ATE497975T1 - Il-21-varianten - Google Patents
Il-21-variantenInfo
- Publication number
- ATE497975T1 ATE497975T1 AT06763042T AT06763042T ATE497975T1 AT E497975 T1 ATE497975 T1 AT E497975T1 AT 06763042 T AT06763042 T AT 06763042T AT 06763042 T AT06763042 T AT 06763042T AT E497975 T1 ATE497975 T1 AT E497975T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acids
- variants
- deleting
- seq
- peptide
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500562 | 2005-04-18 | ||
| PCT/EP2006/061635 WO2006111524A2 (en) | 2005-04-18 | 2006-04-18 | Il-21 variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE497975T1 true ATE497975T1 (de) | 2011-02-15 |
Family
ID=36950214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06763042T ATE497975T1 (de) | 2005-04-18 | 2006-04-18 | Il-21-varianten |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8034326B2 (de) |
| EP (2) | EP2360181B1 (de) |
| JP (2) | JP2008538290A (de) |
| KR (1) | KR20080013878A (de) |
| CN (1) | CN101180315A (de) |
| AT (1) | ATE497975T1 (de) |
| AU (1) | AU2006237329B2 (de) |
| BR (1) | BRPI0609079A2 (de) |
| CA (1) | CA2604222A1 (de) |
| DE (1) | DE602006020032D1 (de) |
| ES (1) | ES2357550T3 (de) |
| IL (1) | IL186265A0 (de) |
| MX (1) | MX2007012887A (de) |
| NO (1) | NO20075927L (de) |
| RU (1) | RU2412199C2 (de) |
| WO (1) | WO2006111524A2 (de) |
| ZA (1) | ZA200708407B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
| AU2006237329B2 (en) | 2005-04-18 | 2012-04-12 | Novo Nordisk A/S | IL-21 variants |
| AU2007310777A1 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | IL-21 variants |
| EP2109620B1 (de) | 2006-12-21 | 2012-08-22 | Novo Nordisk A/S | Interleukin-21-varianten mit geänderter bindung an den il-21-rezeptor |
| US20100111851A1 (en) * | 2007-01-05 | 2010-05-06 | The University Of Tokyo | Diagnosis and treatment of cancer by using anti-prg-3 antibody |
| AR065803A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Uso de un polipeptido de il- 18 humana y un anticuerpo anti- cd para preparar unmedicamento |
| KR100902340B1 (ko) * | 2007-08-02 | 2009-06-12 | 한국생명공학연구원 | Ｙｃ－１ 또는 ｉｌ－２１을 유효성분으로 포함하는자연살해세포 분화제 및 분화 방법 |
| JP2012514586A (ja) * | 2009-01-05 | 2012-06-28 | フラウンホーファーゲゼルシャフト ツール フォルデルング デル アンゲヴァンテン フォルシユング エー．フアー． | Ｉｌ−２１およびｉｌ−２１変異体に基づく抗体欠乏性疾患を治療するための手段および方法 |
| CA2824515C (en) | 2011-01-18 | 2022-09-13 | Bioniz, Llc | Compositions and methods for modulating gamma-c-cytokine activity |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| EP3978512A1 (de) | 2015-10-09 | 2022-04-06 | Bioniz, LLC | Modulation der gamma-c-zytokin-aktivität |
| US11291721B2 (en) * | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| KR102707650B1 (ko) | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| CN118126157A (zh) | 2017-08-03 | 2024-06-04 | 美国安进公司 | 白介素-21突变蛋白和治疗方法 |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| MX2020007291A (es) | 2018-01-12 | 2020-09-10 | Amgen Inc | Anticuerpos anti-pd-1 y metodos de tratamiento. |
| EP3765517A1 (de) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | An calreticulin bindende multifunktionsmoleküle und ihre verwendungen |
| WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN111205361B (zh) | 2018-11-22 | 2022-05-06 | 海珂分子（北京）科技有限责任公司 | 白介素21蛋白(il21)突变体及其应用 |
| JP7579795B2 (ja) | 2019-02-21 | 2024-11-08 | マレンゴ・セラピューティクス，インコーポレーテッド | ＮＫｐ３０に結合する抗体分子およびその使用 |
| AU2020226893B2 (en) | 2019-02-21 | 2025-02-27 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| BR112021021878A2 (pt) | 2019-05-03 | 2022-01-18 | Bioniz Llc | Modulação dos efeitos de sinalização da gama-c-citocina para tratamento da alopecia e distúrbios associados |
| WO2021138474A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| KR20230112632A (ko) | 2020-10-23 | 2023-07-27 | 애셔 바이오테라퓨틱스, 인크. | 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합 |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| CN115232797A (zh) * | 2021-04-23 | 2022-10-25 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
| WO2022245500A1 (en) | 2021-05-19 | 2022-11-24 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| KR20230044130A (ko) | 2021-09-24 | 2023-04-03 | 바이오엔시스템스 주식회사 | Pd-1 및 il-21을 포함하는 융합단백질 이량체 및 이의 용도 |
| KR102796245B1 (ko) * | 2022-05-10 | 2025-04-18 | 아주대학교산학협력단 | 인터루킨21 변이체, 이를 포함하는 융합단백질 및 이의 용도 |
| WO2024002170A1 (en) * | 2022-06-29 | 2024-01-04 | Beijing Neox Biotech Limited | Il-21 polypeptides and methods of use |
| CN117210411A (zh) * | 2023-09-13 | 2023-12-12 | 中国科学院生物物理研究所 | 一种免疫细胞及其表达载体、应用和制备方法 |
| WO2025109155A1 (en) * | 2023-11-24 | 2025-05-30 | Prokarium Limited | Interleukin variant |
| WO2025191136A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof |
| WO2025191139A1 (en) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Conjugates of her2-specific antigen binding proteins and cytokines |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| CN118546233B (zh) * | 2024-07-30 | 2024-10-18 | 成都微芯新域生物技术有限公司 | 白介素-21突变体及其应用 |
| WO2026087748A1 (en) | 2024-10-24 | 2026-04-30 | Avidicure Ip B.V. | Multispecific antigen binding proteins for the expansion of γδ t cells and use thereof |
| WO2026087747A1 (en) | 2024-10-24 | 2026-04-30 | Avidicure Ip B.V. | Multispecific antigen binding proteins for tumor-targeting of γδ1 t cells and use thereof |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203570A (en) | 1978-08-23 | 1980-05-20 | The Western States Machine Company | Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| JPS60501140A (ja) | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
| NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| JP2523562B2 (ja) | 1985-10-25 | 1996-08-14 | ザイモジェネティックス インコーポレーテッド | 外来タンパク質を分泌することを目的としたｂａｒ１の使用法 |
| AU607690B2 (en) | 1985-12-24 | 1991-03-14 | Marion Laboratories, Inc. | Use of synthetic sulfated saccharides to enhance wound healing |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| US5024947A (en) | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
| DE3856247T2 (de) | 1987-07-24 | 1999-04-29 | Chiron Corp., Emeryville, Calif. | Züchtung von insektenzellen mit airlift-reaktoren |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| AU4647889A (en) | 1988-11-18 | 1990-06-12 | Cetus Corporation | Insect signal peptide mediated secretion of recombinant proteins |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| GB8910962D0 (en) | 1989-05-12 | 1989-06-28 | Natural Environment Res | Novel baculovirus expression vectors and use thereof in the expression of foreign proteins in insects or insect cells |
| US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
| US5077214A (en) | 1989-07-07 | 1991-12-31 | The Texas A&M University System | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells |
| US5155037A (en) | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
| US5023328A (en) | 1989-08-04 | 1991-06-11 | The Texas A&M University System | Lepidopteran AKH signal sequence |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| US5494662A (en) | 1992-04-27 | 1996-02-27 | Ono Pharmaceutical Co., Ltd. | Stimulator for bone formation |
| US5643756A (en) | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| MY124565A (en) * | 1996-07-19 | 2006-06-30 | Bayer Corp | High-affinity interleukin-4-muteins |
| DE69921102T2 (de) | 1998-03-05 | 2006-02-02 | Chiron Corp., Emeryville | Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US20010023070A1 (en) | 1998-05-29 | 2001-09-20 | Reinhard Ebner | Interleukins-21 and 22 |
| JP2002516103A (ja) | 1998-05-29 | 2002-06-04 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | インターロイキン２１およびインターロイキン２２ |
| PT1974747E (pt) | 1998-08-11 | 2012-09-05 | Biogen Idec Inc | Terapias de combinação para linfomas de células b compreendendo a administração de anticorpo anti-cd20 |
| US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| UA84387C2 (ru) | 1999-03-09 | 2008-10-27 | Займодженетикс, Инк. | Человеческий цитокин как лиганд зальфа рецептора и его применение |
| US6926898B2 (en) | 2000-04-12 | 2005-08-09 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP3254687A1 (de) | 2001-10-04 | 2017-12-13 | Genetics Institute LLC | Verfahren und zusammensetzungen zur modulation der interleukin-21-rezeptoraktivität |
| EP2130919A1 (de) | 2001-11-05 | 2009-12-09 | ZymoGenetics, Inc. | IL-21-Antagonisten |
| OA13063A (en) | 2001-11-20 | 2006-11-10 | Pharmacia Corp | Chemically-modified human growth hormone conjugates. |
| CA2481304A1 (en) | 2002-03-27 | 2003-10-09 | Patrick Hwu | Method for treating cancer in humans |
| AU2003230834A1 (en) | 2002-04-09 | 2003-10-27 | Beth Israel Deaconess Medical Center, Inc. | Antagonists of il-21 and modulation of il-21-mediated t cell responses |
| MXPA04012116A (es) | 2002-06-07 | 2005-04-19 | Zymogenetics Inc | Uso del il-21 en cancer y otras aplicaciones terapeuticas. |
| AU2003282955A1 (en) | 2002-10-17 | 2004-05-04 | Alkermes Controlled Therapeutics, Inc. Ii | Microencapsulation and sustained release of biologically active polypeptides |
| MXPA05006117A (es) | 2002-12-13 | 2005-09-30 | Zymogenetics Inc | Produccion de il-21 en hospederos procarioticos. |
| TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
| RU2005132458A (ru) * | 2003-03-21 | 2006-03-20 | Уайт (Us) | Лечение иммунологических расстройств с использованием агонистов интерлейкина-21/рецептора интерлейкина-21 |
| PL1625156T3 (pl) | 2003-05-12 | 2013-03-29 | Affymax Inc | Peptydy wiążące się do receptora erytropoetyny |
| CA2529520A1 (en) | 2003-06-19 | 2004-12-29 | Centocor, Inc. | Interleukin-21 analogs |
| US7276478B2 (en) * | 2003-09-25 | 2007-10-02 | Zymogenetics, Inc. | Methods of treating autoimmune diseases using IL-21 |
| DE602004029173D1 (de) | 2003-10-10 | 2010-10-28 | Novo Nordisk As | Il-21-derivate |
| EP1692276B1 (de) | 2003-11-19 | 2010-07-21 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Verfahren zur induktion der entwicklung und terminalen differenzierung von gedächtnis-b-zellen |
| EP1753458A4 (de) | 2004-05-19 | 2009-07-22 | Wyeth Corp | Modulation der immunglobulinproduktion und atopische erkrankungen |
| MX2007001509A (es) | 2004-08-05 | 2007-03-27 | Wyeth Corp | Antagonismo de la actividad del receptor de interleuquina 21. |
| AU2006237329B2 (en) * | 2005-04-18 | 2012-04-12 | Novo Nordisk A/S | IL-21 variants |
| EP2109620B1 (de) | 2006-12-21 | 2012-08-22 | Novo Nordisk A/S | Interleukin-21-varianten mit geänderter bindung an den il-21-rezeptor |
-
2006
- 2006-04-18 AU AU2006237329A patent/AU2006237329B2/en not_active Expired - Fee Related
- 2006-04-18 CA CA002604222A patent/CA2604222A1/en not_active Abandoned
- 2006-04-18 RU RU2007136026/04A patent/RU2412199C2/ru not_active IP Right Cessation
- 2006-04-18 DE DE602006020032T patent/DE602006020032D1/de not_active Expired - Lifetime
- 2006-04-18 JP JP2008507065A patent/JP2008538290A/ja not_active Ceased
- 2006-04-18 BR BRPI0609079-6A patent/BRPI0609079A2/pt not_active Application Discontinuation
- 2006-04-18 US US11/911,815 patent/US8034326B2/en active Active
- 2006-04-18 WO PCT/EP2006/061635 patent/WO2006111524A2/en not_active Ceased
- 2006-04-18 EP EP10195721.5A patent/EP2360181B1/de not_active Expired - Lifetime
- 2006-04-18 ES ES06763042T patent/ES2357550T3/es not_active Expired - Lifetime
- 2006-04-18 EP EP06763042A patent/EP1877439B1/de not_active Expired - Lifetime
- 2006-04-18 KR KR1020077025354A patent/KR20080013878A/ko not_active Ceased
- 2006-04-18 MX MX2007012887A patent/MX2007012887A/es active IP Right Grant
- 2006-04-18 CN CNA2006800172976A patent/CN101180315A/zh active Pending
- 2006-04-18 AT AT06763042T patent/ATE497975T1/de active
-
2007
- 2007-09-25 IL IL186265A patent/IL186265A0/en unknown
- 2007-10-02 ZA ZA200708407A patent/ZA200708407B/xx unknown
- 2007-11-19 NO NO20075927A patent/NO20075927L/no not_active Application Discontinuation
-
2011
- 2011-09-19 US US13/236,163 patent/US8383367B2/en not_active Expired - Lifetime
- 2011-11-08 JP JP2011244452A patent/JP2012070742A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2360181B1 (de) | 2013-09-18 |
| WO2006111524A2 (en) | 2006-10-26 |
| EP1877439B1 (de) | 2011-02-09 |
| US20120082996A1 (en) | 2012-04-05 |
| WO2006111524A3 (en) | 2006-12-07 |
| NO20075927L (no) | 2007-12-07 |
| JP2008538290A (ja) | 2008-10-23 |
| US20090035254A1 (en) | 2009-02-05 |
| EP1877439A2 (de) | 2008-01-16 |
| ES2357550T3 (es) | 2011-04-27 |
| MX2007012887A (es) | 2007-12-10 |
| AU2006237329B2 (en) | 2012-04-12 |
| RU2412199C2 (ru) | 2011-02-20 |
| KR20080013878A (ko) | 2008-02-13 |
| JP2012070742A (ja) | 2012-04-12 |
| RU2007136026A (ru) | 2009-05-27 |
| CN101180315A (zh) | 2008-05-14 |
| IL186265A0 (en) | 2008-01-20 |
| BRPI0609079A2 (pt) | 2010-11-16 |
| ZA200708407B (en) | 2008-10-29 |
| US8034326B2 (en) | 2011-10-11 |
| CA2604222A1 (en) | 2006-10-26 |
| EP2360181A1 (de) | 2011-08-24 |
| DE602006020032D1 (de) | 2011-03-24 |
| AU2006237329A1 (en) | 2006-10-26 |
| US8383367B2 (en) | 2013-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20075927L (no) | IL-21 varianter | |
| DK1476541T3 (da) | Cytokin (zcytor17-ligand) | |
| ATE462003T1 (de) | Aus wt1 stammende krebsantigenpeptide | |
| ES2530670T3 (es) | Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo | |
| DE602005008996D1 (de) | Radiofluorierte peptide | |
| NZ596658A (en) | Dig-10 insecticidal cry toxins | |
| EP2865387A3 (de) | Priming einer Immunantwort | |
| NZ595303A (en) | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides | |
| DE602007004110D1 (de) | Hausstaubmilbenallergen | |
| DE60322613D1 (de) | Frostschutzproteine aus Basidiomyceten | |
| ECSP066495A (es) | Composiciones y metodos para inhibir la infección por virus de síndrome de punto blanco (wssv) | |
| DK2076532T3 (da) | Cytokinderivater | |
| ITMI20030789A1 (it) | Valvola di iniezione di comustibile. | |
| BRPI0413437A (pt) | preparação de peptìdeos de somatostatina | |
| JP2005535281A5 (de) | ||
| DE602007006493D1 (de) | Peptide mit proliferationshemmender wirkung | |
| EP1497307A4 (de) | Impfstoff mit rekombinantem p.falciparum-merozoitprotein-1 42 | |
| EP1567542A4 (de) | Neue, mit inhibin verwandte multiantigenepeptidzusammensetzungen, die die produktionsleistung von vögeln erhöhen | |
| DE60229966D1 (de) | Diabetesmodell | |
| GB0409559D0 (en) | Polypeptide | |
| DE602006017806D1 (de) | Behandlung von neurodegeneration | |
| ATE441865T1 (de) | Neue polypeptide zur in-vintro-isolierung und vorbeugung von infektionen mit legionella pneumophila | |
| DK1794294T3 (da) | Rekombinant carboxypeptidase B | |
| FR2874025B1 (fr) | Nouvelles proteines permettant, notamment, la mise en evidence in vitro et la prevention des infections a legionella pneumophila | |
| PT1537210E (pt) | Inibicao de oliconucleotidos decoy de expressao cd-40 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1877439 Country of ref document: EP |