ES2530874T3 - Formulaciones de depósito de corta duración - Google Patents

Formulaciones de depósito de corta duración Download PDF

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Publication number
ES2530874T3
ES2530874T3 ES03739271T ES03739271T ES2530874T3 ES 2530874 T3 ES2530874 T3 ES 2530874T3 ES 03739271 T ES03739271 T ES 03739271T ES 03739271 T ES03739271 T ES 03739271T ES 2530874 T3 ES2530874 T3 ES 2530874T3
Authority
ES
Spain
Prior art keywords
polymer
composition
aromatic
miscibility
biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03739271T
Other languages
English (en)
Inventor
Guohua Chen
David Priebe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Durect Corp
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Application granted granted Critical
Publication of ES2530874T3 publication Critical patent/ES2530874T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B18/00—Use of agglomerated or waste materials or refuse as fillers for mortars, concrete or artificial stone; Treatment of agglomerated or waste materials or refuse, specially adapted to enhance their filling properties in mortars, concrete or artificial stone
    • C04B18/04—Waste materials; Refuse
    • C04B18/18—Waste materials; Refuse organic
    • C04B18/20—Waste materials; Refuse organic from macromolecular compounds
    • C04B18/22—Rubber, e.g. ground waste tires
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
    • C04B28/02—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
    • C04B28/04—Portland cements
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/40—Porous or lightweight materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/50—Reuse, recycling or recovery technologies
    • Y02W30/91—Use of waste materials as fillers for mortars or concrete

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Civil Engineering (AREA)
  • Environmental & Geological Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una composición de depósito inyectable que comprende: (a) un polímero biocompatible bioerosionable de bajo peso molecular; (b) un disolvente seleccionado de entre el grupo que consiste en alcoholes aromáticos, ésteres de ácidos aromáticos, cetonas aromáticas y mezclas de los mismos, teniendo dicho disolvente una miscibilidad en agua de menos de o igual a 7% a 25 °C y presente en una cantidad eficaz para plastificar el polímero y formar un gel con el mismo; y (c) un agente beneficioso; en el que el polímero de bajo peso molecular tiene un peso molecular promedio en peso que varía de 3.000 a 10.000; y en el que dicha composición inyectable no es una de las siguientes (i) a (iii): (i) una composición de depósito inyectable que comprende: un polímero biocompatible, bioerosionable, un alcohol aromático que tiene miscibilidad en agua de menos de o igual a 7% en peso a 25 °C, en una cantidad efectiva para plastificar el polímero y formar un gel con el mismo y un agente beneficioso; en el que la composición está libre de alcanoles inferiores monohídricos; (ii) una composición de depósito inyectable que comprende: un polímero biocompatible, bioerosionable; un disolvente seleccionado de entre el grupo que consiste en ésteres de ácidos aromáticos, cetonas aromáticas y mezclas de los mismos, teniendo dicho disolvente una miscibilidad en agua de menos de o igual a 7% a 25 °C y presente en una cantidad efectiva para plastificar el polímero y formar un gel con el mismo; una cantidad tixotrópica eficaz de un alcohol aromático que tiene miscibilidad en agua de menos de o igual a 7% y un agente beneficioso; en la que la composición está libre de alcanoles inferiores monohídricos; y (iii) una formulación que consiste en: 58,5% de polímero poli(D,L-láctido-co-glicólido) 50:50 que tiene un peso molecular de 8.000; 31,5% de benzoato de bencilo y 10% de bupivacaína.
ES03739271T 2002-06-25 2003-06-25 Formulaciones de depósito de corta duración Expired - Lifetime ES2530874T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39186702P 2002-06-25 2002-06-25
PCT/US2003/019762 WO2004000269A1 (en) 2002-06-25 2003-06-25 Short duration depot formulations

Publications (1)

Publication Number Publication Date
ES2530874T3 true ES2530874T3 (es) 2015-03-06

Family

ID=30000765

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03739271T Expired - Lifetime ES2530874T3 (es) 2002-06-25 2003-06-25 Formulaciones de depósito de corta duración

Country Status (20)

Country Link
EP (3) EP2311431A1 (es)
JP (2) JP2005533081A (es)
KR (1) KR101172721B1 (es)
CN (1) CN1671357B (es)
AR (1) AR039729A1 (es)
AU (1) AU2003245643B2 (es)
BR (1) BR0312033A (es)
CA (1) CA2492047C (es)
EC (1) ECSP055566A (es)
ES (1) ES2530874T3 (es)
IL (1) IL165865A0 (es)
MA (1) MA27371A1 (es)
MX (1) MXPA05000199A (es)
NO (1) NO20050366L (es)
NZ (1) NZ574443A (es)
PL (1) PL207147B1 (es)
RU (1) RU2320321C2 (es)
TW (1) TWI353854B (es)
WO (1) WO2004000269A1 (es)
ZA (1) ZA200500677B (es)

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US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
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US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US8658210B2 (en) 2006-04-17 2014-02-25 Advanced Cardiovascular Systems, Inc. Polyesteramide platform for site specific drug delivery
WO2008143992A2 (en) 2007-05-18 2008-11-27 Durect Corporation Improved depot formulations
BRPI0811319A2 (pt) 2007-05-25 2015-02-10 Tolmar Therapeutics Inc Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento
US8846068B2 (en) * 2008-04-18 2014-09-30 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
RS60051B1 (sr) * 2011-06-10 2020-04-30 Ramscor Inc Formulacije sa produženim oslobađanjem za isporuku proteina u oko i postupci njihove pripreme
EP2986278A1 (en) 2013-03-11 2016-02-24 DURECT Corporation Injectable controlled release composition comprising high viscosity liquid carrier
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN111388406B (zh) * 2020-03-24 2024-02-23 西安力邦医药科技有限责任公司 氟维司群或其衍生物可注射递药贮库及其制备方法和应用
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法

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Also Published As

Publication number Publication date
IL165865A0 (en) 2006-01-15
RU2320321C2 (ru) 2008-03-27
JP5631708B2 (ja) 2014-11-26
HK1082412A1 (en) 2006-06-09
JP2011068670A (ja) 2011-04-07
AU2003245643A1 (en) 2004-01-06
MXPA05000199A (es) 2005-06-06
CN1671357A (zh) 2005-09-21
CN1671357B (zh) 2010-08-11
PL373123A1 (en) 2005-08-08
AR039729A1 (es) 2005-03-09
BR0312033A (pt) 2005-04-26
AU2003245643B2 (en) 2009-02-26
MA27371A1 (fr) 2005-06-01
EP1515697B1 (en) 2014-11-19
KR101172721B1 (ko) 2012-08-30
NZ574443A (en) 2010-08-27
CA2492047A1 (en) 2003-12-31
KR20050026414A (ko) 2005-03-15
TW200404578A (en) 2004-04-01
EP2316421A1 (en) 2011-05-04
JP2005533081A (ja) 2005-11-04
WO2004000269A1 (en) 2003-12-31
EP2311431A1 (en) 2011-04-20
EP1515697A1 (en) 2005-03-23
PL207147B1 (pl) 2010-11-30
TWI353854B (en) 2011-12-11
NO20050366L (no) 2005-03-23
ZA200500677B (en) 2006-08-30
CA2492047C (en) 2014-08-12
ECSP055566A (es) 2005-04-18
RU2005101640A (ru) 2005-08-10

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