ES2506116T3 - Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo - Google Patents

Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo Download PDF

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Publication number
ES2506116T3
ES2506116T3 ES09749849.7T ES09749849T ES2506116T3 ES 2506116 T3 ES2506116 T3 ES 2506116T3 ES 09749849 T ES09749849 T ES 09749849T ES 2506116 T3 ES2506116 T3 ES 2506116T3
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Spain
Prior art keywords
trem
sepsis
subject
sample
prognosis
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Active
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ES09749849.7T
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English (en)
Inventor
Koen Kas
Griet Vanpoucke
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Biocartis NV
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Biocartis NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Método para la predicción, pronóstico y/o diagnóstico de septicemia, septicemia grave, choque septicémico, o MODS en un sujeto de prueba que comprende: (a) medir el nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 en una muestra de sangre o suero extraída de dicho sujeto de prueba, y (b) comparar dicho nivel de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 con un nivel de referencia de transcrito de receptor similar a TREM-1 soluble (sTLT1) y TREM-1 obtenido de una muestra de un sujeto sano, en la que (c) un nivel de expresión reducida de sTLT-1 y una expresión aumentada de TREM-1 en la muestra del sujeto de prueba en comparación con los de una muestra de un sujeto sano o sin septicemia indica que el sujeto de prueba tiene o corre el riesgo de tener septicemia, septicemia grave, choque septicémico o MODS.

Description

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Claims (1)

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ES09749849.7T 2008-05-23 2009-05-19 Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo Active ES2506116T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08156837 2008-05-23
EP08156837 2008-05-23
PCT/EP2009/056094 WO2009141359A1 (en) 2008-05-23 2009-05-19 New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof

Publications (1)

Publication Number Publication Date
ES2506116T3 true ES2506116T3 (es) 2014-10-13

Family

ID=40897625

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09749849.7T Active ES2506116T3 (es) 2008-05-23 2009-05-19 Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo

Country Status (5)

Country Link
US (1) US8697370B2 (es)
EP (2) EP2300829B1 (es)
CA (1) CA2721742A1 (es)
ES (1) ES2506116T3 (es)
WO (1) WO2009141359A1 (es)

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RU2463606C1 (ru) * 2011-08-17 2012-10-10 Учреждение Российской академии медицинских наук Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний Сибирского отделения Российской академии медицинских наук (УРАМН НИИ КПССЗ СО РАМН) Способ ранней диагностики осложненного системного воспалительного ответа у пациентов, оперированных в условиях искусственного кровообращения
US9238841B2 (en) 2012-02-07 2016-01-19 Children's Hospital Medical Center Multi-biomarker-based outcome risk stratification model for pediatric septic shock
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ES2640268T3 (es) 2012-02-15 2017-11-02 Novo Nordisk A/S Anticuerpos que se unen a y bloquean un receptor desencadenante expresado en células mieloides 1 (TREM-1)
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EP3030576A4 (en) * 2013-08-07 2017-04-05 University Of Rochester Method of diagnosing sepsis or sepsis risk
CA2931614A1 (en) 2013-11-25 2015-05-28 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
KR101569334B1 (ko) 2013-12-20 2015-11-17 경북대학교 산학협력단 래프틀린을 함유하는 패혈증 진단용 바이오마커 조성물 및 이를 이용한 진단방법
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
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US10761093B2 (en) 2014-10-09 2020-09-01 Texas Tech University System Microdevice for cell separation utilizing activation phenotype
US20170234873A1 (en) 2014-10-14 2017-08-17 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
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JP2018517892A (ja) 2015-04-10 2018-07-05 アプライド プロテオミクス，インク． 結腸直腸癌と進行腺腫を検知するためのタンパク質バイオマーカーパネル
US10261068B2 (en) 2015-06-04 2019-04-16 Children's Hospital Medical Center Persevere-II: redefining the pediatric sepsis biomarker risk model with septic shock phenotype
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US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
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KR102831552B1 (ko) 2018-09-28 2025-07-08 이노트렘 항염 요법에 반응할 수 있는 대상체를 식별하기 위한 가용성 trem-1 수준의 용도
US11154240B2 (en) 2019-04-02 2021-10-26 Kpn Innovations Llc Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance
WO2021123249A1 (en) * 2019-12-20 2021-06-24 Gerencia Regional de Salud de Castilla y León In vitro method for the differential diagnosis between septic shock and non-septic shock patients
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CN117280218A (zh) * 2021-04-30 2023-12-22 豪夫迈·罗氏有限公司 用于脓毒症的早期检测的strem1标志物组
JP2024546046A (ja) * 2021-11-15 2024-12-17 アセンド バイオテクノロジー インク Ｔｒｅｍｌ１により誘導された免疫抑制を逆転させる方法
CN117214442B (zh) * 2023-10-27 2026-04-14 重庆医科大学 中脑星形细胞源性神经营养因子作为生物标志物和治疗靶点在脓毒血症中的用途
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CN118914567B (zh) * 2024-08-13 2025-03-25 山东第一医科大学附属省立医院(山东省立医院) Ctrp1作为生物标志物在制备儿童脓毒症早期诊断产品中的应用

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Also Published As

Publication number Publication date
US8697370B2 (en) 2014-04-15
EP2300829B1 (en) 2014-07-23
WO2009141359A1 (en) 2009-11-26
EP2300829A1 (en) 2011-03-30
US20110059858A1 (en) 2011-03-10
CA2721742A1 (en) 2009-11-26
EP2796878A1 (en) 2014-10-29

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