ES2425298R1 - PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METASTASIS - Google Patents

PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METASTASIS

Info

Publication number
ES2425298R1
ES2425298R1 ES201230195A ES201230195A ES2425298R1 ES 2425298 R1 ES2425298 R1 ES 2425298R1 ES 201230195 A ES201230195 A ES 201230195A ES 201230195 A ES201230195 A ES 201230195A ES 2425298 R1 ES2425298 R1 ES 2425298R1
Authority
ES
Spain
Prior art keywords
treatment
metastasis
pharmaceutical compositions
mannoprotein
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201230195A
Other languages
Spanish (es)
Other versions
ES2425298A2 (en
ES2425298B1 (en
Inventor
Echevarria Fernando Hernando
Garcia Andoni Ramirez
Fernando Vidal-Vanaclocha
Arteche Lorea Mendoza
Escobal Natalia Gallot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of the Basque Country
Original Assignee
University of the Basque Country
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of the Basque Country filed Critical University of the Basque Country
Priority to ES201230195A priority Critical patent/ES2425298B1/en
Publication of ES2425298A2 publication Critical patent/ES2425298A2/en
Publication of ES2425298R1 publication Critical patent/ES2425298R1/en
Application granted granted Critical
Publication of ES2425298B1 publication Critical patent/ES2425298B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composiciones farmacéuticas para el tratamiento de la metástasis. La presente invención se relaciona con el empleo de un compuesto con capacidad de unión a una manoproteína y bloquear la unión de dicha manoproteína a un receptor de las células endoteliales, en la elaboración de una composición farmacéutica para el tratamiento de una enfermedad asociada a una adhesión celular indeseada. Asimismo, la presente invención también contempla métodos dirigidos a identificar un compuesto potencialmente útil para la prevención y/o el tratamiento de una enfermedad asociada a una adhesión celular indeseada, a pronosticar la probabilidad de un paciente que padece cáncer a sufrir metástasis y a diseñar una terapia personalizada a un paciente que padece cáncer.Pharmaceutical compositions for the treatment of metastasis. The present invention relates to the use of a compound capable of binding to a mannoprotein and blocking the binding of said mannoprotein to an endothelial cell receptor, in the preparation of a pharmaceutical composition for the treatment of an adhesion-associated disease. unwanted cell phone Likewise, the present invention also contemplates methods aimed at identifying a compound potentially useful for the prevention and / or treatment of a disease associated with unwanted cell adhesion, to predict the probability of a patient suffering from cancer to metastasize and to design a therapy. personalized to a patient suffering from cancer.

ES201230195A 2009-04-02 2009-04-02 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS Active ES2425298B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201230195A ES2425298B1 (en) 2009-04-02 2009-04-02 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201230195A ES2425298B1 (en) 2009-04-02 2009-04-02 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS

Publications (3)

Publication Number Publication Date
ES2425298A2 ES2425298A2 (en) 2013-10-14
ES2425298R1 true ES2425298R1 (en) 2013-11-08
ES2425298B1 ES2425298B1 (en) 2014-10-01

Family

ID=49231804

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201230195A Active ES2425298B1 (en) 2009-04-02 2009-04-02 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF METALASIS

Country Status (1)

Country Link
ES (1) ES2425298B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050153361A1 (en) * 2003-09-09 2005-07-14 Sullivan Dianne C. Therapeutic and diagnostic applications of protein disulphide isomerases
WO2006110814A2 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050153361A1 (en) * 2003-09-09 2005-07-14 Sullivan Dianne C. Therapeutic and diagnostic applications of protein disulphide isomerases
WO2006110814A2 (en) * 2005-04-12 2006-10-19 Romark Laboratories, L.C. Methods for treating diseases through inhibition the function of molecular chaperones such as protein disulfide isomerases, pharmaceutical compositions comprising them, and screening methods for identifying therapeutic agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bertram G. et al. Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase. Yeast. 1996, Vol. 12, páginas 115-127 (todo el documento) *
Klotz S. A. et al. Antibodies to a5b1 and avb3 integrins react with Candida albicans alcohol dehydrogenase. Microbiology. 2001, Vol. 147, páginas 3159-3164 (todo el documento) *
Orozco A. S. et al. Mechanisms of the proinflammatory response of endotelial cells to Candida albicans infection Infection and Immunity. 03.2000, Vol. 68, Nº3, páginas 1134-1141, ISSN 0019-9567/00 (todo el documento) *
Polonelli L. et al. Antibody Complementarity-Determining Regions (CDRs) can display differential antimicrobial, antiviral and antitumor activities. Plos ONE. 06.2008, Vol. 3, Nº 6, e2371 (todo el documento) *

Also Published As

Publication number Publication date
ES2425298A2 (en) 2013-10-14
ES2425298B1 (en) 2014-10-01

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