ES2376225T3 - Genes de elongasa y usos de los mismos. - Google Patents
Genes de elongasa y usos de los mismos. Download PDFInfo
- Publication number
- ES2376225T3 ES2376225T3 ES03756242T ES03756242T ES2376225T3 ES 2376225 T3 ES2376225 T3 ES 2376225T3 ES 03756242 T ES03756242 T ES 03756242T ES 03756242 T ES03756242 T ES 03756242T ES 2376225 T3 ES2376225 T3 ES 2376225T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- elongasa
- genes
- same
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61Q19/00—Preparations for care of the skin
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
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- C12P7/00—Preparation of oxygen-containing organic compounds
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- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
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- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Hematology (AREA)
- Polymers & Plastics (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
Abstract
Una secuencia de nucleótidos aislada o fragmento de la misma que comprende o es complementaria de una secuencia de nucleótidos que codifica un polipéptido que tiene actividad elongasa, en la que el polipéptido elonga ácidos grasos poliinsaturados de cadena de 20 carbonos de longitud y en la que la secuencia de aminoácidos de dicho polipéptido tiene al menos 50 % de identidad con una secuencia de aminoácidos que comprende SEC ID Nº: 121.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US156911 | 2002-05-29 | ||
| US10/156,911 US20030163845A1 (en) | 1998-09-02 | 2002-05-29 | Elongase genes and uses thereof |
| PCT/US2003/016863 WO2003102138A2 (en) | 2002-05-29 | 2003-05-29 | Elongase genes and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2376225T3 true ES2376225T3 (es) | 2012-03-12 |
| ES2376225T5 ES2376225T5 (es) | 2015-01-12 |
Family
ID=29709610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03756242.8T Expired - Lifetime ES2376225T5 (es) | 2002-05-29 | 2003-05-29 | Genes de elongasa y usos de los mismos |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20030163845A1 (es) |
| EP (1) | EP1507855B2 (es) |
| JP (1) | JP4434944B2 (es) |
| AT (1) | ATE538198T1 (es) |
| AU (1) | AU2003243335B2 (es) |
| BR (1) | BR0306655A (es) |
| CA (1) | CA2487095C (es) |
| ES (1) | ES2376225T5 (es) |
| MX (1) | MXPA04011902A (es) |
| WO (1) | WO2003102138A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2166067B1 (de) | 2003-08-01 | 2015-07-01 | BASF Plant Science GmbH | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
| US9458436B2 (en) | 2004-02-27 | 2016-10-04 | Basf Plant Science Gmbh | Method for producing polyunsaturated fatty acids in transgenic plants |
| EP1720988B1 (de) | 2004-02-27 | 2011-10-12 | BASF Plant Science GmbH | Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen |
| CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| CA3023314C (en) | 2004-04-22 | 2019-12-10 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| EP1766023B1 (en) | 2004-06-04 | 2010-09-01 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US8431165B2 (en) * | 2004-12-13 | 2013-04-30 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer and other diseases |
| US8092839B2 (en) * | 2004-12-13 | 2012-01-10 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer and other diseases |
| JP5181486B2 (ja) * | 2006-02-16 | 2013-04-10 | 大正製薬株式会社 | 亜鉛化合物配合経口用組成物 |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| EP2059588A4 (en) | 2006-08-29 | 2010-07-28 | Commw Scient Ind Res Org | FATTY ACID SYNTHESIS |
| KR20100031528A (ko) | 2007-06-01 | 2010-03-22 | 더 트러스티즈 오브 프린스턴 유니버시티 | 숙주세포 대사경로의 조절을 통한 바이러스 감염 치료 |
| US7892792B2 (en) | 2008-06-27 | 2011-02-22 | Indian Institute Of Science | Cells expressing Pichia cytochrome C |
| US8809559B2 (en) | 2008-11-18 | 2014-08-19 | Commonwelath Scientific And Industrial Research Organisation | Enzymes and methods for producing omega-3 fatty acids |
| CA2853849C (en) * | 2011-08-04 | 2015-10-13 | Suntory Holdings Limited | Protein exhibiting fatty acid elongation promoting activity, gene encoding same and use thereof |
| BR122019026149A8 (pt) | 2012-06-15 | 2022-06-28 | Commw Scient Ind Res Org | Célula hospedeira, processo de produzir um lipídio de planta extraído, método de produzir semente, farinha de semente, método para produzir um produto alimentício, uso e processo para produzir ésteres de etila |
| CA2907622C (en) * | 2013-03-27 | 2022-08-16 | Suntory Holdings Limited | Promoter exhibiting high expression activity in mortierella microorganisms |
| PE20170253A1 (es) | 2013-12-18 | 2017-04-14 | Nuseed Pty Ltd | Lipido que comprende acidos grasos poliinsaturados de cadena larga |
| AU2015281791A1 (en) | 2014-06-27 | 2017-01-12 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising docosapentaenoic acid |
| CN110373436B (zh) | 2018-12-11 | 2022-09-23 | 山东理工大学 | 一种产双高-γ-亚麻酸卷枝毛霉细胞工厂的构建方法及发酵技术 |
| CN110923261B (zh) * | 2019-12-20 | 2021-12-17 | 江南大学 | 一种提高酿酒酵母细胞膜脂肪酸c20:0和/或c22:0含量的方法 |
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| US4943674A (en) * | 1987-05-26 | 1990-07-24 | Calgene, Inc. | Fruit specific transcriptional factors |
| US5420034A (en) * | 1986-07-31 | 1995-05-30 | Calgene, Inc. | Seed-specific transcriptional regulation |
| GB8507058D0 (en) * | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524275D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| GB8524276D0 (en) * | 1985-10-02 | 1985-11-06 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US5188958A (en) * | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| WO1988007577A1 (en) | 1987-03-31 | 1988-10-06 | Schering Biotech Corporation | Glycosylation inhibiting factors |
| GB8714772D0 (en) | 1987-06-24 | 1987-07-29 | Efamol Ltd | Essential fatty acid compositions |
| IE63225B1 (en) * | 1988-09-13 | 1995-04-05 | Efamol Holdings | Use of fatty acids in the treatment of myalgic encephalomyelitis |
| US5106739A (en) * | 1989-04-18 | 1992-04-21 | Calgene, Inc. | CaMv 355 enhanced mannopine synthase promoter and method for using same |
| US5196198A (en) * | 1989-06-02 | 1993-03-23 | Abbott Laboratories | Parenteral nutrition product |
| FR2648347B1 (fr) | 1989-06-15 | 1994-04-29 | Sederma Sa | Preparations cosmetiques possedant des proprietes adoucissantes |
| US5175095A (en) * | 1989-07-19 | 1992-12-29 | Calgene, Inc. | Ovary-tissue transcriptional factors |
| AU659087B2 (en) * | 1990-05-25 | 1995-05-11 | E.I. Du Pont De Nemours And Company | Nucleotide sequence of soybean stearoyl-ACP desaturase gene |
| PH31293A (en) * | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
| JPH07501701A (ja) | 1991-12-04 | 1995-02-23 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 植物由来の脂肪酸不飽和化酵素遺伝子 |
| DE69333025T2 (de) | 1992-11-17 | 2004-04-29 | E.I. Du Pont De Nemours And Co., Wilmington | Für mikrosom delta 12 fettsäuredesaturase kodierende gene und verwandte enzyme von pflanzen |
| DE69424861T2 (de) * | 1993-02-26 | 2000-12-28 | Calgene Llc., Davis | Geminivirus-basiertes-genexpressionsystem |
| WO1995024488A1 (en) * | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Transgenic animals producing oligosaccharides and glycoconjugates |
| AU694181B2 (en) | 1994-03-09 | 1998-07-16 | Abbott Laboratories | Humanized milk |
| US5750176A (en) * | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
| US5484724A (en) * | 1994-05-26 | 1996-01-16 | Merck & Co., Inc. | DNA encoding GLSI |
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| US5654402A (en) | 1994-10-26 | 1997-08-05 | Michigan State University | Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase |
| CA2283299A1 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| AU5394100A (en) | 1999-05-20 | 2000-12-12 | Karolinska Innovations Ab | Fatty acid elongation genes and uses thereof |
| PL207026B1 (pl) | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
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2002
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2003
- 2003-05-29 ES ES03756242.8T patent/ES2376225T5/es not_active Expired - Lifetime
- 2003-05-29 CA CA2487095A patent/CA2487095C/en not_active Expired - Fee Related
- 2003-05-29 JP JP2004510380A patent/JP4434944B2/ja not_active Expired - Fee Related
- 2003-05-29 EP EP03756242.8A patent/EP1507855B2/en not_active Expired - Lifetime
- 2003-05-29 AU AU2003243335A patent/AU2003243335B2/en not_active Ceased
- 2003-05-29 AT AT03756242T patent/ATE538198T1/de active
- 2003-05-29 WO PCT/US2003/016863 patent/WO2003102138A2/en not_active Ceased
- 2003-05-29 MX MXPA04011902A patent/MXPA04011902A/es active IP Right Grant
- 2003-05-29 BR BR0306655-0A patent/BR0306655A/pt active Search and Examination
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2004
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2008
- 2008-03-12 US US12/046,857 patent/US7968692B2/en not_active Expired - Fee Related
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| WO2003102138A2 (en) | 2003-12-11 |
| US20030163845A1 (en) | 2003-08-28 |
| CA2487095A1 (en) | 2003-12-11 |
| ES2376225T5 (es) | 2015-01-12 |
| AU2003243335A1 (en) | 2003-12-19 |
| US20050009140A1 (en) | 2005-01-13 |
| ATE538198T1 (de) | 2012-01-15 |
| EP1507855A2 (en) | 2005-02-23 |
| US7375205B2 (en) | 2008-05-20 |
| US7968692B2 (en) | 2011-06-28 |
| CA2487095C (en) | 2011-08-16 |
| AU2003243335B2 (en) | 2008-07-17 |
| EP1507855B2 (en) | 2014-12-03 |
| US20080176944A1 (en) | 2008-07-24 |
| MXPA04011902A (es) | 2005-03-31 |
| BR0306655A (pt) | 2005-05-10 |
| WO2003102138A3 (en) | 2004-06-17 |
| EP1507855A4 (en) | 2006-06-21 |
| JP4434944B2 (ja) | 2010-03-17 |
| EP1507855B1 (en) | 2011-12-21 |
| JP2005527238A (ja) | 2005-09-15 |
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