ES2529385T3 - Métodos y sustancias para la obtención de compuestos de piridinio sustituidos sobre N - Google Patents
Métodos y sustancias para la obtención de compuestos de piridinio sustituidos sobre N Download PDFInfo
- Publication number
- ES2529385T3 ES2529385T3 ES10740156.4T ES10740156T ES2529385T3 ES 2529385 T3 ES2529385 T3 ES 2529385T3 ES 10740156 T ES10740156 T ES 10740156T ES 2529385 T3 ES2529385 T3 ES 2529385T3
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- alkyl
- aryl
- formula
- alkynyl
- alkenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un método para la síntesis de un compuesto de piridinio sustituido sobre N que consta de los pasos de a) proporcionar una sal de Zincke de la fórmula I**Fórmula** que tiene un contraión, en la que R1 se elige entre H, alquilo, arilo, 2-metil-1,3-dioxolan-2-ilo, ariloxi, alquiloxi, hidroxialquilo, arilalquilo, aminoalquilo protegido sobre N, alquenilo, alquinilo, arilalquenilo, arilalquinilo C>=XNH2, C>=XNH-alquilo, C>=XN(alquilo)2 C>=XNH-arilo, C>=XN(arilo)2, C>=X-arilo, C>=X-alquilo, COO-alquilo, en la que R2 se elige entre H, alquilo, arilo, pirid-4-ilo, alquilpiridinio-4-ilo, 2-metil-1,3-dioxolan-2-ilo, ariloxi, alquiloxi, hidroxialquilo, arilalquilo, aminoalquilo protegido, alquenilo, alquinilo, arilalquenilo, arilalquinilo, C>=XNH2, C>=XNHalquilo, C>=XN(alquilo)2, C>=XNH-arilo, C>=XN(arilo)2, C>=X-arilo, C>=X-alquilo, COO-alquilo, alquilsulfanilo y**Fórmula** en la que por lo menos uno de R1 o R2 es H o alquilo o los restos R1 y R2 juntos son un resto butano-1,4-diilo o butadieno-1,4-diilo que están unidos entre para formar un ciclo de 6 eslabones, en la que con independencia en R1 o R2 alquilo es alquilo C1-C6 lineal o ramificado o cicloalquilo C5-C6, alquenilo es alquenilo C2-C6 lineal o ramificado, alquinilo es alquinilo C2-C6 lineal o ramificado y arilo es fenilo o naftilo, en la que X >= S u O, en la que Y es N o C; en el caso de que Y sea N, no está presente ningún R3 y en el caso de que Y sea C, entonces R3 es H, alquilo C1-C3 o junto con R4 y los dos átomos de carbono sp2, a los que están unidos R3 y R4, forman un sistema de anillo aromático de 5 ó 6 eslabones, que contiene opcionalmente 1 ó 2 átomos de nitrógeno, en la que R4 es H, alquilo C1-C3, hidroxi, O-alquilo C1-C3, amino, (alquil C1-C3)-amino, fenilamino, fenilo o junto con R3 y los dos átomos de carbono sp2, a los que están unidos R3 y R4, forman un sistema de anillo aromático de 5 ó 6 eslabones, que contiene opcionalmente 1 ó 2 átomos de nitrógeno, en la que R5 es H, alquilo C1-C3, hidroxi, O-alquilo C1-C3, amino, (alquil C1-C3)-amino, fenilamino, fenilo o halógeno, y en la que en el caso de que la fórmula I represente a un compuesto bipiridilo, cada uno de Y', R1', R3', R4' y R5', tienen los mismos significados que los restos Y, R1, R3, R4 y R5 correspondientes, (b) hacer reaccionar la sal de Zincke del paso (a) con una amina primaria de la fórmula II:**Fórmula** en la que R6 forma parte de una amina orgánica primaria, que contiene un átomo de carbono sp2 o sp3 que está unido al resto -NH2, o en la que R6 es un resto, que junto con -NH2, es una hidrazina, una hidroxilamina, una sulfonil-hidrazida o una carbohidrazida, (c) con lo cual se obtiene un compuesto de piridinio sustituido sobre N de la fórmula III:**Fórmula** que tiene un contraión y en la que R1, R2, y R6 tienen los significados definidos antes.
Description
Claims (1)
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imagen1 imagen2 imagen3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166455 | 2009-07-27 | ||
| EP09166455 | 2009-07-27 | ||
| PCT/EP2010/004522 WO2011012269A2 (en) | 2009-07-27 | 2010-07-23 | Method and substances for preparation of n-substituted pyridinium compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2529385T3 true ES2529385T3 (es) | 2015-02-19 |
Family
ID=41119556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10740156.4T Active ES2529385T3 (es) | 2009-07-27 | 2010-07-23 | Métodos y sustancias para la obtención de compuestos de piridinio sustituidos sobre N |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8895747B2 (es) |
| EP (1) | EP2459537B1 (es) |
| JP (1) | JP5542931B2 (es) |
| CN (1) | CN102471274B (es) |
| CA (1) | CA2769154C (es) |
| ES (1) | ES2529385T3 (es) |
| WO (1) | WO2011012269A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104854457B (zh) | 2012-12-20 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | 用于分析体液样本的方法 |
| HUE034313T2 (en) | 2012-12-20 | 2018-02-28 | Hoffmann La Roche | Procedures for evaluating medical measurement curves |
| EP2781919A1 (en) | 2013-03-19 | 2014-09-24 | Roche Diagniostics GmbH | Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid |
| KR102372113B1 (ko) | 2016-10-05 | 2022-03-07 | 에프. 호프만-라 로슈 아게 | 다중 분석물 진단 테스트 엘리먼트들을 위한 검출 시약들 및 전극 배열들, 그리고 그것을 사용하는 방법들 |
| HUE064713T2 (hu) | 2018-02-28 | 2024-04-28 | Hoffmann La Roche | Biokompatibilitási bevonat folyamatos analitméréshez |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411995A (en) | 1981-09-28 | 1983-10-25 | Massachusetts Institute Of Technology | Synthesis of nicotinamide cofactors |
| US7553615B2 (en) | 2005-07-28 | 2009-06-30 | Roche Diagnostics Operations, Inc. | Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH |
| DE102005035461A1 (de) * | 2005-07-28 | 2007-02-15 | Roche Diagnostics Gmbh | Stabile NAD/NADH-Derivate |
| DE102006035020B4 (de) | 2005-07-28 | 2018-08-23 | Roche Diabetes Care Gmbh | Stabilisierung von NAD/NADH |
| DE102006039186A1 (de) | 2006-08-21 | 2008-03-13 | Siemens Ag | Elektrochrome Formulierungen und Verwendungen dazu |
| EP2023418A1 (en) | 2007-08-09 | 2009-02-11 | Sony Corporation | Memory device |
| KR101458207B1 (ko) | 2007-11-20 | 2014-11-12 | 삼성전자주식회사 | 전기변색 물질 및 이를 이용한 전기변색 소자 |
-
2010
- 2010-07-23 CA CA2769154A patent/CA2769154C/en active Active
- 2010-07-23 ES ES10740156.4T patent/ES2529385T3/es active Active
- 2010-07-23 CN CN201080035008.1A patent/CN102471274B/zh active Active
- 2010-07-23 EP EP10740156.4A patent/EP2459537B1/en active Active
- 2010-07-23 JP JP2012522012A patent/JP5542931B2/ja active Active
- 2010-07-23 WO PCT/EP2010/004522 patent/WO2011012269A2/en not_active Ceased
-
2012
- 2012-01-27 US US13/359,667 patent/US8895747B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2769154A1 (en) | 2011-02-03 |
| CN102471274A (zh) | 2012-05-23 |
| WO2011012269A3 (en) | 2011-08-11 |
| JP2013500288A (ja) | 2013-01-07 |
| WO2011012269A2 (en) | 2011-02-03 |
| CA2769154C (en) | 2015-10-27 |
| US20120171730A1 (en) | 2012-07-05 |
| US8895747B2 (en) | 2014-11-25 |
| EP2459537B1 (en) | 2014-12-17 |
| CN102471274B (zh) | 2016-08-03 |
| JP5542931B2 (ja) | 2014-07-09 |
| EP2459537A2 (en) | 2012-06-06 |
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