ES2551459T3 - Método para producir un parche de ropinirol supersaturado - Google Patents
Método para producir un parche de ropinirol supersaturado Download PDFInfo
- Publication number
- ES2551459T3 ES2551459T3 ES14174708.9T ES14174708T ES2551459T3 ES 2551459 T3 ES2551459 T3 ES 2551459T3 ES 14174708 T ES14174708 T ES 14174708T ES 2551459 T3 ES2551459 T3 ES 2551459T3
- Authority
- ES
- Spain
- Prior art keywords
- adhesive agent
- agent layer
- patch
- ropinirole
- supersaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical class CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000853 adhesive Substances 0.000 abstract 6
- 229960001879 ropinirole Drugs 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Método para producir un parche que comprende una capa de soporte y una capa de agente adhesivo dispuesta sobre al menos una superficie de la capa de soporte, comprendiendo el método: etapa A) obtener una composición de capa de agente adhesivo que comprende ropinirol libre en una cantidad que da como resultado del 5 al 13,2% en masa en relación con la masa total de una capa de agente adhesivo obtenida; etapa B) calentar la composición de capa de agente adhesivo a una temperatura en un intervalo de desde 50 hasta 76ºC durante de 5 minutos a 24 horas; y etapa C) enfriar la composición de capa de agente adhesivo calentada hasta temperatura normal a una velocidad promedio de disminución de temperatura de 1 a 20ºC/hora, obteniendo de ese modo la capa de 1agente adhesivo que comprende el ropinirol libre a una concentración supersaturada en forma disuelta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013137147 | 2013-06-28 | ||
| JP2013137147A JP5415645B1 (ja) | 2013-06-28 | 2013-06-28 | 貼付剤の製造方法、貼付剤及び包装体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2551459T3 true ES2551459T3 (es) | 2015-11-19 |
Family
ID=50202791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14174708.9T Active ES2551459T3 (es) | 2013-06-28 | 2014-06-27 | Método para producir un parche de ropinirol supersaturado |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9320728B2 (es) |
| EP (1) | EP2818161B1 (es) |
| JP (1) | JP5415645B1 (es) |
| KR (1) | KR101516122B1 (es) |
| CN (1) | CN104138366B (es) |
| CA (1) | CA2855309C (es) |
| ES (1) | ES2551459T3 (es) |
| TW (1) | TWI488644B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101937073B1 (ko) | 2015-04-15 | 2019-01-09 | 히사미쓰 세이야꾸 가부시키가이샤 | 로피니롤 함유 첩부제 |
| WO2017006974A1 (ja) * | 2015-07-08 | 2017-01-12 | 王子ホールディングス株式会社 | 経皮吸収型貼付剤 |
| IL260290B2 (en) | 2015-12-30 | 2023-11-01 | Corium Inc | Systems and methods for long-term percutaneous administration |
| US11541018B2 (en) | 2016-06-23 | 2023-01-03 | Corium, Llc | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
| JP7153010B2 (ja) | 2016-07-27 | 2022-10-13 | コリウム， インコーポレイテッド | 塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法 |
| MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
| KR102279552B1 (ko) | 2016-12-28 | 2021-07-19 | 히사미쓰 세이야꾸 가부시키가이샤 | 부토르파놀 함유 첩부제 |
| EP3586841B1 (en) * | 2017-02-24 | 2023-12-27 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product thereof |
| CN110545816B (zh) | 2017-04-25 | 2023-04-11 | 久光制药株式会社 | 贴附剂 |
| CN110573160B (zh) | 2017-04-25 | 2022-11-18 | 久光制药株式会社 | 贴附剂 |
| DE102018120506A1 (de) | 2017-10-20 | 2019-04-25 | Amw Gmbh | Stabilisiertes transdermales Darreichungssystem |
| CA3086163A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| TW201940199A (zh) * | 2018-01-22 | 2019-10-16 | 日商鐘化股份有限公司 | 皮膚貼附用黏著片材 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH066534B2 (ja) | 1986-10-09 | 1994-01-26 | 積水化学工業株式会社 | 経皮吸収貼付剤 |
| US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5308621A (en) | 1991-02-18 | 1994-05-03 | Commonwealth Scientific And Industrial Research Organisation | Ascorbic acid composition and transdermal administration method |
| GB9511366D0 (en) | 1995-06-06 | 1995-08-02 | Smithkline Beecham Plc | Novel formulations |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5807570A (en) | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
| WO1997020550A2 (en) | 1995-12-01 | 1997-06-12 | Alza Corporation | Improved method for preventing crystal formation in a dispersion of a liquid in a matrix |
| JP4205778B2 (ja) | 1998-04-17 | 2009-01-07 | 久光製薬株式会社 | 貼付製剤 |
| US20040142024A1 (en) | 1999-07-27 | 2004-07-22 | Hisamitsu Pharmaceutical Co., Inc. | Patch formulation for external use |
| DK1201232T3 (da) | 1999-07-27 | 2007-08-13 | Hisamitsu Pharmaceutical Co | Plastre til ydre anvendelse |
| DE10060550C1 (de) | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
| EP1366762B1 (en) | 2001-03-07 | 2015-12-30 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch |
| JP4792193B2 (ja) | 2002-08-28 | 2011-10-12 | 久光製薬株式会社 | 貼付剤 |
| JP4354678B2 (ja) | 2002-08-28 | 2009-10-28 | 久光製薬株式会社 | 貼付剤 |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
| US20080038328A1 (en) | 2004-05-28 | 2008-02-14 | Naruhito Higo | Pasting Preparation |
| JP5075334B2 (ja) | 2004-11-22 | 2012-11-21 | 久光製薬株式会社 | 薬物含有貼付剤 |
| GB0524961D0 (en) | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents for systemic effect |
| WO2008044336A1 (en) * | 2006-10-11 | 2008-04-17 | Hisamitsu Pharmaceutical Co., Inc. | Crystal-containing adhesive preparation |
| US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
| ES2648197T3 (es) | 2008-02-27 | 2017-12-29 | Hisamitsu Pharmaceutical Co., Inc. | Parche medicado |
| US9155725B2 (en) | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
| ES2589008T3 (es) | 2009-04-24 | 2016-11-08 | Hisamitsu Pharmaceutical Co., Inc. | Bolsa de envase que contiene parche adhesivo y método para almacenar parche adhesivo |
| KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
| US20130053357A1 (en) | 2010-04-28 | 2013-02-28 | Hisamitsu Pharmaceutical Co., Inc. | Skin irritation suppressant and transdermal preparation |
| US9155710B2 (en) | 2011-05-31 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Ropinirole-containing patch and package thereof |
| CN103561737A (zh) * | 2011-05-31 | 2014-02-05 | 久光制药株式会社 | 含有罗匹尼罗的贴附剂及其包装体 |
| WO2013081102A1 (ja) * | 2011-12-01 | 2013-06-06 | 帝國製薬株式会社 | ロピニロール含有貼付剤 |
| JP5270035B1 (ja) | 2012-12-06 | 2013-08-21 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
| JP5307931B1 (ja) | 2012-12-27 | 2013-10-02 | 久光製薬株式会社 | 貼付剤及びその製造方法 |
-
2013
- 2013-06-28 JP JP2013137147A patent/JP5415645B1/ja active Active
-
2014
- 2014-06-24 TW TW103121756A patent/TWI488644B/zh active
- 2014-06-25 KR KR1020140077844A patent/KR101516122B1/ko active Active
- 2014-06-27 EP EP14174708.9A patent/EP2818161B1/en active Active
- 2014-06-27 CN CN201410300630.0A patent/CN104138366B/zh active Active
- 2014-06-27 ES ES14174708.9T patent/ES2551459T3/es active Active
- 2014-06-27 CA CA2855309A patent/CA2855309C/en active Active
- 2014-06-27 US US14/317,976 patent/US9320728B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2818161A1 (en) | 2014-12-31 |
| CA2855309C (en) | 2015-02-17 |
| TWI488644B (zh) | 2015-06-21 |
| KR20150002491A (ko) | 2015-01-07 |
| JP5415645B1 (ja) | 2014-02-12 |
| CA2855309A1 (en) | 2014-10-16 |
| JP2015010066A (ja) | 2015-01-19 |
| CN104138366A (zh) | 2014-11-12 |
| KR101516122B1 (ko) | 2015-04-29 |
| CN104138366B (zh) | 2016-05-11 |
| TW201446268A (zh) | 2014-12-16 |
| EP2818161B1 (en) | 2015-10-07 |
| US9320728B2 (en) | 2016-04-26 |
| US20150004215A1 (en) | 2015-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2551459T3 (es) | Método para producir un parche de ropinirol supersaturado | |
| CO2019002744A2 (es) | Composiciones solubles en agua que comprenden cannabinoides purificadas | |
| MX2017017172A (es) | Conjugados de ligador-principio activo (adcs) y conjugados de ligador-profarmaco (apdcs) con grupos enzimaticamente escindibles. | |
| AR098191A1 (es) | Aparato para calentar material fumable | |
| AR088558A1 (es) | Sistema que genera aerosol con control mejorado de la produccion de aerosol | |
| BR112017023516A2 (pt) | composição de polímero reforçado com fibra, e, artigo. | |
| BR112018008915A2 (pt) | aparelho ortodôntico com memória de formato contínuo | |
| CL2017001377A1 (es) | Una nueva forma cristalina de un derivado de bencimidazol y un método de preparación de los mismos | |
| ES2722207T3 (es) | Procedimientos para la crioconservación de células epiteliales de pigmento retiniano derivadas de citoblastos crecidas sobre un sustrato polimérico | |
| MX362375B (es) | Extracto de saliva entera de sanguijuela. | |
| AR102563A1 (es) | Composición densificada para el tratamiento de una formación subterránea | |
| AR096502A1 (es) | Proceso para la producción de semilla granulada recubierta | |
| WO2014113779A3 (en) | Molds for shaping glass and methods for making the same | |
| BR112015017500A2 (pt) | dispositivo optoeletrônico e método para produzir o mesmo | |
| BR112017017096A2 (pt) | ?método de fabricar nano bobina de metal? | |
| MX2015012444A (es) | Metodos de diagnostico, seleccion y tratamiento de enfermedades y afecciones provocadas por o asociadas con metanogenos. | |
| AR098704A1 (es) | Producto de confitería congelado con una cubierta de gel fácilmente despegable y un método para la fabricación del mismo | |
| MX2017001645A (es) | Derivados de difosfito de 3-fenil-benzofuran-2-ona- como estabilizantes. | |
| AR106069A1 (es) | Electrodo y proceso para su manufactura | |
| FR2973387B1 (fr) | Composition polyamide de forte conductivite thermique | |
| BR112016014305B8 (pt) | Lenço com gel e método para fabricar um lenço com gel | |
| MX2017010133A (es) | Intercapa de vidrio laminado y vidrio laminado. | |
| MY176809A (en) | High temperature geomembrane liners and master batch compositions | |
| MX389168B (es) | Procedimiento para preparar inhibidores de la glucosilceramida sintasa. | |
| MX2015009390A (es) | Metodo de produccion de composiciones de beta-caseina y productos relacionados. |