ES2602971T3 - Composición de anticuerpo modificado - Google Patents

Composición de anticuerpo modificado Download PDF

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Publication number
ES2602971T3
ES2602971T3 ES11750612.1T ES11750612T ES2602971T3 ES 2602971 T3 ES2602971 T3 ES 2602971T3 ES 11750612 T ES11750612 T ES 11750612T ES 2602971 T3 ES2602971 T3 ES 2602971T3
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Prior art keywords
amino acid
ser
asn
thr
sequence
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ES11750612.1T
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English (en)
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Rinpei Niwa
Mami Tsuchiya
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Kyowa Kirin Co Ltd
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Kyowa Hakko Kirin Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Image Processing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Composición de variante de anticuerpo y fragmento de la composición de variante de anticuerpo, que comprende los residuos de aminoácidos de una secuencia Asn-X-Ser/Thr (X representa un residuo de aminoácido diferente de Pro) en una región Fc de un anticuerpo IgG humano, realizándose en dicha secuencia Asn-X-Ser/Thr por lo menos una sustitución de aminoácido seleccionada de entre una sustitución de aminoácido de Asn por otro residuo de aminoácido, una sustitución de aminoácido de X por Pro y una sustitución de aminoácido de Ser/Thr por otro residuo de aminoácido, en la/el que la secuencia Asn-X-Ser/Thr (X es un residuo de aminoácido diferente de Pro) son los residuos de aminoácidos en las posiciones 392 a 394 según el índice EU, y en la/el que la región Fc de un anticuerpo IgG humano comprende la secuencia de aminoácidos de SEC ID nº 1.

Description

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Claims (1)

  1. imagen1
ES11750612.1T 2010-03-02 2011-02-28 Composición de anticuerpo modificado Active ES2602971T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30963110P 2010-03-02 2010-03-02
US309631P 2010-03-02
PCT/JP2011/054549 WO2011108502A1 (ja) 2010-03-02 2011-02-28 改変抗体組成物

Publications (1)

Publication Number Publication Date
ES2602971T3 true ES2602971T3 (es) 2017-02-23

Family

ID=44542154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11750612.1T Active ES2602971T3 (es) 2010-03-02 2011-02-28 Composición de anticuerpo modificado

Country Status (9)

Country Link
US (2) US9556279B2 (es)
EP (1) EP2543727B1 (es)
JP (1) JP5820800B2 (es)
KR (1) KR101913440B1 (es)
CN (1) CN102782131B (es)
AU (1) AU2011222012C1 (es)
CA (1) CA2791652C (es)
ES (1) ES2602971T3 (es)
WO (1) WO2011108502A1 (es)

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Also Published As

Publication number Publication date
EP2543727A1 (en) 2013-01-09
JP5820800B2 (ja) 2015-11-24
AU2011222012A1 (en) 2012-09-27
US9556279B2 (en) 2017-01-31
CA2791652C (en) 2018-06-12
US10040861B2 (en) 2018-08-07
JPWO2011108502A1 (ja) 2013-06-27
CA2791652A1 (en) 2011-09-09
AU2011222012B2 (en) 2014-07-17
KR20130002987A (ko) 2013-01-08
EP2543727A4 (en) 2013-11-20
US20120010387A1 (en) 2012-01-12
CN102782131B (zh) 2015-08-05
AU2011222012C1 (en) 2015-02-26
WO2011108502A1 (ja) 2011-09-09
EP2543727B1 (en) 2016-08-31
KR101913440B1 (ko) 2018-10-30
CN102782131A (zh) 2012-11-14
US20170166650A1 (en) 2017-06-15

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