ES2494015T3 - Composiciones para tratar nauseas y vómitos de origen central - Google Patents
Composiciones para tratar nauseas y vómitos de origen central Download PDFInfo
- Publication number
- ES2494015T3 ES2494015T3 ES10805301.8T ES10805301T ES2494015T3 ES 2494015 T3 ES2494015 T3 ES 2494015T3 ES 10805301 T ES10805301 T ES 10805301T ES 2494015 T3 ES2494015 T3 ES 2494015T3
- Authority
- ES
- Spain
- Prior art keywords
- vomiting
- administered
- nausea
- patient
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Una combinación de (i) netupitant o una sal farmacéuticamente aceptable del mismo, (ii) un antagonista de 5-HT3 o una sal farmacéuticamente aceptable del mismo, (iii) dexametasona, para su uso en el tratamiento de náuseas y vómitos durante cinco días consecutivos en un paciente que lo necesita, en la que: a) se administra dicho netupitant o una sal farmacéuticamente aceptable del mismo a dicho paciente el día uno, en una cantidad terapéuticamente eficaz que es eficaz para tratar náuseas y vómitos durante las fases aguda y tardía de emesis, y que entra en la circulación sistémica, cruza la barrera hematoencefálica y ocupa al menos el 70 % de receptores NK1 en el cuerpo estriado setenta y dos horas después de dicha administración; b) se administra el antagonista de 5-HT3 o una sal farmacéuticamente aceptable del mismo a dicho paciente el día uno, en una cantidad terapéuticamente eficaz, que es eficaz para tratar náuseas y vómitos durante las fases aguda y tardía; y c) se administra dexametasona a dicho paciente el día uno en una primera dosis que es ineficaz contra náuseas y vómitos cuando se administra sola, pero eficaz contra náuseas y vómitos cuando se administra en combinación con dicho netupitant, en la que la primera dosis comprende del 50 al 70 % de una dosis eficaz mínima cuando se administra sola.
Description
E10805301
12-08-2014
• Gravedad de las náuseas para la fase global, aguda y tardía; • Satisfacción global del paciente con el tratamiento antiemético por medio de VAS para cada intervalo de 24 horas.
Las tasas de respuesta completa se resumen en la tabla 5. El porcentaje de pacientes con respuesta completa sobre 0-120 horas después del inicio de la administración de cisplatino fue del 76,5 % en el grupo de palonosetrón solo y del 87,4 %, 87,6 %, y del 89,6 % en los grupos de netupitant 100 mg, 200 mg, y 300 mg, respectivamente. Las diferencias de palonosetrón solo fueron mayores del 10 % (del 10,9 % al 13,2 %). Todas las dosis de netupitant fueron estadísticamente superiores a palonosetrón solo (valor p = 0,004 para el grupo de combinación de netupitant 300 mg).
Tabla 5: Tasa de respuesta completa para la fase global, aguda y tardía: Población MFAS
- Criterio de valoración de eficacia
- Palo solo (n=136) Palo + Netu 100 mg (n=135) Palo + Netu 200 mg (n=137) Palo + Netu 300 mg (n=135) Régimen de aprepitant (N=134)
- RC, fase global, 0-120 h
- Porcentaje de pacientes
- 76,5 87,4 87,6 89,6 86,6
- Diferencia de Palo solo (%)
- 10,9 11,1 13,2 10,1
- Valor p (*)
- 0,018 0,017 0,004 0,027
- RC, fase aguda, 0-24 h
- Porcentaje de pacientes
- 89,7 93,3 92,7 98,5 94,8
- Diferencia de Palo solo (%)
- 3,6 3,0 8,8 5,1
- Valor p (*)
- 0,278 0,383 0,007 0,114
- RC, fase tardía, 25-120 h
- Porcentaje de pacientes
- 80,1 90,4 91,2 90,4 88,8
- Diferencia de Palo solo (%)
- 10,2 11,1 10,2 8,7
- Valor p (*)
- 0,018 0,010 0,018 0,043
(*) valor p del análisis de regresión logística, valor p de aprepitant del análisis de regresión logística a posteriori.
10 La tabla 6 resume los principales criterios de valoración secundarios. En la fase global, el 76,5 % de los pacientes en el grupo de palonosetrón solo no experimentó emesis, mientras que el 87,4, 87,6, y 91,1 % de los pacientes no experimentó emesis en los grupos de combinación de netupitant 100 mg, 200 mg y 300 mg, respectivamente (p<0,05 para todas las dosis).
Tabla 6: Resumen de los resultados de eficacia secundaria: porcentaje de pacientes. Población MFAS
- Criterio de valoración de eficacia
- Palo solo (n=136) Palo + Netu 100 mg (n=135) Palo + Netu 200 mg (n=137) Palo + Netu 300 mg (n=135) Régimen de aprepitant (N=134) Palo + Aprep 285 mg (N=41) **
- Sin emesis
- Global
- 76,5 87,4* 87,6* 91,1* 87,3*
- Aguda
- 89,7 93,3 92,7 98,5* 94,8
- Tardía
- 80,1 90,4* 91,2* 91,9* 89,6*
- Sin rescate
- Global
- 95,6 97,8 100 98,5 97,8
- Aguda
- 97,8 99,3 100 100 100
- Tardía
- 97,1 97,8 100 98,5 97,8
- Sin náuseas
- Global
- 50,7 54,8 62,0 61,5 58,2 32
- Aguda
- 75,0 72,6 77,4 80,0 77,6 59
- Tardía
- 53,7 59,3 65,0 68,1* 60,4 41
- Sin náuseas significativas
- Global
- 79,4 80,0 86,1 89,6* 85,8 56
- Aguda
- 93,4 94,1 94,2 98,5* 94,0 79
- Tardía
- 80,9 81,5 89,8* 90,4* 88,1 59
- Control total
- Global
- 50,0 54,8 61,3 59,3 56,0
- Aguda
- 71,3 71,9 76,6 80,0 74,6
- Tardía
- 52,2 59,3 65,0* 65,9* 58,2
- Protección completa
- Global
- 69,9 76,3 80,3* 83,0* 78,4 51
- Aguda
- 87,5 89,6 88,3 97,0* 89,6 76
14
Claims (1)
-
imagen1 imagen2 imagen3 imagen4
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26247009P | 2009-11-18 | 2009-11-18 | |
| US262470P | 2009-11-18 | ||
| US38270910P | 2010-09-14 | 2010-09-14 | |
| US382709P | 2010-09-14 | ||
| PCT/IB2010/003106 WO2011061622A1 (en) | 2009-11-18 | 2010-11-18 | Compositions for treating centrally mediated nausea and vomiting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2494015T3 true ES2494015T3 (es) | 2014-09-12 |
Family
ID=43608757
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14151678.1T Active ES2623503T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
| ES14151676.5T Active ES2559475T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos de origen central |
| ES10805301.8T Active ES2494015T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar nauseas y vómitos de origen central |
| ES14151683.1T Active ES2595077T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14151678.1T Active ES2623503T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
| ES14151676.5T Active ES2559475T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos de origen central |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14151683.1T Active ES2595077T3 (es) | 2009-11-18 | 2010-11-18 | Composiciones para tratar náuseas y vómitos mediados centralmente |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US12042494B2 (es) |
| EP (3) | EP2727590B1 (es) |
| JP (1) | JP5890780B2 (es) |
| KR (1) | KR101615108B1 (es) |
| CN (6) | CN106421793B (es) |
| AP (1) | AP3083A (es) |
| AU (1) | AU2010320598B2 (es) |
| BR (1) | BR112012011485B1 (es) |
| CA (1) | CA2778301C (es) |
| CL (1) | CL2012001276A1 (es) |
| CO (1) | CO6551693A2 (es) |
| CR (1) | CR20120216A (es) |
| CU (1) | CU24048B1 (es) |
| CY (1) | CY1118062T1 (es) |
| DK (2) | DK2361090T3 (es) |
| DO (1) | DOP2012000138A (es) |
| EA (1) | EA026815B1 (es) |
| EC (1) | ECSP12011907A (es) |
| ES (4) | ES2623503T3 (es) |
| GE (1) | GEP20156226B (es) |
| GT (1) | GT201200156A (es) |
| HK (2) | HK1214148A1 (es) |
| HR (3) | HRP20140759T1 (es) |
| HU (1) | HUE029677T2 (es) |
| IL (1) | IL219576A (es) |
| LT (1) | LT2722045T (es) |
| MA (1) | MA33810B1 (es) |
| MX (1) | MX2012005347A (es) |
| MY (1) | MY159393A (es) |
| NI (1) | NI201200090A (es) |
| NZ (1) | NZ599439A (es) |
| PE (1) | PE20121483A1 (es) |
| PH (1) | PH12012500887A1 (es) |
| PL (3) | PL2361090T3 (es) |
| PT (2) | PT2361090E (es) |
| RS (2) | RS55206B1 (es) |
| SI (2) | SI2361090T1 (es) |
| SM (1) | SMT201400112B (es) |
| TN (1) | TN2012000170A1 (es) |
| WO (1) | WO2011061622A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
| EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
| WO2013004766A1 (en) * | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| CN105412110B (zh) * | 2011-10-18 | 2018-05-25 | 赫尔森保健股份公司 | 奈妥匹坦和帕洛诺司琼的治疗性组合 |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| US9403772B2 (en) | 2011-11-29 | 2016-08-02 | Helsinn Healthcare Sa | 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator |
| CN103520725B (zh) * | 2012-07-05 | 2017-10-24 | 海思科医药集团股份有限公司 | 一种治疗呕吐的药物组合物 |
| ES2824552T3 (es) | 2015-03-04 | 2021-05-12 | Vanda Pharmaceuticals Inc | Método de tratamiento con tradipitant |
| CN106902086B (zh) * | 2015-12-23 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种包含奈妥匹坦的固体组合物 |
| GB201618425D0 (en) * | 2016-11-01 | 2016-12-14 | Acacia Pharma Ltd | method |
| GB201702250D0 (en) | 2017-02-10 | 2017-03-29 | Acacia Pharma Ltd | Method |
| CN108721214B (zh) * | 2017-04-14 | 2020-06-16 | 和龙 | 奈妥吡坦和帕洛诺司琼复方纳米粒溶液、纳米粒及制备方法和用途 |
| CN108853010A (zh) * | 2017-05-15 | 2018-11-23 | 和龙 | 奈妥吡坦环糊精包合物、复方组合制剂及其制备方法和用途 |
| CN109200018A (zh) * | 2017-07-04 | 2019-01-15 | 南京诺瑞特医药科技有限公司 | 含有奈妥吡坦的微乳制剂 |
| CN119074729A (zh) * | 2017-11-17 | 2024-12-06 | 万达制药公司 | 使用川地匹坦治疗胃肠疾病的方法 |
| EP3746078A4 (en) * | 2018-02-02 | 2021-11-17 | Eustralis Pharmaceuticals Limited (Trading as Pressura Neuro) | ORAL FORMULATIONS AND USES THEREOF |
| AU2021407138A1 (en) * | 2020-12-25 | 2023-06-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Use of nk1 antagonist prodrug compound in combination with 5-ht3 receptor antagonist |
| EP4385500A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Fixed dose combination comprising netupitant and palonosetron |
| WO2024126398A1 (en) | 2022-12-12 | 2024-06-20 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Fixed dose combination comprising netupitant and palonosetron |
| EP4633608A1 (en) | 2022-12-12 | 2025-10-22 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| EP4385497A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
| WO2025246530A1 (en) * | 2024-05-30 | 2025-12-04 | The Chinese University Of Hong Kong | Personalized anti-emetic treatment for chemotherapy-induced nausea and vomiting |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL166267B1 (pl) | 1989-11-28 | 1995-04-28 | Syntex Inc | Sposób wytwarzania nowych zwiazków trójpierscieniowych PL PL PL PL |
| US5510486A (en) | 1994-07-26 | 1996-04-23 | Syntex (U.S.A.) Inc. | Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one |
| US6297395B1 (en) | 1995-11-10 | 2001-10-02 | The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Calixarenes and their use for sequestration of metals |
| PT1035115E (pt) | 1999-02-24 | 2005-01-31 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1 |
| MXPA03000366A (es) | 2000-07-14 | 2003-05-27 | Hoffmann La Roche | N-oxidos como profarmacos antagonistas del receptor nk1 de derivados de 4-fenil-piridina. |
| JP4116436B2 (ja) | 2000-12-14 | 2008-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | 自己乳化脂質マトリックス（ｓｅｌｍ） |
| DE10393729T5 (de) | 2002-11-15 | 2005-10-13 | Helsinn Healthcare S.A. | Verfahren zur Behandlung von Emesis |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formulations of palonosetron |
| MY143789A (en) | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
| MXPA05010819A (es) * | 2003-04-08 | 2006-03-30 | Progenics Pharm Inc | Uso de antagonistas de opioide perifericos, especialmente metilnaltrexona para tratar sindrome de intestino irritable. |
| KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
| US7479312B2 (en) | 2005-07-07 | 2009-01-20 | Konica Minolta Opto, Inc. | Retardation film, polarizing plate, and liquid crystal display device |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007096763A2 (en) | 2006-02-23 | 2007-08-30 | Pfizer Limited | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines |
| KR101441459B1 (ko) | 2006-10-24 | 2014-09-18 | 헬신 헬쓰케어 에스.에이. | 안정성 및 생체이용률이 개선된 염산 팔로노세트론을 포함하는 연질 캡슐 |
| US20110014117A1 (en) * | 2007-06-28 | 2011-01-20 | Schering Corporation | Anti-igf1r |
| JP2011505873A (ja) * | 2007-12-18 | 2011-03-03 | シェーリング コーポレイション | 抗ｉｇｆ１ｒ療法に対する感受性のバイオマーカー |
| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
-
2010
- 2010-11-18 ES ES14151678.1T patent/ES2623503T3/es active Active
- 2010-11-18 CN CN201610795827.5A patent/CN106421793B/zh active Active
- 2010-11-18 KR KR1020127015676A patent/KR101615108B1/ko active Active
- 2010-11-18 SI SI201030688T patent/SI2361090T1/sl unknown
- 2010-11-18 MX MX2012005347A patent/MX2012005347A/es active IP Right Grant
- 2010-11-18 EP EP14151676.5A patent/EP2727590B1/en active Active
- 2010-11-18 AU AU2010320598A patent/AU2010320598B2/en active Active
- 2010-11-18 CN CN201610795817.1A patent/CN107050455B/zh active Active
- 2010-11-18 CA CA2778301A patent/CA2778301C/en active Active
- 2010-11-18 EP EP14151678.1A patent/EP2722044B1/en active Active
- 2010-11-18 ES ES14151676.5T patent/ES2559475T3/es active Active
- 2010-11-18 PL PL10805301T patent/PL2361090T3/pl unknown
- 2010-11-18 PL PL14151678T patent/PL2722044T3/pl unknown
- 2010-11-18 RS RS20160833A patent/RS55206B1/sr unknown
- 2010-11-18 DK DK10805301.8T patent/DK2361090T3/da active
- 2010-11-18 EA EA201290356A patent/EA026815B1/ru active Protection Beyond IP Right Term
- 2010-11-18 GE GEAP201012752A patent/GEP20156226B/en unknown
- 2010-11-18 CN CN201510047631.3A patent/CN104856999A/zh active Pending
- 2010-11-18 PT PT108053018T patent/PT2361090E/pt unknown
- 2010-11-18 HR HRP20140759AT patent/HRP20140759T1/hr unknown
- 2010-11-18 RS RSP20140423 patent/RS53491B1/sr unknown
- 2010-11-18 CN CN201610797549.7A patent/CN106512010A/zh active Pending
- 2010-11-18 ES ES10805301.8T patent/ES2494015T3/es active Active
- 2010-11-18 JP JP2012539433A patent/JP5890780B2/ja active Active
- 2010-11-18 ES ES14151683.1T patent/ES2595077T3/es active Active
- 2010-11-18 EP EP10805301.8A patent/EP2361090B1/en active Active
- 2010-11-18 CN CN2010800521070A patent/CN102655864A/zh active Pending
- 2010-11-18 MY MYPI2012002073A patent/MY159393A/en unknown
- 2010-11-18 WO PCT/IB2010/003106 patent/WO2011061622A1/en not_active Ceased
- 2010-11-18 CN CN201510046972.9A patent/CN104856998A/zh active Pending
- 2010-11-18 DK DK14151683.1T patent/DK2722045T3/en active
- 2010-11-18 AP AP2012006278A patent/AP3083A/xx active
- 2010-11-18 SI SI201031291T patent/SI2722045T1/sl unknown
- 2010-11-18 HU HUE14151683A patent/HUE029677T2/hu unknown
- 2010-11-18 PE PE2012000686A patent/PE20121483A1/es active IP Right Grant
- 2010-11-18 PH PH1/2012/500887A patent/PH12012500887A1/en unknown
- 2010-11-18 PT PT141516831T patent/PT2722045T/pt unknown
- 2010-11-18 BR BR112012011485-9A patent/BR112012011485B1/pt active IP Right Grant
- 2010-11-18 NZ NZ599439A patent/NZ599439A/en unknown
- 2010-11-18 LT LTEP14151683.1T patent/LT2722045T/lt unknown
- 2010-11-18 PL PL14151683T patent/PL2722045T3/pl unknown
-
2012
- 2012-04-13 TN TNP2012000170A patent/TN2012000170A1/en unknown
- 2012-04-26 CR CR20120216A patent/CR20120216A/es unknown
- 2012-05-03 IL IL219576A patent/IL219576A/en active IP Right Grant
- 2012-05-10 NI NI201200090A patent/NI201200090A/es unknown
- 2012-05-15 DO DO2012000138A patent/DOP2012000138A/es unknown
- 2012-05-16 CL CL2012001276A patent/CL2012001276A1/es unknown
- 2012-05-17 EC ECSP12011907 patent/ECSP12011907A/es unknown
- 2012-05-18 GT GT201200156A patent/GT201200156A/es unknown
- 2012-05-18 CO CO12082329A patent/CO6551693A2/es not_active Application Discontinuation
- 2012-05-18 CU CU2012000078A patent/CU24048B1/es active IP Right Grant
- 2012-06-11 MA MA34953A patent/MA33810B1/fr unknown
-
2014
- 2014-08-18 SM SM201400112T patent/SMT201400112B/xx unknown
-
2016
- 2016-02-24 HK HK16102110.3A patent/HK1214148A1/zh unknown
- 2016-02-24 HK HK16102109.6A patent/HK1214147A1/zh unknown
- 2016-10-05 HR HRP20161277TT patent/HRP20161277T1/hr unknown
- 2016-10-05 CY CY20161100991T patent/CY1118062T1/el unknown
-
2017
- 2017-03-14 HR HRP20170419TT patent/HRP20170419T1/hr unknown
-
2022
- 2022-12-16 US US18/082,737 patent/US12042494B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2494015T3 (es) | Composiciones para tratar nauseas y vómitos de origen central | |
| ES2866933T3 (es) | Regímenes de dosificación de amisulprida para tratar náuseas y vómitos | |
| UY35624A (es) | Uso de dosis elevadas de pridopidina para tratar la enfermedad de huntington | |
| MX2020003381A (es) | Composicion para la prevencion o el tratamiento de enfermedades relacionadas con el factor de necrosis tumoral (tnf), que contiene un nuevo derivado como ingrediente activo, y metodo para inhibir la actividad del factor de necrosis tumoral (tnf) mediante el uso de la misma. | |
| AR082150A1 (es) | N-etil-n-fenil-1,2-dihidro-4-hidroxi-5-cloro-1-metil-2-oxoquinolin-3-carboxamida deuterada, sales y usos de la misma, metodo de tratamiento, mezcla compuestos, composicion farmaceutica, proceso de preparacion, compuesto enriquecido con deuterio | |
| EA201491285A1 (ru) | Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты | |
| EA201490163A1 (ru) | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения | |
| RU2013121788A (ru) | Ингибиторы репликации вич | |
| EA201790406A1 (ru) | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения | |
| EA202191079A1 (ru) | Способы лечения синдрома ретта с применением фенфлурамина | |
| JP2018507243A5 (es) | ||
| JP2012502047A5 (es) | ||
| CO2022008437A2 (es) | Métodos de tratamiento del cáncer de pulmón de cé-lulas pequeñas con formulaciones de lurbinectedina | |
| JP2020500864A5 (es) | ||
| JP2015522015A5 (es) | ||
| RU2019121690A (ru) | Дексмедетомидин или медетомидин для применения для лечения сепарационной тревожности у собак | |
| JP2016505050A5 (es) | ||
| JP2016515137A5 (es) | ||
| AR046410A1 (es) | Composiciones farmaceuticas para la liberacion modificada de modafinilo | |
| Collaborative Group of the Spanish Society of Clinical Pharmacology et al. | Comparative study of the efficacy of dipyrone, diclofenac sodium and pethidine in acute renal colic | |
| PE20061126A1 (es) | Formas de dosificacion oral solidas que contienen una dosis baja de estradiol | |
| Gelb et al. | Long-term efficacy and safety of twice-daily aclidinium bromide in COPD patients: a one-year study | |
| Chapman et al. | P234 QVA149 once daily improves lung function, dyspnoea and health status independent of prior medications and disease severity: the SHINE study | |
| CN112437661A (zh) | 苯甲酸或其盐用于预防或治疗抗n-甲基-d-天冬氨酸受体脑炎的用途 | |
| WO2007062837A2 (en) | Use of a 5-ht4 agonist for the treatment of irritable bowel syndrome characterized by mixed or alternating bowel habits |