ES247237A1 - UN MÉTODO PARA LA PREPARACION DE GRáNULOS DE ACCIoN PROLONGADA - Google Patents
UN MÉTODO PARA LA PREPARACION DE GRáNULOS DE ACCIoN PROLONGADAInfo
- Publication number
- ES247237A1 ES247237A1 ES0247237A ES247237A ES247237A1 ES 247237 A1 ES247237 A1 ES 247237A1 ES 0247237 A ES0247237 A ES 0247237A ES 247237 A ES247237 A ES 247237A ES 247237 A1 ES247237 A1 ES 247237A1
- Authority
- ES
- Spain
- Prior art keywords
- granules
- coated
- tabletted
- medicament
- mixed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008187 granular material Substances 0.000 title abstract 15
- 239000003814 drug Substances 0.000 abstract 4
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 3
- 229930006000 Sucrose Natural products 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000005720 sucrose Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- 239000001856 Ethyl cellulose Substances 0.000 abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000001079 digestive effect Effects 0.000 abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000008101 lactose Substances 0.000 abstract 2
- 229940113116 polyethylene glycol 1000 Drugs 0.000 abstract 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 abstract 1
- 239000001836 Dioctyl sodium sulphosuccinate Substances 0.000 abstract 1
- BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 229920003086 cellulose ether Polymers 0.000 abstract 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 abstract 1
- 229940038472 dicalcium phosphate Drugs 0.000 abstract 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 abstract 1
- 229960002534 ephedrine hydrochloride Drugs 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Un método par ala preparación de gránulos de acción prolongada de un medicamentoque comprende el recubrimiento de los gránulos de medicamento con una composición que contiene una substancia no tóxicaimpermeableformadora de película que sea muy débilmente soluble en los fluidos del aparato digestivo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB523358A GB908282A (en) | 1958-02-18 | 1958-02-18 | Coated pharmaceutical granules and tablets thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES247237A1 true ES247237A1 (es) | 1959-06-16 |
Family
ID=9792213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0247237A Expired ES247237A1 (es) | 1958-02-18 | 1959-02-14 | UN MÉTODO PARA LA PREPARACION DE GRáNULOS DE ACCIoN PROLONGADA |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE575775A (es) |
| BR (1) | BR5908484D0 (es) |
| ES (1) | ES247237A1 (es) |
| GB (1) | GB908282A (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5840529B2 (ja) * | 1975-09-29 | 1983-09-06 | 明治製菓株式会社 | ケイコウヨウセイザイノセイホウ |
| GB1598458A (en) * | 1977-04-01 | 1981-09-23 | Hoechst Uk Ltd | Tableting of microcapsules |
| DD146547A5 (de) * | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
| JP2514078B2 (ja) * | 1988-08-22 | 1996-07-10 | エスエス製薬株式会社 | 圧縮成型製剤 |
| IE64128B1 (en) * | 1990-02-26 | 1995-07-12 | Byrne Rynne Holdings Ltd | A pharmaceutical composition |
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| CA2558065A1 (en) * | 2004-03-04 | 2005-09-15 | Cem Goekhan | Artificial fruit |
| CN110882281B (zh) * | 2019-11-30 | 2023-01-10 | 江苏艾兰得营养品有限公司 | 一种益生菌肠溶片剂及其制备方法 |
-
0
- BE BE575775D patent/BE575775A/xx unknown
-
1958
- 1958-02-18 GB GB523358A patent/GB908282A/en not_active Expired
-
1959
- 1959-02-14 ES ES0247237A patent/ES247237A1/es not_active Expired
- 1959-02-16 BR BR10848459A patent/BR5908484D0/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB908282A (en) | 1962-10-17 |
| BR5908484D0 (pt) | 1973-06-12 |
| BE575775A (es) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU1706373A3 (ru) | Способ получени средства с регулируемым высвобождением активного соединени | |
| US3080294A (en) | Sustained release type of pharmaceutical vehicles | |
| FI97445C (fi) | Menetelmä hitaasti vapautuvan farmaseuttisen koostumuksen valmistamiseksi | |
| US4478819A (en) | Novel oral preparations | |
| EP0438249B1 (en) | Controlled absorption naproxen formulation for once-daily administration | |
| US3082154A (en) | Improved free-flowing coated antimalarial salts in particulate form | |
| KR840000230A (ko) | 브롬헥신 서방출성 제형의 제조방법 | |
| US3562806A (en) | Rumen stable medicament and/or nutrient compositions | |
| UA29513C2 (uk) | Фармацевтична композиція, що включає (е)-3,5-дигідрокси-7-[4'-4''-фторфеніл-2'-циклопропілхінолін-3'-іл]-6- гептенову кислоту | |
| ES408226A1 (es) | Procedimiento para preparar acidos quinazolin-4-il?indol-3-ilaceticos. | |
| GB1235787A (en) | Sustained release pharmaceutical tablets | |
| ES247237A1 (es) | UN MÉTODO PARA LA PREPARACION DE GRáNULOS DE ACCIoN PROLONGADA | |
| US3128226A (en) | Composition for relieving pain | |
| US5322698A (en) | Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure | |
| US2298122A (en) | Digitalis capsule | |
| GB760403A (en) | Improvements in or relating to enteric coatings | |
| GB630439A (en) | Improvements in or relating to pharmaceutical preparations | |
| US3244596A (en) | Coated medicinal agents and coating compositions therefor | |
| US3197370A (en) | Pyrilamine tannate compositions | |
| US3398225A (en) | Coated 2, 2-dichlorovinyl phosphate and polyvinyl chloride resin anthelmintic compositions | |
| US3326760A (en) | Choline salicylate polygalacturonate therapy | |
| US4900559A (en) | Stabilized enteric coated aspirin granules and process of preparation | |
| US5049374A (en) | Oral (coated bead) dosage form for sodium iodide I-131 | |
| EP0159735A1 (en) | Pharmaceutical composition containing tetracyclin or doxycyclin salts and a process of preparing such a composition | |
| GB2061111A (en) | Long acting pharmaceutical composition |