ES2560676T3 - Combinación farmacéutica para el tratamiento del dolor - Google Patents
Combinación farmacéutica para el tratamiento del dolor Download PDFInfo
- Publication number
- ES2560676T3 ES2560676T3 ES11730199.4T ES11730199T ES2560676T3 ES 2560676 T3 ES2560676 T3 ES 2560676T3 ES 11730199 T ES11730199 T ES 11730199T ES 2560676 T3 ES2560676 T3 ES 2560676T3
- Authority
- ES
- Spain
- Prior art keywords
- addition salt
- acid addition
- pharmaceutical combination
- pain treatment
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Combinación que comprende como componente(s): a) al menos un 3-(3-dimetilamino-1-etil-2-metilpropil)fenol de fórmula (I), **Fórmula** opcionalmente en forma de uno de sus estereoisómeros, en particular un enantiómero o un diastereoisómero, en forma de racemato o en forma de mezcla de sus estereoisómeros, en particular enantiómeros y/o diastereoisómeros, en cualquier proporción de mezcla, o cualquier sal de adición de ácido correspondiente del mismo, y b) al menos un antagonista de NMDA seleccionado entre el grupo consistente 10 en (R,S)-ketamina o una sal de adición de ácido de la misma como la sal de adición clorhidrato, (S)-ketamina o una sal de adición de ácido de la misma como la sal de adición clorhidrato, y memantina o una sal de adición de ácido de la misma como la sal de adición clorhidrato.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10006202 | 2010-06-15 | ||
| EP10006202 | 2010-06-15 | ||
| PCT/EP2011/002905 WO2011157391A1 (en) | 2010-06-15 | 2011-06-14 | Pharmaceutical combination for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2560676T3 true ES2560676T3 (es) | 2016-02-22 |
Family
ID=42395008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11730199.4T Active ES2560676T3 (es) | 2010-06-15 | 2011-06-14 | Combinación farmacéutica para el tratamiento del dolor |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8846765B2 (es) |
| EP (2) | EP2992877A1 (es) |
| JP (3) | JP6133772B2 (es) |
| KR (1) | KR101831616B1 (es) |
| CN (1) | CN103108631B (es) |
| AR (1) | AR081931A1 (es) |
| AU (2) | AU2011267474B2 (es) |
| BR (1) | BR112012031836A2 (es) |
| CA (1) | CA2796774C (es) |
| CL (1) | CL2012002551A1 (es) |
| CO (1) | CO6602157A2 (es) |
| CY (1) | CY1117118T1 (es) |
| DK (1) | DK2582366T3 (es) |
| EC (2) | ECSP12012217A (es) |
| ES (1) | ES2560676T3 (es) |
| HK (1) | HK1215787A1 (es) |
| HR (1) | HRP20151327T1 (es) |
| HU (1) | HUE026619T2 (es) |
| IL (1) | IL221926A (es) |
| MX (1) | MX2012014482A (es) |
| NZ (1) | NZ602625A (es) |
| PE (2) | PE20160531A1 (es) |
| PL (1) | PL2582366T3 (es) |
| PT (1) | PT2582366E (es) |
| RS (1) | RS54439B1 (es) |
| RU (2) | RU2589692C2 (es) |
| SI (1) | SI2582366T1 (es) |
| WO (1) | WO2011157391A1 (es) |
| ZA (1) | ZA201208646B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2589692C2 (ru) | 2010-06-15 | 2016-07-10 | Грюненталь Гмбх | Фармацевтическая комбинация для лечения от боли |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| WO2013138322A1 (en) * | 2012-03-12 | 2013-09-19 | Janssen Pharmaceutica Nv | Esketamine for the treatment of treatment-refractory or treatment-resistant depression |
| HRP20240812T1 (hr) | 2013-01-22 | 2024-09-27 | Vistagen Therapeutics, Inc. | Oblici doziranja i terapijska primjena l-4-klorokinurenina |
| US20140275278A1 (en) | 2013-03-15 | 2014-09-18 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
| CN103655523A (zh) * | 2013-12-24 | 2014-03-26 | 南京艾德凯腾生物医药有限责任公司 | 他喷他多组合物 |
| WO2015171770A1 (en) * | 2014-05-06 | 2015-11-12 | Northwestern University | Combinations of nmdar modulating compounds |
| EP3179993B1 (en) | 2014-08-13 | 2021-01-20 | Janssen Pharmaceutica NV | Esketamine for use in a method for the treatment of depression |
| CA2961208A1 (en) | 2014-09-15 | 2016-03-24 | Janssen Pharmaceutica Nv | Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression |
| US20160332962A1 (en) | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
| AU2016288188B2 (en) | 2015-06-27 | 2021-08-05 | Shenox Pharmaceuticals, Llc | Ketamine transdermal delivery system |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| CN112105349A (zh) * | 2018-04-12 | 2020-12-18 | 阿纳韦克斯生命科学公司 | A2-73结晶多晶型物质组合物及其使用方法 |
| WO2020178653A1 (en) | 2019-03-05 | 2020-09-10 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3391142A (en) | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| US6248789B1 (en) * | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| US6007841A (en) * | 1998-03-13 | 1999-12-28 | Algos Pharmaceutical Corporation | Analgesic composition and method for treating pain |
| CN1309562A (zh) * | 1998-07-16 | 2001-08-22 | 纪念斯隆-凯特林癌症中心 | 包括一种阿片样物质镇痛剂和一种nmda拮抗剂的局部给药组合物 |
| DE10005302A1 (de) * | 2000-02-07 | 2002-01-17 | Gruenenthal Gmbh | Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate |
| US20010036943A1 (en) | 2000-04-07 | 2001-11-01 | Coe Jotham W. | Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines |
| PE20030527A1 (es) * | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| DE10163421A1 (de) * | 2001-12-21 | 2003-07-31 | Gruenenthal Gmbh | Verwendung von (+)-(1S,2S)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)phenol als Antiemetikum |
| JP2003201254A (ja) * | 2001-12-28 | 2003-07-18 | Hisamitsu Pharmaceut Co Inc | 鎮痛剤活性増強剤の治療上有効な血中濃度を維持するための製剤 |
| JP2003210254A (ja) * | 2002-01-18 | 2003-07-29 | Nihon Form Service Co Ltd | 車椅子専用ラック |
| EP1545461A4 (en) | 2002-09-09 | 2011-06-22 | Endo Pharmaceuticals Inc | COMBINED ANALGESIC COMPOSITION WITH IMMEDIATE AND PROLONGED RELEASE |
| US7273889B2 (en) * | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
| US20090082466A1 (en) * | 2006-01-27 | 2009-03-26 | Najib Babul | Abuse Resistant and Extended Release Formulations and Method of Use Thereof |
| HRP20110271T1 (hr) | 2006-04-28 | 2011-05-31 | Grnenthal Gmbh | Farmaceutska kombinacija koja sadrži 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol i nsaid (nesteroidni antiinflamatorni lijek) |
| CN101431990B (zh) | 2006-04-28 | 2011-08-03 | 格吕伦塔尔有限公司 | 包含3-（3-二甲基氨基-1-乙基-2-甲基-丙基）-酚和对乙酰氨基酚的药物结合 |
| US20070254960A1 (en) | 2006-04-28 | 2007-11-01 | Gruenenthal Gmbh | Pharmaceutical combination |
| EP1857463A1 (en) | 2006-05-03 | 2007-11-21 | Ebewe Pharma Ges.m.b.H. Nfg. KG | Peptide having neuroprotective effects |
| AU2007256352A1 (en) | 2006-06-08 | 2007-12-13 | Ucb Pharma Gmbh | Therapeutic combination for painful medical conditions |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| DE102007012165A1 (de) * | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
| EP2219633A2 (en) * | 2007-11-23 | 2010-08-25 | Nectid, Inc. | Tapentadol compositions |
| US7872046B2 (en) * | 2008-01-25 | 2011-01-18 | Xenoport, Inc. | Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use |
| CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| US20100190752A1 (en) | 2008-09-05 | 2010-07-29 | Gruenenthal Gmbh | Pharmaceutical Combination |
| KR101730924B1 (ko) | 2008-09-05 | 2017-04-27 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| RU2589692C2 (ru) | 2010-06-15 | 2016-07-10 | Грюненталь Гмбх | Фармацевтическая комбинация для лечения от боли |
| CA2810356C (en) | 2010-09-21 | 2016-06-14 | Purdue Pharma L.P. | Buprenorphine analogs |
| EP2826467B1 (en) | 2010-12-22 | 2017-08-02 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
| MX348831B (es) | 2011-03-04 | 2017-06-30 | Gruenenthal Gmbh | Administración parenteral de tapentadol. |
| TWI522101B (zh) | 2012-04-17 | 2016-02-21 | 普渡製藥有限合夥事業 | 處理由類鴉片引起之不利的藥效動力反應之系統和方法 |
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2011
- 2011-06-14 RU RU2013101515/15A patent/RU2589692C2/ru active
- 2011-06-14 HU HUE11730199A patent/HUE026619T2/en unknown
- 2011-06-14 RS RS20150842A patent/RS54439B1/sr unknown
- 2011-06-14 HR HRP20151327TT patent/HRP20151327T1/hr unknown
- 2011-06-14 EP EP15003060.9A patent/EP2992877A1/en not_active Withdrawn
- 2011-06-14 KR KR1020127032555A patent/KR101831616B1/ko not_active Expired - Fee Related
- 2011-06-14 NZ NZ602625A patent/NZ602625A/en not_active IP Right Cessation
- 2011-06-14 PE PE2016000337A patent/PE20160531A1/es unknown
- 2011-06-14 CA CA2796774A patent/CA2796774C/en not_active Expired - Fee Related
- 2011-06-14 MX MX2012014482A patent/MX2012014482A/es active IP Right Grant
- 2011-06-14 SI SI201130695T patent/SI2582366T1/sl unknown
- 2011-06-14 ES ES11730199.4T patent/ES2560676T3/es active Active
- 2011-06-14 WO PCT/EP2011/002905 patent/WO2011157391A1/en not_active Ceased
- 2011-06-14 PL PL11730199T patent/PL2582366T3/pl unknown
- 2011-06-14 PT PT117301994T patent/PT2582366E/pt unknown
- 2011-06-14 CN CN201180029405.2A patent/CN103108631B/zh not_active Expired - Fee Related
- 2011-06-14 AU AU2011267474A patent/AU2011267474B2/en not_active Ceased
- 2011-06-14 EP EP11730199.4A patent/EP2582366B1/en not_active Not-in-force
- 2011-06-14 PE PE2012002241A patent/PE20130243A1/es active IP Right Grant
- 2011-06-14 BR BR112012031836A patent/BR112012031836A2/pt active Search and Examination
- 2011-06-14 US US13/159,845 patent/US8846765B2/en not_active Expired - Fee Related
- 2011-06-14 JP JP2013514579A patent/JP6133772B2/ja not_active Expired - Fee Related
- 2011-06-14 DK DK11730199.4T patent/DK2582366T3/en active
- 2011-06-14 AR ARP110102069A patent/AR081931A1/es not_active Application Discontinuation
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2012
- 2012-09-13 IL IL221926A patent/IL221926A/en active IP Right Grant
- 2012-09-14 CL CL2012002551A patent/CL2012002551A1/es unknown
- 2012-09-14 CO CO12158816A patent/CO6602157A2/es unknown
- 2012-10-03 EC ECSP12012217 patent/ECSP12012217A/es unknown
- 2012-11-16 ZA ZA2012/08646A patent/ZA201208646B/en unknown
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2013
- 2013-10-02 HK HK16103593.7A patent/HK1215787A1/en unknown
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2014
- 2014-06-26 US US14/315,603 patent/US20140309311A1/en not_active Abandoned
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2015
- 2015-07-30 JP JP2015151003A patent/JP6197007B2/ja not_active Expired - Fee Related
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2016
- 2016-01-14 CY CY20161100034T patent/CY1117118T1/el unknown
- 2016-05-17 RU RU2016119041A patent/RU2675261C2/ru active
- 2016-08-25 AU AU2016219643A patent/AU2016219643B2/en not_active Ceased
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2017
- 2017-04-05 JP JP2017075145A patent/JP6423036B2/ja not_active Expired - Fee Related
- 2017-08-10 US US15/674,407 patent/US10813890B2/en not_active Expired - Fee Related
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2019
- 2019-07-02 EC ECSENADI201947259A patent/ECSP19047259A/es unknown
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