DK1294414T3 - Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv - Google Patents

Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv

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Publication number
DK1294414T3
DK1294414T3 DK01947086T DK01947086T DK1294414T3 DK 1294414 T3 DK1294414 T3 DK 1294414T3 DK 01947086 T DK01947086 T DK 01947086T DK 01947086 T DK01947086 T DK 01947086T DK 1294414 T3 DK1294414 T3 DK 1294414T3
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DK
Denmark
Prior art keywords
blood
bone
tissue
composition
present
Prior art date
Application number
DK01947086T
Other languages
English (en)
Inventor
Marc D Mckee
Caroline D Hoemann
Michael D Buschmann
Original Assignee
Biosyntech Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosyntech Canada Inc filed Critical Biosyntech Canada Inc
Application granted granted Critical
Publication of DK1294414T3 publication Critical patent/DK1294414T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/46—Hydrolases (3)
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    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01947086T 2000-06-29 2001-06-29 Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv DK1294414T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21471700P 2000-06-29 2000-06-29

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DK1294414T3 true DK1294414T3 (da) 2006-07-24

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Country Status (20)

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US (4) US20020082220A1 (da)
EP (1) EP1294414B1 (da)
JP (1) JP5089006B2 (da)
KR (1) KR100880622B1 (da)
CN (1) CN1471412B8 (da)
AT (1) ATE320277T1 (da)
AU (2) AU2001268882B2 (da)
BR (1) BR0112109A (da)
CA (1) CA2412505C (da)
CY (1) CY1106313T1 (da)
DE (1) DE60117984T8 (da)
DK (1) DK1294414T3 (da)
ES (1) ES2260241T3 (da)
IL (2) IL153490A0 (da)
MX (1) MXPA03000203A (da)
NZ (1) NZ523763A (da)
PT (1) PT1294414E (da)
SG (1) SG149679A1 (da)
WO (1) WO2002000272A2 (da)
ZA (1) ZA200300597B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2765601C1 (ru) * 2021-08-17 2022-02-01 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Способ дифференцированного лечения эрозий и язв роговицы

Families Citing this family (299)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081704A1 (en) * 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
US6964685B2 (en) 1999-06-22 2005-11-15 The Brigham And Women's Hospital, Inc. Biologic replacement for fibrin clot
EP1229940B1 (en) * 1999-11-15 2014-05-14 Piramal Healthcare (Canada) Limited Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
WO2001041822A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
CN1471412B8 (zh) * 2000-06-29 2016-06-15 生物合成技术加拿大公司 用于修复和再生软骨和其它组织的组合物以及该组合物的用途
US7548865B2 (en) * 2000-10-20 2009-06-16 Arthrex, Inc. Method of selling procedure specific allografts and associated instrumentation
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
WO2003031483A1 (en) 2001-10-10 2003-04-17 The Regents Of The University Of Colorado Degradable thiol-ene polymers
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2003079985A2 (en) * 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
US7468192B2 (en) 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
US7608258B2 (en) * 2002-04-13 2009-10-27 Allan Mishra Method for treatment of tendinosis using platelet rich plasma
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7179391B2 (en) 2002-05-24 2007-02-20 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US20050008629A1 (en) * 2002-05-08 2005-01-13 Interpore Orthopaedics, A Delaware Corporation Encapsulated AGF cells
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CA2493083C (en) * 2002-07-16 2012-11-06 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
JP2004123576A (ja) * 2002-09-30 2004-04-22 Medgel Corp 多血小板血漿を含有する徐放性製剤
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
CN100415093C (zh) * 2003-01-27 2008-09-03 哈维斯特技术公司 从抗凝全血生产的自体或同种促凝剂
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
DE10348219A1 (de) * 2003-10-13 2005-05-12 Aesculap Ag & Co Kg Knorpelersatzimplantat und Verfahren zur Herstellung eines Knorpelersatzimplantats
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
WO2005065242A2 (en) * 2003-12-29 2005-07-21 Am Biosolutions Method of treating cancer using platelet releasate
WO2005065419A2 (en) * 2003-12-29 2005-07-21 Am Biosolutions Method of culturing cells
US20070110737A1 (en) * 2003-12-29 2007-05-17 Allan Mishra Compositions and method for decreasing the appearance of skin wrinkles
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
EP1576957A1 (en) 2004-03-18 2005-09-21 Universiteit Twente Tissue repair using pluripotent cells
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
BRPI0515191A (pt) * 2004-08-13 2008-07-08 Angiotech Internac Ag composição farmacêutica, método para aumentar osso ou substituir perda óssea, método para reduzir a dor associada com cicatriz pós-cirúrgica, método para prevenir aderência cirúrgicas, método para aumento ou reparo de pele ou tecido, método para manter volume em fluido ocular durante cirurgia ocular, método para reduzir a dor associada com osteoartrite, método para tratar doença de refluxo gastroesofágico, método para tratar ou prevenir incontinência urinária, método para tratar ou prevenir incontinência fecal, implante método e dispositivo médico
US7462268B2 (en) 2004-08-20 2008-12-09 Allan Mishra Particle/cell separation device and compositions
US20060085003A1 (en) * 2004-10-05 2006-04-20 Arthrex, Inc. Use of autogenous growth factors in bone tunnels during ligament reconstruction
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060111778A1 (en) * 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US8128658B2 (en) 2004-11-05 2012-03-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
US7601165B2 (en) 2006-09-29 2009-10-13 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable suture loop
US8088130B2 (en) 2006-02-03 2012-01-03 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7909851B2 (en) 2006-02-03 2011-03-22 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US9017381B2 (en) 2007-04-10 2015-04-28 Biomet Sports Medicine, Llc Adjustable knotless loops
US8118836B2 (en) 2004-11-05 2012-02-21 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7905904B2 (en) 2006-02-03 2011-03-15 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
US8361113B2 (en) 2006-02-03 2013-01-29 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US7749250B2 (en) 2006-02-03 2010-07-06 Biomet Sports Medicine, Llc Soft tissue repair assembly and associated method
US9801708B2 (en) 2004-11-05 2017-10-31 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8137382B2 (en) 2004-11-05 2012-03-20 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8298262B2 (en) 2006-02-03 2012-10-30 Biomet Sports Medicine, Llc Method for tissue fixation
US8303604B2 (en) 2004-11-05 2012-11-06 Biomet Sports Medicine, Llc Soft tissue repair device and method
IS7572A (is) * 2004-11-29 2006-05-30 Genis Ehf Aðferð og efni til lækninga
ITRM20040638A1 (it) 2004-12-24 2005-03-24 Advance Holdings Ltd Gel piastrinico semisintetico e metodo per la sua preparazione.
US7825083B2 (en) * 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
JP4545015B2 (ja) * 2005-02-24 2010-09-15 国立大学法人 東京医科歯科大学 骨移植片製造装置
US20080299212A1 (en) * 2005-02-25 2008-12-04 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum
US20060253068A1 (en) * 2005-04-20 2006-11-09 Van Bilsen Paul Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
DE102005030614B4 (de) 2005-06-30 2014-05-08 Biotissue Ag Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
KR100774089B1 (ko) * 2005-07-20 2007-11-06 세원셀론텍(주) 주입형 연골세포치료제의 이식방법
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
CA2628313A1 (en) * 2005-11-04 2007-05-31 Bio Syntech Canada Inc. Composition and method for efficient delivery of nucleic acids to cells using chitosan
US20090149421A1 (en) * 2005-11-04 2009-06-11 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
WO2007061889A2 (en) 2005-11-17 2007-05-31 Biomimetic Therapeutics, Inc. Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
AU2007208243B2 (en) 2006-01-25 2013-09-19 Children's Medical Center Corporation Methods and procedures for ligament repair
US8968364B2 (en) 2006-02-03 2015-03-03 Biomet Sports Medicine, Llc Method and apparatus for fixation of an ACL graft
US8652171B2 (en) 2006-02-03 2014-02-18 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US9538998B2 (en) 2006-02-03 2017-01-10 Biomet Sports Medicine, Llc Method and apparatus for fracture fixation
US8801783B2 (en) 2006-09-29 2014-08-12 Biomet Sports Medicine, Llc Prosthetic ligament system for knee joint
US11311287B2 (en) 2006-02-03 2022-04-26 Biomet Sports Medicine, Llc Method for tissue fixation
US8562647B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for securing soft tissue to bone
US11259792B2 (en) 2006-02-03 2022-03-01 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US8597327B2 (en) 2006-02-03 2013-12-03 Biomet Manufacturing, Llc Method and apparatus for sternal closure
US9468433B2 (en) 2006-02-03 2016-10-18 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9149267B2 (en) 2006-02-03 2015-10-06 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US8562645B2 (en) 2006-09-29 2013-10-22 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9078644B2 (en) 2006-09-29 2015-07-14 Biomet Sports Medicine, Llc Fracture fixation device
US10517587B2 (en) 2006-02-03 2019-12-31 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
EP1991282B1 (en) 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
WO2007109137A1 (en) * 2006-03-20 2007-09-27 Worcester Polytechnic Institute Fibrin microthreads
WO2007129453A1 (ja) * 2006-04-19 2007-11-15 National University Corporation Nagoya University 歯周軟組織再生用組成物及びその製造方法
US20070258941A1 (en) * 2006-05-02 2007-11-08 Pfister Brian E Methods and compositions for remediation of disc herniation by modifying structure
ITPD20060203A1 (it) * 2006-05-22 2007-11-23 Univ Degli Studi Trieste Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN100428964C (zh) * 2006-06-29 2008-10-29 武汉理工大学 RGD多肽接枝聚(羟基乙酸-L-赖氨酸-L-乳酸)/β-磷酸三钙复合材料及其制备方法
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2829865A1 (en) * 2006-07-21 2008-01-24 Genera Istrazivanja D.O.O. Bmp-1 procollagen c-proteinase for diagnosis and treatment of bone and soft tissue defects and disorders
KR100825995B1 (ko) * 2006-08-03 2008-04-29 연세대학교 산학협력단 나노크기의 중합체와 자가혈액젤을 포함하는 골이식물질 및그 제조방법
TW200825176A (en) * 2006-08-22 2008-06-16 Univ Columbia Progenitor cell replication and differentiation in 3D
WO2008060361A2 (en) 2006-09-28 2008-05-22 Children's Medical Center Corporation Methods and collagen products for tissue repair
US11259794B2 (en) 2006-09-29 2022-03-01 Biomet Sports Medicine, Llc Method for implanting soft tissue
US8672969B2 (en) 2006-09-29 2014-03-18 Biomet Sports Medicine, Llc Fracture fixation device
DE102006047346A1 (de) 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix-Gel-Transplantat ohne Zellen
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20090169628A1 (en) * 2006-10-17 2009-07-02 Armark Authentication Technologies, Llc Article and method for focused delivery of therapeutic and/or diagnostic materials
US8106008B2 (en) 2006-11-03 2012-01-31 Biomimetic Therapeutics, Inc. Compositions and methods for arthrodetic procedures
GB0622846D0 (en) * 2006-11-16 2006-12-27 Univ Leeds Preparation of tissue for meniscal implantation
EP2094283A4 (en) * 2006-11-30 2010-09-01 Biosyntech Canada Inc PROCESS FOR FIXING BLOOD-POLYMER COMPOSITIONS IN SITU FOR REGENERATIVE MEDICAL AND CARTILAGE REPAIR APPLICATIONS
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US12502169B2 (en) 2007-01-16 2025-12-23 Biomet Sports Medicine, Llc Soft tissue repair device and associated methods
WO2008100442A1 (en) * 2007-02-09 2008-08-21 Biomet Biologics, Inc. Treatment of tissue defects with a therapeutic composition
ES2552842T3 (es) 2007-02-19 2015-12-02 Marine Polymer Technologies, Inc. Composiciones hemostáticas y regímenes terapéuticos
WO2008102568A1 (ja) * 2007-02-22 2008-08-28 Pg Research Co., Ltd. 骨軟骨形成促進剤
US7670381B2 (en) * 2007-02-26 2010-03-02 Marvin Schwartz Prosthesis for interpositional location between bone joint articular surfaces and method of use
US8506637B2 (en) 2007-02-26 2013-08-13 Marvin Schwartz Mobile prosthesis for interpositional location between bone joint articular surfaces and method of use
US9814581B2 (en) 2007-02-26 2017-11-14 Marvin Schwartz Mobile prosthesis for interpositional location between bone joint articular surfaces and method of use
US8034014B2 (en) 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
WO2008112230A1 (en) * 2007-03-12 2008-09-18 Thomas Lally Hemostatic bio-material composition and method
US20100034898A1 (en) * 2007-03-12 2010-02-11 Thomas Joseph Lally Cartilage simulating bio-material composition and method
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2146794B1 (en) 2007-04-12 2016-10-19 Biomet Biologics, LLC Buoy suspension fractionation system
US8137354B2 (en) * 2007-04-25 2012-03-20 Biomet Sports Medicine, Llc Localized cartilage defect therapy
US20080268064A1 (en) * 2007-04-25 2008-10-30 Biomet Biologics, Inc. Method for treating cartilage defects
US20080269762A1 (en) * 2007-04-25 2008-10-30 Biomet Manufacturing Corp. Method and device for repair of cartilage defects
US7901344B2 (en) * 2007-05-11 2011-03-08 Biomet Biologics, Llc Methods of reducing surgical complications in cancer patients
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US9421304B2 (en) 2007-07-03 2016-08-23 Histogenics Corporation Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US7947081B2 (en) * 2007-07-11 2011-05-24 Linares Medical Devices, Llc Skeletal implant for replacing a human bone
ES2333498B1 (es) * 2007-08-02 2011-01-10 Biotechnology Institute, I Mas D, S.L. Metodo y compuesto para el tratamiento de enfermedades o dolencias articulares o para el tratamiento de la piel con fines esteticos u otros, y el metodo de preparacion del compuesto.
WO2009039171A2 (en) * 2007-09-17 2009-03-26 Linares Medical Devices, Llc Artificial joint support between first and second bones
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US20110230973A1 (en) * 2007-10-10 2011-09-22 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
AU2008311957A1 (en) * 2007-10-15 2009-04-23 Wake Forest University Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
US9539097B2 (en) 2007-11-08 2017-01-10 Linares Medical Devices, Llc Hip and knee joint assemblies incorporating debris collection architecture between the ball and seat interface
US8979938B2 (en) * 2007-11-08 2015-03-17 Linares Medical Devices, Llc Artificial knee implant including liquid ballast supporting / rotating surfaces and incorporating flexible multi-material and natural lubricant retaining matrix applied to a joint surface
US8828088B2 (en) * 2007-11-08 2014-09-09 Linares Medical Devices, Llc Joint assembly incorporating undercut surface design to entrap accumulating wear debris from plastic joint assembly
US8197507B2 (en) * 2008-01-14 2012-06-12 Sri International Sutureless methods for laceration closure
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
US20090192528A1 (en) * 2008-01-29 2009-07-30 Biomet Biologics, Inc. Method and device for hernia repair
US20090198286A1 (en) * 2008-02-05 2009-08-06 Zimmer, Inc. Bone fracture fixation system
DE102008008540A1 (de) * 2008-02-07 2009-08-13 Beiersdorf Ag Hautpflegezubereitung zur Pflege von gestresster Haut
ES2422259T3 (es) * 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
US8702801B2 (en) * 2008-02-25 2014-04-22 Linares Medical Devices, Llc Artificial wear resistant plug for mounting to existing joint bone
EP2620139B1 (en) 2008-02-27 2016-07-20 Biomet Biologics, LLC Interleukin-1 receptor antagonist rich solutions
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
CA2717725A1 (en) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
WO2009120776A2 (en) * 2008-03-26 2009-10-01 Linares Medical Devices, Llc Joint construction, such as for use by athletes
RU2366404C1 (ru) * 2008-04-07 2009-09-10 Государственное образовательное учреждение дополнительного профессионального образования "Новокузнецкий государственный институт усовершенствования врачей Федерального агентства по здравоохранению и социальному развитию" Способ лечения капсулярно-связочно-сухожильной формы плечелопаточного периартроза
HUE043642T2 (hu) * 2008-07-02 2019-08-28 Allergan Inc Kompozíció lágy szövet feltöltésére és regenerálására
WO2010014446A1 (en) * 2008-07-28 2010-02-04 Zimmer, Inc. Mosaicplasty constructs
US12419632B2 (en) 2008-08-22 2025-09-23 Biomet Sports Medicine, Llc Method and apparatus for coupling anatomical features
US12245759B2 (en) 2008-08-22 2025-03-11 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to bone
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． ヒアルロン酸および／またはその誘導体の糸、その作製方法、ならびにその使用
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
US20100078848A1 (en) * 2008-09-29 2010-04-01 Armark Authentication Technologies, Llc Spinneret and method of spinning fiber
WO2010042658A1 (en) * 2008-10-07 2010-04-15 Bioparadox, Llc Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities
GB0820492D0 (en) 2008-11-07 2008-12-17 Sportcell Cell compositions and uses thereof
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US9308070B2 (en) 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US20100291214A1 (en) * 2008-12-23 2010-11-18 Armark Authentication Technologies, Llc Three-dimensional microfiber extrudate structure and process for forming three-dimensional microfiber extrudate structure
AU2010221089A1 (en) * 2009-03-05 2011-09-15 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US20100233282A1 (en) * 2009-03-13 2010-09-16 Allan Mishra Device and methods for delivery of bioactive materials to the right side of the heart
US20110171180A1 (en) * 2009-03-19 2011-07-14 Worcester Polytechnic Institute Bioengineered skin substitutes
US20100249924A1 (en) * 2009-03-27 2010-09-30 Allergan, Inc. Bioerodible matrix for tissue involvement
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
ES2443045T5 (es) 2009-04-20 2021-05-10 Allergan Inc Hidrogeles de fibroína de seda y usos de éstos
WO2010142507A2 (en) * 2009-05-13 2010-12-16 Kitozyme S.A. Adhesive composition
WO2010132763A1 (en) * 2009-05-15 2010-11-18 Armark Authentication Technologies, Llc Fiber having non-uniform composition and method for making same
US12096928B2 (en) 2009-05-29 2024-09-24 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US12551209B2 (en) 2009-06-22 2026-02-17 Biomet Sports Medicine, Llc Method and apparatus for coupling soft tissue to a bone
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
WO2011011808A1 (en) * 2009-07-30 2011-02-03 Roman Buga A cosmetic composition comprising sodium chloride in combination with one or more of protein, collagen, gelatin or amino acid
US8377432B2 (en) * 2009-09-02 2013-02-19 Khay-Yong Saw Method and composition for neochondrogenesis
US20110060412A1 (en) * 2009-09-08 2011-03-10 Musculoskeletal Transplant Foundation Inc. Tissue Engineered Meniscus Repair Composition
WO2011031637A2 (en) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Tissue engineered meniscus repair composition
US12616462B2 (en) 2009-09-30 2026-05-05 Biomet Sports Medicine, Llc Soft tissue repair device and method
KR101114712B1 (ko) * 2009-10-23 2012-02-29 세원셀론텍(주) 염화칼슘용액과 제1형 콜라겐으로 혈소판풍부혈장(ｐｒｐ)을 활성화하여 조직재생을 유도하는 조성물의 제조방법
EP2498820B1 (en) 2009-11-13 2019-01-09 University of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
WO2011060553A1 (en) * 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Formulation and method for rapid preparation of isotonic and cytocompatible chitosan solutions without inducing chitosan precipitation
WO2011060554A1 (en) * 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Presolidified composition and method for in situ delivery of broad molecular weight range of chitosan implants with or without therapeutics for regenerative medicine and cartilage repair applications
WO2011060545A1 (en) * 2009-11-19 2011-05-26 Corporation De L'ecole Polytechnique De Montreal Specific blood:chitosan mixing ratios producing a viscous paste-like implant with good handling properties for tissue repair
US20120321721A1 (en) * 2009-11-19 2012-12-20 Corporation De L'ecole Polytechnique De Montreal Novel formulation of physiological chitosan-inorganic salt solution/blood mixtures for tissue repair
EP2512516B1 (en) * 2009-12-18 2016-02-17 The Governing Council Of The University Of Toronto Injectable polymer composition for use as a cell delivery vehicle
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
CN107080834A (zh) 2010-02-22 2017-08-22 生物模拟治疗有限责任公司 用于治疗腱病的血小板衍生生长因子组合物和方法
EP2361640A1 (en) * 2010-02-25 2011-08-31 Université de Liège Cell cultivation in chitosan alginate hydrogel beads
GB201004072D0 (en) * 2010-03-11 2010-04-28 Turzi Antoine Process, tube and device for the preparation of wound healant composition
HUE030138T2 (en) 2010-03-22 2017-04-28 Allergan Inc Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US8926705B2 (en) 2010-05-10 2015-01-06 Linares Medical Devices, Llc Implantable joint assembly featuring debris entrapment chamber subassemblies along with opposing magnetic fields generated between articulating implant components in order to minimize frictional force and associated wear
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8900571B2 (en) 2010-08-19 2014-12-02 Allergan, Inc. Compositions and soft tissue replacement methods
US8741281B2 (en) 2010-08-19 2014-06-03 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
WO2012024072A1 (en) 2010-08-19 2012-02-23 Allergan, Inc. Compositions comprising adipose tissue and a pge2 analogue and their use in the treatment of a soft tissue condition
US8894992B2 (en) 2010-08-19 2014-11-25 Allergan, Inc. Compositions and soft tissue replacement methods
US8926963B2 (en) 2010-08-19 2015-01-06 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8506972B2 (en) * 2010-08-27 2013-08-13 Oligo Medic Inc Highly biocompatible dual thermogelling chitosan/glucosamine salt compositions
ES2552659T3 (es) * 2010-08-27 2015-12-01 Oligo Medic Inc. Composiciones de sales de quitosano/glucosamina termogelificantes, duales y altamente biocompatibles
JP2013536841A (ja) 2010-09-03 2013-09-26 バイオメット、バイオロジクス、リミテッド、ライアビリティー、カンパニー インターロイキン−１受容体アンタゴニストを送達するための方法および組成物
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
US20120231542A1 (en) * 2011-03-11 2012-09-13 General Biotechnology, Llc Biologically Active Human Umbilical Cord Blood Cell Extract Compounds and Methods
US12329373B2 (en) 2011-05-02 2025-06-17 Biomet Sports Medicine, Llc Method and apparatus for soft tissue fixation
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
AU2012262047A1 (en) 2011-06-03 2014-01-16 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
RU2462255C1 (ru) * 2011-06-23 2012-09-27 Общество с ограниченной ответственностью Научно-производственное объединение "ЛИОМАТРИКС" Органоспецифический регенерант gi
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US12582395B2 (en) 2011-11-03 2026-03-24 Biomet Sports Medicine, Llc Method and apparatus for forming a self-locking adjustable loop
US9357991B2 (en) 2011-11-03 2016-06-07 Biomet Sports Medicine, Llc Method and apparatus for stitching tendons
US9381013B2 (en) 2011-11-10 2016-07-05 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
US9357992B2 (en) 2011-11-10 2016-06-07 Biomet Sports Medicine, Llc Method for coupling soft tissue to a bone
EP2591812A1 (en) * 2011-11-14 2013-05-15 University of Twente, Institute for Biomedical Technology and Technical Medicine (MIRA) A dextran-based tissuelette containing platelet-rich plasma lysate for cartilage repair
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
US11484578B2 (en) * 2012-02-01 2022-11-01 Children's Medical Center Corporation Biomaterial for articular cartilage maintenance and treatment of arthritis
WO2013116791A1 (en) * 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
CN103316330B (zh) * 2012-06-28 2016-03-09 西藏贝珠雅药业有限公司 一种软组织创伤护理材料的组方与用途
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
PL2900247T3 (pl) * 2012-09-26 2018-05-30 Bone Therapeutics S.A. Kompozycje zawierające osocze poddane obróbce rozpuszczalnikiem/detergentem i kwas hialuronowy do zastosowania w leczeniu zaburzeń układu mięśniowo-szkieletowego
US10016527B2 (en) 2012-10-23 2018-07-10 Orthovita, Inc. Materials and methods for repair of cartilage defects
US10058352B2 (en) 2012-11-08 2018-08-28 Smith & Nephew, Inc. Methods and devices suitable for improved reattachment of detached cartilage to subchondral bone
WO2014074804A2 (en) 2012-11-08 2014-05-15 Smith & Nephew, Inc. Methods and compositions suitable for improved reattachment of detached cartilage to subchondral bone
US12599700B2 (en) 2013-02-01 2026-04-14 The Children's Medical Center Corporation System and methods for connective tissue repair using scaffolds
US9757495B2 (en) 2013-02-01 2017-09-12 Children's Medical Center Corporation Collagen scaffolds
US10016459B1 (en) 2013-03-13 2018-07-10 BioDlogics, LLC Platelet-rich plasma derived from human umbilical cord blood
GB201304514D0 (en) * 2013-03-13 2013-04-24 Univ Birmingham Cell delivery
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9918827B2 (en) 2013-03-14 2018-03-20 Biomet Sports Medicine, Llc Scaffold for spring ligament repair
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
KR102312720B1 (ko) 2013-03-15 2021-10-13 알로소스 연조직 회복 및 재생을 위한 세포 재배치된 콜라겐 매트릭스
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140356893A1 (en) 2013-06-04 2014-12-04 Allan Mishra Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation
JP6775751B2 (ja) 2013-09-30 2020-10-28 エボルブド バイ ネイチャー， インコーポレイテッド 絹タンパク質断片組成物及びそれから製造された物品
DK2874546T3 (da) 2013-10-07 2016-11-21 Regentis Biomaterials Ltd Anordning til behandling af kaviteter i en menneskekrop
US9872705B2 (en) 2013-10-07 2018-01-23 Regentis Biomaterials Ltd. Treatment of cavities in a human body
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
AU2015221389B2 (en) * 2014-02-20 2018-12-13 Ortho Regenerative Technologies Inc. Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections
US11083758B2 (en) * 2014-05-14 2021-08-10 Prime Merger Sub, Llc Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
US20170157296A1 (en) * 2014-07-21 2017-06-08 The Board Of Trustees Of The Leland Stanford Junior University Macrophage or monocyte enhanced wound healing
EP4509147A2 (en) * 2014-08-01 2025-02-19 Isto Technologies, Inc. Cartilage compositions and methods for modifying proteoglycan content
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
EP3256167B1 (en) 2015-02-09 2020-11-11 Mosaic Biosciences, Inc. Degradable thiol-ene polymers and methods of making thereof
EP3653232A1 (en) 2015-02-13 2020-05-20 Allergan Industrie, SAS Implants for sculpting, augmenting or correcting facial features such as the chin
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US20180085490A1 (en) * 2015-05-29 2018-03-29 Launchpad Medical, Llc Compositions and methods for adhesion to surfaces
FR3038838B1 (fr) 2015-07-13 2017-08-18 Synolyne Pharma Chitosane pour melange avec un fluide coagulable
HK1255640A1 (zh) 2015-07-14 2019-08-23 Evolved By Nature, Inc. 丝性能服装和产品及其制备方法
KR20170025011A (ko) * 2015-08-27 2017-03-08 고려대학교 산학협력단 통증완화약물의 지속성 방출을 위한 약학적 조성물 및 그 투여를 위한 투여 장치
US10299916B2 (en) * 2016-01-07 2019-05-28 Medtronic Vascular, Inc. Bioprosthetic tissue repair and reinforcement
US10322206B2 (en) 2016-03-29 2019-06-18 Worcester Polytechnic Institute Compositions and methods for wound healing
US9861410B2 (en) 2016-05-06 2018-01-09 Medos International Sarl Methods, devices, and systems for blood flow
CN105944149A (zh) * 2016-06-13 2016-09-21 齐鲁工业大学 一种可吸收软骨修复系统及其制备方法
US12377193B2 (en) 2016-07-06 2025-08-05 The Children's Medical Center Corporation Indirect method of articular tissue repair
CN109310800B (zh) * 2016-07-29 2022-01-07 医药研究有限公司 包含核酸和壳聚糖的肩袖撕裂修复用组合物
CN106841258A (zh) * 2016-12-30 2017-06-13 遵义医学院附属医院 一种筛选用于促进骨愈合的药物的方法
RU2651768C1 (ru) * 2017-03-07 2018-04-23 Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" (ФГАОУ ВО "КФУ им. В.И. Вернадского") Способ лечения периодонтита
CN108478864B (zh) * 2017-08-07 2020-10-23 上海交通大学医学院附属第九人民医院 复合纤维支架
US11390988B2 (en) 2017-09-27 2022-07-19 Evolved By Nature, Inc. Silk coated fabrics and products and methods of preparing the same
CN107753138A (zh) * 2017-11-09 2018-03-06 中山大学附属口腔医院 一种评估微量元素成骨作用的方法及其动物模型的构建方法
CN108042544B (zh) * 2017-11-21 2020-02-21 北京德得创业科技有限公司 一种甲苯胺蓝光动力杀菌及促进愈合组合物及其应用
CN107754002A (zh) * 2017-12-04 2018-03-06 广州市天河诺亚生物工程有限公司 一种具有干细胞活性的生物材料制备方法
CN108888385B (zh) * 2018-05-10 2020-08-07 北京工业大学 基于皮肤软组织形变的修复体再修复方法
JP7370560B2 (ja) * 2018-05-29 2023-10-30 公立大学法人大阪 生体活性セメントペーストおよび生体活性セメントを製造するためのキット、生体活性セメントペーストおよびその製造方法
CA3103439A1 (en) * 2018-06-11 2019-12-19 Histogenics Corporation Scaffold with adhesive for articular cartilage repair
ES2690392B2 (es) * 2018-07-19 2019-07-05 Univ Valencia Politecnica Material inyectable para la regeneracion del cartilago articular
KR20210080370A (ko) * 2018-09-17 2021-06-30 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 뼈 손상 치료용 조성물 및 방법
US11701232B2 (en) 2019-01-15 2023-07-18 University Of Maryland, College Park Acellular bioactive scaffold device and methods of fabrication and treatment relating thereto
CN111012946B (zh) * 2019-12-31 2022-05-17 广州润虹医药科技股份有限公司 一种温敏性磷酸钙骨水泥及其制备方法
BR102020017697A2 (pt) * 2020-08-31 2022-03-15 Fundação Universidade Federal De São Carlos Processo de preparação de enxertos ósseos e enxertos ósseos obtidos
IT202200004574A1 (it) 2022-03-10 2023-09-10 Sergio Ammendola Nanoparticelle di N-acetilglucosammina e loro applicazioni
IL300830B2 (en) * 2023-02-21 2024-08-01 Reddress Ltd The implantable device coated with clotted blood
CN117018292B (zh) * 2023-06-29 2025-03-04 动之医学技术(上海)有限公司 生物修复膜及其制备方法
EP4686486A1 (en) 2024-07-30 2026-02-04 Paul Hartmann AG Gel composition comprising whole blood

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976574A (en) 1956-07-31 1961-03-28 Union Carbide Corp Chemical process and product
US3266906A (en) 1962-12-13 1966-08-16 Kelco Co Algin gel and gelatin composition having high bloom strength and process
US3586654A (en) 1969-04-15 1971-06-22 Nat Distillers Chem Corp Process for the preparation of polymer powders of controlled particle shape,size and size distribution and product
US3755558A (en) 1971-02-23 1973-08-28 Du Pont Polylactide drug mixtures for topical application atelet aggregation
IT1021282B (it) 1973-10-11 1978-01-30 Basf Ag Processo per la preparazione di dispersioni di poliesterimidi
JPS51136033A (en) * 1975-05-19 1976-11-25 Nissan Motor Co Ltd Exhaust reflux device of engine
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4185618A (en) 1976-01-05 1980-01-29 Population Research, Inc. Promotion of fibrous tissue growth in fallopian tubes for female sterilization
US4195175A (en) 1978-01-03 1980-03-25 Johnson Edwin L Process for the manufacture of chitosan
US4337760A (en) 1978-10-13 1982-07-06 Adolf Schwimmer Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals
JPS5943041B2 (ja) 1979-02-16 1984-10-19 大日精化工業株式会社 尿素基を有する糖誘導体およびその製造方法
US4391909A (en) 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4933105A (en) 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
DE3026762C2 (de) 1980-07-15 1985-04-25 Akzo Gmbh, 5600 Wuppertal Verfahren zum Herstellen von porösem, pulverförmigem Polypropylen und Verwendung der Verfahrensprodukte
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US4394373A (en) * 1981-04-06 1983-07-19 Malette William Graham Method of achieving hemostasis
US4424346A (en) 1981-06-04 1984-01-03 Canadian Patents And Development Ltd. Derivatives of chitins, chitosans and other polysaccharides
SE441009B (sv) 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4605623A (en) 1982-11-08 1986-08-12 Malette William Graham Method of altering growth and development and suppressing contamination microorganisms in cell or tissue culture
US4474769A (en) 1983-05-13 1984-10-02 Pfanstiehl Laboratories, Inc. Chitosan as a contraceptive
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4659700A (en) 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US4722948A (en) 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US4731081A (en) 1984-09-11 1988-03-15 Mentor Corporation Rupture-resistant prosthesis with creasable shell and method of forming same
US4902792A (en) 1985-04-19 1990-02-20 Kanebo Ltd. Fine cellulose particles and process for production thereof
US4678470A (en) 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4895724A (en) * 1985-06-07 1990-01-23 Pfizer Inc. Chitosan compositions for controlled and prolonged release of macromolecules
JPS624702A (ja) 1985-06-28 1987-01-10 Lion Corp 水溶性アシル化キトサンの製造方法
US6005161A (en) * 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4877775A (en) 1986-06-16 1989-10-31 E. I. Du Pont De Nemours And Company Polymeric aminosaccharides as antihypercholesterolemic agents
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
JPH01104305A (ja) 1987-10-15 1989-04-21 Tadashi Uragami 液体分離用膜
US4861627A (en) 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
DE3869850D1 (de) 1987-07-10 1992-05-14 Asahi Optical Co Ltd Zusammensetzung zur herstellung eines haertbaren kalziumphosphatartigen materials und verfahren zur produktion eines derartigen materials.
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US6610669B1 (en) * 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
US4956350A (en) * 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5073202A (en) 1989-03-09 1991-12-17 Micro Vesicular Systems, Inc. Method of using a biodegradable superabsorbing sponge
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
WO1991001720A1 (en) 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
JPH0678372B2 (ja) 1990-06-19 1994-10-05 信越化学工業株式会社 重合体スケール付着防止用溶液および重合体スケールの付着防止方法
US5071644A (en) 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
GB2261672A (en) * 1991-11-18 1993-05-26 Michael Braden The use of biomaterials for tissue repair
IL100096A (en) 1991-11-20 1996-03-31 Univ Ramot Method for entrapment of active materials in chitosan
US5658593A (en) 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
US5708152A (en) 1992-03-27 1998-01-13 Ciba Specialty Chemicals Corporation N-substituted chitosan derivatives in a process for their preparation
US5266326A (en) 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
US5871985A (en) * 1992-09-28 1999-02-16 Brown University Research Foundation Particulate non cross-linked chitosan core matrices for encapsulated cells
US5318710A (en) * 1993-03-12 1994-06-07 Chevron Research And Technology Company Low viscosity Group II metal overbased sulfurized C16 to C22 alkylphenate compositions
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5368051A (en) * 1993-06-30 1994-11-29 Dunn; Allan R. Method of regenerating articular cartilage
CA2130295A1 (en) 1993-08-26 1995-02-27 Richard A. Berg Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US6743783B1 (en) * 1993-12-01 2004-06-01 Marine Polymer Technologies, Inc. Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine
US5422116A (en) 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US5626861A (en) 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
JPH10505250A (ja) * 1994-06-06 1998-05-26 ケース ウエスターン リザーブ ユニバーシティ 組織再生のためのバイオマトリックス
EP0717630A1 (de) * 1994-07-08 1996-06-26 SULZER Medizinaltechnik AG Verfahren zur herstellung von implantationsmaterialien
SE9402531L (sv) * 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
US5749874A (en) * 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5620706A (en) * 1995-04-10 1997-04-15 Universite De Sherbrooke Polyionic insoluble hydrogels comprising xanthan and chitosan
US5655546A (en) * 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
CA2224253A1 (en) * 1995-06-09 1996-12-27 Martin J. Macphee Chitin hydrogels, methods of their production and use
JP3881707B2 (ja) 1995-07-20 2007-02-14 学校法人松本歯科大学 骨形成促進剤の製造方法及び骨形成促進剤を用いた骨形成組成物の製造方法
US5900238A (en) 1995-07-27 1999-05-04 Immunex Corporation Vaccine delivery system
TW389694B (en) 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
WO1997017038A1 (en) 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
WO1997018299A1 (en) * 1995-11-16 1997-05-22 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
PT876165E (pt) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp Composicoes de polimeros reticulados e processos para a sua utilizacao
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US5830503A (en) 1996-06-21 1998-11-03 Andrx Pharmaceuticals, Inc. Enteric coated diltiazem once-a-day formulation
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6649192B2 (en) * 1996-07-29 2003-11-18 Universidade De Santiago De Compostela Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
US5964807A (en) 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US5872880A (en) * 1996-08-12 1999-02-16 Ronald S. Maynard Hybrid-optical multi-axis beam steering apparatus
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
AU4941297A (en) 1996-11-15 1998-06-10 Dumex-Alpharma A/S A method for promoting tissue repair
JPH10259134A (ja) * 1997-01-16 1998-09-29 Sekisui Chem Co Ltd 創傷治癒促進剤
US5866415A (en) * 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
US5981221A (en) * 1997-03-26 1999-11-09 Incyte Pharmaceuticals, Inc. Histone fusion protein
CA2212300A1 (en) * 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6110209A (en) * 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US6417247B1 (en) 1997-10-14 2002-07-09 Beth L. Armstrong Polymer/ceramic composites
CA2219399A1 (en) * 1997-10-24 1999-04-24 Bio Syntech Ltd. Bulk formation of monolithic polysaccharide-based hydrogels
WO1999022747A1 (en) * 1997-10-30 1999-05-14 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
EP1056413A4 (en) 1998-02-27 2003-08-20 Bioelastics Res Ltd INJECTABLE IMPLANTS FOR TISSUE ENHANCEMENT AND RESTORATION
US7019192B2 (en) 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US6911212B2 (en) * 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US7045141B2 (en) * 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
WO1999047186A1 (en) * 1998-03-18 1999-09-23 University Of Pittsburgh Chitosan-based composite materials containing glycosaminoglycan for cartilage repair
US20030147860A1 (en) 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
DE19817698A1 (de) 1998-04-22 1999-10-28 Jan Zoellner Verwendung einer autopolymerisierenden Zusammensetzung auf Organosiloxanbasis
US6060514A (en) * 1998-05-04 2000-05-09 Conlin Co., Inc. Isomer enriched conjugated linoleic acid compositions
DE69911609T2 (de) 1998-07-13 2004-07-01 University Of Southern California, Los Angeles Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel
BR0007892A (pt) 1999-02-01 2001-10-30 Genetics Inst Processos e composições para cicatrização ereparo de cartilagem articular
WO2000048550A2 (en) 1999-02-16 2000-08-24 Sulzer Biologics, Inc. Device and method for regeneration and repair of cartilage lesions
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
ATE538730T1 (de) * 1999-06-01 2012-01-15 Closys Corp Gebrauchsverfahren und gerät zum einleiten einer blutgerinnungskaskade
AU782394B2 (en) 1999-06-29 2005-07-21 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
EP1229940B1 (en) * 1999-11-15 2014-05-14 Piramal Healthcare (Canada) Limited Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
WO2001041822A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
US20050244393A1 (en) 1999-12-22 2005-11-03 Henogen S.A. Sealant or tissue generating product
ES2304359T3 (es) * 1999-12-28 2008-10-16 The Regents Of The University Of Michigan Procedimiento de formacion ex vivo de hueso de mamiferos y usos del mismo.
DE10026467A1 (de) * 2000-05-27 2001-12-13 Prec Motors Deutsche Minebea G Spindelmotor für Festplattenlaufwerke mit verbesserter Laufgenauigkeit
CN1471412B8 (zh) 2000-06-29 2016-06-15 生物合成技术加拿大公司 用于修复和再生软骨和其它组织的组合物以及该组合物的用途
US6866866B1 (en) 2000-11-03 2005-03-15 Andrx Labs, Llc Controlled release metformin compositions
DE60125973D1 (de) * 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US20040047892A1 (en) 2000-11-15 2004-03-11 Desrosiers Eric Andre Filler composition for soft tissue augmentation and reconstructive surgery
US6756363B1 (en) 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
US20020146385A1 (en) * 2001-04-10 2002-10-10 Lin Tung Liang Ionic antimicrobial coating
JP2002344242A (ja) * 2001-05-18 2002-11-29 Nippon Precision Circuits Inc 電圧制御発振器
ATE312615T1 (de) * 2001-08-14 2005-12-15 Medipost Co Ltd Zusammensetzung zur behandlung von schäden des gelenkknorpels
US8740973B2 (en) * 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
SI1455802T1 (sl) * 2001-12-14 2009-06-30 Dnp Canada Inc Uporaba hitozanskih oligosaharidov
TWI245634B (en) 2001-12-28 2005-12-21 Ind Tech Res Inst Preparation of a biodegradable thermal-sensitive gel system
JP3933949B2 (ja) * 2002-02-05 2007-06-20 三菱電機株式会社 反射鏡支持機構
US7514249B2 (en) * 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
US20060204544A1 (en) * 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
WO2004011054A2 (en) 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
KR20050038008A (ko) 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
DE50209292D1 (de) * 2002-08-14 2007-03-08 Herrenknecht Ag Schildschwanz für eine Schildvortriebseinrichtung
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
GB0302738D0 (en) * 2003-02-06 2003-03-12 Advanced Biopolymers As Composition
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
US20060062768A1 (en) * 2004-09-23 2006-03-23 Olexander Hnojewyj Biocompatible hydrogel compositions
ITRM20040539A1 (it) * 2004-11-02 2005-02-02 Mavi Sud S R L Preparati a base di chitina o suoi derivati per uso cosmetico o medico.
US7309622B2 (en) * 2005-02-14 2007-12-18 Stats Chippac Ltd. Integrated circuit package system with heat sink
WO2007127795A2 (en) * 2006-04-25 2007-11-08 Bumgardner Joel D Chitosan/nanocrystalline hydroxyapatite composite microsphere-based scaffolds
EP2094283A4 (en) 2006-11-30 2010-09-01 Biosyntech Canada Inc PROCESS FOR FIXING BLOOD-POLYMER COMPOSITIONS IN SITU FOR REGENERATIVE MEDICAL AND CARTILAGE REPAIR APPLICATIONS
US8153612B2 (en) * 2006-12-11 2012-04-10 Chi2Gel Ltd. Injectable chitosan mixtures forming hydrogels
US7776840B2 (en) * 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2765601C1 (ru) * 2021-08-17 2022-02-01 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Способ дифференцированного лечения эрозий и язв роговицы

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