ES2571207T3 - Antibiótico aminoglucósido novedoso, método para producir el mismo, y uso farmacéutico del mismo - Google Patents

Antibiótico aminoglucósido novedoso, método para producir el mismo, y uso farmacéutico del mismo

Info

Publication number
ES2571207T3
ES2571207T3 ES08854513T ES08854513T ES2571207T3 ES 2571207 T3 ES2571207 T3 ES 2571207T3 ES 08854513 T ES08854513 T ES 08854513T ES 08854513 T ES08854513 T ES 08854513T ES 2571207 T3 ES2571207 T3 ES 2571207T3
Authority
ES
Spain
Prior art keywords
produce
same
pharmaceutical use
aminoglycoside antibiotic
novel aminoglycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08854513T
Other languages
English (en)
Inventor
Naomi Sumida
Koji Yanai
Masato Tani
Takayoshi Fukushima
Yasumasa Ota
Shuichi Gomi
Akitaka Nakane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Pharma Co Ltd
Original Assignee
Meiji Seika Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Pharma Co Ltd filed Critical Meiji Seika Pharma Co Ltd
Application granted granted Critical
Publication of ES2571207T3 publication Critical patent/ES2571207T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un compuesto representado por la fórmula (I) o su sal farmacológicamente aceptable:**Fórmula** en donde R representa amino o hidroxilo.
ES08854513T 2007-11-30 2008-12-01 Antibiótico aminoglucósido novedoso, método para producir el mismo, y uso farmacéutico del mismo Active ES2571207T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007310618 2007-11-30
PCT/JP2008/071795 WO2009069800A1 (ja) 2007-11-30 2008-12-01 新規アミノグリコシド抗生物質、その製造方法およびその医薬用途

Publications (1)

Publication Number Publication Date
ES2571207T3 true ES2571207T3 (es) 2016-05-24

Family

ID=40678687

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08854513T Active ES2571207T3 (es) 2007-11-30 2008-12-01 Antibiótico aminoglucósido novedoso, método para producir el mismo, y uso farmacéutico del mismo

Country Status (7)

Country Link
US (2) US9469863B2 (es)
EP (1) EP2226388B1 (es)
JP (2) JP5350269B2 (es)
KR (1) KR101688235B1 (es)
CN (1) CN101918577B (es)
ES (1) ES2571207T3 (es)
WO (1) WO2009069800A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019001717A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
JP2019001718A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
US12110310B2 (en) 2020-01-23 2024-10-08 Utah State University Amphiphilic kanamycin compositions and methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3669838A (en) 1970-03-17 1972-06-13 Univ Illinois Method of making antibiotics containing the aminocyclitol subunit
JPH0771493B2 (ja) 1988-10-26 1995-08-02 国税庁長官 遺伝子破壊または遺伝子置換のプラスミドベクター、形質転換体及びその利用
JP2003061671A (ja) 2001-08-24 2003-03-04 Inst Of Physical & Chemical Res テストステロン代謝系に関与する酵素の遺伝子破壊株
JP2004173537A (ja) 2002-11-25 2004-06-24 Meiji Seika Kaisha Ltd カナマイシン生合成遺伝子
JP2006296419A (ja) 2005-03-04 2006-11-02 Hiroshima Univ 遺伝子破壊による抗生物質産生微生物の生産方法およびこれを用いて得られる抗生物質産生微生物、並びに抗生物質代謝中間体の生産方法
CN101074249A (zh) * 2006-05-19 2007-11-21 黄振华 新的氨基糖苷类抗生素衍生物

Also Published As

Publication number Publication date
US9469863B2 (en) 2016-10-18
KR101688235B1 (ko) 2016-12-20
WO2009069800A1 (ja) 2009-06-04
EP2226388B1 (en) 2016-02-17
JP2013188213A (ja) 2013-09-26
KR20100102130A (ko) 2010-09-20
JP6033732B2 (ja) 2016-11-30
JP5350269B2 (ja) 2013-11-27
JPWO2009069800A1 (ja) 2011-04-21
US20110034405A1 (en) 2011-02-10
CN101918577A (zh) 2010-12-15
EP2226388A1 (en) 2010-09-08
CN101918577B (zh) 2014-03-26
EP2226388A4 (en) 2013-11-20
US20160367585A1 (en) 2016-12-22

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