ES2571127T3 - Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos - Google Patents

Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos

Info

Publication number
ES2571127T3
ES2571127T3 ES11788227T ES11788227T ES2571127T3 ES 2571127 T3 ES2571127 T3 ES 2571127T3 ES 11788227 T ES11788227 T ES 11788227T ES 11788227 T ES11788227 T ES 11788227T ES 2571127 T3 ES2571127 T3 ES 2571127T3
Authority
ES
Spain
Prior art keywords
particles
target molecules
separation
samples containing
fibrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11788227T
Other languages
English (en)
Inventor
Amar Rida
Nicolas Mermod
Patrice Francois
Vladimir Lazarevic
Jacques Schrenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm International SA
Original Assignee
Debiopharm International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm International SA filed Critical Debiopharm International SA
Application granted granted Critical
Publication of ES2571127T3 publication Critical patent/ES2571127T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Método para el procesamiento de una muestra líquida que comprende fibrinógeno, para la separación y concentración de moléculas o partículas objetivo de la muestra, que comprende: a. Atrapar dichas moléculas o partículas objetivo en una red de fibrina sometiendo la muestra a trombina o enzimas de tipo trombina para convertir, como mínimo, parcialmente el fibrinógeno contenido en la dicha muestra en fibrina para formar la red de fibrina b. Retraer dicha red de fibrina para formar un coágulo de fibrina c. Separar de dicho coágulo de fibrina del medio de muestra circundante.
ES11788227T 2010-09-15 2011-09-15 Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos Active ES2571127T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH14782010 2010-09-15
CH20412010 2010-12-07
CH12072011 2011-07-20
PCT/IB2011/054035 WO2012035508A2 (en) 2010-09-15 2011-09-15 Method for separating target molecules or particles from fibrinogen-containing samples including blood components

Publications (1)

Publication Number Publication Date
ES2571127T3 true ES2571127T3 (es) 2016-05-24

Family

ID=45044632

Family Applications (2)

Application Number Title Priority Date Filing Date
ES16154770T Active ES2751660T3 (es) 2010-09-15 2011-09-15 Dispositivo que incluye componentes sanguíneos para separar moléculas o partículas diana de muestras
ES11788227T Active ES2571127T3 (es) 2010-09-15 2011-09-15 Método para la separación de moléculas o partículas objetivo a partir de muestras que contienen fibrinógeno, incluyendo componentes sanguíneos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES16154770T Active ES2751660T3 (es) 2010-09-15 2011-09-15 Dispositivo que incluye componentes sanguíneos para separar moléculas o partículas diana de muestras

Country Status (17)

Country Link
US (4) US9689881B2 (es)
EP (2) EP2616550B1 (es)
JP (1) JP5999776B2 (es)
KR (1) KR101948944B1 (es)
CN (2) CN103108959B (es)
AU (2) AU2011303467C1 (es)
CA (1) CA2811493C (es)
CY (1) CY1122166T1 (es)
DK (2) DK3067431T3 (es)
ES (2) ES2751660T3 (es)
HR (1) HRP20191785T1 (es)
HU (2) HUE045771T2 (es)
LT (1) LT3067431T (es)
PL (2) PL3067431T3 (es)
PT (1) PT3067431T (es)
SI (1) SI3067431T1 (es)
WO (1) WO2012035508A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2811493C (en) 2010-09-15 2020-06-16 Debiopharm International Sa Method for separating target molecules or particles from fibrinogen-containing samples including blood components
WO2013003356A1 (en) 2011-06-27 2013-01-03 Emory University Compositions, uses, and preparation of platelet lysates
WO2014160796A1 (en) * 2013-03-29 2014-10-02 Siemens Healthcare Diagnostics Inc. Rare cell concentration
HRP20191225T1 (hr) 2014-06-01 2019-10-18 Debiopharm International Sa Uređaj za prikupljanje uzoraka i preradu
EP3383547A4 (en) 2015-11-30 2019-08-07 DH Technologies Development PTE. Ltd. ELECTROMAGNETIC MODULES FOR PROCESSING FLUIDS
US10596236B2 (en) 2016-03-10 2020-03-24 Arthrex, Inc. Systems and methods for preparing a thrombin serum
AU2017230810B2 (en) 2016-03-10 2022-03-10 Arthrex, Inc. Systems and methods for preparing protein enhanced serums
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
JP7298449B2 (ja) * 2019-11-14 2023-06-27 株式会社島津製作所 血液凝固分析装置、及び分注ノズルの洗浄方法

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FR2625321B1 (fr) * 1987-12-24 1992-10-02 Pasteur Institut Reactif pour le diagnostic de staphylococcus aureus par agglutination
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CA2176810A1 (en) 1993-12-03 1995-06-08 Gordon L. Dorn Method for improving quantitative recovery of microorganisms from speci mens containing blood components
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JP2000262499A (ja) * 2000-01-01 2000-09-26 Terumo Corp 採血管
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CA2484554C (en) * 2002-05-01 2012-12-04 Synapse B.V. Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media
ATE335816T1 (de) 2002-09-18 2006-09-15 Sirs Lab Gmbh Verfahren zum nachweis prokaryontischer dna
PT2103694E (pt) * 2003-08-15 2011-07-26 Univ South Florida Materiais e métodos para a captura de patogénios e a remoção de ácido aurintricarboxílico de uma amostra
US20050065454A1 (en) * 2003-09-22 2005-03-24 Becton, Dickinson And Company Non-evacuated blood collection tube
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JP2009502166A (ja) * 2005-07-29 2009-01-29 エコール ポリテクニーク フェデラル ドゥ ローザンヌ 分子改変体フィブリノゲン融合タンパク質
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Also Published As

Publication number Publication date
AU2016266066B2 (en) 2017-12-21
HUE028915T2 (en) 2017-01-30
EP3067431A1 (en) 2016-09-14
CN107389932B (zh) 2019-11-22
WO2012035508A3 (en) 2012-05-18
US20240280593A1 (en) 2024-08-22
US20170336424A1 (en) 2017-11-23
CY1122166T1 (el) 2020-11-25
AU2016266066A1 (en) 2016-12-22
ES2751660T3 (es) 2020-04-01
DK2616550T3 (en) 2016-05-23
HRP20191785T1 (hr) 2019-12-27
CA2811493A1 (en) 2012-03-22
CN103108959A (zh) 2013-05-15
JP5999776B2 (ja) 2016-09-28
EP2616550B1 (en) 2016-02-10
KR20130107300A (ko) 2013-10-01
LT3067431T (lt) 2019-11-11
US9689881B2 (en) 2017-06-27
WO2012035508A4 (en) 2012-07-19
AU2011303467A1 (en) 2013-04-04
PT3067431T (pt) 2019-10-29
PL2616550T3 (pl) 2016-08-31
US20210148940A1 (en) 2021-05-20
JP2013538355A (ja) 2013-10-10
DK3067431T3 (da) 2019-10-14
KR101948944B1 (ko) 2019-02-15
AU2011303467B2 (en) 2016-09-15
WO2012035508A2 (en) 2012-03-22
HUE045771T2 (hu) 2020-01-28
EP3067431B1 (en) 2019-07-24
CN103108959B (zh) 2017-06-09
CN107389932A (zh) 2017-11-24
US20130164737A1 (en) 2013-06-27
PL3067431T3 (pl) 2019-12-31
EP2616550A2 (en) 2013-07-24
HK1247280A1 (zh) 2018-09-21
CA2811493C (en) 2020-06-16
AU2011303467C1 (en) 2017-03-09
SI3067431T1 (sl) 2019-11-29

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