ES2570627T3 - Ensayo in vitro de Ezrina para el diagnóstico del cáncer colorrectal - Google Patents

Ensayo in vitro de Ezrina para el diagnóstico del cáncer colorrectal

Info

Publication number
ES2570627T3
ES2570627T3 ES08827062T ES08827062T ES2570627T3 ES 2570627 T3 ES2570627 T3 ES 2570627T3 ES 08827062 T ES08827062 T ES 08827062T ES 08827062 T ES08827062 T ES 08827062T ES 2570627 T3 ES2570627 T3 ES 2570627T3
Authority
ES
Spain
Prior art keywords
seq
colorectal cancer
ezrina
diagnosis
vitro test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08827062T
Other languages
English (en)
Inventor
Monique Arpin
Yasemin Ataman-Önal
Corinne Beaulieu
Sandrine Busseret
Jean-Philippe Charrier
Geneviève Choquet-Kastylevsky
Dominique Rolland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Centre National de la Recherche Scientifique
Institute Curie
Original Assignee
Biomerieux SA
Centre National de la Recherche Scientifique
Institute Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA, Centre National de la Recherche Scientifique, Institute Curie filed Critical Biomerieux SA
Application granted granted Critical
Publication of ES2570627T3 publication Critical patent/ES2570627T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Oncology (AREA)

Abstract

Procedimiento de diagnóstico in vitro del cáncer colorrectal por determinación del aumento de la concentración, con respecto a los valores de referencia determinados para los sujetos sanos, del marcador Ezrina en una muestra biológica procedente de un paciente sospechoso de padecer cáncer colorrectal utilizando al menos un anticuerpo monoclonal anti-ezrina dirigido contra un epítopo de la ezrina seleccionado entre los epítopos de secuencia SEQ ID nº 1, SEQ ID nº 2, SEQ ID nº 3, SEQ ID nº 4 + SEQ ID nº 5, SEQ ID nº 6 + SEQ ID nº 7 y SEQ ID nº 8.
ES08827062T 2007-07-19 2008-07-10 Ensayo in vitro de Ezrina para el diagnóstico del cáncer colorrectal Active ES2570627T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705197A FR2919060B1 (fr) 2007-07-19 2007-07-19 Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal.
PCT/FR2008/051289 WO2009019365A2 (fr) 2007-07-19 2008-07-10 Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal

Publications (1)

Publication Number Publication Date
ES2570627T3 true ES2570627T3 (es) 2016-05-19

Family

ID=38736063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08827062T Active ES2570627T3 (es) 2007-07-19 2008-07-10 Ensayo in vitro de Ezrina para el diagnóstico del cáncer colorrectal

Country Status (9)

Country Link
US (3) US8361731B2 (es)
EP (1) EP2167971B1 (es)
JP (2) JP5690139B2 (es)
CN (1) CN101802617B (es)
AU (1) AU2008285554B2 (es)
CA (1) CA2693648C (es)
ES (1) ES2570627T3 (es)
FR (1) FR2919060B1 (es)
WO (1) WO2009019365A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2919062B1 (fr) * 2007-07-19 2009-10-02 Biomerieux Sa Procede de dosage de l'aminoacylase 1 pour le diagnostic in vitro du cancer colorectal.
FR2944019B1 (fr) * 2009-04-03 2011-04-22 Biomerieux Sa Procede de dosage de la prodefensine-a6 pour le diagnostic in vitro du cancer colorectal.
FR2968767B1 (fr) 2010-12-08 2012-12-21 Biomerieux Sa Procede et coffret pour le diagnostic in vitro du cancer de la prostate
FR2991777B1 (fr) 2012-06-07 2015-08-21 Biomerieux Sa Procede de detection et/ou de dosage de l'annexine a3 d'un mammifere dans le sang ou au moins un de ses derives
FR3001806B1 (fr) * 2013-02-01 2016-05-20 Biomerieux Sa Procede de detection d'une lesion colorectale
FR3001805B1 (fr) 2013-02-01 2015-02-20 Biomerieux Sa Procede de detection d'un cancer colorectal
CN103214557A (zh) * 2013-03-20 2013-07-24 苏州纽微生物技术有限公司 一种Ezrin抗原决定簇多肽及其磷酸化Thr566抗体制备方法和采用该抗体制备的试剂盒
US20160109460A1 (en) * 2014-10-16 2016-04-21 The Board Of Regents Of The University Of Texas System Methods And Compositions For Determining Fortilin Levels
WO2017100789A1 (en) * 2015-12-11 2017-06-15 Expression Pathology, Inc. Srm/mrm assays
JP6080184B1 (ja) * 2016-02-29 2017-02-15 常雄 小林 癌の一生を分類する際に用いるデータ採取方法
CN109471147B (zh) * 2018-09-25 2022-10-18 中国辐射防护研究院 一种基于变权重离散的γ剂量率计算方法及系统
CN113321721B (zh) * 2021-06-11 2022-06-03 中南大学湘雅二医院 一种细胞外Ezrin蛋白及其应用

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Also Published As

Publication number Publication date
JP2015096508A (ja) 2015-05-21
AU2008285554B2 (en) 2014-06-26
FR2919060A1 (fr) 2009-01-23
JP2010533688A (ja) 2010-10-28
US20150233933A1 (en) 2015-08-20
CN101802617A (zh) 2010-08-11
AU2008285554A8 (en) 2010-07-29
US20130102758A1 (en) 2013-04-25
CA2693648A1 (fr) 2009-02-12
CN101802617B (zh) 2014-07-09
CA2693648C (fr) 2017-04-18
EP2167971B1 (fr) 2016-02-17
JP5690139B2 (ja) 2015-03-25
FR2919060B1 (fr) 2012-11-30
WO2009019365A3 (fr) 2009-04-09
US9890196B2 (en) 2018-02-13
US8361731B2 (en) 2013-01-29
WO2009019365A2 (fr) 2009-02-12
AU2008285554A1 (en) 2009-02-12
US20100136539A1 (en) 2010-06-03
EP2167971A2 (fr) 2010-03-31

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