ES2541178T3 - Método de detección de cáncer colorrectal - Google Patents

Método de detección de cáncer colorrectal Download PDF

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Publication number
ES2541178T3
ES2541178T3 ES10702339.2T ES10702339T ES2541178T3 ES 2541178 T3 ES2541178 T3 ES 2541178T3 ES 10702339 T ES10702339 T ES 10702339T ES 2541178 T3 ES2541178 T3 ES 2541178T3
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colorectal cancer
predisposition
incidence
epigenetic modification
screening method
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Louwagie Joost
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MDxHealth SA
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MDxHealth SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5753—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the stomach or small intestine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un método para detectar una predisposición a, o la incidencia de, cáncer colorrectal en una muestra fecal, que comprende: (a) detectar la presencia de sangre en la muestra fecal, en donde la detección de la presencia de sangre es indicativa de una predisposición a, o la incidencia de, cáncer colorrectal; y (b) detectar una modificación epigenética en el ADN contenido dentro de la muestra fecal, en donde la modificación epigenética es detectada en al menos un gen seleccionado entre NDRG4, PHACTR3, FOXE1, GATA4, GPNMB, TFPI2, SOX17, SYNE1, LAMA, MMP2, OSMR, SFRP2 y CDO1 y en donde la detección de la modificación epigenética en al menos uno de los genes es indicativa de una predisposición a, o la incidencia de, cáncer colorrectal y sobre la base de un resultado positivo obtenido en (a) o (b) o tanto en (a) como en (b) detectar una predisposición a, o la incidencia de, cáncer colorrectal.

Description

imagen1

Claims (1)

  1. imagen1
ES10702339.2T 2009-02-03 2010-02-03 Método de detección de cáncer colorrectal Active ES2541178T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14958109P 2009-02-03 2009-02-03
US149581P 2009-02-03
PCT/GB2010/000180 WO2010089538A2 (en) 2009-02-03 2010-02-03 Methods of detecting colorectal cancer

Publications (1)

Publication Number Publication Date
ES2541178T3 true ES2541178T3 (es) 2015-07-16

Family

ID=42078343

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10702339.2T Active ES2541178T3 (es) 2009-02-03 2010-02-03 Método de detección de cáncer colorrectal

Country Status (6)

Country Link
US (11) US20120164238A1 (es)
EP (1) EP2394170B1 (es)
CA (1) CA2751303C (es)
DK (1) DK2394170T3 (es)
ES (1) ES2541178T3 (es)
WO (1) WO2010089538A2 (es)

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US20230272488A1 (en) 2023-08-31
US20170298448A1 (en) 2017-10-19
EP2394170B1 (en) 2015-04-01
US11987848B2 (en) 2024-05-21
US20250092464A1 (en) 2025-03-20
DK2394170T3 (en) 2015-07-13
US20120164238A1 (en) 2012-06-28
US11634781B2 (en) 2023-04-25
WO2010089538A2 (en) 2010-08-12
CA2751303C (en) 2020-09-01
US11970746B2 (en) 2024-04-30
CA2751303A1 (en) 2010-08-12
EP2394170A2 (en) 2011-12-14
US20230313317A1 (en) 2023-10-05
WO2010089538A9 (en) 2011-05-26
US20250084487A1 (en) 2025-03-13
US11845991B2 (en) 2023-12-19
US20190276900A1 (en) 2019-09-12
WO2010089538A3 (en) 2010-11-25
US20230048152A1 (en) 2023-02-16
US20240318260A1 (en) 2024-09-26
US20250034653A1 (en) 2025-01-30
US20160194723A1 (en) 2016-07-07

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