ES2571383T3 - Péptidos novedosos moduladores de la proteína TRF2 y composiciones que comprenden estos - Google Patents
Péptidos novedosos moduladores de la proteína TRF2 y composiciones que comprenden estosInfo
- Publication number
- ES2571383T3 ES2571383T3 ES12725474T ES12725474T ES2571383T3 ES 2571383 T3 ES2571383 T3 ES 2571383T3 ES 12725474 T ES12725474 T ES 12725474T ES 12725474 T ES12725474 T ES 12725474T ES 2571383 T3 ES2571383 T3 ES 2571383T3
- Authority
- ES
- Spain
- Prior art keywords
- lys
- gln
- amino acid
- trp
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000007316 Telomeric Repeat Binding Protein 2 Human genes 0.000 title 1
- 108010033710 Telomeric Repeat Binding Protein 2 Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 5
- 229940024606 amino acid Drugs 0.000 abstract 5
- 150000001413 amino acids Chemical class 0.000 abstract 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 3
- 239000004473 Threonine Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229960001230 asparagine Drugs 0.000 abstract 3
- 235000009582 asparagine Nutrition 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003141 primary amines Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuesto peptídico de la fórmula general (I) siguiente: R1-(AA)n-X1-X2-X3-Lys-Lys-Gln-Lys-Trp-X4-(AA)p-R2 en la cual, X1 representa una asparagina, une glicina, una treonina, una alanina o ningún aminoácido, X2 representa una isoleucina, una leucina, una metionina, una prolina o ningún aminoácido, X3 representa una treonina, una asparagina, una serina o ningún aminoácido, X4 representa una serina, una cisteína, una treonina, una asparagina, una glutamina o ningún aminoácido, AA representa un aminoácido cualquiera, y n y p son números enteros comprendidos entre 0 y 2, R1 representa la función amina primaria del aminoácido N-terminal, -NH2, en la cual uno de los dos átomos de hidrógeno puede estar sustituido o no sustituido, bien por una cadena alquilo de C1 a C30 saturada o insaturada de tipo acetilo o por un grupo aromático de tipo benzoílo, tosilo o benciloxicarbonilo, R2 representa el grupo hidroxilo de la función carboxilo del aminoácido C-terminal, -OH, en el que el átomo de hidrógeno puede estar sustituido o no sustituido, bien por una cadena alquilo de C1 a C30 o por un grupo NH2, NHY o NYY en el que Y representa una cadena alquilo de C1 a C4, estando constituida dicha secuencia de fórmula general (I) por 5 a 13 residuos de aminoácidos, caracterizado por que se corresponde con una de las fórmulas siguientes: (SEQ ID n°1) Asn-Thr-Lys-Lys-Gln-Lys-Trp-Thr-Asn-NH2; (SEQ ID n°2) Lys-Lys-Gln-Lys-Trp-NH2; (SEQ ID n°3) Gly-Gly-Leu-Lys-Lys-Gln-Lys-Trp-Asn-Leu-Tyr; (SEQ ID n°4) Ala-Met-Lys-Lys-Gln-Lys-Trp-NH2; (SEQ ID n°5) Ala-Leu-Ser-Lys-Lys-Gln-Lys-Trp-Gln; (SEQ ID n°6) Cys-Lys-Lys-Gln-Lys-Trp-Ser-NH2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1101348A FR2974805B1 (fr) | 2011-05-02 | 2011-05-02 | Nouveaux peptides modulateurs de la proteine trf-2 et compositions les comprenant |
| PCT/FR2012/000166 WO2012153015A1 (fr) | 2011-05-02 | 2012-04-27 | Nouveaux peptides modulateurs de la proteine trf2 et compositions les comprenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2571383T3 true ES2571383T3 (es) | 2016-05-25 |
Family
ID=46208093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12725474T Active ES2571383T3 (es) | 2011-05-02 | 2012-04-27 | Péptidos novedosos moduladores de la proteína TRF2 y composiciones que comprenden estos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8809279B2 (es) |
| EP (1) | EP2705050B1 (es) |
| JP (1) | JP6065236B2 (es) |
| CN (1) | CN103562219B (es) |
| ES (1) | ES2571383T3 (es) |
| FR (1) | FR2974805B1 (es) |
| WO (1) | WO2012153015A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11497708B2 (en) * | 2016-06-16 | 2022-11-15 | BEMY Cosmetics, Inc. | Customized cosmetic compositions, and methods of rejuvenating and utilizing conditioned media and/or components thereof |
| CN110604823B (zh) * | 2019-10-21 | 2020-10-20 | 兰州大学 | 一种快速筛选抗糖化和/或抗衰老物质的方法 |
| CN114478695B (zh) * | 2021-11-25 | 2024-01-23 | 暨南大学 | 一类促进组织修复的新多肽及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297356B1 (en) * | 1995-08-25 | 2001-10-02 | The Rockfeller University | Telomere repeat binding factors and diagnostic and therapeutic use thereof |
| US5917019A (en) | 1997-02-13 | 1999-06-29 | The Rockefeller University | Altered telomere repeat binding factor 2 |
| CA2391814A1 (en) * | 1999-12-16 | 2001-06-21 | Ribotargets Limited | Assays |
| US20040242461A1 (en) | 2003-04-08 | 2004-12-02 | Schneider Michael D. | Modulators of telomere stability |
| JP2005229957A (ja) * | 2004-02-23 | 2005-09-02 | Japan Science & Technology Agency | テロメアタンパク質ｔｒｆ２ｄｎａ結合ドメイン変異体タンパク質、テロメアｄｎａ変異体及びｔｒｆ２ｄｎａ結合ドメインと二重らせんｄｎａとの複合体構造の利用 |
| CA2597270A1 (en) * | 2005-02-09 | 2006-08-17 | Nsure Holding B.V. | Methods and means for determining and conferring stress tolerance in plants |
-
2011
- 2011-05-02 FR FR1101348A patent/FR2974805B1/fr not_active Expired - Fee Related
-
2012
- 2012-04-27 ES ES12725474T patent/ES2571383T3/es active Active
- 2012-04-27 JP JP2014508851A patent/JP6065236B2/ja not_active Expired - Fee Related
- 2012-04-27 WO PCT/FR2012/000166 patent/WO2012153015A1/fr not_active Ceased
- 2012-04-27 US US14/114,965 patent/US8809279B2/en active Active
- 2012-04-27 EP EP12725474.6A patent/EP2705050B1/fr active Active
- 2012-04-27 CN CN201280026902.1A patent/CN103562219B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012153015A1 (fr) | 2012-11-15 |
| HK1191957A1 (zh) | 2014-08-08 |
| EP2705050B1 (fr) | 2016-02-24 |
| US20140066381A1 (en) | 2014-03-06 |
| FR2974805B1 (fr) | 2013-05-10 |
| FR2974805A1 (fr) | 2012-11-09 |
| EP2705050A1 (fr) | 2014-03-12 |
| US8809279B2 (en) | 2014-08-19 |
| JP6065236B2 (ja) | 2017-01-25 |
| JP2014514342A (ja) | 2014-06-19 |
| CN103562219B (zh) | 2016-03-23 |
| CN103562219A (zh) | 2014-02-05 |
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