ES2390192T3 - Stabilization of a cosmetic or dermatological formulation with mandelic acid - Google Patents
Stabilization of a cosmetic or dermatological formulation with mandelic acid Download PDFInfo
- Publication number
- ES2390192T3 ES2390192T3 ES08784833T ES08784833T ES2390192T3 ES 2390192 T3 ES2390192 T3 ES 2390192T3 ES 08784833 T ES08784833 T ES 08784833T ES 08784833 T ES08784833 T ES 08784833T ES 2390192 T3 ES2390192 T3 ES 2390192T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogenated castor
- mandelic acid
- peg
- castor oil
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 229960002510 mandelic acid Drugs 0.000 title claims abstract description 31
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 238000009472 formulation Methods 0.000 title claims abstract description 22
- 239000002537 cosmetic Substances 0.000 title claims abstract description 18
- 230000006641 stabilisation Effects 0.000 title claims description 8
- 238000011105 stabilization Methods 0.000 title claims description 8
- 239000000126 substance Substances 0.000 claims abstract description 34
- 239000004359 castor oil Substances 0.000 claims abstract description 24
- 235000019438 castor oil Nutrition 0.000 claims abstract description 18
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 18
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000013543 active substance Substances 0.000 claims abstract description 14
- 230000001166 anti-perspirative effect Effects 0.000 claims abstract description 14
- 239000003213 antiperspirant Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910001629 magnesium chloride Inorganic materials 0.000 claims abstract description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 6
- 239000001110 calcium chloride Substances 0.000 claims abstract description 6
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 6
- 239000002530 phenolic antioxidant Substances 0.000 claims abstract description 6
- CSABAZBYIWDIDE-UHFFFAOYSA-N sulfino hydrogen sulfite Chemical class OS(=O)OS(O)=O CSABAZBYIWDIDE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims description 29
- 239000002304 perfume Substances 0.000 claims description 14
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 7
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 5
- MGQIWUQTCOJGJU-UHFFFAOYSA-N [AlH3].Cl Chemical compound [AlH3].Cl MGQIWUQTCOJGJU-UHFFFAOYSA-N 0.000 claims description 4
- DNXNYEBMOSARMM-UHFFFAOYSA-N alumane;zirconium Chemical class [AlH3].[Zr] DNXNYEBMOSARMM-UHFFFAOYSA-N 0.000 claims description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- DXCHWXWXYPEZKM-UHFFFAOYSA-N 2,4-ditert-butyl-6-[1-(3,5-ditert-butyl-2-hydroxyphenyl)ethyl]phenol Chemical compound C=1C(C(C)(C)C)=CC(C(C)(C)C)=C(O)C=1C(C)C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1O DXCHWXWXYPEZKM-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 16
- 239000002781 deodorant agent Substances 0.000 description 9
- 239000000499 gel Substances 0.000 description 8
- 235000019645 odor Nutrition 0.000 description 7
- 239000004471 Glycine Substances 0.000 description 6
- YCLAMANSVUJYPT-UHFFFAOYSA-L aluminum chloride hydroxide hydrate Chemical compound O.[OH-].[Al+3].[Cl-] YCLAMANSVUJYPT-UHFFFAOYSA-L 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical class [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- ZGUQGPFMMTZGBQ-UHFFFAOYSA-N [Al].[Al].[Zr] Chemical compound [Al].[Al].[Zr] ZGUQGPFMMTZGBQ-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 229910052726 zirconium Inorganic materials 0.000 description 3
- CRDAMVZIKSXKFV-YFVJMOTDSA-N (2-trans,6-trans)-farnesol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CO CRDAMVZIKSXKFV-YFVJMOTDSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 2
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000013065 commercial product Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000004042 decolorization Methods 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 2
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- IWYDHOAUDWTVEP-ZETCQYMHSA-N (S)-mandelic acid Chemical compound OC(=O)[C@@H](O)C1=CC=CC=C1 IWYDHOAUDWTVEP-ZETCQYMHSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 239000004904 UV filter Substances 0.000 description 1
- DOKRKLWRNKOHQE-UHFFFAOYSA-J [Pb+2].[Cl-].[Ca+2].[Cl-].[Cl-].[Cl-] Chemical class [Pb+2].[Cl-].[Ca+2].[Cl-].[Cl-].[Cl-] DOKRKLWRNKOHQE-UHFFFAOYSA-J 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940053431 aluminum sesquichlorohydrate Drugs 0.000 description 1
- WYANSMZYIOPJFV-UHFFFAOYSA-L aluminum;2-aminoacetic acid;zirconium(4+);chloride;hydroxide;hydrate Chemical compound O.[OH-].[Al+3].[Cl-].[Zr+4].NCC(O)=O WYANSMZYIOPJFV-UHFFFAOYSA-L 0.000 description 1
- HAMGNFFXQJOFRZ-UHFFFAOYSA-L aluminum;zirconium(4+);chloride;hydroxide;hydrate Chemical compound O.[OH-].[Al+3].[Cl-].[Zr+4] HAMGNFFXQJOFRZ-UHFFFAOYSA-L 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- VNSBYDPZHCQWNB-UHFFFAOYSA-N calcium;aluminum;dioxido(oxo)silane;sodium;hydrate Chemical compound O.[Na].[Al].[Ca+2].[O-][Si]([O-])=O VNSBYDPZHCQWNB-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000490 cosmetic additive Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- -1 fatty acid esters Chemical class 0.000 description 1
- 238000001595 flow curve Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000004872 foam stabilizing agent Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910000273 nontronite Inorganic materials 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920005862 polyol Chemical class 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Chemical class 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229910000275 saponite Inorganic materials 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 229910021647 smectite Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 150000003755 zirconium compounds Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Formulación cosmética y/o dermatológica que comprende por lo menos una substancia activaantitranspirante, ácido mandélico, agua y por lo menos una substancia auxiliar, escogida del grupo:- aceites de ricino hidrogenados polietoxilados, aceite de ricino hidrogenado con PEG-40, aceite de ricinohidrogenado con PEG- 60,- antioxidantes fenólicos y/o- uno o varios disulfitos, caracterizada porque la formulación contiene cloruro de magnesio y/o cloruro decalcio.Cosmetic and / or dermatological formulation comprising at least one antiperspirant active substance, mandelic acid, water and at least one auxiliary substance, chosen from the group: - polyethoxylated hydrogenated castor oils, PEG-40 hydrogenated castor oil, castor oil with PEG-60, - phenolic antioxidants and / or - one or more disulfites, characterized in that the formulation contains magnesium chloride and / or calcium chloride.
Description
Estabilizacion de una formulacion cosmetica o dermatologica con acido mandelico Stabilization of a cosmetic or dermatological formulation with mandelic acid
5 La invencion se refiere a una formulacion cosmetica o dermatologica que comprende acido mandelico, antitranspirantes y substancias auxiliares para mejorar su estabilizacion. En la patente DE 102005017032 se dan a conocer microemulsiones que contienen una substancia activa antitranspirante, acido mandelico y emulsionantes O/W polietoxilados. En la patente WO 2005105026 se dan a conocer formulaciones cosmeticas y/o formulaciones dermatologicas transparentes, las cuales por lo menos contienen una substancia activa antitranspirante y/o una substancia activa desodorante, por lo menos un acido a-hidroxicarboxilico y agua. Como acido hidroxilico se escoge de preferencia el acido mandelico. The invention relates to a cosmetic or dermatological formulation comprising mandelic acid, antiperspirants and auxiliary substances to improve its stabilization. In DE 102005017032, microemulsions containing an active antiperspirant substance, mandelic acid and polyethoxylated O / W emulsifiers are disclosed. WO 2005105026 discloses cosmetic formulations and / or transparent dermatological formulations, which contain at least one antiperspirant active substance and / or an active deodorant substance, at least one a-hydroxycarboxylic acid and water. As hydroxyl acid, mandelic acid is preferably chosen.
15 Con ayuda de la tecnologia gel del acido mandelico, como se describe en la patente WO 2005 105026, es posible en primer lugar obtener sistemas para aplicacion "roll-on", en particular transparentes, en los cuales debido a los limites de fluidez de estas formulaciones pueden introducirse por ejemplo tambien efectos visuales como por ejemplo particulas en suspension, perlas, etc.. La patente EP 1787629 A1 da a conocer una formulacion cosmetica y/o dermatologica que comprende por lo menos una substancia activa antitranspirante, acido mandelico, agua y aceite de ricino hidrogenado con PEG-40. En la misma se muestra que estos sistemas de acido mandelico bajo particulares condiciones de almacenamiento With the help of the gel technology of the mandelic acid, as described in WO 2005 105026, it is possible first of all to obtain systems for roll-on application, in particular transparent, in which due to the fluidity limits of These formulations can, for example, also introduce visual effects such as suspended particles, beads, etc. The patent EP 1787629 A1 discloses a cosmetic and / or dermatological formulation comprising at least one antiperspirant active substance, mandelic acid, water and hydrogenated castor oil with PEG-40. It shows that these mandelic acid systems under particular storage conditions
25 (almacenamiento a la luz, almacenamiento a 40 'C) no permanecen estables durante mucho tiempo, sin que tengan lugar precipitaciones o cristalizaciones. Es deseable por lo tanto preparar geles de acido mandelico, en particular transparentes y en particular como productos antitranspirantes o desodorantes, que tengan una mejor estabilizacion a la irradiacion solar y/o a elevada temperatura. La presente invencion comprende una formulacion cosmetica que contiene por lo menos una substancia activa antitranspirante de acido mandelico, agua, cloruro de magnesio y/o cloruro de calcio y una o varias substancias auxiliares. 25 (light storage, storage at 40 'C) do not remain stable for a long time, without precipitation or crystallization taking place. It is therefore desirable to prepare mandelic acid gels, in particular transparent and in particular as antiperspirant or deodorant products, which have a better stabilization to solar irradiation and / or at high temperature. The present invention comprises a cosmetic formulation containing at least one antiperspirant active substance of mandelic acid, water, magnesium chloride and / or calcium chloride and one or more auxiliary substances.
35 Como substancias auxiliares se escogen los compuestos ya mencionados: 35 The compounds mentioned above are chosen as auxiliary substances:
a.) Aceites de ricino hidroxilados polietoxilados, aceite de ricino hidrogenado con PEG-40, aceite de ricino hidrogenado con PEG-60, b.) Antioxidantes fenolicos, como por ejemplo el producto comercial Tinogard TS, Tinogard TT, Tinogard NOA, de la firma Ciba, y/o a.) Polyethoxylated hydroxylated castor oils, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, b.) Phenolic antioxidants, such as the commercial product Tinogard TS, Tinogard TT, Tinogard NOA, of the Ciba signature, and / or
c.) Uno o varios disulfitos, en particular el disulfito de sodio. Son preferidos los aceites de ricino hidrogenados polietoxilados, en particular el aceite de ricino hidrogenado con c.) One or more disulfites, in particular sodium disulfite. Preferred are polyethoxylated hydrogenated castor oils, in particular hydrogenated castor oil with
45 PEG-40. El aceite de ricino hidrogenado con PEG-40 puede obtenerse como producto comercial bajo el nombre de Solutor, Eumulgin, o Fancol. Como ejemplos preferidos pueden citarse el aceite de ricino hidrogenado con PEG-40 y el aceite de ricino hidrogenado con PEG-60. El aceite de ricino hidrogenado con PEG-40 puede emplearse ademas ventajosamente en combinacion con un perfume. Se exceptuan como substancias auxiliares las nombradas en la patente DE 102005017032 como emulsionantes, los esteres de acido grasos con polietilenglicolglicerina, el glicerillaurato de polietilenglicol (15) y/o el monoestearato de glicerilo. 45 PEG-40. Hydrogenated castor oil with PEG-40 can be obtained as a commercial product under the name of Solutor, Eumulgin, or Fancol. As preferred examples there may be mentioned hydrogenated castor oil with PEG-40 and hydrogenated castor oil with PEG-60. Hydrogenated castor oil with PEG-40 can also be used advantageously in combination with a perfume. Except as auxiliary substances are those mentioned in the patent DE 102005017032 as emulsifiers, fatty acid esters with polyethylene glycol glycerin, polyethylene glycol glycerillaurate (15) and / or glyceryl monostearate.
55 El perfume es para muchos cosmeticos un componente esencial, pero a menudo conduce a problemas e inestabilidades. Con la o las substancias auxiliares, en particular la substancia auxiliar o solubilizador Solutor (PEG-40), se pueden introducir perfumes segun la invencion en el gel de acido mandelico sin que este se enturbie o se vuelva inestable. Es decir, se anade ademas una ventajosa transparencia y estabilidad de los geles de acido mandelico, como se describe en en la patente WO 2005 105026. Las ventajas comunes en las substancias auxiliares estan presentes ventajosamente en el margen desde un 0,1 55 Perfume is for many cosmetics an essential component, but it often leads to problems and instabilities. With the auxiliary substance (s), in particular the Solutor auxiliary or solubilizing substance (PEG-40), perfumes according to the invention can be introduced into the mandelic acid gel without it becoming cloudy or unstable. That is, an advantageous transparency and stability of the mandelic acid gels is also added, as described in WO 2005 105026. The common advantages in auxiliary substances are advantageously present in the range from 0.1
65 hasta un 10% del peso, en particular aproximadamente desde un 4 hasta un 7% del peso, de preferencia en el margen desde un 5 hasta un 6% del peso, cada vez referido a la masa total de la preparacion. 65 to 10% of the weight, in particular about 4 to 7% of the weight, preferably in the range of 5 to 6% of the weight, each time referred to the total mass of the preparation.
Como substancias auxiliares preferidas pueden escogerse por lo tanto, solubilizadores, en particular el PEG-40 HYDROGENATED CASTOR OIL ("aceite de ricino hidrogenado con PEG-40") (nombres comerciales: Solutor, Eumulgin, Fancol, Cremophor), en combinacion con un perfume y/o sus componentes. Los grupos de substancias auxiliares de los antioxidantes fenolicos comprenden de preferencia el pentaeritritil tetraAs preferred auxiliary substances, solubilizers can therefore be chosen, in particular PEG-40 HYDROGENATED CASTOR OIL ("hydrogenated castor oil with PEG-40") (trade names: Solutor, Eumulgin, Fancol, Cremophor), in combination with a perfume and / or its components. The groups of auxiliary substances of the phenolic antioxidants preferably comprise pentaerythrityl tetra
5 di-t-butil ' hidroxihidrocinamato (nombre comercial: Tinogard TT, Ciba), el tetrabutil etilidenobisfenol (nombre comercial: Tinogard NOA, Ciba) o el di-t-butil-4-hidroxihidrocinamato de octadecilo (nombre comercial: Tinogard TS, Ciba). 5 di-t-butyl 'hydroxyhydrocinamate (trade name: Tinogard TT, Ciba), tetrabutyl ethylidenobisphenol (trade name: Tinogard NOA, Ciba) or octadecyl di-t-butyl-4-hydroxyhydrocinamate (trade name: Tinogard TS, Ciba)
Como substancias auxiliares pueden emplearse ademas ventajosamente los disulfitos, en particular el disulfito de 10 sodio. As auxiliary substances, disulfites, in particular sodium disulfite, can also be used advantageously.
La adicion de disulfito de sodio conduce a que se eviten las reacciones de decoloracion y/o la formacion de malos olores. The addition of sodium disulfite leads to the prevention of discoloration reactions and / or the formation of bad odors.
15 Los malos olores y las decoloraciones se forman por procesos de oxidacion no deseados. Estos se producen por ejemplo mediante la luz y el calor. En el caso del acido mandelico puede formarse benzaldehido durante el almacenamiento. Mediante la adicion de substancias auxiliares, en particular de disulfitos, en particular el disulfito de sodio, o combinaciones de EDTA y disulfito de sodio, estos procesos de oxidacion se reprimen y con ello se minimiza la decoloracion y la formacion de malos olores. La proporcion de disulfitos es ventajosamente de 15 Bad odors and discolorations are formed by unwanted oxidation processes. These are produced, for example, by light and heat. In the case of mandelic acid, benzaldehyde can be formed during storage. By the addition of auxiliary substances, in particular of disulfites, in particular sodium disulfite, or combinations of EDTA and sodium disulfite, these oxidation processes are repressed and thereby decolorization and the formation of bad odors are minimized. The disulfite ratio is advantageously of
20 aproximadamente 0,1 a 0,2% en peso. 20 about 0.1 to 0.2% by weight.
En combinacion con EDTA, se anade EDTA de preferencia aproximadamente un 1% en peso. In combination with EDTA, EDTA is preferably added approximately 1% by weight.
La formulacion segun la invencion se puede gelificar dando una formulacion viscosa hasta pastosa, y hace posible la The formulation according to the invention can be gelled giving a viscous formulation to pasty, and makes possible the
25 preparacion de una preparacion cosmetica transparente y poco pegajosa, en particular una preparacion antitranspirante o respectivamente desodorante como esta descrito en la patente WO 2005105026. Como diferencia se minimizan temporalmente los problemas aparecidos por precipitaciones segun la invencion mediante el empleo de substancias auxiliares. Preparation of a transparent and non-sticky cosmetic preparation, in particular an antiperspirant or respectively deodorant preparation as described in WO 2005105026. As a difference, the problems caused by precipitation are temporarily minimized according to the invention by the use of auxiliary substances.
30 El acido hidroxifenilacetico o tambien el acido fenilglicolico de formula H5C6-CH(OH)-NOCH, C6H8O3, es conocido con el nombre de acido mandelico. El acido mandelico se disuelve bien en agua, alcohol, eter y 2-propanol. Sinteticamente se obtiene el (±), el D-o el acido L-mandelico, a partir del benzaldehido y el acido cianhidrico mediante el a-hidroxinitrilo (cianohidrina) y su hidrolisis acida correspondiente a la figura 1: The hydroxyphenylacetic acid or also the phenylglycolic acid of formula H5C6-CH (OH) -NOCH, C6H8O3, is known as mandelic acid. Mandelic acid dissolves well in water, alcohol, ether and 2-propanol. Synthetically, the (±), D- or L-mandelic acid are obtained from benzaldehyde and cyanhydric acid by means of a-hydroxynitrile (cyanohydrin) and its acid hydrolysis corresponding to Figure 1:
35 Figura 1: Obtencion del acido mandelico 35 Figure 1: Obtaining Mandelic Acid
Mediante el acido mandelico puede obtener sorprendentemente una preparacion AT o respectivamente una preparacion desodorante pero tambien una preparacion cosmetica cualquiera, lo cual hace posible las ventajosas By means of mandelic acid you can surprisingly obtain an AT preparation or respectively a deodorant preparation but also any cosmetic preparation, which makes the advantageous possible
40 propiedades como la transparencia, escasa pegajosidad, ingredientes del perfume y ademas tambien el ajuste de un determinado limite de fluidez de la preparacion. Ademas la formulacion segun la invencion penetra con rapidez sin dejar residuo en la piel. 40 properties such as transparency, low stickiness, perfume ingredients and also the adjustment of a certain fluidity limit of the preparation. In addition, the formulation according to the invention penetrates rapidly without leaving residue on the skin.
Ademas, el acido mandelico conduce mediante sus propiedades queratinoliticas a la regeneracion de la piel axilar y In addition, mandelic acid leads through its keratinolytic properties to the regeneration of axillary skin and
45 actua como bacteriostatico en el medio acido de las axilas. Debido a sus propiedades, el acido mandelico es apropiado tambien como un excelente componente activo en los productos cosmeticos y en particular en los productos Deo/AT. 45 acts as a bacteriostatic in the acidic environment of the armpits. Due to its properties, mandelic acid is also suitable as an excellent active component in cosmetic products and in particular in Deo / AT products.
El limite de fluidez o temperatura de fluidez es una denominacion que se da al mas pequeno esfuerzo de The fluidity limit or fluidity temperature is a designation that is given to the smallest effort of
50 cizallamiento por encima del cual una substancia plastica se comporta reologicamente como un liquido (DIN 1342-1: 1983-10). La determinacion del limite de fluidez tiene lugar mediante el trazado de una curva de fluidez (DIN 53019: 1980-05., DIN 53214: 1982-02). El valor obtenido depende fuertemente de la escala de tiempo (velocidad de carga), en la cual se basa la medicion. Este es independiente de si la medicion se efectua con un viscosimetro de esfuerzo cortante o de un viscosimetro regulado por el numero de revoluciones. Las escalas de tiempo cortas (cargas 50 shearing above which a plastic substance behaves rheologically like a liquid (DIN 1342-1: 1983-10). The determination of the flow limit takes place by drawing a flow curve (DIN 53019: 1980-05., DIN 53214: 1982-02). The value obtained depends strongly on the time scale (loading speed), on which the measurement is based. This is independent of whether the measurement is made with a shear force viscometer or a viscometer regulated by the number of revolutions. Short time scales (loads
55 rapidas) dan como resultado por regla general valores altos de limites de fluidez. Un limite de fluidez demasiado alto puede ser la causa de trastornos de fluidez. Por otra parte, con un valor apropiado de la fluidez, puede vencerse la inclinacion de las formulaciones liquidas a escurrirse. 55 fast) result in high flow limit values as a rule. A fluidity limit that is too high may be the cause of fluidity disorders. On the other hand, with an appropriate fluidity value, the inclination of the liquid formulations to be drained can be overcome.
La preparacion segun la invencion esta presente ventajosamente como gel o respectivamente como hidrogel, y tiene un limite de fluidez mediante el cual el empleo y la aplicacion respecto a las preparaciones del actual estado de la tecnica es mucho mejor. The preparation according to the invention is advantageously present as a gel or respectively as a hydrogel, and has a fluidity limit whereby the use and application with respect to the preparations of the current state of the art is much better.
5 De preferencia, la cantidad total de acido mandelico tiene segun la invencion un maximo de hasta un 4% en peso, ventajosamente un maximo de un 2,8% en peso, referido a la masa total de la preparacion. 5 Preferably, the total amount of mandelic acid has, according to the invention, a maximum of up to 4% by weight, advantageously a maximum of 2.8% by weight, based on the total mass of the preparation.
La combinacion segun la invencion de una substancia activa AT, acido mandelico, una substancia auxiliar y agua, hace posible mediante un mecanismo de espesamiento especial, la obtencion de una preparacion cosmetica particularmente transparente. El usuario tiene con ello por primera vez en mano una preparacion clara como el agua y sin embargo extremadamente activa. La preparacion segun la invencion es en forma de gel, es comoda de aplicar y tiene un agradable tacto con la piel debido a su falta de pegajosidad. The combination according to the invention of an active substance AT, mandelic acid, an auxiliary substance and water, makes possible by means of a special thickening mechanism, the obtaining of a particularly transparent cosmetic preparation. The user has with it for the first time in hand a clear preparation like water and yet extremely active. The preparation according to the invention is in the form of a gel, is comfortable to apply and has a pleasant touch with the skin due to its lack of stickiness.
Como substancias activas antitranspirantes, se pueden incorporar ventajosamente sales acidas de aluminio y/o As active antiperspirant substances, acidic salts of aluminum and / or may be advantageously incorporated
15 aluminio/zirconio en solucion acuosa. A este respecto, los margenes de concentracion descritos se refieren a los contenidos activos mencionados de los complejos antitranspirantes: en los compuestos de aluminio a los complejos exentos de agua, en los compuestos de aluminio/zirconio a los complejos exentos de agua y tampon. Como tampon se emplea aqui habitualmente la glicina. 15 aluminum / zirconium in aqueous solution. In this regard, the concentration ranges described refer to the aforementioned active contents of antiperspirant complexes: in aluminum compounds to water-free complexes, in aluminum / zirconium compounds to water and buffer-free complexes. As a buffer, glycine is usually used here.
El siguiente listado de substancias activas antitranspirantes para emplear ventajosamente, no pretende de ninguna manera ser limitativo. The following list of active antiperspirant substances to be used advantageously, is not intended in any way to be limiting.
Sales de aluminio (de formula empirica [Al2(OH)mCln], en donde m + n = 6): Aluminum salts (empirically formulated [Al2 (OH) mCln], where m + n = 6):
25 Clorhidrato de aluminio [Al2(OH)5Cl] x H2O Complejos estandar de Al: Locron L, Locron LIC, Locron LIF (Clariant), Chlorhydrol (Reheis), ACH-303 (Summit), Aloxicoll L (Giulini). Complejos de Al activados: Reach 501 (Reheis), Aloxicoll 51 L Sesquiclorhidrato de aluminio [Al2(OH)4,5Cl1,5] x H2O Complejos estandar de Al: Aloxicoll 31 L(Giulini),Westehlor 186 (Westtood Chemicals) Complejos de Al activados: Reach 301 (Reheis) Diclorhidrato de aluminio [Al2(OH)4Cl2] x H2O 25 Aluminum Hydrochloride [Al2 (OH) 5Cl] x H2O Standard Al complexes: Locron L, Locron LIC, Locron LIF (Clariant), Chlorhydrol (Reheis), ACH-303 (Summit), Aloxicoll L (Giulini). Activated Al complexes: Reach 501 (Reheis), Aloxicoll 51 L Aluminum sesquichlorohydrate [Al2 (OH) 4,5Cl1,5] x H2O Standard Al complexes: Aloxicoll 31 L (Giulini), Westehlor 186 (Westtood Chemicals) Complexes Al activated: Reach 301 (Reheis) Aluminum Hydrochloride [Al2 (OH) 4Cl2] x H2O
Sales de aluminio - zirconio: 35 Triclorhidrex de aluminio/zirconio con glicina, complejos estandar de Al/Zr [Al4Zr(OH)13Cl3] x H2O x Gly : Rezal 33 GC (Reheis), AZG-7164 (Summit) Aluminum salts - zirconium: 35 Trichlorohydrex aluminum / zirconium with glycine, standard Al / Zr complexes [Al4Zr (OH) 13Cl3] x H2O x Gly: Rezal 33 GC (Reheis), AZG-7164 (Summit)
- --
- Tetraclorhidrex de aluminio-zirconio con glicina, complejos estandar de Al/Zr : [Al4Zr(OH)12Cl4] x H2O x Gly: Rezal 36, Rezal 36 G, Rezal 36 GC (Reheis), AZG-368 (Summit), Zirconal L435G (Giulini), Westchlor ZR 35 BX5, Westchlor ZR 41 (Westtood Chemicals) Tetrachlorhydrex aluminum-zirconium with glycine, standard Al / Zr complexes: [Al4Zr (OH) 12Cl4] x H2O x Gly: Rezal 36, Rezal 36 G, Rezal 36 GC (Reheis), AZG-368 (Summit), Zirconal L435G (Giulini), Westchlor ZR 35 BX5, Westchlor ZR 41 (Westtood Chemicals)
Pentaclorhidrex de aluminio-zirconio con glicina, complejos estandar de Al/Zr: [Al8Zr(OH)23Cl5] x H2O x Gly: Rezal 67 (Reheis), Zirconal L540, Zirconal L530PG (Giulini), Westchlor ZR 80 B, (Westtood Chemicals) Octaclorhidrex de aluminio-zirconio con glicina [Al8Zr(OH)20Cl8] x H2O x Gly: Westchlor ZR 82 B Pentachlorhydrex aluminum-zirconium with glycine, standard Al / Zr complexes: [Al8Zr (OH) 23Cl5] x H2O x Gly: Rezal 67 (Reheis), Zirconal L540, Zirconal L530PG (Giulini), Westchlor ZR 80 B, (Westtood Chemicals ) Octachlorhydrex aluminum-zirconium with glycine [Al8Zr (OH) 20Cl8] x H2O x Gly: Westchlor ZR 82 B
45 Tambien pueden emplearse ventajosamente las sales de aluminio -zirconio exentas de glicina. 45 Aluminum-zirconium salts free of glycine can also be used advantageously.
Las substancias activas antitranspirantes se emplean en las formulaciones segun la invencion en una cantidad desde un 1 hasta un 35% en peso, de preferencia desde un 1 hasta un 20% en peso. The antiperspirant active substances are used in the formulations according to the invention in an amount from 1 to 35% by weight, preferably from 1 to 20% by weight.
Ventajosamente, la substancia activa AT se escoge de las sales de aluminio, en particular, el clorhidrato de aluminio, activado o sin activar. Advantageously, the active substance AT is chosen from the aluminum salts, in particular, the aluminum hydrochloride, activated or not activated.
Ventajosamente, pueden anadirse tambien desodorantes a las preparaciones segun la invencion. Los desodorantes cosmeticos habituales se basan en diferentes principios activos. Advantageously, deodorants can also be added to the preparations according to the invention. The usual cosmetic deodorants are based on different active ingredients.
55 Mediante el empleo de substancias antimicrobianas en los desodorantes cosmeticos puede reducirse la flora bacteriana sobre la piel. A este respecto, en el caso ideal, pueden reducirse eficazmente solamente los microorganismos causantes del olor. El propio sudor no es influido por ellos, en el caso ideal solamente se interrumpe la descomposicion microbiana del sudor, temporalmente. Tambien es habitual la combinacion de astringentes con substancias activas antimicrobianas en una y la misma composicion. 55 The use of antimicrobial substances in cosmetic deodorants can reduce bacterial flora on the skin. In this respect, in the ideal case, only the microorganisms causing the odor can be effectively reduced. The sweat itself is not influenced by them, in the ideal case only the microbial decomposition of sweat is temporarily interrupted. The combination of astringent with antimicrobial active substances in one and the same composition is also common.
Todas las substancias activas desodorantes habituales pueden ser empleadas ventajosamente, por ejemplo los enmascaradores del olor, como los perfumes habituales o los componentes del perfume, los absorbedores del olor, por ejemplo los filosilicatos descritos en la patente DE 40 09 347, entre los cuales en particular la montmorillonita, la caolinita, la beidellita, la nontronita, la saponita, la hectorita, la bentonita, la esmectita, ademas por ejemplo las sales 65 de zinc del acido ricinoleico, los medios inhibidores de germenes son igualmente apropiados para ser incorporados All the usual deodorant active substances can be advantageously employed, for example odor masks, such as usual perfumes or perfume components, odor absorbers, for example the phyllosilicates described in DE 40 09 347, among which in Particularly montmorillonite, kaolinite, beidellite, nontronite, saponite, hectorite, bentonite, smectite, in addition, for example, zinc salts 65 of ricinoleic acid, germ inhibitory means are equally suitable for incorporation.
en las preparaciones segun la invencion. Substancias ventajosas son por ejemplo, el 2,4,4'-tricloro-2'hidroxidifenileter (Irgasan), 1,6-di-(4-clorofenilbiguanido)-hexano (Chlorhexidin), 3, 4, 4'-triclorocarbanilida, compuestos de amonio cuaternario, esencia de clavo, esencia de menta, esencia de tomillo, citrato de trietilo, farnesol (3, 7, 11-trimetil-2, 6, 10-dodecatrien-1-ol) asi como los agentes activos descritos en las patentes DE 37 40 in the preparations according to the invention. Advantageous substances are, for example, 2,4,4'-trichloro-2'hydroxydiphenylether (Irgasan), 1,6-di- (4-chlorophenylbiguanide) -hexane (Chlorhexidin), 3, 4, 4'-trichlorocarbanilide, compounds quaternary ammonium, clove essence, peppermint essence, thyme essence, triethyl citrate, farnesol (3, 7, 11-trimethyl-2, 6, 10-dodecatrien-1-ol) as well as the active agents described in 37 37 patents
De preferencia, la preparacion segun la invencion comprende uno o varios perfumes y/o sus componentes. Preferably, the preparation according to the invention comprises one or more perfumes and / or their components.
10 La cantidad de desodorantes (uno o mas compuestos) en las preparaciones es de preferencia desde un 0,01 hasta un 10% en peso, de preferencia desde un 0,05 hasta un 5% en peso, referidos al peso total de la preparacion. The amount of deodorants (one or more compounds) in the preparations is preferably from 0.01 to 10% by weight, preferably from 0.05 to 5% by weight, based on the total weight of the preparation. .
Al sistema segun la invencion pueden anadirse ademas adicionalmente: The system according to the invention can also be added additionally:
15 -co-espesantes, como por ejemplo la polivinilpirrolidona (por ejemplo el Luvis�ol 30, BASF). 15 -co-thickeners, such as polyvinylpyrrolidone (for example, Luvisol 30, BASF).
- --
- polimeros que contienen acido maleico o anhidrido maleico (por ejemplo el Gantrez S o los tipos de Gantrez AN, ISP Internationale Specialty Products) y/o polymers containing maleic acid or maleic anhydride (for example Gantrez S or types of Gantrez AN, ISP Internationale Specialty Products) and / or
- --
- celulosas hidrofobas modificadas (Natrosol 250 HHX Pharm, Hercules) modified hydrophobic celluloses (Natrosol 250 HHX Pharm, Hercules)
- --
- sales, en particular sales bivalentes como por ejemplo, el cloruro de magnesio o el cloruro de calcio, en 20 concentraciones desde un 10,1% hasta un 5%, solas, o en combinacion. salts, in particular bivalent salts such as magnesium chloride or calcium chloride, in 20 concentrations from 10.1% to 5%, alone, or in combination.
Estos co-espesantes, polimeros o respectivamente celulosa y sales, tienen tambien una influencia estabilizadora adicional sobre los geles de acido mandelico segun la invencion. These co-thickeners, polymers or respectively cellulose and salts, also have an additional stabilizing influence on mandelic acid gels according to the invention.
25 La adicion de sales conduce por ejemplo a una elevacion de la estabilidad al cizallamiento de los geles de acido mandelico. The addition of salts leads, for example, to an increase in shear stability of mandelic acid gels.
Las sales neutrales bivalentes de cloruro de magnesio y de cloruro de calcio conducen a una estabilidad al cizallamiento de las preparaciones segun la invencion, pudiendo aparecer sin la adicion de las mismas, turbideces The bivalent neutral salts of magnesium chloride and calcium chloride lead to shear stability of the preparations according to the invention, and may appear without the addition thereof, turbidity
30 blancas cuando la formulacion por ejemplo se agita fuertemente, o cuando la formula se aplica con un rodillo o eventualmente cuando se envasa demasiado tarde. Con la adicion de las sales esto ya no ocurre mas. 30 white when the formulation, for example, is strongly agitated, or when the formula is applied with a roller or if it is too late packed. With the addition of salts this no longer occurs.
Es posible segun la invencion, mejorar la estabilidad de las preparaciones cosmeticas que contienen acido mandelico mediante la adicion de una o varias substancias auxiliares. Como mejora de la estabilidad se entiende a It is possible according to the invention, to improve the stability of cosmetic preparations containing mandelic acid by adding one or more auxiliary substances. The improvement of stability means
35 este respecto en particular el evitar precipitaciones, turbideces o cristalizaciones, la estabilizacion en presencia de radiacion solar y/o temperatura elevada, el evitar reacciones de decoloracion y/o la formacion de malos olores asi como el aumento de la estabilidad al cizallamiento de las preparaciones con acido mandelico. In this regard, in particular, avoiding precipitation, turbidity or crystallization, stabilization in the presence of solar radiation and / or high temperature, avoiding decolorization reactions and / or the formation of bad odors, as well as increasing the shear stability of the Mandelic acid preparations.
Es posible el empleo de substancias activas escogidas del grupo de los aceites de ricino hidrogenados The use of active substances chosen from the group of hydrogenated castor oils is possible
40 polietoxilados, el aceite de ricino hidrogenado con PEG 40, el aceite de ricino hidrogenado con PEG-60, los antioxidantes fenolicos, y/o los sulfitos, para la estabilizacion de las preparaciones conteniendo acido mandelico, las cuales contienen cloruro de magnesio y/o cloruro de calcio. 40 polyethoxylates, hydrogenated castor oil with PEG 40, hydrogenated castor oil with PEG-60, phenolic antioxidants, and / or sulphites, for stabilization of mandelic acid containing preparations, which contain magnesium chloride and / or calcium chloride.
La estabilizacion es particularmente ventajosa cuando en la preparacion estan contenidos como se ha mencionado 45 anteriormente un perfume o uno o varios de sus componentes. Stabilization is particularly advantageous when a perfume or one or more of its components are contained in the preparation as mentioned above.
Las preparaciones cosmeticas y dermatologicas segun la invencion pueden contener aditivos cosmeticos, como los que se emplean habitualmente en dichas preparaciones, por ejemplo agentes conservantes, bactericidas, filtros de UV, antioxidantes, vitaminas solubles en agua, substancias minerales, particulas solidas en suspension, perfumes, Cosmetic and dermatological preparations according to the invention may contain cosmetic additives, such as those commonly used in such preparations, for example preservatives, bactericides, UV filters, antioxidants, water-soluble vitamins, mineral substances, solid particles in suspension, perfumes ,
50 EDTA, substancias inhibidoras de la espuma, colorantes, pigmentos, que tienen una accion colorante, agentes espesantes, substancias humectantes y/o mantenedores de la humedad, u otros componentes habituales de una formulacion cosmetica o dermatologica como por ejemplo, alcoholes, polioles, polimeros, estabilizadores de la espuma, o derivados de la silicona. EDTA, foam inhibiting substances, dyes, pigments, which have a coloring action, thickening agents, wetting and / or moisture-keeping substances, or other usual components of a cosmetic or dermatological formulation such as, for example, alcohols, polyols, polymers, foam stabilizers, or silicone derivatives.
55 Estos aditivos deben diferenciarse de las substancias auxiliares mencionadas segun la invencion. 55 These additives must be distinguished from the auxiliary substances mentioned according to the invention.
Ventajosamente, para la obtencion de las preparaciones segun la invencion, pueden anadirse en primer lugar una o varias substancias auxiliares y eventualmente un perfume. La substancia activa y el perfume se dispersan a continuacion aproximadamente a partes iguales sobre las soluciones acuosas de acido mandelico y ACH, antes de Advantageously, in order to obtain the preparations according to the invention, one or more auxiliary substances and possibly a perfume can be added first. The active substance and the perfume are then dispersed approximately equally over the aqueous solutions of mandelic acid and ACH, before
60 que estos se anadan con fines gelificantes. 60 that these are added for gelling purposes.
Claims (5)
- --
- aceites de ricino hidrogenados polietoxilados, aceite de ricino hidrogenado con PEG-40, aceite de ricino hidrogenado con PEG- 60, polyethoxylated hydrogenated castor oils, hydrogenated castor oil with PEG-40, hydrogenated castor oil with PEG-60,
- --
- antioxidantes fenolicos y/o phenolic antioxidants and / or
- --
- uno o varios disulfitos, caracterizada porque la formulacion contiene cloruro de magnesio y/o cloruro de 10 calcio. one or more disulfites, characterized in that the formulation contains magnesium chloride and / or calcium chloride.
- 3. 3.
- Formulacion segun la reivindicacion 1 o 2, la cual comprende uno o varios perfumes y/o sus componentes. Formula according to claim 1 or 2, which comprises one or more perfumes and / or their components.
- 4. Four.
- Formulacion segun una de las precedentes reivindicaciones, caracterizada porque, el disulfito de sodio se ha Formulation according to one of the preceding claims, characterized in that the sodium disulfite has
- 25 6. Empleo de substancias auxiliares escogidas del grupo de los aceites de ricino hidrogenados polietoxilados, aceite de ricino hidrogenado con PEG-40, aceite de ricino hidrogenado con PEG-60, antioxidantes fenolicos y/o uno o varios disulfitos para la estabilizacion de las preparaciones que contienen acido mandelico, caracterizado porque, la formulacion contiene cloruro de magnesio y/o cloruro de calcio. 25 6. Use of auxiliary substances chosen from the group of polyethoxylated hydrogenated castor oils, hydrogenated castor oil with PEG-40, hydrogenated castor oil with PEG-60, phenolic antioxidants and / or one or more disulfites for the stabilization of preparations containing mandelic acid, characterized in that the formulation contains magnesium chloride and / or calcium chloride.
- 30 7. Empleo segun la reivindicacion 6, caracterizado porque en la preparacion, estan contenidos adicionalmente un perfume o uno o varios de sus componentes. Use according to claim 6, characterized in that in the preparation, a perfume or one or more of its components are additionally contained.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102070035742 | 2007-07-24 | ||
| DE102070035742 | 2007-07-24 | ||
| PCT/EP2008/005851 WO2009012927A2 (en) | 2007-07-24 | 2008-07-17 | Stabilization of a cosmetic or dermatological formulation containing mandelic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2390192T3 true ES2390192T3 (en) | 2012-11-07 |
Family
ID=47040483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08784833T Active ES2390192T3 (en) | 2007-07-24 | 2008-07-17 | Stabilization of a cosmetic or dermatological formulation with mandelic acid |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2390192T3 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021250130A1 (en) * | 2020-06-10 | 2021-12-16 | Firmenich Sa | Prevention, reduction, or amelioration of old person smell |
-
2008
- 2008-07-17 ES ES08784833T patent/ES2390192T3/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021250130A1 (en) * | 2020-06-10 | 2021-12-16 | Firmenich Sa | Prevention, reduction, or amelioration of old person smell |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4937069A (en) | Anhydrous semi-solid antiperspirant suspension | |
| RU2213556C2 (en) | Antiperspirant with dibezylidene sorbitol | |
| HUP0302849A2 (en) | Antiperspirant products | |
| JPH05170633A (en) | Transparent gel cosmetic composition and method for producing the same | |
| JP6070571B2 (en) | Deodorant composition | |
| ES2324822T3 (en) | TRANSPARENT COSMETIC OR DERMATOLOGICAL FORMULATION. | |
| ES2329151T3 (en) | AQUOSA ANTITRANSPIRANTE FORMULA. | |
| US8883130B2 (en) | Transparent antiperspirant gels | |
| EP2949313A1 (en) | Deodorant antiperspirant compositions | |
| BR112017012806B1 (en) | soluble zinc polyphosphate complex and zinc polyphosphate production method | |
| ES2984223T3 (en) | Antiperspirant compositions | |
| ES2372175T3 (en) | ANTITRANSPIRING COMPOSITIONS CONTAINING VASELINE. | |
| ES2399467T3 (en) | Cosmetic or dermatological formula containing pure D-o L-Mandelic acid | |
| US20150037264A1 (en) | Anhydrous antiperspirant compositions | |
| CA2813345C (en) | Antiperspirant compositions containing triethylhexanoin | |
| AU2014415217B2 (en) | Zinc phosphate complex | |
| US10357446B2 (en) | Cosmetic antiperspirants with alkylsuphonic acids | |
| ES2926826T3 (en) | Method to reduce perspiration | |
| CN116615173A (en) | Personal care compositions and methods | |
| EP4259066A1 (en) | An antiperspirant composition | |
| US20160206541A1 (en) | Antiperspirant cosmetic agents having polyphosphoric acids | |
| BR112017013014B1 (en) | personal hygiene composition, and method for depositing zinc on an individual's skin and / or hair | |
| BR112015029492B1 (en) | COSMETIC USE, COSMETIC PROCESS TO TREAT BODY ODOR AND COMPOSITION | |
| EP2183029B1 (en) | Stabilization of a cosmetic or dermatological formulation containing mandelic acid | |
| WO2017209020A1 (en) | Composition for oral cavity |