ES2384242T3 - 4-(Aminometil)piperidinbenzamidas sustituidas con aminosulfonilo como antagonistas de 5HT4 - Google Patents

4-(Aminometil)piperidinbenzamidas sustituidas con aminosulfonilo como antagonistas de 5HT4 Download PDF

Info

Publication number: ES2384242T3
Authority: ES; Spain
Prior art keywords: formula; mol; mixture; alkyl; stirred
Prior art date: 2003-06-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES04739781T

Other languages

English (en)

Spanish (es)

Inventor

Jean-Paul René Marie André Bosmans

Henricus Jacobus Maria Gijsen

Laurence Anne Mevellec

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-19

Filing date

2004-06-10

Publication date

2012-07-02

2004-06-10 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2004-06-10 Priority claimed from PCT/EP2004/006280 external-priority patent/WO2005000837A1/en

2012-07-02 Application granted granted Critical

2012-07-02 Publication of ES2384242T3 publication Critical patent/ES2384242T3/es

2024-06-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 title claims abstract description 14
239000003523 serotonin 4 antagonist Substances 0.000 title description 6
150000001875 compounds Chemical class 0.000 claims abstract description 93
-1 cyano, amino Chemical group 0.000 claims abstract description 40
239000001257 hydrogen Substances 0.000 claims abstract description 30
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 30
150000003839 salts Chemical class 0.000 claims abstract description 25
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 19
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 17
125000003386 piperidinyl group Chemical group 0.000 claims abstract description 17
239000002253 acid Substances 0.000 claims abstract description 16
125000003545 alkoxy group Chemical group 0.000 claims abstract description 10
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 9
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims abstract description 4
125000000217 alkyl group Chemical group 0.000 claims abstract description 4
229910052799 carbon Inorganic materials 0.000 claims abstract description 4
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 4
125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract description 4
125000001475 halogen functional group Chemical group 0.000 claims abstract 4
208000002551 irritable bowel syndrome Diseases 0.000 claims description 18
238000006243 chemical reaction Methods 0.000 claims description 15
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FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 8
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VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES04739781T 2003-06-19 2004-06-10 4-(Aminometil)piperidinbenzamidas sustituidas con aminosulfonilo como antagonistas de 5HT4 Expired - Lifetime ES2384242T3 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03502380		2003-06-19
EP03502380		2003-06-19
PCT/EP2004/006280 WO2005000837A1 (en)	2003-06-19	2004-06-10	Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists

Publications (1)

Publication Number	Publication Date
ES2384242T3 true ES2384242T3 (es)	2012-07-02

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ES04739781T Expired - Lifetime ES2384242T3 (es)	2003-06-19	2004-06-10	4-(Aminometil)piperidinbenzamidas sustituidas con aminosulfonilo como antagonistas de 5HT4

Country Status (2)

Country	Link
AT (1)	ATE551338T1 (de)
ES (1)	ES2384242T3 (de)

2004
- 2004-06-10 AT AT04739781T patent/ATE551338T1/de active
- 2004-06-10 ES ES04739781T patent/ES2384242T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE551338T1 (de)	2012-04-15

Publication	Publication Date	Title
ES2288258T3 (es)	2008-01-01	4-(aminometil)-piperidina benzamidas como antagonistas de 5ht4.
HRP20010445A2 (en)	2002-06-30	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
KR101151642B1 (ko)	2012-06-08	5ｈｔ4-길항제로서의 아미노설포닐 치환된4-(아미노메틸)-피페리딘 벤즈아미드
ES2384242T3 (es)	2012-07-02	4-(Aminometil)piperidinbenzamidas sustituidas con aminosulfonilo como antagonistas de 5HT4
ES2293262T3 (es)	2008-03-16	4-(aminometil)-piperidin benzamidas 5ht4-antagonistas.
ES2355824T3 (es)	2011-03-31	4-(aminometil)-piperidina-benzamidas sustituidas con hidroxicarbonilfenilo como antagonistas 5ht4.
ES2336448T3 (es)	2010-04-13	4-(aminometil)-piperidina-benzamidas con sustituyentes heterociclicos como antagonistas de 5ht4.
HK1095327B (en)	2010-04-16	4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists