ES2570855T3 - Péptidos de unión al calcio - Google Patents

Péptidos de unión al calcio

Info

Publication number
ES2570855T3
ES2570855T3 ES12170747T ES12170747T ES2570855T3 ES 2570855 T3 ES2570855 T3 ES 2570855T3 ES 12170747 T ES12170747 T ES 12170747T ES 12170747 T ES12170747 T ES 12170747T ES 2570855 T3 ES2570855 T3 ES 2570855T3
Authority
ES
Spain
Prior art keywords
peptide
binding peptides
calcium binding
amino acids
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12170747T
Other languages
English (en)
Inventor
Daniel Yarbrough
Wenyuan Shi
Elizabeth Hagerman
Sotirios Tetradis
Fengxia Qi
Jian He
Bruce Rutherford
Randal Eckert
Ben Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California, San Diego
Original Assignee
University of California Berkeley
University of California, San Diego
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California, San Diego filed Critical University of California Berkeley
Application granted granted Critical
Publication of ES2570855T3 publication Critical patent/ES2570855T3/es
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Un péptido de unión al calcio que comprende una secuencia de repetición de tres aminoácidos que tiene la fórmula (X-Y-Z)n, en donde: X es un aminoácido seleccionado del grupo que consiste en ácido aspártico, ácido glutámico, asparagina y glutamina; Y y Z son aminoácidos seleccionados entre alanina, serina, y treonina; n es un número de 3 a 15; dicho péptido tiene una longitud de hasta 100 aminoácidos; dicho péptido no es fosforilado; y dicho péptido se une al fosfato de calcio.
ES12170747T 2005-09-28 2006-09-27 Péptidos de unión al calcio Active ES2570855T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72207105P 2005-09-28 2005-09-28

Publications (1)

Publication Number Publication Date
ES2570855T3 true ES2570855T3 (es) 2016-05-20

Family

ID=37900466

Family Applications (3)

Application Number Title Priority Date Filing Date
ES12170736.8T Active ES2574810T3 (es) 2005-09-28 2006-09-27 Péptidos de unión a calcio
ES12170747T Active ES2570855T3 (es) 2005-09-28 2006-09-27 Péptidos de unión al calcio
ES06804228.2T Active ES2549857T3 (es) 2005-09-28 2006-09-27 Péptidos de unión a calcio

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES12170736.8T Active ES2574810T3 (es) 2005-09-28 2006-09-27 Péptidos de unión a calcio

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES06804228.2T Active ES2549857T3 (es) 2005-09-28 2006-09-27 Péptidos de unión a calcio

Country Status (9)

Country Link
US (1) US20090098050A1 (es)
EP (3) EP1957094B1 (es)
JP (3) JP5322646B2 (es)
CN (2) CN101272801B (es)
AU (1) AU2006294578B2 (es)
CA (1) CA2622915A1 (es)
ES (3) ES2574810T3 (es)
IL (1) IL190180A (es)
WO (1) WO2007038683A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807141B2 (en) 2003-09-08 2010-10-05 E.I. Du Pont De Nemours And Company Peptide-based oral care surface reagents for personal care
AU2006294578B2 (en) * 2005-09-28 2013-02-07 The Regents Of The University Of California Calcium binding peptides
US8647119B1 (en) 2006-04-18 2014-02-11 President And Fellows Of Harvard College Methods and kits with fluorescent probes for caries detection
CA2661634C (en) 2006-09-06 2017-03-28 The Regents Of The University Of California Selectively targeted antimicrobial peptides and the use thereof
GB0625678D0 (en) * 2006-12-21 2007-01-31 Lux Biotechnology Ltd Composition and method for detection of demineralisation
CN101622271B (zh) * 2007-01-16 2014-08-27 加利福尼亚大学董事会 抗微生物肽
CN102438580B (zh) * 2009-02-06 2015-06-17 加利福尼亚大学董事会 钙结合剂诱导毛发生长和/或甲生长
WO2010114638A1 (en) * 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Peptide-based tooth whitening reagents
PL2547311T3 (pl) * 2010-03-19 2020-11-16 Incisive Technologies Pty Ltd Zestaw i sposób do wykrywania porowatego hydroksyapatytu zębowego
US20110294151A1 (en) * 2010-05-27 2011-12-01 Hongwei Hanna Rao Fluorescently Labeled Calcium Phosphate Surfaces
US20110294142A1 (en) * 2010-05-27 2011-12-01 Joydeep Lahiri Multiply Fluorescently Labeled Calcium Phosphate-Protein Surfaces
US9221888B2 (en) * 2012-11-13 2015-12-29 University of Pittsburgh—of the Commonwealth System of Higher Education Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides
GB2510587B (en) * 2013-02-07 2020-05-20 Orthopaedic Res Uk Biospecific agents for bone
WO2014164684A1 (en) * 2013-03-11 2014-10-09 The Board Of Trustees Of The University Of Illinois Protein delivery systems
US20140314691A1 (en) * 2013-03-14 2014-10-23 C3 Jian, Inc. Compositions for improving the appearance and/or health of teeth
US9469677B2 (en) 2013-11-13 2016-10-18 University of Pittsburgh—of the Commonwealth System of Higher Education Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition
GB201700317D0 (en) 2017-01-09 2017-02-22 Calcivis Ltd Detection device
CN109111506A (zh) * 2018-01-17 2019-01-01 上海长征医院 一种用于治疗骨质疏松的多肽及其制备方法和应用
CA3115298A1 (en) 2018-10-12 2020-04-16 Theradaptive, Inc. Polypeptides including a beta-tricalcium phosphate-binding sequence and uses thereof
EP3718529A1 (en) * 2019-04-02 2020-10-07 Koninklijke Philips N.V. Kit for tooth remineralising and dentine hypersensitivity treatment
KR102437393B1 (ko) * 2020-04-29 2022-08-30 주식회사 대호 가축용 성장촉진제의 제조방법
USD1042180S1 (en) 2020-05-28 2024-09-17 Calcivis Limited Dental detection device
CN112006918B (zh) * 2020-09-16 2022-03-22 四川大学 复合材料及其制备方法和应用
CN112457371B (zh) * 2020-11-29 2021-12-10 北京泽勤生物医药有限公司 一种促骨形成多肽及其应用
CN112694520B (zh) * 2020-12-02 2023-01-17 图凌(杭州)生物医药有限公司 一种人工多肽hm、其抗体及在病理检测中的应用
CN114133441B (zh) * 2021-11-15 2024-02-06 同济大学 一种促进牙本质矿化的活性短肽及其应用
CN115043908B (zh) * 2022-06-10 2023-10-13 浙江大学 一种羟基磷灰石靶向肽及用途
KR102821945B1 (ko) * 2022-12-02 2025-06-17 성균관대학교산학협력단 광화학적 전환 가능한 펩티드-소분자 복합체
WO2026131642A1 (en) 2024-12-17 2026-06-25 Leibniz-Institut Für Pflanzenbiochemie (Ipb), Stiftung Des Öffentlichen Rechts Mineral-binding peptides for direct, high-affinity protein immobilization, purification and targeting

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312442B1 (en) 1992-06-02 2001-11-06 General Surgical Innovations, Inc. Method for developing an anatomic space for laparoscopic hernia repair
JP3560252B2 (ja) * 1992-08-28 2004-09-02 アベンティス ファーマ株式会社 骨関連カドヘリン様タンパク質およびその製造法
US5658739A (en) * 1994-05-10 1997-08-19 The Regents Of The University Of California Method for characterization of the fine structure of protein binding sites
US6042848A (en) * 1996-08-15 2000-03-28 The Board Of Trustees Of Southern Illinois University Enhancement of antimicrobial peptide activity by metal ions
AUPO566297A0 (en) 1997-03-13 1997-04-10 University Of Melbourne, The Calcium phosphopeptide complexes
US6673900B2 (en) * 1999-11-04 2004-01-06 University College London Polypeptide hormone-phosphatonin
GB0001711D0 (en) * 2000-01-25 2000-03-15 Btg Int Ltd Data compression having improved compression speed
AU2001274374A1 (en) * 2000-06-20 2002-01-02 Biora Ab Matrix protein compositions for dentin regeneration
US20030104979A1 (en) * 2000-11-13 2003-06-05 Zhong-Min Wei Methods of inhibiting desiccation of cuttings removed from ornamental plants
JP2003111870A (ja) * 2001-10-03 2003-04-15 Sumitomo Rubber Ind Ltd マルチピースゴルフボール
JP3646167B2 (ja) * 2002-02-19 2005-05-11 独立行政法人産業技術総合研究所 フォスフォフォリンを含む複合生体材料
AU2003221582A1 (en) * 2002-05-03 2003-11-17 Millenium Biologix Inc. Connective tissue stimulating peptides
US20040136926A1 (en) * 2002-11-08 2004-07-15 Periathamby Antony Raj Intra-oral drug delivery system
US20070087959A1 (en) * 2003-08-19 2007-04-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of inducing biomineralization method of inducing bone regeneration and methods related thereof
KR101013999B1 (ko) * 2004-03-19 2011-02-14 재단법인서울대학교산학협력재단 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
US8071131B2 (en) * 2004-07-15 2011-12-06 Ivoclar Vivadent, Inc. Mineralizing composite materials for restoring teeth
AU2006294578B2 (en) * 2005-09-28 2013-02-07 The Regents Of The University Of California Calcium binding peptides

Also Published As

Publication number Publication date
EP1957094B1 (en) 2015-09-16
CN103819538A (zh) 2014-05-28
CA2622915A1 (en) 2007-04-05
JP2013032363A (ja) 2013-02-14
IL190180A (en) 2015-07-30
JP5322646B2 (ja) 2013-10-23
CN101272801B (zh) 2014-01-22
ES2574810T3 (es) 2016-06-22
JP5768025B2 (ja) 2015-08-26
CN101272801A (zh) 2008-09-24
US20090098050A1 (en) 2009-04-16
EP2510935A1 (en) 2012-10-17
AU2006294578B2 (en) 2013-02-07
WO2007038683A3 (en) 2007-05-24
EP2510935B1 (en) 2016-03-23
EP2510936B1 (en) 2016-04-13
AU2006294578A1 (en) 2007-04-05
WO2007038683A2 (en) 2007-04-05
EP2510936A1 (en) 2012-10-17
JP2009510089A (ja) 2009-03-12
ES2549857T3 (es) 2015-11-02
JP2015147779A (ja) 2015-08-20
EP1957094A4 (en) 2010-03-10
IL190180A0 (en) 2008-11-03
EP1957094A2 (en) 2008-08-20

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