ES2547579T3 - Un aparato para tratamiento sanguíneo extracorpóreo - Google Patents

Un aparato para tratamiento sanguíneo extracorpóreo Download PDF

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Publication number
ES2547579T3
ES2547579T3 ES12712734.8T ES12712734T ES2547579T3 ES 2547579 T3 ES2547579 T3 ES 2547579T3 ES 12712734 T ES12712734 T ES 12712734T ES 2547579 T3 ES2547579 T3 ES 2547579T3
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chamber
value
transmembrane pressure
path
blood
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Francesco Fontanazzi
Alessandro SURACE
Francesco Paolini
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Gambro Lundia AB
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Gambro Lundia AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1611—Weight of the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/3406—Physical characteristics of the filtrate, e.g. urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441—Substitution rate control as a function of the ultrafiltration rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3462—Circuits for the preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3465—Substitution fluids using dialysate as substitution fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3413—Diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
  • Surgical Instruments (AREA)

Abstract

Un aparato para tratamiento sanguíneo extracorpóreo, que comprende: al menos una unidad de tratamiento (2) que tiene al menos una primera cámara (3) y al menos una segunda cámara (4) separadas entre sí por una membrana semipermeable (5); al menos una vía de extracción de sangre (6) conectada a un orificio de entrada de la primera cámara y predispuesta para extraer sangre de un paciente, al menos una vía de retorno de sangre (7) conectada con un orificio de salida de la primera cámara y predispuesta para devolver sangre tratada al paciente, formando la vía de extracción de sangre (6), la vía de retorno de sangre (7) y la primera cámara parte de un circuito sanguíneo extracorpóreo (8); al menos una vía de infusión (9; 9a ,9b) de un fluido de sustitución conectada con el circuito extracorpóreo o conectable directamente con un paciente; al menos una vía de diálisis conectada en la entrada a la segunda cámara (4); al menos una vía de evacuación de fluido (10) conectada a un orificio de salida de la segunda cámara; medios sensores para determinar: - un primer parámetro relativo a un volumen de sangre (BV%) del paciente; - al menos un segundo y un tercer parámetro relativos seleccionados entre: un caudal de ultrafiltración (UFR) a través de la membrana, una velocidad de pérdida de peso (WLR) del paciente, un caudal de infusión (QINF) del fluido de sustitución que atraviesa la vía de infusión (9; 9a, 9b); - un cuarto parámetro relativo a una presión transmembrana (TMP) entre la primera cámara y la segunda cámara; un primer dispositivo regulador (20) activo en al menos uno del circuito extracorpóreo (8) y la vía de evacuación de fluido (10) y configurado para regular un caudal del ultrafiltración (UFR) o una presión transmembrana (TMP) entre la primera y la segunda cámara de la unidad de tratamiento, una unidad de control (15) conectada a los medios sensores y al primer dispositivo regulador (20) y configurada para realizar: a) al menos en un instante de control (t), un procedimiento de control que comprende: - recibir de los medios sensores valores medidos del primer parámetro (BV%mes(t)) y el segundo y tercer parámetro (UFRmes(t), WLRmes(t), QINFmes(t)), y - calcular, tomando como base dichos valores medidos y al menos un valor de prescripción de la variación del volumen de sangre (BV%target), un valor de control relativo a la velocidad de pérdida de peso (WLR(t)) que el aparato debe imponer, - imponer el valor de control (WLR(t)) en la velocidad de pérdida de peso, y para realizar: b) al menos en un instante de ajuste (π) una secuencia de ajuste de la presión transmembrana, comprendiendo dicha secuencia de ajuste: - imponer en un primer valor de la presión transmembrana (TMPn) un primer incremento (δTMPn) para alcanzar un segundo valor de presión transmembrana (TMPn+1); - determinar una variación (ΔUFR(n)) entre el flujo de ultrafiltración a través de la membrana (5) en el primer valor de presión transmembrana (TMPn) y el flujo de ultrafiltración en el segundo valor de presión transmembrana (TMPn +1), en el que la variación del caudal de ultrafiltración se determina mediante medición directa del flujo de ultrafiltración o indirectamente, teniendo en cuenta tanto la variación de flujo de líquido de sustitución (ΔQINF(n)) a lo largo de la vía de infusión como las variaciones de velocidad de pérdida de peso (ΔWLR(n)) debidas al procedimiento de control; - comparar la variación de ultrafiltración (ΔUFR(n)) con un valor de referencia y, si el valor de la variación (ΔUFR(n)) es mayor que el valor de referencia, ordenar al primer dispositivo de regulación, imponer un segundo incremento (δTMPn+1) en la segunda presión transmembrana para alcanzar un tercer valor de la presión transmembrana (TMPn+2).

Description

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Claims (1)

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ES12712734.8T 2011-03-21 2012-03-20 Un aparato para tratamiento sanguíneo extracorpóreo Active ES2547579T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20110442 2011-03-21
IT000442A ITMI20110442A1 (it) 2011-03-21 2011-03-21 Apparecchiatura per il trattamento extracorporeo di sangue.
PCT/IB2012/000537 WO2012127298A1 (en) 2011-03-21 2012-03-20 An apparatus for extracorporeal blood treatment

Publications (1)

Publication Number Publication Date
ES2547579T3 true ES2547579T3 (es) 2015-10-07

Family

ID=43977108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12712734.8T Active ES2547579T3 (es) 2011-03-21 2012-03-20 Un aparato para tratamiento sanguíneo extracorpóreo

Country Status (9)

Country Link
US (1) US9220830B2 (es)
EP (1) EP2688600B1 (es)
KR (1) KR101531457B1 (es)
CN (1) CN103547299B (es)
AU (1) AU2012232839B2 (es)
CA (1) CA2830039C (es)
ES (1) ES2547579T3 (es)
IT (1) ITMI20110442A1 (es)
WO (1) WO2012127298A1 (es)

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KR101862425B1 (ko) 2010-07-05 2018-05-29 감브로 룬디아 아베 이동식 한외 여과 장치，관련 방법 및 컴퓨터 프로그램 제품
PL2436406T3 (pl) 2010-09-30 2014-09-30 Gambro Lundia Ab Urządzenie do pozaustrojowego oczyszczania krwi
PL2687248T3 (pl) 2012-07-18 2015-04-30 Gambro Lundia Ab Przyrząd i sposób do określania parametru wskazującego na postęp pozaustrojowej obróbki krwi
WO2014076519A1 (fr) * 2012-10-29 2014-05-22 Debiotech S.A. Dispositif de traitement extra corporel du sang
EP2732834B1 (en) 2012-11-14 2015-07-29 Gambro Lundia AB Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment
ITMO20120285A1 (it) * 2012-11-21 2014-05-22 Monica Zanotti Apparato di emodiafiltrazione
ES2628375T3 (es) 2012-12-20 2017-08-02 Gambro Lundia Ab Un aparato para el tratamiento extracorpóreo de sangre
EP3015123B1 (en) 2014-10-29 2017-03-22 B. Braun Avitum AG Acute renal replacement therapy apparatus
US10688233B2 (en) 2014-12-19 2020-06-23 Fenwal, Inc. Method and system for the automated processing of biological fluid during low level alert condition
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WO2017080969A1 (en) * 2015-11-09 2017-05-18 Gambro Lundia Ab Apparatus for extracorporeal blood treatment i
CN105363084B (zh) * 2015-12-10 2018-06-26 威海威高血液净化制品有限公司 一种血液净化装置的液体平衡系统及应用
CN113304341B (zh) * 2016-03-31 2024-05-14 旭化成医疗株式会社 血液净化系统和其启动加注方法
EP3544651B1 (en) 2016-11-25 2025-01-08 Gambro Lundia AB Apparatus for extracorporeal blood treatment
CN110225772B (zh) * 2016-11-25 2021-10-22 甘布罗伦迪亚股份公司 用于体外血液处理的装置
US11376354B2 (en) 2016-11-25 2022-07-05 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
US10881347B2 (en) 2017-12-29 2021-01-05 Fresenius Medical Care Holdings, Inc. Closed loop dialysis treatment using adaptive ultrafiltration rates
EP3542707A1 (en) * 2018-03-20 2019-09-25 Gambro Lundia AB Sensor and apparatus for determining at least one parameter of blood circulating in an extracorporeal blood circuit
EP3636296B1 (en) * 2018-10-11 2024-06-19 Gambro Lundia AB Extracorporeal blood treatment apparatus and method for monitoring pressures in an extracorporeal blood treatment apparatus
DE102019126048A1 (de) * 2019-09-26 2021-04-01 B.Braun Avitum Ag Blutbehandlungsvorrichtung mit automatischer Substitutionsvolumenkompensation
WO2021119112A1 (en) * 2019-12-10 2021-06-17 Baxter International Inc. Combined extracorporeal and drug delivery system and method
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ES2942002T3 (es) * 2020-04-09 2023-05-29 Gambro Lundia Ab Aparato para tratamiento sanguíneo extracorporal
ES2987202T3 (es) * 2020-05-29 2024-11-14 Gambro Lundia Ab Aparato para el tratamiento extracorpóreo de sangre
CA3196690A1 (en) 2020-10-26 2022-05-05 Daniel M. Abal Real time detection and monitoring of fluid volume and flow rate
US12246122B2 (en) * 2021-05-07 2025-03-11 Terumo Cardiovascular Systems Corporation Heart-lung machine with semi-autonomous initiation mode

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IT1391086B1 (it) * 2008-07-09 2011-11-18 Gambro Lundia Ab Apparato trattamento extracorporeo sangue

Also Published As

Publication number Publication date
ITMI20110442A1 (it) 2012-09-22
WO2012127298A1 (en) 2012-09-27
AU2012232839A1 (en) 2013-10-31
CA2830039C (en) 2016-02-16
CN103547299A (zh) 2014-01-29
CN103547299B (zh) 2015-08-26
EP2688600A1 (en) 2014-01-29
KR101531457B1 (ko) 2015-06-24
CA2830039A1 (en) 2012-09-27
KR20130135958A (ko) 2013-12-11
EP2688600B1 (en) 2015-07-15
US20140074008A1 (en) 2014-03-13
US9220830B2 (en) 2015-12-29
AU2012232839B2 (en) 2014-12-04

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