ES2543463T3 - Dispositivo para cultivar células - Google Patents

Dispositivo para cultivar células Download PDF

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Publication number
ES2543463T3
ES2543463T3 ES10723936.0T ES10723936T ES2543463T3 ES 2543463 T3 ES2543463 T3 ES 2543463T3 ES 10723936 T ES10723936 T ES 10723936T ES 2543463 T3 ES2543463 T3 ES 2543463T3
Authority
ES
Spain
Prior art keywords
transport
radial
axial
elements
transport elements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10723936.0T
Other languages
English (en)
Inventor
Marco Jenzsch
Max Lechner
Michael Pohlscheidt
Christoph Reese
Alexander Scholz
Hermann Tebbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2543463T3 publication Critical patent/ES2543463T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1122—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades anchor-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/113—Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/192—Stirrers with two or more mixing elements mounted in sequence on the same axis with dissimilar elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Aviation & Aerospace Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Dispositivo que comprende un agitador y un módulo de diálisis dentro de un recipiente de cultivo, caracterizado por que el agitador comprende - un elemento de transporte radial que comprende al menos dos palas de mezclador, y - uno o más elementos de transporte axial que comprenden, cada uno, al menos dos palas de mezclador, en el que las palas de mezclador del elemento de transporte radial son paralelas entre sí, en el que el diámetro externo de todos los elementos de transporte axial es igual a o menor que el diámetro interno del elemento de transporte radial, en el que todos los elementos de transporte axial están conectados individualmente al elemento de transporte radial, en el que todos los elementos de transporte axial están ubicados dentro del elemento de transporte radial, y en el que todos los elementos de transporte tienen una orientación espacial fija unos con respecto a otros.

Description

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Claims (1)

  1. imagen1
ES10723936.0T 2009-06-05 2010-06-02 Dispositivo para cultivar células Active ES2543463T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09007457 2009-06-05
EP09007457 2009-06-05
PCT/EP2010/003356 WO2010139470A1 (en) 2009-06-05 2010-06-02 Combination stirrer

Publications (1)

Publication Number Publication Date
ES2543463T3 true ES2543463T3 (es) 2015-08-19

Family

ID=41217580

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10723936.0T Active ES2543463T3 (es) 2009-06-05 2010-06-02 Dispositivo para cultivar células

Country Status (12)

Country Link
US (3) US10076731B2 (es)
EP (1) EP2437874B1 (es)
JP (1) JP5827617B2 (es)
CN (1) CN102458629B (es)
CA (1) CA2762656C (es)
DK (1) DK2437874T3 (es)
ES (1) ES2543463T3 (es)
HU (1) HUE025488T2 (es)
PL (1) PL2437874T3 (es)
SG (1) SG176639A1 (es)
SI (1) SI2437874T1 (es)
WO (1) WO2010139470A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2543463T3 (es) 2009-06-05 2015-08-19 F. Hoffmann-La Roche Ag Dispositivo para cultivar células
CN103391994B (zh) * 2011-01-11 2015-07-22 通用电气医疗集团生物科学公司 可线性缩放规模的单次使用的生物反应器系统
NO342292B1 (no) * 2016-08-09 2018-04-30 Wahl Prosess Utvikling As Røreverk
CN108410734A (zh) * 2018-05-17 2018-08-17 江苏弗洛瑞生物工程设备有限公司 一种细胞培养生物反应器
CN111154645A (zh) * 2018-11-08 2020-05-15 华道(上海)生物医药有限公司 搅拌器、细胞培养罐以及培养方法
CN109694812B (zh) * 2019-03-07 2022-10-25 慕恩（广州）生物科技有限公司 孢子分离设备、孢子分离方法及孢子收集系统
EP4400206A1 (en) 2023-01-16 2024-07-17 Universidad de Sevilla Agitated tank with improved homogeneity bubble distribution and method thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US737433A (en) 1903-03-10 1903-08-25 E J Riffle Wrench.
US3445342A (en) * 1966-02-11 1969-05-20 New Brunswick Scientific Co Fermentation apparatus
SE436168C (sv) 1980-09-25 1987-05-18 Landskrona Finans Ab Tippbar kokgryta med omrorare
US4438074A (en) 1981-07-21 1984-03-20 Phillips Petroleum Company Continuous polymerization reactor
DE3332069A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag Ruehrer fuer wandnahes ruehren
JPS61200842A (ja) 1985-02-28 1986-09-05 Sumitomo Heavy Ind Ltd 撹拌機
DE3516027A1 (de) 1985-05-04 1986-11-06 Huels Chemische Werke Ag Ruehrsystem und verfahren zum begasen von fluessigkeiten
DE3541738A1 (de) * 1985-11-26 1987-05-27 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum kultivieren von zellen
US5286646A (en) * 1985-11-25 1994-02-15 Boehringer Mannheim Gmbh Method for mammalian cell culture
JPH0642733Y2 (ja) * 1988-06-15 1994-11-09 株式会社日立製作所 撹拌装置
JPH0348904A (ja) 1989-07-17 1991-03-01 Mitsubishi Electric Corp 数値制御装置
JP2749002B2 (ja) * 1992-01-31 1998-05-13 宇部興産株式会社 高粘度液体撹拌槽
US5342763A (en) 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
CN1044334C (zh) 1994-12-28 1999-07-28 黄为民 搅拌釜
JPH08252445A (ja) 1996-03-22 1996-10-01 Sumitomo Heavy Ind Ltd 攪拌機
US5865539A (en) * 1997-09-30 1999-02-02 Rogers; Mike Rotary mixing device for fluidic material
US5972661A (en) * 1998-09-28 1999-10-26 Penn State Research Foundation Mixing systems
WO2001041919A1 (en) 1999-12-10 2001-06-14 Inca International S.P.A. Impeller draft tube agitation system for gas-liquid mixing in a stirred tank reactor
ATE321606T1 (de) * 2000-09-28 2006-04-15 Kansai Chem Eng Wärmeübertragungsvorrichtung
DE10248333A1 (de) 2002-01-25 2003-12-04 Bayer Ag Dynamischer Mischer
US7153480B2 (en) * 2003-05-22 2006-12-26 David Robert Bickham Apparatus for and method of producing aromatic carboxylic acids
US7273950B2 (en) * 2003-06-13 2007-09-25 Tereftalatos Mexicanos, S.A. De C.V. Process and apparatus for the efficient oxidation of alkyl aromatic compounds
JP4081478B2 (ja) 2004-04-22 2008-04-23 エフ．ホフマン−ラ ロシュ アーゲー 攪拌機
KR20070015178A (ko) 2004-04-27 2007-02-01 백스터 인터내셔널 인코포레이티드 교반-탱크 반응기 시스템
US7682067B2 (en) 2005-04-22 2010-03-23 Hyclone Laboratories, Inc. Mixing systems and related mixers
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
US7879599B2 (en) 2005-04-22 2011-02-01 Hyclone Laboratories, Inc. Tube ports and related container systems
DE102005053333A1 (de) * 2005-11-07 2007-05-10 Bayer Technology Services Gmbh Multistatoren
JP2007330847A (ja) * 2006-06-12 2007-12-27 Nippon Kagaku Kikai Seizo Kk 攪拌装置
EP2143801A4 (en) 2007-03-30 2013-06-19 Mitsui Shipbuilding Eng PROCESS FOR PRODUCING CONTINUOUS ALCOHOL
JP2009072133A (ja) 2007-09-21 2009-04-09 Hitachi Plant Technologies Ltd 培養槽装置、細胞培養方法及び物質生産方法
ES2543463T3 (es) 2009-06-05 2015-08-19 F. Hoffmann-La Roche Ag Dispositivo para cultivar células
DE202010018640U1 (de) 2009-07-24 2019-11-14 F. Hoffmann-La Roche Ag Rührersystem
US9311297B2 (en) 2013-03-14 2016-04-12 Prateek Bhatnagar Method and system for outputting information

Also Published As

Publication number Publication date
DK2437874T3 (en) 2015-06-15
US20220143562A1 (en) 2022-05-12
US20120070860A1 (en) 2012-03-22
CN102458629A (zh) 2012-05-16
EP2437874A1 (en) 2012-04-11
WO2010139470A1 (en) 2010-12-09
CN102458629B (zh) 2014-12-24
CA2762656C (en) 2017-11-28
SI2437874T1 (sl) 2015-08-31
EP2437874B1 (en) 2015-05-06
JP2012528708A (ja) 2012-11-15
CA2762656A1 (en) 2010-12-09
US11253826B2 (en) 2022-02-22
JP5827617B2 (ja) 2015-12-02
SG176639A1 (en) 2012-01-30
HUE025488T2 (en) 2016-04-28
US20190168177A1 (en) 2019-06-06
US10076731B2 (en) 2018-09-18
PL2437874T3 (pl) 2015-10-30

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