ES2526759T3 - Composición para inducir la regeneración tisular por activación de plasma rico en plaquetas (PRP) y procedimiento para fabricarla - Google Patents

Composición para inducir la regeneración tisular por activación de plasma rico en plaquetas (PRP) y procedimiento para fabricarla Download PDF

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Publication number
ES2526759T3
ES2526759T3 ES09850622.3T ES09850622T ES2526759T3 ES 2526759 T3 ES2526759 T3 ES 2526759T3 ES 09850622 T ES09850622 T ES 09850622T ES 2526759 T3 ES2526759 T3 ES 2526759T3
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prp
whole blood
activation
layer
composition
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Hyun-Shin Park
Ji-Chul Yu
Ju-Hee Park
Jang-Hoon Kim
Hun Kim
Sae-Bom Lee
Jae-Deog Jang
Cheong-Ho Jang
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Cellontech Co Ltd
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Sewon Cellontech Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

Un procedimiento de fabricación de una composición para inducir la regeneración tisular por activación de plasma rico en plaquetas (PRP), comprendiendo el procedimiento las etapas de: separar el PRP de la sangre completa; mezclar el PRP con una solución de cloruro de calcio; y mezclar una mezcla del PRP y la solución de cloruro de calcio con colágeno de tipo I; en el que la etapa de separar el PRP de la sangre completa comprende las etapas de: obtener 10 ml de la sangre completa de un animal o un paciente en un tubo de ensayo a vacío que contenga citrato de sodio al 3,2 % y, primariamente, centrifugar la sangre completa obtenida (1.750~1.900 g) durante de 3 a 5 minutos; obtener un sobrenadante líquido (capa de plasma) que comprende la capa leucocítica a través de dicha centrifugación; transferir el sobrenadante líquido obtenido(capa de plasma) que comprende la capa leucocítica a un nuevo tubo de ensayo a vacío con una aguja roma y centrifugarlo una segunda vez (4.500~5.000 g) durante de 4 a 6 minutos; y obtener el PRP concentrado en una capa inferior (desde el fondo hasta una altura de aproximadamente 1 ml del tubo de ensayo) con una aguja roma

Description

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Claims (1)

  1. imagen1
ES09850622.3T 2009-10-23 2009-11-17 Composición para inducir la regeneración tisular por activación de plasma rico en plaquetas (PRP) y procedimiento para fabricarla Active ES2526759T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020090101387A KR101114712B1 (ko) 2009-10-23 2009-10-23 염화칼슘용액과 제1형 콜라겐으로 혈소판풍부혈장(ｐｒｐ)을 활성화하여 조직재생을 유도하는 조성물의 제조방법
KR20090101387 2009-10-23
PCT/KR2009/006745 WO2011049263A1 (ko) 2009-10-23 2009-11-17 혈소판풍부혈장(ｐｒｐ)을 활성화하여 조직재생을 유도하는 조성물 및 그 제조방법

Publications (1)

Publication Number Publication Date
ES2526759T3 true ES2526759T3 (es) 2015-01-15

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ES09850622.3T Active ES2526759T3 (es) 2009-10-23 2009-11-17 Composición para inducir la regeneración tisular por activación de plasma rico en plaquetas (PRP) y procedimiento para fabricarla

Country Status (18)

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US (1) US9011929B2 (es)
EP (1) EP2491961B1 (es)
JP (1) JP5550732B2 (es)
KR (1) KR101114712B1 (es)
CN (1) CN102573943B (es)
AU (2) AU2009354233B2 (es)
BR (1) BR112012009560B8 (es)
CA (1) CA2778351C (es)
CY (1) CY1115850T1 (es)
DK (1) DK2491961T3 (es)
ES (1) ES2526759T3 (es)
HR (1) HRP20141098T1 (es)
MX (1) MX2012004635A (es)
PL (1) PL2491961T3 (es)
PT (1) PT2491961E (es)
SI (1) SI2491961T1 (es)
SM (1) SMT201400189B (es)
WO (1) WO2011049263A1 (es)

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CN107771079B (zh) * 2015-07-02 2021-11-05 阿瑟雷克斯股份有限公司 用于制备富集的生物流体的方法和装置
KR20170006820A (ko) 2015-07-10 2017-01-18 주식회사 글로원 혈소판 농축 방법 및 이를 위한 농축기구
WO2017082441A1 (ko) * 2015-11-13 2017-05-18 중부대학교 산학협력단 활성화된 혈소판 풍부 혈장을 유효성분으로 포함하는 동물의 창상 치료용 수의학적 조성물
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Also Published As

Publication number Publication date
AU2009354233A1 (en) 2012-06-07
CY1115850T1 (el) 2017-01-25
WO2011049263A1 (ko) 2011-04-28
KR20110044615A (ko) 2011-04-29
SMT201400189B (it) 2015-01-15
MX2012004635A (es) 2012-07-30
HRP20141098T1 (hr) 2015-02-13
US9011929B2 (en) 2015-04-21
PT2491961E (pt) 2014-11-14
KR101114712B1 (ko) 2012-02-29
BR112012009560B1 (pt) 2021-03-09
JP5550732B2 (ja) 2014-07-16
CN102573943A (zh) 2012-07-11
BR112012009560B8 (pt) 2021-06-22
DK2491961T3 (en) 2014-12-01
BR112012009560A2 (pt) 2020-11-17
PL2491961T3 (pl) 2015-03-31
US20120201897A1 (en) 2012-08-09
EP2491961A1 (en) 2012-08-29
CA2778351C (en) 2015-06-09
JP2013508066A (ja) 2013-03-07
AU2009354233B2 (en) 2014-08-28
EP2491961A4 (en) 2013-09-04
CN102573943B (zh) 2015-04-08
CA2778351A1 (en) 2011-04-28
AU2014210601A1 (en) 2014-08-28
SI2491961T1 (sl) 2015-01-30
EP2491961B1 (en) 2014-10-01

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