CR20200522A - Inhibidor de ret para uso en tratar cáncer que tiene una alteración de ret - Google Patents
Inhibidor de ret para uso en tratar cáncer que tiene una alteración de retInfo
- Publication number
- CR20200522A CR20200522A CR20200522A CR20200522A CR20200522A CR 20200522 A CR20200522 A CR 20200522A CR 20200522 A CR20200522 A CR 20200522A CR 20200522 A CR20200522 A CR 20200522A CR 20200522 A CR20200522 A CR 20200522A
- Authority
- CR
- Costa Rica
- Prior art keywords
- ret
- treating cancer
- alteration
- inhibitor
- ret inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
<p>Se describe en la presente el tratamiento de un sujeto afectado por un cáncer que tiene una alteración de RET activadora al administrar una cantidad efectiva de un inhibidor de RET selectivo, por ejemplo, Compuesto 1 o sales farmacéuticamente aceptables del mismo, incluyendo, por ejemplo, administrar una cantidad de 300 mg a 400 mg del inhibidor de RET selectivo una vez al día.</p>
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652284P | 2018-04-03 | 2018-04-03 | |
| US201862656297P | 2018-04-11 | 2018-04-11 | |
| US201862657605P | 2018-04-13 | 2018-04-13 | |
| US201862741683P | 2018-10-05 | 2018-10-05 | |
| PCT/US2019/025655 WO2019195471A1 (en) | 2018-04-03 | 2019-04-03 | Ret inhibitor for use in treating cancer having a ret alteration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20200522A true CR20200522A (es) | 2021-02-17 |
Family
ID=66223846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20200522A CR20200522A (es) | 2018-04-03 | 2019-04-03 | Inhibidor de ret para uso en tratar cáncer que tiene una alteración de ret |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US20210100795A1 (es) |
| EP (2) | EP4353317A3 (es) |
| JP (3) | JP7422084B2 (es) |
| KR (1) | KR20200139749A (es) |
| AU (1) | AU2019247766A1 (es) |
| BR (1) | BR112020020273A2 (es) |
| CA (1) | CA3096043A1 (es) |
| CL (1) | CL2020002544A1 (es) |
| CR (1) | CR20200522A (es) |
| DK (1) | DK3773589T3 (es) |
| ES (1) | ES2970041T3 (es) |
| FI (1) | FI3773589T3 (es) |
| HR (1) | HRP20240124T1 (es) |
| HU (1) | HUE065374T2 (es) |
| IL (1) | IL277629A (es) |
| LT (1) | LT3773589T (es) |
| MX (1) | MX2020010417A (es) |
| MY (1) | MY203645A (es) |
| PE (1) | PE20210096A1 (es) |
| PL (1) | PL3773589T3 (es) |
| PT (1) | PT3773589T (es) |
| RS (1) | RS65127B1 (es) |
| SG (1) | SG11202009681YA (es) |
| SI (1) | SI3773589T1 (es) |
| WO (1) | WO2019195471A1 (es) |
| ZA (1) | ZA202006072B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| CN111423416B (zh) | 2015-11-02 | 2023-05-26 | 缆图药品公司 | Ret的抑制剂 |
| AU2019247766A1 (en) | 2018-04-03 | 2020-10-15 | Blueprint Medicines Corporation | RET inhibitor for use in treating cancer having a RET alteration |
| US11666570B2 (en) * | 2019-07-11 | 2023-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnosis and regulation of epidermal differentiation and cancer cell activity |
| BR112022024382A2 (pt) | 2020-05-29 | 2023-05-02 | Blueprint Medicines Corp | Formas sólidas de pralsetinibe |
| US11946935B2 (en) * | 2020-08-25 | 2024-04-02 | Regents Of The University Of Minnesota | Circulating tumor markers for meningiomas |
| JP1746261S (ja) * | 2022-10-17 | 2023-06-14 | 量子暗号鍵伝送機 |
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| AU2019247766A1 (en) | 2018-04-03 | 2020-10-15 | Blueprint Medicines Corporation | RET inhibitor for use in treating cancer having a RET alteration |
| CN112703014A (zh) | 2018-08-10 | 2021-04-23 | 缆图药品公司 | Egfr突变型癌症的治疗 |
| CN111440151A (zh) | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
| CN111362923A (zh) | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
| AU2021281283A1 (en) | 2020-05-29 | 2022-12-15 | Blueprint Medicines Corporation | Pralsetinib pharmaceutical compositions |
| BR112022024382A2 (pt) | 2020-05-29 | 2023-05-02 | Blueprint Medicines Corp | Formas sólidas de pralsetinibe |
| AR124245A1 (es) | 2020-12-04 | 2023-03-01 | Blueprint Medicines Corp | Método para preparar pralsetinib |
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2019
- 2019-04-03 AU AU2019247766A patent/AU2019247766A1/en not_active Withdrawn
- 2019-04-03 BR BR112020020273-8A patent/BR112020020273A2/pt not_active Application Discontinuation
- 2019-04-03 KR KR1020207031426A patent/KR20200139749A/ko not_active Withdrawn
- 2019-04-03 CA CA3096043A patent/CA3096043A1/en active Pending
- 2019-04-03 PT PT197185317T patent/PT3773589T/pt unknown
- 2019-04-03 SG SG11202009681YA patent/SG11202009681YA/en unknown
- 2019-04-03 PE PE2020001523A patent/PE20210096A1/es unknown
- 2019-04-03 US US17/044,884 patent/US20210100795A1/en not_active Abandoned
- 2019-04-03 PL PL19718531.7T patent/PL3773589T3/pl unknown
- 2019-04-03 ES ES19718531T patent/ES2970041T3/es active Active
- 2019-04-03 MY MYPI2020005148A patent/MY203645A/en unknown
- 2019-04-03 LT LTEPPCT/US2019/025655T patent/LT3773589T/lt unknown
- 2019-04-03 SI SI201930702T patent/SI3773589T1/sl unknown
- 2019-04-03 HU HUE19718531A patent/HUE065374T2/hu unknown
- 2019-04-03 EP EP23199171.2A patent/EP4353317A3/en not_active Withdrawn
- 2019-04-03 EP EP19718531.7A patent/EP3773589B1/en active Active
- 2019-04-03 RS RS20240107A patent/RS65127B1/sr unknown
- 2019-04-03 JP JP2020553633A patent/JP7422084B2/ja active Active
- 2019-04-03 FI FIEP19718531.7T patent/FI3773589T3/fi active
- 2019-04-03 DK DK19718531.7T patent/DK3773589T3/da active
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- 2019-04-03 HR HRP20240124TT patent/HRP20240124T1/hr unknown
- 2019-04-03 WO PCT/US2019/025655 patent/WO2019195471A1/en not_active Ceased
- 2019-04-03 MX MX2020010417A patent/MX2020010417A/es unknown
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2020
- 2020-09-27 IL IL277629A patent/IL277629A/en unknown
- 2020-09-30 ZA ZA2020/06072A patent/ZA202006072B/en unknown
- 2020-10-01 CL CL2020002544A patent/CL2020002544A1/es unknown
- 2020-10-02 US US17/061,743 patent/US11963958B2/en active Active
- 2020-12-18 US US17/127,041 patent/US11273160B2/en active Active
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2021
- 2021-07-16 US US17/377,885 patent/US11872192B2/en active Active
- 2021-12-09 JP JP2021199945A patent/JP2022022391A/ja active Pending
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2023
- 2023-09-28 JP JP2023167564A patent/JP2023165937A/ja not_active Withdrawn
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2024
- 2024-03-15 US US18/606,346 patent/US12539303B2/en active Active
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