ES2600359T3 - Hilo quirúrgico que comprende células y método de fabricación del hilo - Google Patents
Hilo quirúrgico que comprende células y método de fabricación del hilo Download PDFInfo
- Publication number
- ES2600359T3 ES2600359T3 ES10728212.1T ES10728212T ES2600359T3 ES 2600359 T3 ES2600359 T3 ES 2600359T3 ES 10728212 T ES10728212 T ES 10728212T ES 2600359 T3 ES2600359 T3 ES 2600359T3
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- thread
- cells
- surgical
- cell retention
- manufacturing
- Prior art date
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Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000014759 maintenance of location Effects 0.000 abstract description 6
- 210000004027 cell Anatomy 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 230000031852 maintenance of location in cell Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000006444 vascular growth Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000006727 cell loss Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00889—Material properties antimicrobial, disinfectant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06004—Means for attaching suture to needle
- A61B2017/06028—Means for attaching suture to needle by means of a cylindrical longitudinal blind bore machined at the suture-receiving end of the needle, e.g. opposite to needle tip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
- A61B2017/06176—Sutures with protrusions, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Hilo quirúrgico (100) que comprende una estructura de retención celular (110) y células (120), donde la estructura de retención celular (110) comprende elementos de retención celular (115) que sobresalen de la superficie del hilo (100), caracterizado por el hecho de que el hilo (100) está colonizado sólo parcialmente por las células (120), y las células (120) están fijadas entre los elementos de retención celular (115) y áreas de superficie del hilo bajo los elementos de retención celular (115).
Description
debajo de los elementos de retención celular.
[0080] Respecto a los detalles y ventajas adicionales, en particular respecto al hilo y a las células, se hace referencia en su totalidad a la descripción precedente.
[0081] También se describe un método para la reparación de tejidos, en particular para el cierre de bordes de heridas, que comprende el paso de insertar un hilo según la invención en un tejido que ha de ser reparado, en particular en los bordes de herida que ha de ser cerrada.
[0082] Más específicamente, el hilo puede ser insertado, ventajosamente por medios endoscópicos, en un órgano, por ejemplo para favorecer la regeneración de un tejido. Para este propósito, el hilo preferiblemente comprende células diseñadas para segregar factores de crecimiento tales como factores de crecimiento vascular con el objetivo de favorecer el crecimiento vascular local en una área que necesita suministro de sangre, tal como un corazón isquémico o un área recién trasplantada.
[0083] En otra forma de realización, el hilo se puede insertar en el tejido para inhibir la proliferación celular, por ejemplo para tratamientos cancerosos. Con este fin, el hilo preferiblemente comprende células madre que están diseñadas para llevar una sustancia citotóxica.
[0084] El hilo se puede insertar mediante un instrumento quirúrgico adecuado tal como una aguja o cánula quirúrgica.
[0085] Además, se describe un método para rellenar un área del cuerpo, como por ejemplo arrugas, pliegues, el área malar, la nariz, la barbilla, el área mamaria y similares, que comprende el paso de la colocación de un hilo según la presente invención en un área del cuerpo que ha de ser rellenada.
[0086] El hilo se puede colocar en el área del cuerpo deseada de forma mínimamente invasiva.
[0087] En una forma de realización ventajosa, se puede inducir a las células, mediante la administración de agentes útiles, particularmente factores, para que expresen características deseadas, por ejemplo, para segregar sustancias terapéuticas y/o, cuando las células estén presentes como células madre, para favorecer su diferenciación a un tipo de célula deseada. Como alternativa o en combinación, el hilo ya puede estar acabado con agentes y factores útiles, respectivamente.
[0088] Respecto a las otras características y ventajas, en particular respecto al hilo, se hace referencia en su totalidad a la descripción precedente.
[0089] Otras características y ventajas de la invención se harán aparentes a partir de la descripción siguiente de formas de realización preferidas y en referencia a los ejemplos y descripciones de las figuras conjuntamente con las características de las reivindicaciones dependientes y la figura.
[0090] La figura muestra esquemáticamente: Figura 1: una forma de realización del hilo según la invención.
Descripción de la figura
[0091] La Figura 1 muestra esquemáticamente una forma de realización alternativa de un hilo 100 según la presente invención. El hilo 100 comprende una estructura de retención celular 110 que tiene elementos de retención celular 115 en forma de protuberancias, preferiblemente en forma de púas. Las células 120 están fijadas entre las protuberancias 115 y áreas de superficie 108 del hilo bajo las protuberancias
115. De este modo, el riesgo de una pérdida celular, en particular por arancamiento de las células 120 durante la inserción del hilo 100, se puede minimizar eficazmente.
[0092] El hilo 100, como se representa en la figura 1, es útil especialmente como producto de relleno quirúrgico, en particular para rellenar áreas pequeñas del cuerpo. De este modo, el hilo 100 se puede aplicar, por ejemplo, al campo de la cirugía plástica y/o reconstructiva, particularmente para tratar arrugas y pliegues con el objetivo de minimizar su apariencia.
8
Claims (1)
-
imagen1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22114009P | 2009-06-29 | 2009-06-29 | |
| US221140P | 2009-06-29 | ||
| WOPCT/EP2009/007950 | 2009-11-06 | ||
| WOPCT/EP2009/007948 | 2009-11-06 | ||
| PCT/EP2009/007950 WO2010052007A2 (en) | 2008-11-06 | 2009-11-06 | Surgical suture material with barbs cut into it in the undrawn state |
| PCT/EP2009/007948 WO2010052005A1 (en) | 2008-11-06 | 2009-11-06 | Surgical thread with sheath-core construction |
| PCT/EP2010/059091 WO2011000788A1 (en) | 2009-06-29 | 2010-06-25 | Surgical thread comprising cells and method of manufacturing the thread |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2600359T3 true ES2600359T3 (es) | 2017-02-08 |
Family
ID=42537628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10728212.1T Active ES2600359T3 (es) | 2009-06-29 | 2010-06-25 | Hilo quirúrgico que comprende células y método de fabricación del hilo |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9017378B2 (es) |
| EP (2) | EP3085313B1 (es) |
| BR (1) | BRPI1016020B8 (es) |
| ES (1) | ES2600359T3 (es) |
| PL (1) | PL2448498T3 (es) |
| WO (1) | WO2011000788A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101256908B1 (ko) | 2011-04-28 | 2013-04-23 | (주)에이치비메디컬스 | 주름제거용 충전체 |
| US20140178343A1 (en) * | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| US9986999B2 (en) | 2013-08-29 | 2018-06-05 | Teleflex Medical Incorporated | High-strength multi-component suture |
| IL243461A0 (en) * | 2016-01-05 | 2016-02-29 | Amir Avraham | Skin-augmenting surgical sutures |
| KR101742658B1 (ko) * | 2016-02-24 | 2017-06-01 | 조승현 | 의료용 봉합사 및 이의 제조 장치 및 제조 방법 |
| US12383246B2 (en) | 2020-10-12 | 2025-08-12 | Abbott Cardiovascular Systems, Inc. | Vessel closure device with improved safety and tract hemostasis |
| FR3119634B1 (fr) | 2021-02-09 | 2023-04-28 | Ferco | Dispositif de roulement pour ouvrant coulissant de porte ou fenêtre |
| KR102491158B1 (ko) * | 2022-12-06 | 2023-01-20 | (주)시지바이오 | 지그재그 형태로 굴곡진 의료용 리프팅 실 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| US6976223B1 (en) | 1999-10-04 | 2005-12-13 | Xerox Corporation | Method and system to establish dedicated interfaces for the manipulation of segmented images |
| US7194388B2 (en) | 2002-03-25 | 2007-03-20 | Alcoa Inc. | Method for determining a die profile for forming a metal part having a desired shape and associated methods |
| US8100940B2 (en) | 2002-09-30 | 2012-01-24 | Quill Medical, Inc. | Barb configurations for barbed sutures |
| AU2004296810B2 (en) * | 2003-12-04 | 2009-11-19 | Ethicon, Inc. | Active suture for the delivery of therapeutic fluids |
| EP1997456B1 (en) * | 2004-02-13 | 2011-12-07 | Innovational Holdings, LLC | Drug coating device and method for wire filaments |
| ES2264862B8 (es) | 2004-08-25 | 2017-01-20 | Cellerix, S.L. | Biomaterial para sutura. |
| US8663277B2 (en) | 2005-06-29 | 2014-03-04 | Ethicon, Inc. | Braided barbed suture |
| KR100724706B1 (ko) * | 2006-03-29 | 2007-06-07 | 한스바이오메드 주식회사 | 미세기공을 갖는 수술용 실 |
| US20080046094A1 (en) | 2006-06-27 | 2008-02-21 | Kwang Hee Han | Linear tension material for plastic surgery |
| US20080221618A1 (en) | 2007-03-09 | 2008-09-11 | Gaoyuan Chen | Co-extruded tissue grasping monofilament |
| US20080255612A1 (en) * | 2007-04-13 | 2008-10-16 | Angiotech Pharmaceuticals, Inc. | Self-retaining systems for surgical procedures |
| WO2009105663A2 (en) | 2008-02-21 | 2009-08-27 | Angiotech Pharmaceuticals, Inc. | Method and apparatus for elevating retainers on self-retaining sutures |
| AU2009240477A1 (en) | 2008-04-24 | 2009-10-29 | Ethicon Llc | Shape-memory self-retaining sutures, methods of manufacture, and methods of use |
-
2010
- 2010-06-25 WO PCT/EP2010/059091 patent/WO2011000788A1/en not_active Ceased
- 2010-06-25 US US13/378,170 patent/US9017378B2/en active Active
- 2010-06-25 BR BRPI1016020A patent/BRPI1016020B8/pt not_active IP Right Cessation
- 2010-06-25 PL PL10728212T patent/PL2448498T3/pl unknown
- 2010-06-25 EP EP16168219.0A patent/EP3085313B1/en not_active Not-in-force
- 2010-06-25 EP EP10728212.1A patent/EP2448498B1/en active Active
- 2010-06-25 ES ES10728212.1T patent/ES2600359T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2448498A1 (en) | 2012-05-09 |
| WO2011000788A1 (en) | 2011-01-06 |
| BRPI1016020A2 (pt) | 2017-07-18 |
| EP2448498B1 (en) | 2016-08-10 |
| PL2448498T3 (pl) | 2017-08-31 |
| US20120232588A1 (en) | 2012-09-13 |
| BRPI1016020B1 (pt) | 2020-09-29 |
| EP3085313B1 (en) | 2021-11-17 |
| BRPI1016020B8 (pt) | 2022-05-10 |
| US9017378B2 (en) | 2015-04-28 |
| EP3085313A1 (en) | 2016-10-26 |
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