ES2563191T3 - Compuestos de triazolona como inhibidores de mPGES-1 - Google Patents

Compuestos de triazolona como inhibidores de mPGES-1 Download PDF

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ES2563191T3
ES2563191T3 ES13745477.3T ES13745477T ES2563191T3 ES 2563191 T3 ES2563191 T3 ES 2563191T3 ES 13745477 T ES13745477 T ES 13745477T ES 2563191 T3 ES2563191 T3 ES 2563191T3
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8alkyl
independently selected
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Laxmikant Atmaram Gharat
Nagarajan Muthukaman
Neelima Khairatkar-Joshi
Vidya Ganapati Kattige
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Ichnos Sciences SA
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Glenmark Pharmaceuticals SA
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    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Un compuesto de formula (II)**Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde, X1, X2,X3 y X4 se seleccionan cada uno independientemente de CH y N; cada ocurrencia de L se selecciona independientemente de -CH2NHC(O)-y -CH2NHS(O)2-; cada ocurrencia de P se selecciona independientemente de -CH2NHC(O)-y -CH2NHS(O)2-; cada ocurrencia de Q se selecciona independientemente de C1-8alquilo, haloC1-8alquilo, C1-8alcoxiC1-8alquilo, hidroxiC1--8alquilo, carboxiloC1-8alquilo, C3-12cicloalquilo, C6-14arilo, heterociclilo de 3-15 miembros, y heteroarilo de 5-14 miembros; cada ocurrencia de W se selecciona independientemente de isopropilo, tert-butilo, trifluorometilo, 1-fluoro-2- metilpropan-2-ilo, 1-Hidroxi-2-metilpropan-2-il y ciclopropil; cada ocurrencia de R1 se selecciona independientemente de halógeno ciano, C1-8alquilo, C1-8alcoxi, haloC1- 8alcoxiC1-8alquilo, haloC1-8alquilo, C3-6cicloalquilo, heterocicliloC1-8alquilo de 5 miembros, heteroarilo de 5 miembros, heteroariloC1-8alquilo de 5 miembros, y -C≡CR; cada ocurrencia de R2 se selecciona independientemente de halógeno ciano, C1-8alquilo, C1-8alcoxi, haloC1-8alquilo, C3-6cicloalquilo, heteroarilo de 5 miembros, -C(O)NHR, -NHC(O)R,-S(O)2NHR y -C≡CR; cada ocurrencia de R se selecciona independientemente de C1-8alquilo, C3-12cicloalquilo, y C6-14arilo; "m" es un entero que varía de 0 a 3, ambos inclusive; "n" es un entero que varía de 0 a 3, ambos inclusive; "s" es un entero que varía de 0 a 1, ambos inclusive; y "t" es un entero que varía de 0 a 1, ambos inclusive; con la condición de que (i) "s" y "t" no son "0" simultáneamente, y (ii) "m" y "n" no son "0" simultáneamente.
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KR102403306B1 (ko) 2013-01-15 2022-06-02 인사이트 홀딩스 코포레이션 Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물

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