ES2425298B1 - PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS - Google Patents
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS Download PDFInfo
- Publication number
- ES2425298B1 ES2425298B1 ES201230195A ES201230195A ES2425298B1 ES 2425298 B1 ES2425298 B1 ES 2425298B1 ES 201230195 A ES201230195 A ES 201230195A ES 201230195 A ES201230195 A ES 201230195A ES 2425298 B1 ES2425298 B1 ES 2425298B1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- pharmaceutical compositions
- metalasis
- mannoprotein
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102100024023 Histone PARylation factor 1 Human genes 0.000 abstract 2
- 101001047783 Homo sapiens Histone PARylation factor 1 Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000021164 cell adhesion Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones farmacéuticas para el tratamiento de la metástasis.#La presente invención se relaciona con el empleo de un compuesto con capacidad de unión a una manoproteína y bloquear la unión de dicha manoproteína a un receptor de las células endoteliales, en la elaboración de una composición farmacéutica para el tratamiento de una enfermedad asociada a una adhesión celular indeseada. Asimismo, la presente invención también contempla métodos dirigidos a identificar un compuesto potencialmente útil para la prevención y/o el tratamiento de una enfermedad asociada a una adhesión celular indeseada, a pronosticar la probabilidad de un paciente que padece cáncer a sufrir metástasis y a diseñar una terapia personalizada a un paciente que padece cáncer.Pharmaceutical compositions for the treatment of metastasis. # The present invention relates to the use of a compound capable of binding to a mannoprotein and blocking the binding of said mannoprotein to a receptor of endothelial cells, in the preparation of a pharmaceutical composition for the treatment of a disease associated with unwanted cell adhesion. Likewise, the present invention also contemplates methods aimed at identifying a compound potentially useful for the prevention and / or treatment of a disease associated with unwanted cell adhesion, to predict the probability of a patient suffering from cancer to metastasize and to design a therapy. personalized to a patient suffering from cancer.
Description
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201230195A ES2425298B1 (en) | 2009-04-02 | 2009-04-02 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201230195A ES2425298B1 (en) | 2009-04-02 | 2009-04-02 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ES2425298A2 ES2425298A2 (en) | 2013-10-14 |
| ES2425298R1 ES2425298R1 (en) | 2013-11-08 |
| ES2425298B1 true ES2425298B1 (en) | 2014-10-01 |
Family
ID=49231804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201230195A Active ES2425298B1 (en) | 2009-04-02 | 2009-04-02 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2425298B1 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050153361A1 (en) * | 2003-09-09 | 2005-07-14 | Sullivan Dianne C. | Therapeutic and diagnostic applications of protein disulphide isomerases |
| AU2006235490A1 (en) * | 2005-04-12 | 2006-10-19 | Romark Laboratories, L.C. | Methods for treating diseases through the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents |
-
2009
- 2009-04-02 ES ES201230195A patent/ES2425298B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2425298R1 (en) | 2013-11-08 |
| ES2425298A2 (en) | 2013-10-14 |
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| FG2A | Definitive protection |
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