ES253120A1 - Procedimiento para la obtenciën de un nuevo medio de contraste radiolëgico - Google Patents

Procedimiento para la obtenciën de un nuevo medio de contraste radiolëgico

Info

Publication number: ES253120A1
Authority: ES; Spain
Prior art keywords: radical; amino; acid; group; chloride
Prior art date: 1958-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0253120A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Patheon Austria GmbH and Co KG

Original Assignee

Chemie Linz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1958-12-03

Filing date

1959-11-03

Publication date

1960-05-16

1958-12-03 Priority claimed from AT835958A external-priority patent/AT209897B/de

1959-04-07 Priority claimed from AT261559A external-priority patent/AT210564B/de

1959-04-23 Priority claimed from AT305259A external-priority patent/AT211953B/de

1959-06-12 Priority claimed from AT433959A external-priority patent/AT211816B/de

1959-11-03 Application filed by Chemie Linz AG filed Critical Chemie Linz AG

1960-05-16 Publication of ES253120A1 publication Critical patent/ES253120A1/es

Status Expired legal-status Critical Current

Links

ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title abstract 3
229910052740 iodine Inorganic materials 0.000 title abstract 3
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000011630 iodine Substances 0.000 title 1
-1 polymethylene Polymers 0.000 abstract 11
125000004432 carbon atom Chemical group C* 0.000 abstract 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
231100000252 nontoxic Toxicity 0.000 abstract 4
230000003000 nontoxic effect Effects 0.000 abstract 4
150000003254 radicals Chemical class 0.000 abstract 4
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 3
ODZVWOVYLZASJG-UHFFFAOYSA-N 1,2,2,3,3,4,4,5,5,6-decaiodocyclohexane-1-carboxamide Chemical class IC1C(C(C(C(C1(C(=O)N)I)(I)I)(I)I)(I)I)(I)I ODZVWOVYLZASJG-UHFFFAOYSA-N 0.000 abstract 2
QYCLHZCJRVKGQB-UHFFFAOYSA-N 2,3,4,5,6-pentaiodobenzoyl chloride Chemical compound ClC(=O)C1=C(I)C(I)=C(I)C(I)=C1I QYCLHZCJRVKGQB-UHFFFAOYSA-N 0.000 abstract 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
WKWMZADGBXQVIT-UHFFFAOYSA-N 3-amino-2,4,5,6-tetraiodobenzoic acid Chemical compound NC=1C(=C(C(=O)O)C(=C(C1I)I)I)I WKWMZADGBXQVIT-UHFFFAOYSA-N 0.000 abstract 2
FZIQGPNHFDEWRM-UHFFFAOYSA-N 3-amino-2,4,5,6-tetraiodobenzoyl chloride Chemical compound NC=1C(=C(C(=O)Cl)C(=C(C1I)I)I)I FZIQGPNHFDEWRM-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
229920002472 Starch Polymers 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000004442 acylamino group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
150000005840 aryl radicals Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 2
239000008107 starch Substances 0.000 abstract 2
235000019698 starch Nutrition 0.000 abstract 2
FEOHYDSNGHIXOM-WLDMJGECSA-N (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)-2-methyloxane-2,4,5-triol Chemical compound CC1(O)[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO FEOHYDSNGHIXOM-WLDMJGECSA-N 0.000 abstract 1
LNLWJOZRHQPFML-UHFFFAOYSA-N 2,3,4,5,6-pentaiodobenzoic acid Chemical compound OC(=O)C1=C(I)C(I)=C(I)C(I)=C1I LNLWJOZRHQPFML-UHFFFAOYSA-N 0.000 abstract 1
KBYLCDHIWWCZLX-UHFFFAOYSA-N 3-amino-5-iodobenzoic acid Chemical compound NC1=CC(I)=CC(C(O)=O)=C1 KBYLCDHIWWCZLX-UHFFFAOYSA-N 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
239000001828 Gelatine Substances 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
235000019483 Peanut oil Nutrition 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002872 contrast media Substances 0.000 abstract 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 abstract 1
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 abstract 1
229920000159 gelatin Polymers 0.000 abstract 1
235000019322 gelatine Nutrition 0.000 abstract 1
239000004310 lactic acid Substances 0.000 abstract 1
235000014655 lactic acid Nutrition 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
235000019359 magnesium stearate Nutrition 0.000 abstract 1
NHQZRZUWLGBZDO-UHFFFAOYSA-N methyl 2-[(2,3,4,5,6-pentaiodobenzoyl)amino]butanoate Chemical compound IC1=C(C(=C(C(=C1C(=O)NC(C(=O)OC)CC)I)I)I)I NHQZRZUWLGBZDO-UHFFFAOYSA-N 0.000 abstract 1
OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000312 peanut oil Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
159000000000 sodium salts Chemical class 0.000 abstract 1
239000000454 talc Substances 0.000 abstract 1
229910052623 talc Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0495—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound intended for oral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ES0253120A 1958-12-03 1959-11-03 Procedimiento para la obtenciën de un nuevo medio de contraste radiolëgico Expired ES253120A1 (es)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
AT835958A AT209897B (de)	1958-12-03	1958-12-03	Verfahren zur Herstellung von neuen O- bzw. N-2,3,4,6-Tetrajodbenzoylverbindungen
AT261559A AT210564B (de)	1959-04-07	1959-04-07	Röntgenkontrastmittell
AT305259A AT211953B (de)	1959-04-23	1959-04-23	Röntgenkontrastmittel
AT433959A AT211816B (de)	1959-06-12	1959-06-12	Verfahren zur Herstellung von neuen polyjodierten Benzoylverbindungen

Publications (1)

Publication Number	Publication Date
ES253120A1 true ES253120A1 (es)	1960-05-16

Family

ID=27421801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0253120A Expired ES253120A1 (es)	1958-12-03	1959-11-03	Procedimiento para la obtenciën de un nuevo medio de contraste radiolëgico

Country Status (5)

Country	Link
CH (1)	CH385423A (fr)
ES (1)	ES253120A1 (fr)
FR (1)	FR275M (fr)
GB (1)	GB881510A (fr)
NL (1)	NL124839C (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2717799B1 (fr) *	1994-03-22	1996-07-19	Guerbet Sa	Composés polyiodes : procédé de préparation ; composition de diagnostic.
GB0717189D0 (en)	2007-09-04	2007-10-17	Syngenta Participations Ag	Novel processes and compounds

1959
- 1959-10-24 CH CH7981559A patent/CH385423A/de unknown
- 1959-11-03 ES ES0253120A patent/ES253120A1/es not_active Expired
- 1959-11-20 NL NL245605A patent/NL124839C/xx active
- 1959-11-25 GB GB39989/59A patent/GB881510A/en not_active Expired
1960
- 1960-08-23 FR FR810754A patent/FR275M/fr active Active

Also Published As

Publication number	Publication date
NL124839C (fr)	1968-07-16
FR275M (fr)	1961-03-13
GB881510A (en)	1961-11-01
CH385423A (de)	1964-12-15

Publication	Publication Date	Title
ES445236A1 (es)	1977-06-01	Procedimiento para mejorar el desmoldeo de masas termoplas- ticas de policarbonatos.
ATE28187T1 (de)	1987-07-15	Polyprenylcarbonsaeureamide und verfahren zu ihrer herstellung.
ES304136A1 (es)	1965-03-16	Procedimiento para la preparacion de nuevas amidas n-sustituidas.
ES466531A1 (es)	1979-01-16	Procedimiento para preparar haloacetanilidas n-sustituidas
ES253120A1 (es)	1960-05-16	Procedimiento para la obtenciën de un nuevo medio de contraste radiolëgico
EP0047405A3 (en)	1982-03-24	Azolylalkyl derivatives, process for their preparation and their use as fungicides
US2804474A (en)	1957-08-27	Preparation of aminocarboxylic acids
GB1332833A (en)	1973-10-03	Amindines
GB867880A (en)	1961-05-10	N-acyl derivatives of (3:5-diamino-2:4:6-triiodobenzoyl)-amino acids and x-ray contrast media containing the same
GB870321A (en)	1961-06-14	Improvements in or relating to iodine-containing aminobenzoic acid amides and a method of producing the same
ES427901A1 (es)	1976-12-16	Un procedimiento para la preparacion de nuevas beta-lacta- mas sustituidas.
ES394894A1 (es)	1974-05-16	Procedimiento para la obtencion de acidos fenilacetohidro- xamicos.
WO1991017141A3 (fr)	1991-12-26	Procede diastereoselectif de preparation d'acides amines a substitution n et derives
GB615137A (en)	1949-01-03	Manufacture of amides of ª‡,ª‰-unsaturated carboxylic acids
ES321802A1 (es)	1966-06-16	Procedimiento para la preparaciën de nuevos derivados de la 1, 2, 3, 6-tetrahidropiridina
GB890305A (en)	1962-02-28	Amide colour couplers for colour photography
ES352579A1 (es)	1970-01-01	Un procedimiento para la preparacion de un oxazol sustitui-do por monoarilo.
ES382564A1 (es)	1973-05-01	Procedimiento para la preparacion de derivados de la dihi- dro-10,11 dibenzo (b,f) azepina.
ES423681A1 (es)	1976-04-16	Procedimiento para preparar pentadienos.
GB1202179A (en)	1970-08-12	Bis-amido derivatives of 2,4,6-triiodobenzoic acid, their production and their use in x-ray contrast compositions
GB912920A (en)	1962-12-12	New substituted aminomethanephosphonic acids and processes for their production
ES441151A1 (es)	1977-03-16	Un metodo para preparar una composicion antialergica.
ES394638A3 (es)	1973-12-01	Procedimiento para la preparacion de amidas n-sustituidas en los acidos dialquiltiofosfomercaptoacetidos de elevado poder insecticida.
ES360858A1 (es)	1970-07-16	Procedimiento para la preparacion de nuevos derivados de tiazepina.
GB191210443A (en)	1913-05-02	Manufacture of New Derivatives of Phenyl-Cinchoninic Acid and of Homologues and Derivatives thereof.