ES2500840T3 - Uso de composiciones farmacéuticas en la preparación de productos farmacéuticos para tratar úlcera diabética - Google Patents

Uso de composiciones farmacéuticas en la preparación de productos farmacéuticos para tratar úlcera diabética Download PDF

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ES2500840T3
ES2500840T3 ES10809445.9T ES10809445T ES2500840T3 ES 2500840 T3 ES2500840 T3 ES 2500840T3 ES 10809445 T ES10809445 T ES 10809445T ES 2500840 T3 ES2500840 T3 ES 2500840T3
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preparation
diabetic ulcer
pharmaceutical
treat diabetic
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Rongxiang Xu
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Abstract

Composición farmacéutica para su uso en el tratamiento de úlcera diabética en extremidades o en la superficie corporal, que consiste en (A) del 3 al 15% en peso de cera de abejas comestible y (B) del 85 al 97% en peso de extracto en aceite de sésamo de Huangqin, Huanglian, Huangbai, lombriz de tierra y cápsula de adormidera, basándose en el peso total de la composición farmacéutica, mientras que en el extracto en aceite de sésamo, cada uno de Huangqin, Huanglian, Huangbai, lombriz de tierra y cápsula de adormidera está en una cantidad del 2 al 10% en peso, basándose en el peso total del aceite de sésamo.

Description

imagen1
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-= =
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Tabla: Comparación de la eficacia terapéutica entre dos grupos.
Grupo
Nº. de caso Curación Eficacia obvia Eficacia Ineficacia Eficacia total Tiempo de curación medio (d)
Grupo de control
30 9 12 6 3 27 47,30 ± 20,40
Grupo de prueba
30 27 2 1 0 30 25,00 ± 10,50
Nota: se adoptó la prueba de x 2 para los datos de la tabla fila X columna para la comparación de la tasa, los valores de x 2 de tasa de eficacia y tasa de curación son de 22,71 y 20,07 respectivamente, todos son superiores a 12,84 x 2 0,05 = , por tanto P <0,05; también se adoptó la prueba de x 2 para la comparación de los tiempos de curación medios, t=5,32, P <0,01.
imagen10

Claims (1)

  1. imagen1
ES10809445.9T 2009-08-20 2010-01-20 Uso de composiciones farmacéuticas en la preparación de productos farmacéuticos para tratar úlcera diabética Active ES2500840T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2009100913555A CN101991688A (zh) 2009-08-20 2009-08-20 药物组合物在制备治疗糖尿病溃疡药物中的用途
CN200910091355 2009-08-20
PCT/CN2010/070263 WO2011020311A1 (en) 2009-08-20 2010-01-20 Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer

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ES2500840T3 true ES2500840T3 (es) 2014-09-30

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US (3) US20120171298A1 (es)
EP (1) EP2362777B1 (es)
JP (1) JP5580896B2 (es)
KR (2) KR101534468B1 (es)
CN (1) CN101991688A (es)
AU (1) AU2010283917B2 (es)
BR (1) BRPI1006040B1 (es)
CA (1) CA2746459C (es)
ES (1) ES2500840T3 (es)
MX (1) MX2011007707A (es)
RU (1) RU2523889C2 (es)
WO (1) WO2011020311A1 (es)

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Publication number Priority date Publication date Assignee Title
CN103961445B (zh) * 2013-01-24 2018-04-17 徐荣祥 治疗热损伤、创疡合并骨损伤的药物组合物
CN103893458B (zh) * 2014-04-18 2017-08-11 中国人民解放军第三军医大学第一附属医院 糖尿病足溃疡外用中药组合物、制备方法及其应用
CN104524002A (zh) * 2014-12-12 2015-04-22 陈霞 一种治疗糖尿病足的消炎生皮油纱及其制备方法
US11284991B2 (en) 2016-03-11 2022-03-29 The Regents Of The University Of California Synthetic polymeric implantable artificial cornea device incorporating nanopatterns
US11484028B2 (en) 2016-03-14 2022-11-01 The Regents Of The University Of California Fabrication of nano-structures on multiple sides of a non-planar surface
CN106075538A (zh) * 2016-06-08 2016-11-09 成都森科制药有限公司 防粘油纱条及其制作工艺
US10828394B2 (en) 2017-09-13 2020-11-10 The Regents Of The University Of California Anti-bacterial anti-fungal nanopillared surface
US11086049B2 (en) 2017-10-03 2021-08-10 The Regents Of The University Of California Anti-microbial bandage contact lens with ocular drug delivery
KR20200047220A (ko) 2018-10-27 2020-05-07 장정훈 창상, 당뇨병성 족부/손 궤양 또는 버거씨병 치료용 약학 조성물
JP7286131B2 (ja) * 2018-11-15 2023-06-05 学校法人順天堂 糖尿病性潰瘍の治癒促進剤
KR102072948B1 (ko) 2019-08-06 2020-02-04 주식회사 씨엔엘바이오텍 염증치료용 약학적 발효 조성물
KR20210104319A (ko) 2020-02-17 2021-08-25 노태성 궤양 치료를 위한 조성물
CN112169009A (zh) * 2020-09-01 2021-01-05 茂名市人民医院 一种油纱布及制备方法
CN112843176B (zh) * 2020-11-10 2022-02-08 青岛大学附属医院 一种治疗糖尿病足病的中药组合物及其制备方法
CN116327837A (zh) * 2023-04-25 2023-06-27 北京荣祥再生医学研究所有限公司 一种组合物及其在制备抑制细胞周期蛋白d1的药物中的应用
CN116942739A (zh) * 2023-08-30 2023-10-27 北京中医药大学东直门医院 一种用于治疗压疮的复方黄柏液湿敷联合硅胶泡沫敷料

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86108951A (zh) * 1986-12-31 1988-08-24 徐荣祥 低熔点软膏剂型及湿润烧伤膏的制作工艺
CN1045059C (zh) * 1993-01-15 1999-09-15 徐荣祥 一种治疗温血动物或人类热损伤的药用组合物及其制法
JP3126583B2 (ja) * 1994-01-13 2001-01-22 ロンシャン シュ 熱傷治療剤、その製造方法及びそれを用いた治療方法
GB9510226D0 (en) * 1995-05-20 1995-07-19 Smith & Nephew Sterilisable cream or paste product for topical application
CN1062129C (zh) * 1995-09-14 2001-02-21 徐荣祥 药物基质及其用途
RU2241489C2 (ru) * 1998-02-27 2004-12-10 Биора Биоэкс Аб Композиции матриксных протеинов для залечивания ран
US6555118B1 (en) * 2001-02-22 2003-04-29 Sarfaraz K Niazi Pharmaceutical preparation for the treatment of topical wounds and ulcers
US6685971B2 (en) * 2001-06-28 2004-02-03 Rongxiang Xu Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract
CN1827766B (zh) * 2001-06-28 2010-08-25 徐荣祥 体外细胞的培养方法
RU2264798C2 (ru) * 2002-11-04 2005-11-27 Ардашев Вячеслав Николаевич Аптечка неотложной самопомощи при приступе аритмии с частым пульсом
CN101069753A (zh) * 2006-05-09 2007-11-14 上海美宝生命科技有限公司 一种创面速愈贴及其制造方法

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