacrylates
US3254111A (en)	1960-12-09	1966-05-31	Eastman Kodak Co	Esters of alpha-cyanoacrylic acid and process for the manufacture thereof
US3995641A (en)	1975-04-23	1976-12-07	Ethicon, Inc.	Surgical adhesives
JPS56135455A (en)	1980-03-27	1981-10-22	Toagosei Chem Ind Co Ltd	Novel 2-cyanoacrylate and curable composition
US5254132A (en) *	1992-09-01	1993-10-19	Medlogic, Inc.	Methods for treating suturable wounds by use of sutures and cyanoacrylate adhesives
US5981621A (en)	1996-02-29	1999-11-09	Closure Medical Corporation	Monomeric compositions effective as wound closure devices
US5928611A (en)	1995-06-07	1999-07-27	Closure Medical Corporation	Impregnated applicator tip
US5585407A (en) *	1995-07-13	1996-12-17	Minnesota Mining And Manufacturing Company	Water-based coatable compositions comprising reaction products of acrylic emulsion polymers with organoalkoxysilanes
US5829442A (en) *	1996-06-12	1998-11-03	Medical Concepts Development, Inc.	Antimicrobial containing solventless hot melt adhesive composition
US5684042A (en) *	1997-01-10	1997-11-04	Medlogic Global Corporation	Cyanoacrylate compositions comprising an antimicrobial agent
US5730994A (en) *	1997-01-10	1998-03-24	Medlogic Global Corporation	Methods for draping surgical incision sites
WO1998030090A1 (en)	1997-01-10	1998-07-16	Medlogic Global Corporation	Cyanoacrylate compositions comprising an antimicrobial agent
US5855208A (en) *	1997-10-08	1999-01-05	Medlogic Global Corporation	Methods for draping surgical incision sites using a biocompatible prepolymer
US6475502B1 (en)	1997-11-03	2002-11-05	Flowers Park Ltd.	Kits containing cyanoacrylate compositions comprising an antimicrobial agent
US5957877A (en) *	1997-11-03	1999-09-28	Medlogic Global Corporation	Methods for draping surgical sites using peripheral cyanoacrylate drapes
US6090397A (en)	1997-11-03	2000-07-18	Medlogic Global Corporation	Kits containing cyanoacrylate compositions comprising an antimicrobial agent
FI107309B (fi) *	1998-09-25	2001-06-29	Ericsson Telefon Ab L M	Signalointi telekommuunikaatiojärjestelmässä
WO2000035276A1 (en)	1998-12-18	2000-06-22	Medlogic Global Corporation	Cyanoacrylate compositions comprising a soluble antimicrobial agent
US6310166B1 (en) *	1999-08-12	2001-10-30	Closure Medical Corporation	Sterilized cyanoacrylate solutions containing thickeners
US6555125B2 (en) *	1999-11-30	2003-04-29	Phillip Campbell	Lesion and ulcer medication
US6942875B2 (en)	2001-07-05	2005-09-13	Closure Medical Corporation	Adhesive treatment for skin yeast infections
US6767552B2 (en) *	2001-07-05	2004-07-27	Closure Medical Corporation	Adhesive treatment for oral fungal infection
US20030082116A1 (en)	2001-09-28	2003-05-01	Closure Medical Corporation	Adhesive compositions containing dual function stabilizers and active agents
US20060093572A1 (en) *	2004-11-03	2006-05-04	Bordoloi Binoy K	Cyanoacrylate monomer formulation containing diiodomethyl-p-tolylsulfone and 2,4,4'-trichloro-2' -hydroxydiphenyl ether

2004
- 2004-08-16 JP JP2006525344A patent/JP2007504853A/ja not_active Abandoned
- 2004-08-16 EP EP04786514A patent/EP1667741B1/en not_active Expired - Lifetime
- 2004-08-16 AU AU2004271940A patent/AU2004271940A1/en not_active Abandoned
- 2004-08-16 CA CA2538255A patent/CA2538255C/en not_active Expired - Fee Related
- 2004-08-16 US US10/918,891 patent/US8337881B2/en not_active Expired - Fee Related
- 2004-08-16 DE DE602004023526T patent/DE602004023526D1/de not_active Expired - Lifetime
- 2004-08-16 AT AT04786514T patent/ATE444767T1/de not_active IP Right Cessation
- 2004-08-16 ES ES04786514T patent/ES2332096T3/es not_active Expired - Lifetime
- 2004-08-16 WO PCT/US2004/026544 patent/WO2005025629A1/en not_active Ceased
- 2004-08-16 BR BRPI0414181A patent/BRPI0414181B8/pt not_active IP Right Cessation
- 2004-08-16 KR KR1020067004770A patent/KR20060079802A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
EP1667741B1 (en)	2009-10-07
BRPI0414181B1 (pt)	2016-05-24
DE602004023526D1 (en)	2009-11-19
JP2007504853A (ja)	2007-03-08
BRPI0414181B8 (pt)	2021-05-25
KR20060079802A (ko)	2006-07-06
US8337881B2 (en)	2012-12-25
CA2538255C (en)	2012-11-06
ATE444767T1 (de)	2009-10-15
CA2538255A1 (en)	2005-03-24
US20050053578A1 (en)	2005-03-10
EP1667741A1 (en)	2006-06-14
BRPI0414181A (pt)	2006-10-31
WO2005025629A1 (en)	2005-03-24
AU2004271940A1 (en)	2005-03-24

Publication	Publication Date	Title
JP4391686B2 (ja)	2009-12-24	混合シアノアクリル酸エステル組成物
EP0965623B1 (en)	2003-05-02	Stabilized monomer adhesive compositions
US7534907B2 (en)	2009-05-19	Absorbable α-cyanoacrylate compositions
US20100269749A1 (en)	2010-10-28	Absorbable Cyanoacrylate Compositions
ES2398033T3 (es)	2013-03-13	Exotermia controlada de formulaciones de cianoacrilato
WO2013064059A1 (zh)	2013-05-10	一种可生物降解的医用粘合剂及其制备方法和用途
ES2267290T3 (es)	2007-03-01	Metodo para esterilizar composiciones de cianoacrilato.
US9101683B2 (en)	2015-08-11	Wound healing compositions including cyanoacrylate monomers and phenytoin
US20090297469A1 (en)	2009-12-03	Cyanoacrylate Monomer Formulation Containing Diiodomethyl-p-tolylsulfone and 2,4,4'-Trichloro-2'-Hydroxydiphenyl Ether
US8337881B2 (en)	2012-12-25	Cyanoacrylate monomer formulation containing diiodomethyl-p-tolylsulfone
WO2000035276A1 (en)	2000-06-22	Cyanoacrylate compositions comprising a soluble antimicrobial agent
CA2757973A1 (en)	2010-10-07	Controlled exotherm of cyanoacrylate formulations
JP2004524291A (ja)	2004-08-12	シアノアクリレート組成物の殺菌方法
MXPA00010460A (en)	2001-09-07	Use of an adhesive composition over a bioactive polymerization initiator or accelerator