ES2510565T3 - Envase de ajuste de dosis para neramexano y su uso en el tratamiento de un trastorno del oído interno - Google Patents

Envase de ajuste de dosis para neramexano y su uso en el tratamiento de un trastorno del oído interno Download PDF

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Publication number
ES2510565T3
ES2510565T3 ES08801986.4T ES08801986T ES2510565T3 ES 2510565 T3 ES2510565 T3 ES 2510565T3 ES 08801986 T ES08801986 T ES 08801986T ES 2510565 T3 ES2510565 T3 ES 2510565T3
Authority
ES
Spain
Prior art keywords
neramexane
treatment
dose adjustment
internal ear
ear disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08801986.4T
Other languages
English (en)
Inventor
Barbara Ellers-Lenz
Tanja Rosenberg
Erhard Seiller
Hagen Krueger
Michael Althaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Merz Pharma GmbH and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma GmbH and Co KGaA filed Critical Merz Pharma GmbH and Co KGaA
Application granted granted Critical
Publication of ES2510565T3 publication Critical patent/ES2510565T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

Neramexano o una sal farmacéuticamente aceptable del mismo para su uso en el tratamiento de un trastorno del oído interno, donde dicho neramexano o sal farmacéuticamente aceptable del mismo se administra en un esquema de ajuste de dosis que comprende un ajuste ascendente de la dosis del neramexano o de una sal farmacéuticamente aceptable del mismo en dosis crecientes por etapas de 25 mg o 12,5 mg a intervalos semanales durante un periodo de cuatro a cinco semanas para conseguir una dosis eficaz de 50 a 75 mg al día.

Description

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Claims (1)

  1. imagen1
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ES08801986.4T 2007-09-12 2008-09-10 Envase de ajuste de dosis para neramexano y su uso en el tratamiento de un trastorno del oído interno Active ES2510565T3 (es)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US99339607P 2007-09-12 2007-09-12
US993396P 2007-09-12
EP07253630 2007-09-12
EP07253630 2007-09-12
US6693108P 2008-02-25 2008-02-25
US6708308P 2008-02-25 2008-02-25
US6702608P 2008-02-25 2008-02-25
US67026P 2008-02-25
US66931P 2008-02-25
US67083P 2008-02-25
EP08004778 2008-03-14
EP08004777 2008-03-14
EP08004777 2008-03-14
EP08004778 2008-03-14
EP08004776 2008-03-14
EP08004776 2008-03-14
PCT/EP2008/007420 WO2009033651A1 (en) 2007-09-12 2008-09-10 Titration package for neramexane and its use in the treatment of an inner ear disorder

Publications (1)

Publication Number Publication Date
ES2510565T3 true ES2510565T3 (es) 2014-10-21

Family

ID=40451596

Family Applications (5)

Application Number Title Priority Date Filing Date
ES11005567.0T Active ES2596262T3 (es) 2007-09-12 2008-09-10 Derivados de 1-amino-alquilciclohexano para su uso en el tratamiento de tinnitus asociado con pérdida de audición
ES12006826.7T Active ES2562709T3 (es) 2007-09-12 2008-09-10 Envase de ajuste de dosis para 1-amino-alquilciclohexanos
ES08801986.4T Active ES2510565T3 (es) 2007-09-12 2008-09-10 Envase de ajuste de dosis para neramexano y su uso en el tratamiento de un trastorno del oído interno
ES08801985.6T Active ES2604945T3 (es) 2007-09-12 2008-09-10 Derivados de 1-amino-alquilciclohexano para el tratamiento y prevención de pérdida de audición
ES08801987T Active ES2377253T3 (es) 2007-09-12 2008-09-10 Neramexano para uso en el tratamiento de tinitus subagudo

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES11005567.0T Active ES2596262T3 (es) 2007-09-12 2008-09-10 Derivados de 1-amino-alquilciclohexano para su uso en el tratamiento de tinnitus asociado con pérdida de audición
ES12006826.7T Active ES2562709T3 (es) 2007-09-12 2008-09-10 Envase de ajuste de dosis para 1-amino-alquilciclohexanos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES08801985.6T Active ES2604945T3 (es) 2007-09-12 2008-09-10 Derivados de 1-amino-alquilciclohexano para el tratamiento y prevención de pérdida de audición
ES08801987T Active ES2377253T3 (es) 2007-09-12 2008-09-10 Neramexano para uso en el tratamiento de tinitus subagudo

Country Status (21)

Country Link
US (6) US9498450B2 (es)
EP (6) EP2200598A1 (es)
JP (6) JP5563460B2 (es)
KR (4) KR20100052556A (es)
CN (4) CN101801366A (es)
AR (3) AR070026A1 (es)
AT (1) ATE532507T1 (es)
AU (4) AU2008298018C1 (es)
BR (2) BRPI0816690A2 (es)
CA (4) CA2699207A1 (es)
DK (1) DK2200600T3 (es)
ES (5) ES2596262T3 (es)
HR (1) HRP20120046T1 (es)
MX (4) MX2010002733A (es)
PL (1) PL2200600T3 (es)
PT (1) PT2200600E (es)
RU (1) RU2011137131A (es)
SI (1) SI2200600T1 (es)
TW (3) TW200927087A (es)
WO (4) WO2009033651A1 (es)
ZA (4) ZA201001264B (es)

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CN101801366A (zh) * 2007-09-12 2010-08-11 莫茨药物股份两合公司 用于neramexane的逐步增量包装和其在治疗内耳病中的用途
US20110294890A1 (en) 2010-05-28 2011-12-01 Merz Pharma Gmbh & Co. Kgaa Neramexane for the treatment or prevention of inner ear disorders
JP2013529604A (ja) * 2010-06-24 2013-07-22 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン ネラメキサン複数単位剤形
EP2665474A1 (en) * 2011-01-20 2013-11-27 Merz Pharma GmbH & Co. KGaA Neramexane for the treatment or prevention of tinnitus related with stress or acute hearing loss
US20160129084A1 (en) * 2013-03-06 2016-05-12 Acorda Therapeutics, Inc. Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure
SG11201608630SA (en) * 2014-04-28 2016-11-29 Kyorin Seiyaku Kk Drug for treatment of tinnitus patients
EA201692163A1 (ru) * 2014-04-28 2017-03-31 Керин Фармасьютикал Ко., Лтд. Лекарственное средство для лечения пациентов с тиннитусом
KR102441249B1 (ko) 2014-10-23 2022-09-08 아레나 파마슈티칼스, 인크. Ｐｇｉ2 수용체 관련 병태의 치료 방법
SI3297628T1 (sl) * 2015-05-18 2021-10-29 Sensorion Azasetron za uporabo pri zdravljenju izgube sluha
KR101893604B1 (ko) 2015-08-27 2018-08-30 경희대학교 산학협력단 칸디다 유틸리스 추출물을 포함하는 난청의 예방 또는 치료용 조성물
CN105924362B (zh) * 2016-02-05 2018-08-17 上海龙翔生物医药开发有限公司 芳香环丙基胺类化合物、其药学上可接受的盐、其制备方法及其用途
IL268997B2 (en) 2017-03-01 2023-09-01 Arena Pharm Inc Preparations containing pgi2 receptor agonists and processes for their preparation
US12433865B2 (en) 2018-05-16 2025-10-07 Arena Pharmaceuticals, Inc. Compositions comprising PGI2-receptor agonists and processes for the preparation thereof
KR102268893B1 (ko) 2020-01-16 2021-06-24 경북대학교 산학협력단 림노트릭스 속 knua002 균주를 포함하는 난청의 예방 또는 치료용 조성물
CN111477199B (zh) * 2020-04-02 2021-11-30 北京瑞迪欧文化传播有限责任公司 一种嵌入式音乐控制系统
EP4297708A4 (en) 2021-09-09 2024-08-28 Samsung Electronics Co., Ltd. AUDIO CONTENT DELIVERY MANAGEMENT

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Also Published As

Publication number Publication date
ZA201001263B (en) 2011-07-27
WO2009033651A1 (en) 2009-03-19
PL2200600T3 (pl) 2012-04-30
JP5563460B2 (ja) 2014-07-30
US8877814B2 (en) 2014-11-04
TW200922544A (en) 2009-06-01
WO2009033649A1 (en) 2009-03-19
JP5613053B2 (ja) 2014-10-22
ZA201001261B (en) 2011-08-31
EP2203163B1 (en) 2014-08-27
AU2008298018B2 (en) 2012-01-19
AU2008298018C1 (en) 2012-08-16
CN101801366A (zh) 2010-08-11
CA2699213A1 (en) 2009-03-19
AU2008298017B2 (en) 2012-03-01
PT2200600E (pt) 2012-02-17
AU2008298015A1 (en) 2009-03-19
ES2596262T3 (es) 2017-01-05
JP5563461B2 (ja) 2014-07-30
CN101801365A (zh) 2010-08-11
AU2008298018A1 (en) 2009-03-19
TW200918042A (en) 2009-05-01
HRP20120046T1 (hr) 2012-02-29
CN101835469A (zh) 2010-09-15
RU2011137131A (ru) 2013-03-20
EP2200598A1 (en) 2010-06-30
AU2008298016B2 (en) 2012-02-02
CA2699207A1 (en) 2009-03-19
ZA201001264B (en) 2011-07-27
AR071728A1 (es) 2010-07-14
EP2203163A1 (en) 2010-07-07
WO2009033652A1 (en) 2009-03-19
EP2386299B1 (en) 2016-07-13
BRPI0816690A2 (pt) 2016-11-01
JP2010539116A (ja) 2010-12-16
DK2200600T3 (da) 2012-01-23
US20110077304A1 (en) 2011-03-31
JP2010539118A (ja) 2010-12-16
MX2010002736A (es) 2010-04-01
ES2377253T3 (es) 2012-03-23
BRPI0816712A2 (pt) 2016-11-08
KR20100052556A (ko) 2010-05-19
CA2699209A1 (en) 2009-03-19
JP2014221766A (ja) 2014-11-27
KR20100052559A (ko) 2010-05-19
WO2009033650A1 (en) 2009-03-19
JP5784189B2 (ja) 2015-09-24
EP2548552B1 (en) 2015-11-18
US20100298441A1 (en) 2010-11-25
JP5612473B2 (ja) 2014-10-22
MX2010002733A (es) 2010-04-09
US9468610B2 (en) 2016-10-18
EP2200599B1 (en) 2016-08-31
US20170027885A1 (en) 2017-02-02
ZA201001262B (en) 2011-07-27
AU2008298017A1 (en) 2009-03-19
MX2010002734A (es) 2010-04-01
AU2008298015B2 (en) 2012-03-22
JP5784188B2 (ja) 2015-09-24
AU2008298016A1 (en) 2009-03-19
KR20100052557A (ko) 2010-05-19
CA2699210A1 (en) 2009-03-19
AR070026A1 (es) 2010-03-10
ES2562709T3 (es) 2016-03-07
KR20100052558A (ko) 2010-05-19
EP2386299A2 (en) 2011-11-16
ES2604945T3 (es) 2017-03-10
TW200927087A (en) 2009-07-01
JP2014221767A (ja) 2014-11-27
AR070025A1 (es) 2010-03-10
JP2010539115A (ja) 2010-12-16
EP2386299A3 (en) 2012-05-02
US20110086916A1 (en) 2011-04-14
US9498450B2 (en) 2016-11-22
US20100298440A1 (en) 2010-11-25
ATE532507T1 (de) 2011-11-15
MX2010002735A (es) 2010-04-01
EP2200599A1 (en) 2010-06-30
EP2548552A3 (en) 2013-10-16
EP2548552A2 (en) 2013-01-23
CN101795679A (zh) 2010-08-04
EP2200600B1 (en) 2011-11-09
EP2200600A1 (en) 2010-06-30
US20150018425A1 (en) 2015-01-15
SI2200600T1 (sl) 2012-03-30
JP2010539117A (ja) 2010-12-16

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