ES2616341T3 - Péptidos de proteínas reguladoras o accesorias de VIH, composiciones y la utilización de las mismas - Google Patents
Péptidos de proteínas reguladoras o accesorias de VIH, composiciones y la utilización de las mismas Download PDFInfo
- Publication number
- ES2616341T3 ES2616341T3 ES07705325.4T ES07705325T ES2616341T3 ES 2616341 T3 ES2616341 T3 ES 2616341T3 ES 07705325 T ES07705325 T ES 07705325T ES 2616341 T3 ES2616341 T3 ES 2616341T3
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- 9hiv1
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- hiv
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16071—Demonstrated in vivo effect
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un polipéptido que consiste de 30 a 45 aminoácidos, dicho polipéptido comprende la SEQ ID NO: 1 o una secuencia que tiene al menos un 85% de homología con la SEQ ID NO: 1: SEQ ID NO: 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR donde, el polipéptido es inmunogénico a una cepa de VIH en un vertebrado que expresa un alelo de complejo de histocompatibilidad principal (MHC).
Description
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|59710530|gb|AAW88744.1|, |59710534|gb|AAW88746.1|, |57545352|gb|AAW51579.1|, |62548201|gb|AAX86752.1|, |62548181|gb|AAX86734.1|, |62548191|gb|AAX86743.1|, |77167709|gb|ABA62814.1|, |62548171|gb|AAX86725.1|, |62548161|gb|AAX86716.1|, |77168274|gb|ABA63096.1|, |77167799|gb|ABA62859.1|, |77167803|gb|ABA62861.1|, |77167729|gb|ABA62824.1|, |7416646|dbj|BAA93963.1|, |7416648|dbj|BAA93964.1|, |30027257|gb|AAP06260.1|, |7416678|dbj|BAA93979.1|, |7416676|dbj|BAA93978.1|, |7416682|dbj|BAA93981.1|, |7416680|dbj|BAA93980.1|, |1160087|emb|CAA92897.1|, |77167865|gb|ABA62892.1|, |1185542|gb|AAA87875.1|, |1477844|gb|AAB05505.1|, |77167493|gb|ABA62706.1|, |3327542|gb|AAC41064.1|, |327524|gb|AAC41056.1|, |17046525|gb|AAL34565.1|, |17902151|gb|AAL47814.1|, |17864054|gb|AAL47047.1|, |2570332|gb|AAC32659.1|, |38491483|gb|AAR21895.1|, |62361772|gb|AAX81420.1|, |52421750|gb|AAU45386.1|, |57545374|gb|AAW51590.1|, |74315742|gb|ABA02468.1|, |62467702|gb|AAX83957.1|, |17902129|gb|AAL47796.1|, |17902107|gb|AAL47778.1|, |17902118|gb|AAL47787.1|, |17864034|gb|AAL47029.1|, |17902140|gb|AAL47805.1|, |17902096|gb|AAL47769.1|, |3403229|gb|AAC29062.1|, |31980439|dbj|BAC77758.1|, |31980429|dbj|BAC77749.1|, |4262340|gb|AADI4576.1|, |7321147|emb|CAB82229.1|, |74315752|gb|ABA02477.1|, |60218867|gb|AAX14845.1|, |74315782|gb|ABA02504,1|, |74315735|gb|ABA02462.1|, |17864044|gb|AAL47038.1|, |62467712|gb|AAX83966.1|, |25166949|gb|AAN73726.1|AF48, |22596351|gb|AAN03130.1|AF45, |15281443|gb|AAK94231.1|AF36, |39777387|gb|AAR30968,1|, |39777377|gb|AAR30959.1|, |82284358|sp|Q69GS5|Q69GS5_9, |61102671|gb|AAX37799.1|, |3808282|gb|AAC69308.1|, |22596547|gb|AAN03304.1|AF45, |25166869|gb|AAN73654.|AF48, |39777437|gb|AAR31013.1|, |33331478|gb|AAQ10922.1|, |33331458|gb|AAQ10904.1|, |33331468|gb|AAQ10913.1|, |61102686|gb|AAX37812.1|, |37682444|gb|AAQ98140.1|, |25166647|gb|AAN73455.1|AF48, |22596517|gb|AAN03277.1|AF45, |22596537|gb|AAN03295.1|AF45, |29409329|gb|AAM67405.1|, |71794578|emb|CAI28820.1|, |29409317|gb|AAM67395.1|, |29409298|gb|AAM67378.1|, |71794607|emb|CAI28847.1|, |71794598|emb|CAI28838.1|, |29409310|gb|AAM67389.1|, |71794588|emb|CAI28829.1|, |25166889|gb|AAN73672.1|AP48, |22596507|gb|AAN03268.1|AF45, |14530266|gb|AAK65996.1|AF31, |22596235|gb|AAN03027.1|AF45, |5668926|gb|AAD46078.1|AF076, |62467719|gb|AAX83972.1|, |5733956|gb|AAD49793.1|AF107, |5059053|gb|AAD38892.1|AF119, |3947929|gb|AAC82619.1|, |5059044|gb|AAD38884.1|AF119, |1732488|gb|AAB38835.1|, |6690777|gb|AAF24336.1|AF197, |37683030|gb|AAQ98587.1|, |37683020|gb|AAQ98578.1|, |25166739|gb|AAN73537.1|AF48, |77167783|gb|ABA62851.1|, |49472943|gb|AAT66286.1|, |77167541|gb|ABA62730.1|, |77167311|gb|ABA62615.1|, |1185516|gb|AAA87862.1|, |2801507|gb|AAC82595.1|, |62291052|sp|P69729|VPR_HV1P, |62291051|sp|P69728|VPR_HV11, |62291050|sp|P69727|VPR_HV1H, |62291049|sp|P69726|VPR_HV1H, |62291048|sp|P69725|VPR-HVIB, |328557|gb|AAB59869.1|, |326390|gb|AAA44203.1|, |328455|gb|AAA44998.1|, |139383|sp|P05927|VPR_HV1B5, |327463|gb|AAA44655.1|, |32261273|gb|AAP74173.1|, |37677817|gb|AAQ97491.1|, |37677807|gb|AAQ97482.1|, |32261269|gb|AAP74170.1|, |5001959|gb|AAD37230.1|, |5001949|gb|AAD37225.1|, |5001939|gb|AAD37220.1|, |5001929|gb|AAD37215.1|, |5001919|gb|AAD37210.1|, |77167845|gb|ABA62882.1|, |77167653|gb|ABA62786.1|, |59710511|gb|AAW88735.1|, |77167355|gb|ABA62637.1|, |77167757|gb|ABA62838.1|, |3378125|gb|AAC28448.1|, |77167605|gb|ABA62762.1|, |57901082|gb|AAW57849.1|, |77168137|gb|ABA63028.1|, |57869582|gb|AAW57631.1|, |74273414|gb|ABA01401.1|, |74273394|gb|ABA01383.1|, |74273404|gb|ABA01392.1|, |77167851|gb|ABA62885.1|, |77167751|gb|ABA62835.1|, |4324913|gb|AAD17177.1|, |4324907|gb|AAD17171.1|, |4324919|gb|AAD17183.1|, |17046685|gb|AAL34709.1|, |22596412|gb|AAN03184.1|AF45, |25166909|gb|AAN73690.1|AF48, |25166999|gb|AAN73771.1|AF48, |38491939|gb|AAR22302.1|, |11177449|gb|AAG32286.1|, |11177445|gb|AAG32284.1|, |11177440|gb|AAG32282.1|, |11177438|gb|AAG32281.1|, |11177436|gblAAG32280,1|, |11177434|gb|AAG32279.1|, |11177432|gb|AAG32278.1|, |11177430|gb|AAG32277.1|, |11177443|gb|AAG32283.1|, |1177447|gb|AAG32285.1|, |11177428|gb|AAG32276.1|, |11177451|gb|AAG32287.1|, |77168346|gb|ABA63132.1|, |22596225|gb|AAN03018.1|AF45, |77167597|gb|ABA62758.1|, |2393861|gb|AAB70158.1|, |2393855|gb|AAB70155.1|, |40021886|gb|AAR37196.1|, |40021716|gb|AAR37077.1|, |40021876|gb|AAR37189.1|, |40021866|gb|AAR37182.1|, |40021856|gb|AAR37175.1|, |40021836|gb|AAR37161.1|, |40021826|gb|AAR37154.1|, |40021806|gb|AAR37140.1|, |40021796|gb|AAR37133.1|, |40021776|gb|AAR37119.1|, |40021766|gb|AAR37112.1|, |40021736|gb|AAR37091.1|, |40021726|gb|AAR37084.1|, |40021706|gb|AAR37070.1|, |40021846|gb|AAR37168.1|, |40021746|gb|AAR37098.1|, |40021696|gb|AAR37063.1|, |40021756|gb|AAR37105.1|, |40021816|gb|AAR37147.1|, |40021786|gb|AAR37126.1|, |26518640|gb|AAN83914.1|, |77168358|gb|ABA63138.1|, |77167889|gb|ABA62904.1|, |77167659|gb|ABA62789.1|, |77168129|gb|ABA63024.1|, |77167763|gb|ABA62841.1|, |77167677|gb|ABA62798.1|, |4324801|gb|AAD17065.1|, |4324785|gb|AAD17049.1|, |4324794|gb|AAD17058.1|, |4324776|gb|AAD17040.1|, |4324768|gb|AAD17032.1|, |77168400|gb|ABA63159.1|, |77167701|gb|ABA62810.1|, |77167617|gb|ABA62768.1|, |77167379|gb|ABA62649.1|, |7416654|dbj|BAA93967.1|, |7416652|dbj|BAA93966.1|, |25166677|gb|AAN73482,1|AF48, |37677837|gb|AAQ97509.1|, |7416714|dbj|BAA93997.1|, |7416710|dbj|BAA93995.1|, |7416712|dbj|BAA93996.1|, |62461846|gb|AAX83062.1|, |67552989|gb|AAY68587.1|, |16118284|gb|AAL12661,1|, |77167833|gb|ABA62876.1|, |77168145|gb|ABA63032,1|, |77167927|gb|ABA62923.1|, |71725965|gb|AAZ39101.1|, |77167433|gb|ABA62676,1|, |77167759|gb|ABA62839.1|, |77167753|gb|ABA62836.1|, |7416706|dbj|BAA93993.1|, |7416704|dbj|BAA93992.1|, |818218|gb|AAB47930.1|, |77168270|gb|ABA63094.1|, |45361092|gb|AAS59317.1|, |77168374|gbvABA63146.1|, |25166749|gb|AAN73546.1|AF48, |16118387|gb|AAL12751.1|, |77167537|gb|ABA62728.1|, |15788300|gb|AAL07747.1|, |77167991|gb|ABA62955.1|, |57545336|gb|AAW51571.1|, |57545332|gb|AAW51569.1|, |77168352|gb|ABA63135.1|, |77168115|gb|ABA63017.1|, |57545328|gb|AAW51567.1|, |1185536|gb|AAA87872.1|, |1477842|gb|AAB05504.1|, |1477838|gb|AAB05502.1|, |1477834|gb|AAB05500.1|, |1477840|gb|AAB05503.1|, |1477832|gb|AAB05499.1|, |1477822|gb|AAB05494.1|, |1477828|gb|AAB05497.1|, |1185534|gb|AAA87871.1|,
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|18844730|dbj|BAB85453.1|, |37682744|gb|AAQ98333.1|, |37682882|gb|AAQ98455.1|,
|37682864|gb|AAQ98441.1|, |45361116|gb|AAS59335.1|, |37682871|gb|AAQ98447.1|, |45361150|gb|AAS59362.1|, |19908410|gb|AAL96765.1|, |33328191|gb|AAQ09540.1|, |22297043|gb|AAM94499.1|, |37682931|gb|AAQ98498.1|, |37682714|gb|AAQ98306.1|, |37682961|gb|AAQ98525.1|, |37682774|gb|AAQ98360.1|, |82284899|sp|Q6JNE4|Q6JNE4_9, |45361138|gb|AAS59353.1|, |30720410|gb|AAP33678.1|, |57869667|gb|AAW57707.1|, |57869732|gb|AAW57765.1|, |57869723|gb|AAW57757.1|, |57869687|gb|AAW57725.1|, |37682913|gb|AAQ98482.1|, |37682754|gb|AAQ98342.1|, |37682764|gb|AAQ98351.1|, |77167661|gb|ABA62790.1|, |31559683|dbj|BAC77505.1|, |31559635|dbj|BAC77462.1|, |37682724|gb|AAQ98315.1|, |37682704|gb|AAQ98297.1|, |37682844|gb|AAQ98423.1|, |78100203|gb|ABB20906.1|, |57869714|gb|AAW57749.1|, |57869696|gb|AAW57733.1|, |45361202|gb|AAS59393.1|, |5931486|dbj|BAA84664.1|, |38491834|gb|AAR22208.1|, |57869677|gb|AAW57716.1|, |37682951|gb|AAQ98516.1|, |45361104|gb|AAS59326.1|, |37682903|gb|AAQ98473.1|, |37683011|gb|AAQ98570.1|, 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|77168219|gb|ABA63069.1|, |77167495|gb|ABA62707.1|, |77167993|gb|ABA62956.1|, |77167777|gb|ABA62848.1|, |77168051|gb|ABA62985.1|, |77167435|gb|ABA62677.1|, |82295417|sp|Q8AC04|Q8AC04_9, |23392759|emb|CAD26717.1|, |23392757|emb|CAD26716.1|, |23392755|emb|CAD26715.1|, |27446732|gb|AAL62479.1|, |77168276|gb|ABA63097.1|, |77167691|gb|ABA62805.1|, |77167791|gb|ABA62855.1|, |77167599|gb|ABA62759.1|, |77167309|gb|ABA62614.1|, |77168189|gb|ABA63054.1|, |77167695|gb|ABA62807.1|, |77167419|gb|ABA62669.1|, |1072090|gb|AAC54546.1|, |3002889|gb|AAD03243.1|, |3002853|gb|AAD03211.1|, |37681534|gb|AAQ97644.1|, |37677777|gb|AAQ97455.1|, |77167807|gb|ABA62863.1|, |12964713|gb|AAK11285.1|, |1160049|emb|CAA92878.1|, |77167481|gb|ABA62700.1|, |77167467|gb|ABA62693.1|, |12964711|gb|AAK11284.1|, |77168125|gb|ABA63022.1|, |7416700|dbj|BAA93990.1|, |7416702|dbj|BAA93991.1|, |3327504|gb|AAC41047.1|, |3327540|gb|AAC41063.1|, |3327490|gb|AAC41040.1|, |3327538|gb|AAC41062.1|, |3327536|gb|AAC41061.1|, |3327534|gb|AAC41060.1|, |3327532|gb|AAC41059.1|, |3327521|gb|AAC41055.1|, |3327519|gb|AAC41054.1|, |3327517|gb|AAC41053.1|, |3327514|gb|AAC41052.1|, |3327510|gb|AAC41050.1|, |3327496|gb|AAC41043.1|, |3327488|gb|AAC41039.1|, |3327528|gb|AAC41057.1|, |3327486|gb|AAC41038.1|, |3327530|gb|AAC41058,1|, |3327506|gb|AAC41048.1|, |3327500|gb|AAC41045.1|, |3327498|gb|AAC41044.1|, |3327512|gb|AAC41051.1|, |3327502|gb|AAC41046.1|, |3327494|gb|AAC41042.1|, |3327508|gb|AAC41049.1|, |3327492|gb|AAC41041.1|, |55735997|gb|AAV59725.1|, |50404191|gb|AAT76861.1|, |7168334|gb|ABA63126.1|, |25166759|gb|AAN73555,1|AF48, |77167703|gb|ABA62811.1|, |77167401|gb|ABA62660.1|, |38491919|gb|AAR22284.1|, |23394930|gb|AAN31651.1|, |1160057|emb|CAA92882.1|, |16118254|gb|AAL12634.1|, |7416684|dbj|BAA93982.1|, |3002871|gb|AAD03227.1|, |77167717|gb|ABA62818.1|, |77168149|gb|ABA63034.1|, |46254439|gb|AAS86190.1|, |77168083|gb|ABA63001.1|, |46254417|gb|AAS86175.1|, |3002843|gb|AAD03202.1|, |57869601|gb|AAW57648.1|, |77167583|gb|ABA62751.1|, |77167413|gb|ABA62666.1|, |77167395|gb|ABA62657.1|, |77167861|gb|ABA62890.1|, |77167405|gb|ABA62662.1|, |7416722|dbj|BAA94001.1|, |7416718|dbj|BAA93999.1|, |7416716|dbj|BAA93998.1|, |82283749|sp|Q66MS6|Q66MS6_9, |29119345|gb|AA063258.1|, |82283743|sp|Q66MR4|Q66MR4_9, |7416720|dbj|BAA94000.1|, |77168225|gb|ABA63072.1|, |77167903|gb|ABA62911.1|, |77167651|gb|ABA62785.1|, |77168310|gb|ABA63114.1|, |77168288|gb|ABA63103.1|, |77167869|gb|ABA62894.1|, |77167489|gb|ABA62704.1|, |77167335|gb|ABA62627.1|, |77168201|gb|ABA63060.1|, |77168195|gb|ABA63057.1|, |77167357|gb|ABA62638.1|, |77167905|gb|ABA62912.1|, |77168304|gb|ABA63111.1|, |77168181|gb|ABA63050.1|, |1160045|emb|CAA92876.1|, |29119279|gb|AA063199.1|, |3002862|gb|AAD03219.1|, |77167779|gb|ABA62849.1|, |57545324|gb|AAW51565.1|, |77167863|gb|ABA62891.1|, |15281483|gb|AAK94267.1|AF36, |1160109|emb|CAA92908.1|, |30038317|gb|AAP12630.1|, |1160111|emb|CAA92909.1|, |11641109|gb|AAG38459.1|, |11641105|gb|AAG38457.1|, 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|48476375|gb|AAT44409.1|, |13569260|gb|AAK31001.1|AF28, |45738212|gb|AAS75871.1|, |13569230|gb|AAK30974.1|AF28, |38892672|gb|AAR27674.1|, |59003639|gb|AAW83637.1|, |68522136|gb|AAY98723.1|, |13569310|gb|AAK31046.1|AF28, |57869646|gb|AAW57688.1|, |67553063|gb|AAY68653.1|, |67553073|gb|AAY68662.1|, |57869610|gb|AAW57656.1|, |26000266|gb|AAN75300.1|, |63098402|gb|AAY32443.1|, |68522056|gb|AAY98651.1|, |59003580|gb|AAW83584.1|, |67553113|gb|AAY68698.1|, |12957306|gb|AAK09146.1|AF32, |12957300|gb|AAK09141.1|AF32, |59003520|gb|AAW83530,1|, |58221001|gb|AAW68179.1|, |38892709|gb|AAR27707.1|, |68522026|gb|AAY98624.1|, |57338565|gb|AAW49359.1|, |46486638|gb|AAS98744.1|, |63098382|gb|AAY32425.1|, |59003659|gb|AAW83655.1|, |55139292|gb|AAV41312.1|, |68521946|gb|AAY98552.1|, |67553007|gb|AAY68603.1|, |12957348|gb|AAK09181.1|AF32, |12957342|gb|AAK09176.1|AF32, |67553033|gb|AAY68626.1|, |59003669|gb|AAW83664.1|, |32344848|gb|AAM82303.1|, |12957258|gb|AAK09106.1|AF32, |57338557|gb|AAW49352.1|, 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|54124764|gb|AAV30104.1|, |54124754|gb|AAV30095.1|, |50404188|gb|AAT76858.1|, |47118265|gb|AAT11251.1|, |47118255|gb|AAT11242.1|, |47118245|gb|AAT11224.1|, |47118235|gb|AAT11233.1|, |47118225|gb|AAT11215.1|, |47118215|gb|AAT11206.1|, |1732490|gb|AAB38837.1|, |1732480|gb|AAB38828.1|, |16755648|gb|AAL28060.1|, |32261500|gb|AAP76561.1|truncada, |32261490|gb|AAP76552.1|truncada, |32261480|gb|AAP76543.1|truncada, |32261470|gb|AAP76534.1|truncada, |33359207|gb|AAQ17030.1|, |26245474|gb|AAN77402.1|, |26245464|gb|AAN77393.1|, |26245454|gb|AAN77384.1|, |1478062|gb|AAB51141.1|, |22596257|gb|AAN03047.1|AF457054_6, |6690779|gb|AAF24338.1|AF197341_5, |6690772|gb|AAF24331.1|AF197340_5, |6690765|gb|AAF24324.1|AF197339_3, |6690758|gb|AAF24317.1|AF197338_5, |17981624|gb|AAL51094.1|, |1469312|gb|AAB05048.1|, |328654|gb|AAA80322.1|, |14579617|gb|AAK69334.1|, |14579607|gb|AAK69325.1|, |16118399|gb|AAL12762.1|, |16118389|gb|AAL12753.1|, |16118379|gb|AAL12744.1|, |16118369|gb|AAL12735.1|, |16118361|gb|AAL12728.1|, |16118355|gb|AAL12723.1|, |16118345|gb|AAL12714.1|, |16118333|gb|AAL12704.1|, |16118316|gb|AAL12690.1|, |16118306|gb|AAL12681.1|, |16118296|gb|AAL12672.1|, |16118286|gb|AAL12663.1|, |16118276|gb|AAL12654.1|, |16118266|gb|AAL12645.1|, |16118256|gb|AAL12636.1|, |45360214|gb|AAS59245.1|, |45360204|gb|AAS59236.1|, |45360194|gb|AAS59227.1|, |45360183|gb|AAS59217.1|, |45360173|gb|AAS59208.1|, |45360163|gb|AAS59199.1|, |45360153|gb|AAS59190.1|, |45360143|gb|AAS59181.1|, |82320179|sp|Q9YX51|Q9YX51_9HIV1, |82320178|sp|Q9YW94|Q9YW94_9HIV1, |82320176|sp|Q9YV64|Q9YV64_9HIV1 truncada, |82319767|sp|Q9QRB3|Q9QRB3_9HIV1, |82319624|sp|Q9Q6IS|Q9Q6I5_9HIV1, |82319623|sp|Q9Q6H9|Q9Q6H9_9HIV1, |82319622|sp|Q9Q6H2|Q9Q6H2_9HIV1, |82319621|sp|Q9Q6G5|Q9Q6G5_9HIV1, |82319339|sp|Q9IQP6|Q9IQP6_9HIV1, |82319338|sp|Q9IQP5|Q9IQP5|9HIV1, |82319337|sp|Q9IQP4|Q9IQP4_9HIV1, |82319336|sp|Q9IQP3|Q9IQP3_9HIV1, |82319335|sp|Q9IQP2|Q9IQP2|9HIV1, |82319334|sp|Q9IQP1|Q9IQP1_9HIV1, |82319333|sp|Q9IQP0|Q9IQP0_9HIV1, |82319332|sp|Q9IQN9|Q9IQN9_9HN1, |82319331|sp|Q9IQN8|Q9IQN8_9HIV1, |82319330|sp|Q9IQN7|Q9IQN7_9HIV1, |82319329|sp|Q9IQN6|Q9IQN6_9HIV1, |82319328|sp|Q9IQN5|Q9IQN5_9HIV1, |82319327|sp|Q9IQN4|Q9IQN4_9HIV1, |82319326|sp|Q9IQN3|Q9IQN3_9HIV1, |82319325|sp|Q9IQN2|Q9IQN2_9HIV1, |82319324|sp|Q9IQN1|Q9IQN1_9HIV1, |823l9323|sp|Q9IQNO|Q9IQN0_9HIV1, |82319322|sp|Q9IQM9|Q9IQM9_9HIV1, |82319321|sp|Q9IQM8|Q9IQM8_9HIV1, |82319068|sp|Q9L3N5lQ9IBN5_9HIV1, |82318824|sp|Q9DKG8|Q9DKG8_9HIV1, |82318823|sp|Q9DKG0|Q9DKG0_9HIV1 truncada, |82318822|sp|Q9DKF2|Q9DKF2|9HIV1 truncada, |82318821|sp|Q9DIKE4|Q9DKE4_9HIV1 truncada, |82318820|sp|Q9DKDS|Q9DKD5_9HIV1, |82318682|sp|Q99BZ8|Q99BZ8_9HIV1, |82318620|sp|Q994C7|Q994C7_9HIV1, |82318619|sp|Q994B8|Q994B8_9HIV1, |82318618|sp|Q994A9|Q994A9_9HIV1, |82317959|sp|Q6EK38|Q6EK38_9HIV1, |82317958|sp|Q6EK22|Q6EK22_9HIV1, |82317957|sp|Q6EJW6|Q6EJW6_9HIV1, |82317956|sp|Q6EJV0|Q6EJV0_9HIV1, |82317955|sp|Q6EJR8|Q6EJR8_9HIV1, |82317954|sp|Q6EJQ2|Q6EJQ2_9HIV1, |82317880|sp|Q6E6X6|Q6E6X6_9HIV1, |82317879|sp|Q6E6X0|Q6E6X0_9HIV1, |82317878|sp|Q6E6W3|Q6E6W3_9HIV1, |82317877|sp|Q6E6V6|Q6E6V6_9HIV1, |82317876|sp|Q6E6U8|Q6E6U8_9HIV1, |82317875|sp|Q6E6U1|Q6E6U1_9HIV1, |82317307|sp|Q5VCT6|Q5VCT6_9HIV1, |82317054|sp|Q5S5D0|Q5S5D0_9HIV1, |82317053|sp|Q5S5C2|Q5S5C2_9HIV1, |82317052|sp|Q5S5B4|Q5S5B4_9HIV1, |82317051|sp|Q5S5A2|Q5S5A2_9HIV1, |82317050|sp|Q5S594|QSS594_9HIV1, |82314773|sp|Q90VT0|Q90VT0_9HIV1, |82314204|sp|Q90DD7|Q90DD7_9HIV1, |82314155|sp|Q909R5|Q909R5_9HIV1, |82314069|sp|Q908N3|Q908N3_9HIV1, |82314068|sp|Q908M4|Q908M4_9HIV1, |82314067|sp|Q908L5|Q908L5_9HIV1, |82314066|sp|Q908K6|Q908K6_9HIV1, |82314065|sp|Q908J7|Q908J7_9HIV1, |823140G4|sp|Q908I8|Q908I8_9HIV1, |82314063|sp|Q908H9|Q908H9_9HIV1, |82313862|sp|Q8UTU1|Q8UTU1_9HIV1, |82313861|sp|Q8UTT2|Q8UTT2_9HIV1, |82313860|sp|Q8UTS3|Q8UTS3_9HIV1, |82313859|sp|Q8UTR4|Q8UTR4_9HIV1, |82313858|sp|Q8UTQ5|Q8UTQ5_9HIV1, |82313857|sp|Q8UTP6|Q8UTP6_9HIV1, |82313856|sp|Q8UTN7|Q8UTN7_9HIV1, |82313855|sp|Q8UTM8|Q8UTM8_9HIV1, |82313854|sp|Q8UTL9|Q8UTL9_9HIV1, |82313853|sp|Q8UTL0|Q|8UTL0_9HIV1, |82313852|sp|Q8UTK1|Q8UTK1_9HIV1, |82313850|sp|Q8UTJ2|Q8UTJ2_HIV1, |82313849|sp|Q8UTI3|Q8UTI3_9HIV1, |82313848|sp|Q8UTH4|Q8UTH4_9HIV1, |82313847|sp|Q8UTG5|Q8UTG5_9HIV1, |82313846|sp|Q8UTF6|Q8UTF6_9HIV1, |82313845|sp|Q8UTE7|Q8UTE7_9HIV1, |82313844|sp|Q8UTD8|Q8UTD8_9HIV1, |82313843|sp|Q8UTC9|Q8UTC9_9HIV1, |82313842|sp|Q8UTC0|Q8UTC0_9HIV1, |82313841|sp|Q8UTB1|Q8UTB1_9HIV1, |82313840|sp|Q8UTA2|Q8UTA2_9HIV1, |82313839|sp|Q8UT93|Q8UT93_9HIV1, |82313838|sp|Q8UT84|Q8UT84_9HIV1, |82313837|sp|Q8UT75|Q8UT75_9HIV1, |82313836|sp|Q8UT66|Q8UT66_9HIV1, |82313835|sp|Q8UT57|Q8UT57_9HIV1, |82313834|sp|Q8UT48|Q8UT48_9HIV1, |82313833|sp|Q8UT39|Q8UT39_9HIV1, |82313832|sp|Q8UT30|Q8UT30_9HIV1, |82313831|sp|Q8UT21|Q8UT21_9HIV1, |82313830|sp|Q8UT12|Q8UT12_9HIV1, |82313828|sp|Q8USZ8|Q8USZ8_9HIV1, |82313827|sp|Q8USY9|Q8USY9_9HIV1,
32
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|82313924|sp|Q901Y3|Q901Y3_9HIV1, |82313923|sp|Q901X4|Q901X4_9HIV1, |82313922|sp|Q9O1W5|Q901W5_9HIV1, |82313920|sp|Q900Z6|Q900Z6_9HIV1, |82313919|sp|Q900Y7|Q900Y7_9HIV1, |82313641|sp|Q8UPQ7|Q8UPQ7_9HIV1, |82313640|sp|Q8UPP9|Q8UPP9_9HIV1, |82313639|sp|Q8UPP0|Q8UPP0_9HIV1, |82313638|sp|Q8UPN2|Q8UPN2T_9HIV1, |82313637|sp|Q8UPM3|Q8UPM3_9HIV1, |82313636|sp|Q8UPL4|Q8UPL4_9HIV1, |82313635|sp|Q8UNM1|Q8UNM1_9HIV1, |82313634|sp|Q8UNL2|Q8UNL2_9HIV1, |82313584|sp|Q8UMF8|Q8UMF8_9HIV1, |82313581|sp|Q8UMD6|Q8UMD6_9HIV1, |82313472|sp|Q8QDF7|Q8QDF7_9HIV1, |82313467|sp|Q8Q7Z2|Q8Q7Z2_9HIV1, |82313383|sp|Q8Q2F4|Q8Q2F4_9HIV1, |82313382|spvQ8Q0Y4|Q8Q0Y4_9HIV1, |82313374|sp|Q8JDM8|Q8JDM8_9HIV1, |82313373|sp|Q8JDM4|Q8JDM4_9HIV1, |82313372|sp|Q8JDM1|Q8JDM1_9HIV1, |82313371|sp|Q8JDL7|Q8JDL7_9HIV1, |82313370|sp|Q8JDL3|Q8JDL3_9HIV1, |82313369|sp|Q8JDK9|Q8JDK9_9HIV1, |82313368|sp|Q8JDK5|Q8JDK5_9HIV1, |82313367|sp|Q8JDK1|Q8JDK1_9HIV1, |82313366|sp|Q8JDJ7|Q8JDJ7_9HIV1, |82313365|sp|Q8JDJ3|Q8JDJ3_9HIV1, |82313364|sp|Q8JDI9|Q8JDI9_9HIV1, |82313363|sp|Q8JDI5|Q8JDI5_9HIV1, |82313362|sp|Q8JDI1|Q8JDI1_9HIV1, |82313361|sp|Q8JDH7|Q8JDH7_9HIV1, |82313360|sp|Q8JDH3|Q8JDH3_9HIV1, |82313338|sp|Q8JC73|Q8JC73_9HIV1, |82313337|sp|Q8JC64|Q8JC64_9HIV1, |82313336|sp|Q8JC55|Q8JC55_9HIV1, |82313335|sp|Q8JC46|Q8JC46_9HIV1, |82313334|sp|Q8JC37|Q8JC37_9HIV1, |82313333|sp|Q8JC28|Q8JC28_9HIV1, |82313332|sp|Q8JC19|Q8JC19_9HIV1, |82313331|sp|Q8JC10|Q8JC10_9HIV1, |82313330|sp|Q8JBZ7|Q8JBZ7_9HIV1, |82313329|sp|Q8JBY8|Q8JBY8_9HIV1, |82313328|sp|Q8JBX9|Q8JBX9_9HIV1, |82313327|sp|Q8JBX0|Q8JBX0_9HIV1, |82313326|sp|Q8JBW1|Q8JBW1_9HIV1, |82313325|sp|Q8JBV2|Q8JBV2_9HIV1, |82313324|sp|Q8JBU3|Q8JBU3_9HIV1, |82313323|sp|Q8JBT4|Q8JBT4_9HIV1, |82313322|sp|Q8JBS5|Q8JBS5_9HIV1, |82313321|sp|Q8JBR6|Q8JBR6_9HIV1, |82313320|sp|Q8JBQ7|Q8JBQ7_9HIV1, |82313319|sp|Q8JBP8|Q8JBP8_9HIV1, |82313318|sp|Q8JBN8|Q8JBN8_9HIV1, |82313317|sp|Q8JBM7|Q8JBM7_9HIV1, |82313316|sp|Q8JBL8|Q8JBL8_9HIV1, |82313315|sp|Q8JBK9|Q8JBK9_9HIV1, |82313314|sp|Q8JBK0|Q8JBK0_9HIV1, |82313313|sp|Q8JBJ1|Q8JBJ1_9HIV1, |82313312|sp|Q8JBI2|Q8JBI2_9HIV1, |82313311|sp|Q8JBH3|Q8JBH3_9HIV1, |82313310|sp|Q8JBG4|Q8JBG4_9HIV1, |82313309|sp|Q8JBF5|Q8JBF5_HIV1, |82313308|sp|Q8JBE6|Q8JBE6_9HIV1, |82313307|sp|Q8JBD7|Q8JBD7_9HIV1, |82313306|sp|Q8JBC8|Q8JBC8_9HIV1, |82313305|sp|Q8JBB9|Q8JBB9_9HIV1, |82313304|sp|Q8JBB0|Q8JBB0_9HIV1, |82313303|sp|Q8JBA6|Q8JBA6_9HIV1, |82313302|sp|Q8JAX8|Q8JAX8_9HIV1, |82313301||sp|Q8JAX0|Q8JAX0_9HIV1, |82313290|spvQ8J9C0|Q8J9C0_9HIV1, |82313289|sp|Q8J9B1|Q8J9B1_9HIV1, |82312946|sp|Q8BU5|Q8BU5_9HIV1, |82312899|sp|Q8AUI0|Q8AUI0_9HIV1, |82312898|sp|Q8AU88|Q8AU88_9HIV1, |82312897|sp|Q8AU79|Q8AU79_9HIV1, |82312896|sp|Q8AU70|Q8AU70_9HIV1, |82312895|sp|Q8AU61|Q8AU61_9HIV1, |82312859|sp|Q8ATN9|Q8ATN9_9HIV1, |82312858|sp|Q8ATN3|Q8ATN3_9HIV1, |82312853|sp|Q8AQV9|Q8AQV9_9HIV1, |82312852|sp|Q8AQV0|Q8AQV0_9HIV1, |82312851|sp|Q8AQU1|Q8AQU1_9HIV1, |82312850|sp|Q8AQT2|Q8AQT2_9HIV1, |82312849|sp|Q8AQS3|Q8AQS3_9HIV1, |82312746|sp|QBAMN0|Q8AMN0_9HIV1 truncada, |82312732|sp|Q8AK11|Q8AK11_9HIV1, |82312731|sp|Q8AK02|Q8AK02_9HIV1, |82312587|sp|Q8AF23|Q8AF23_9HIV1, |82312579|sp|Q8AEW6|Q8AEW6_9HIV1, |82312541|sp|Q8AE76|Q8AE76_9HIV1, |82312540|sp|Q8AE68|Q8AE68_9HIV1, |82312539|sp|Q8AE60|Q8AE60_9HIV1, |82312538|sp|Q8AE52|Q8AE52_9HIV1, |82312537|sp|Q8AE44|Q8AE44_9HIV1, |82312536|sp|Q8AE36|Q8AE36_9HIV1, |82312535|sp|Q8AE28|Q8AE28_9HIV1, |82312534|sp|Q8AE24|Q8AE24_9HIV1, |82312533|sp|Q8AE19|Q8AE19_9HIV1truncada, |82312532|sp|Q8AE11|Q8AE11_9HIV1, |82312531|sp|Q8AE03|Q8AE03_9HIV1, |82312530|sp|Q8ADZ5|Q8ADZ5_9HIV1, |82312529|sp|Q8ADY7|Q8ADY7_9HIV1, |82312528|sp|Q8ADX9|Q8ADX9_9HIV1, |82312527|sp|Q8ADX1|Q8ADX1_9HIV1, |82312526|sp|Q8ADW3|Q8ADW3_9HIV1, |82312525|sp|Q8ADV5|Q8ADV5_9HIV1, |82312524|sp|Q8ADU7|Q8ADU7_9HIV1, |82312523|sp|Q8ADT9|Q8ADT9_9HIV1, |82312522|sp|Q8ADT1|Q8ADT1_9HIV1, |82312521|sp|Q8ADS3|Q8ADS3_9HIV1, |82312520|sp|Q8ADR5|Q8ADR5_9HIV1, |82312519|sp|Q8ADQ7|Q8ADQ7_9HIV1, |82312518|sp|Q8ADP9|Q8ADP9_9HIV1, |82312517|sp|Q8ADP1|Q8ADP1_9HIV1, |82312516|sp|Q8ADN3|Q8ADN3_9HIV1, |82312515|sp|Q8ADM5|Q8ADM5_9HIV1, |82312514|sp|Q8ADL7|Q8ADL7_9HIV1, |82312513|sp|Q8ADK9|Q8ADK9_9HIV1, |82312511|sp|Q8ADK1|Q8ADK1_9HIV1, |82312510|sp|Q8ADJ3|Q8ADJ3_9HIV1, |82312509|sp|Q8ADI5|Q8ADI5_9HIV1, |82312508|sp|Q8ADH7|Q8ADH7_9HIV1, |82312507|sp|Q8ADG9|Q8ADG9_9HIV1, |82312506|sp|Q8ADG1|Q8ADG1_9HIV1, |82312505|sp|Q8ADF3|Q8ADF3_9HIV1, |82312504|sp|Q8ADE5|Q8ADE5_9HIV1, |82312503|sp|Q8ADD7|Q8ADD7_9HIV1, |82312502|sp|Q8ADC9|Q8ADC9_9HIV1, |82312501|sp|Q8ADC1|Q8ADC1_9HIV1,
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55
65
|82318815|sp|Q9DH16|Q9DH16_9HIV1, |82318814|sp|Q9DGZ4|Q9DGZ4_9H1V1, |82318813|sp|Q9DGW4|Q9DGW4_9HIVl, |82312479|sp|Q8ACA0|Q8ACA0_9HN1, |82312478|sp|Q8AC91|Q8AC91_9HN1, |82311318|sp|Q78232|Q78232_9HN1, |74273388|gb|ABA01378.1|, |40021891|gb|AAR37201.1|, 1, |40021881|gb|AAR37194.1|, |40021871|gb|AAR37187.1|, |40021861|gb|AAR37180.1|, |40021851|gb|AAR37173.1|, |40021841|gb|AAR37166.1|, |40021831|gb|AAR37159.1|, |40021821|gb|AAR37152.1|, |40021811|gb|AAR37145.1|, |40021801|gb|AAR37138.1|, |40021791|gb|AAR37131.1|, |40021781|gb|AAR37124.1|, |40021771|gb|AAR37117.1|, |40021761|gb|AAR37110.1|, |40021751|gb|AAR37103.1|, |40021741|gb|AAR37096.1|, |40021730|gb|AAR37088.1|, |40021721|gb|AAR37082.1|, |40021711|gb|AAR37075,1, |40021701|gb|AAR37068.1|, |4205071|gb|AAD10942.1| |4205062|gb|AAD10934.1|, |4205053|gb|AAD10926.1|, |4205044|gb|AAD10918.1|, |4205035|gb|AAD10910.1|, |4205026|gb|AAD10902.1|, |4205017|gb|AAD10894.1|, |4205008|gb|AAD10886.1|, |4204999|gb|AAD10878.1|, |4204990|gb|AAD10870.1|, |328660|gb|AAB59880.1|, |326419|gb|AAB59746.1|, |329396|gb|AAB53950.1|, |327781|gb|AAB03525.1|, |328442|gb|AAA83396.1|, |329401|gb|AAA45378.1|, |329391|gb|AAA45375.1|, |329379|gb|AAA45364.1|, |328636|gb|AAA45061.1|, |328567|gb|AAA45051.1|, |328457|gb|AAA45000.1|, |328156|gb|AAA44867.1|, |328032|gb|AAA44852.1|, |327825|gb|AAA44686.1|, |327754|gb|AAA44677.1|, |82320737|sp|Q52S67|Q52S67_9HN1, |82320736|sp|Q52S60|Q52S60_9HN1, |82320733|sp|Q52S51|Q52S51_9HN1, |82320730|sp|Q52S41|Q52S41_9HN1, |82320727|sp|Q52S30|Q52S30_9HIV1, |82320166|sp|Q9YTC6|Q9YTC6_9HN1, |82320064|sp|Q9YP36|Q9YP36_9HN1, |82320063|sp|Q9YP32|Q9YP32_9HN1, |82319934|sp|Q9WJW6lQ9WJW6_9HIV1, |82319933|sp|Q9WJW2|Q9WJW2_9HN1, |82319932|sp|Q9WJV8|Q9WJV8_9HN1, |82319931|sp|Q9WJV6|Q9WJV6_9HN1, |82319930|sp|Q9WJV1|Q9WJV1_9HN1, |82319929|sp|Q9WJU9|Q9WJU9_9HN1, |82319928|sp|Q9WJU5|Q9WJU5_9HN1, |82319927|sp|Q9WJU2|Q9WJU2_9HN1, |82311259vsp|Q77689|Q77689_9HN1, |82308771|sp|Q56CX6|Q56CX6_9HN1, |82308770|sp|Q56CX5|Q56CX5_9HIV1, |82308769|sp|Q56CX4|Q56CX4_9HIV1, |82308767|sp|Q56CX2|Q56CX2_9HIV1, |82308766|sp|Q56CX1|Q56CX1_9HIV1, |82308765|sp|Q56CX0|Q56CX0_9HIV1, |82308764|sp|Q56CW9|Q56CW9_9HIV1, |82308763|sp|Q56CW8|Q56CW8_9HN1, |82308762|sp|Q56CW7|Q56CW7_9HIV1, |82308761|sp|Q56CW6|Q56CW6_9HIV1, |82308760|sp|Q56CW5lQ56CW5_9HIV1, |82308759|sp|Q56CW4|Q56CW4_9HIV1, |82308758|sp|Q56CW3|Q56CW3_9HIV1, |82308757|sp|Q56CW2|Q56CW2_9HIV1, |82308756|sp|Q56CW1|Q56CW1_9HIV1, |82308755|sp|Q56CW0|Q56CW0_9HIV1, |82308754|sp|Q56CV9|Q56CV9_9HIV1, |82308753|sp|Q56CV8|Q56CV8_9HIV1, |82308752|sp|Q56CV7|Q56CV7_9HIV1, |82308751|sp|Q56CV6|Q56CV6_9HN1, |82308750|sp|Q56CV5|Q56CV5_9HIV1, |82308749|sp|Q56CV4|Q56CV4_9HIV1, |82308748|sp|Q56CV3|Q56CV3_9HIV1, |82308747|sp|Q56CV2|Q56CV2_9HIV1, |82308746|sp|Q56CV1|Q56CV1_9HIV1, |82308745|sp|Q56CV0|Q56CV0_9HN1, |82308744|sp|Q56CU9|Q56CU9_9HN1, |82308743|sp|Q56CU8|Q56CU8_9HN1, |82308742|sp|Q56CU7|Q56CU7_9HIV1, |82308741|sp|Q56CU6|Q56CU6_9HN1, |82308740|sp|Q56CU5|Q56CU5_9HIV1, |82308739|sp|Q56CU4|Q56CU4_9HIV1, |82308738|sp|Q56CU3|Q56CU3_9HN1, |82308737|sp|Q56CU2|Q56CU2_9HN1, |82308736|sp|Q56CU1|Q56CU1_9HN1, |82308735|sp|Q56CU0|Q56CU0_9HN1, |82308734|sp|Q56CT9|Q56CT9_9HIV1, |82308733|sp|Q56CT8|56CT8_9HIV1, |82308732|sp|Q56CT7|Q56CT7_9HIV1| |82308731|sp|Q56CT6|Q56CT6_9HIV1, |82308730|sp|Q56CT5|Q56CT5_9HIV1, |82308729|sp|Q56CT4|Q56CT4_9HN1, |82308728|sp|Q56CT3|Q56CT3_9HIV1, |82308727|sp|Q56CT2|Q56CT2_9HN1, |82308726|sp|Q56CT1|Q56CT1_9HIV1, |82308725|sp|Q56CT0|Q56CT0_9HIV1, |82308724|sp|Q56CS9|Q56CS9_9HIV1, |82308723|sp|Q56CS8|Q56CS8_9HIV1, |82308722|sp|Q56CS7|Q56CS7_9HIV1, |82308721|sp|Q56CS6|Q56CS6_9HIV1, |82308720|sp|Q56CS5|Q56CS5_9HIV1, |82308719|sp|Q56CS4|Q56CS4_9HIV1, |82308718|sp|Q56CS3|Q56CS3_9HIV1, |82308717|sp|Q56CS2|Q56CS2_9HIV1, |82308716|sp|Q56CS|Q56CS1_9HIV1, |82308715|sp|Q56CS0|Q56CS0_9HIV1, |82308714|sp|Q56CR9|Q56CR9_9HIV1, |82308713|sp|Q56CR8|Q56CR8_9HIV1, |82308712|sp|Q56CR7|Q56CR7_9HIV1, |82308711|sp|Q56CR6|Q56CR6_9HIV1, |82308710|sp|Q56CR5|Q56CR5_9HIV1, |82308709|sp|Q56CR4|Q56CR4_9HIV1, |82308708|sp|Q56CR3|Q56CR3_9HIV1, |82308707|sp|Q56CR2|Q56CR2_9HIV1, |82308706|sp|Q56CR1|Q56CR1_9HIV1, |82308705|sp|Q56CR0|Q56CR0_9HIV1, |82308704|sp|Q56CQ9|Q56CQ9_9HIV1, |82308703|sp|Q56CQ8|Q56CQ8_9HIV1, |82308702|sp|Q56CQ7|Q56CQ7_9HIV1, |82308701|sp|Q56CQ6|Q56CQ6_9HIV1, |82308700|sp|Q56CQ5|Q56CQ5_9HIV1, |82308699|sp|Q56CQ4|Q56CQ4_9HIV1, |82308698|sp|Q56CQ3|Q56CQ3_9HIV1, |82308697|sp|Q56CQ2|Q56CQ2_9HIV1, |82308696|sp|Q56CQ1|Q56CQ1_9HIV1, |82308695|sp|Q56CQ0|Q56CQ0_9HIV1, |82308694|sp|Q56CP9|Q56CP9_9HIV1, |82308693|sp|Q56CP8|Q56CP8_9HIV1, |82308692|sp|Q56CP7|Q56CP7_9HIV1, |82308691|sp|Q56CP6|Q56CP6_9HIV1, |82308690|sp|Q56CP5|Q56CP5_9HIV1, |82308689|sp|Q56CP4|Q56CP4_9HIV1, |82308688|sp|Q56CP3|Q56CP3_9HIV1, |82308687|sp|Q56CP2|Q56CP2_9HIV1,
42
5
15
25
35
45
55
65
|82300665|sp|Q90MM2|Q90MM2_9HIV1, |82300661|sp|Q90MK4|Q90MK4_9HIV1, |82295352|sp|Q89880|Q89880_9HIV1, |82295322|sp|Q89553|Q89553_9HIV1, |82289662|sp|Q75751|Q75751_9HIV1, |82289660|sp|Q75749|Q75749_9HIV1, |82289658|sp|Q75747|Q75747_9HIV1, |82289656|sp|Q75745|Q75745_9HIV1, |82289654|sp|Q75743|Q75743_9HIV1, |82289652|sp|Q75741|Q75741_9HIV1, |82289650|sp|Q75739|Q75739_9HIV1, |82289648|sp|Q75737|Q75737_9HIV1, |82289646|sp|Q75735|Q75735_9HIV1, |82289644|sp|Q75733|Q75733_9HIV1, |82289639|sp|Q75728|Q75728_9HIV1, |82289637|sp|Q75726|Q75726_9HIV1, |82289635|sp|Q75724|Q75724_9HIV1, |82289633|sp|Q75722|Q75722_9HIV1, |82289630|sp|Q75717|Q75717_9HIV1, |82289628|sp|Q75715|Q75715_9HIV1, |82289497|sp|Q74842|Q74842_9HIV1, |82288768|sp|Q72496|Q72496_9HIV1, |3618129|emb|CAA13527.1|, |3618123|emb|CAA13524.1|, |3618116|emb|CAA13521.1|, |3618108|emb|CAA13518.1|, |3618102|emb|CAA13515.1|, |3618096|emb|CAA13512.1|, |3618088|emb|CAA13508.1|, |3618082|emb|CAA13505.1|, |3618076|emb|CAA13502.1|, |3618070|emb|CAA13499.1|, |3618064|emb|CAA13496.1|, |3618058|emb|CAA13493.1|, |3618052|emb|CAA13490.1|, |3618046|emb|CAA13487.1|, |3618040|emb|CAA13484,1|, |3618032|emb|CAA13480.1|, |1568317|emb|CAA02191.1|,
|82300663|Q90ML3|Q90ML3_9HIV1, |82295355|sp|Q89896|Q89896_9HIV1, |82295344|sp|Q8976G|Q89766_9HIV1,
|3850011|emb|CAA76050.1|, |3618127|emb|CAA13526.1|, |3618121|emb|CAA13523.1|, |3618114|emb|CAA13520.1|, |3618106|emb|CAA13517.1|, |3618100|emb|CAA13514.1|, |3618094|emb|CAA13511.1|, |3618086|emb|CAA13507.1|, |3618080|emb|CAA13504.1|, |3618074|emb|CAA13501.1|, |3618068|emb|CAA13498.1|, |3618062|emb|CAA13495.1|, |3618056|emb|CAA13492.1|, |3618050|emb|CAA13489.1|, |3618044|emb|CAA13486.1|, |3618036|emb|CAA13482.1|, |3618030|emb|CAA13479.1|, |3850017|emb|CAA76053.1|,
|82289664|sp|Q75753|Q75753_9HIV1, |82289661|sp|Q75750|Q75750_9HV1, |82289659|sp|Q75748|Q75748_9HIV1, |82289657|sp|Q75746|Q75746_9HIV1, |82289655|sp|Q75744|Q75744_9HIV1, |82289653|sp|Q75742|Q75742_9HIV1, |82289651|sp|Q75740|Q75740_9HIV1, |82289649|sp|Q75738|Q75738_9HIV1, |82289647|sp|Q75736|Q75736_9HIV1, |82289645|sp|Q75734|Q75734_9HIV1, |82289643|sp|Q75732|Q75732_9HIV1, |82289638|sp|Q75727|Q75727_9HIV1, |82289636|sp|Q75725|Q75725_9HIV1, |82289634|sp|Q75723|Q75723_9HIV1, |82289632|sp|Q75719|Q75719_9HIV1, |82289629|sp|Q75716|Q75716_9HIV1, |82289627|sp|Q75714|Q75714_9HIV1, |82288908|sp|Q73328|Q73328_9HIV1, |3618131|emb|CAA13528.1|, |3618125|emb|CAA13525.1|, |3618118|emb|CAA13522.1|, |3618112|emb|CAA13519.1|, |3618104|emb|CAA13516.1|, |3618098|emb|CAA13513.1|, |3618090|emb|CAA13509.1|, |3618084|emb|CAA13506.1|, |3618078|emb|CAA13503.1|, |3618072|emb|CAA13500.1|, |3618066|emb|CAA13497.1|, |3618060|emb|CAA13494.1|, |3618054|emb|CAA13491.1|, |3618048|emb|CAA13488.1|, |3618042|emb|CAA13485.1|, |3618034|emb|CAA13481.1|, |3618028|emb|CAA13478.1|, |3850015|emb|CAA76052.1|,
|3850013|emb|CAA76051.1|, |3618092|emb|CAA13510.1|, |3618038|emb|CAA13483.1|, |299712|gb|AAB26291.1|, |255653|gb|AAB23301.1|, |5070579|gb|AAD39193.1|, |5070578|gb|AAD39192.1|, |5070577|gb|AAD39191.1|, |5070576|gb|AAD39190.1|, |5070575|gb|AAD39189.1|, |5070574|gb|AAD39188.1|, |5070573|gb|AAD39187.1|, |5070572|gb|AAD39186,1|, |5070571|gb|AAD39185.1|, |5070570|gb|AAD39184.1|,
|5730861|gb|AAD48750.1|AF120923_1, |5730859|gb|AAD48748.1|AF120920_1, |5730857|gb|AAD48746,1|AF120918_1, |5730855|gb|AAD48744,1|AF120916_1, |5730853|gb|AAD48742.1|AF120914_1, |5730851|gb|AAD48740.1|AF120912_1, |5730849|gb|AAD48738.1|AF120909_1, |5730847|gb|AAD48736,1|AF120907_1, |5730845|gb|AAD48734.1|AF120905_1, |5730843|gb|AAD48732,1|AF120897_1, |5730841|gb|AAD48730.1|AF120895_1, |5730839|gb|AAD48728.1|AF120893_1, |5730837|gb|AAD48726.1|AF120891_1, |5730835|gb|AAD48724.1|AF120889_1, |5730833|gb|AAD48722.1|AF120887_1, |5730831|gb|AAD48720.1|AF120885_1, |5730829|gb|AAD48718.1|AF120883_1,
|5730827|gb|AAD48716.1|AF120881_1, |573 0826|gb|AAD48715.1|AF120880_1, |5730825|gb|AAD48714.1|AF120879_1, |5730824|gb|AAD48713.1|AF120878_1, |5730823|gb|AAD48712.1|AF120877_1, |5730822|gb|AAD48711.1|AF120876_1,
|5730821|gb|AAD48710.1|AF120875_1, |5730820|gb|AAD48709.1|AF120874_1, |5730819|gb|AAD48708.1|AF120873_1, |5730818|gb|AAD48707.1|AF120872_1,
47
|5730860|gb|AAD48749.1|AF120922_1, |5730858|gb|AAD48747.1|AF120919_1, |5730856|gb|AAD48745.1|AF120917_1, |5730854|gb|AAD48743,1|AF120915_1, |5730852|gb|AAD48741.1|AF120913_1, |5730850|gb|AAD48739.1|AF120911_1, |5730848|gb|AAD48737,1|AF120908_1, |5730846|gb|AAD48735.1|AF120906_1, |5730844|gb|AAD48733.1|AF120904_1, |5730842|gb|AAD48731.1|AF120896_1, |5730840|gb|AAD48729.1|AF120894_1, |5730838|gb|AAD48727.1|AF120892_1, |5730836|gb|AAD48725.1|AF120890_1, |5730834|gb|AAD48723.1|AF120888_1, |5730832|gb|AAD48721.1|AF120886_1, |5730830|gb|AAD48719.1|AF120884_1, |5730828|gb|AAD48717,1|AF120882_1,
5
15
25
35
45
55
65
|2290046|gb|AAC58856.1|, |2290021|gb|AAC58841.1|, |2289985|gb|AAC58821.1|, |1899104|gb|AAC56988.1|, |3025687|gb|AAC40690,1|, |3025679|gb|AAC40686.1|, |2992619|gb|AAC40646.1|, |2290069|gb|AAC58869.1|, |2290040|gb|AAC58852.1|, |2290010|gb|AAC58835.1|, |2289982|gb|AAC58819.1|, |1899099|gb|AAC56984.1|, |3025685|gb|AAC40689.1|, |2992625|gb|AAC40649.1|, |2992617|gb|AAC40645.1|, |2290060|gb|AAC58864.1|, |2290035|gb|AAC58849.1|, |2289997|gb|AAC58828.1|, |1905983|gb|AAC57005.1|, |3025691|gb|AAC40692.1|, |3025683|gb|AAC40688.1|, |2992623|gb|AAC40648.1|, |2992615|gb|AAC40644.1|, |2992613|gb|AAC40643.1|, |2992611|gb|AAC40642.1|, |2992609|gb|AAC40641.1|, |2992606|gb|AAC40640.1|, |2992604|gb|AAC40639.1|, |2992602|gb|AAC40638.1|, |2992600|gb|AAC40637.1|, |2992598|gb|AAC40636.1|, |2992596|gb|AAC40635.1|, |2992594|gb|AAC40634.1|, |2992592|gb|AAC40633.1|, |2992590|gb|AAC40632.1|, |1469161|gb|AAC37975.1|, |1772633|gb|AAC32301.1|, |3403231|gb|AAC29064.1|, |3403222|gb|AAC29056.1|, |3403213|gb|AAC29048.1|, |3132819|gb|AAC29085.1|, |3132809|gb|AAC29076.1|, |3171209|gb|AAC18382.1|, |3171207|gb|AAC18381.1|, |3171205|gb|AAC18380.1|, |3171203|gb|AAC18379.1|, |3171201|gb|AAC18378.1|, |3171199|gb|AAC18377.1|, |3171197|gb|AAC18376.1|, |3171195|gb|AAC18375.1|, |3171193|gb|AAC18374.1|, |3171191|gb|AAC18373.1|, |3171189|gb|AAC18372.1|, |3171187|gb|AAC18371,1|, |3171185|AAC18370.1|, |3171183|gb|AAC18369.1|, |3171181|gb|AAC18368,1|, |3171179|gb|AAC18367.1|, |3171177|gb|AAC18366.1|, |3171175|gb|AAC18365.1|, |3171173|gb|AAC18364.1|, |3171171|gb|AAC18363,1|, |3171169|gb|AAC18362.1|, |3171167|gb|AAC18361.1|, |3169624|gb|AAC17904.1|, |3169622|gb|AAC17903.1|, |3169620|gb|AAC17902.1|, |3169618|gb|AAC17901,1|, |3169616|gb|AAC17900.1|, |3169614|gb|AAC17899.1|, |3169612|gb|AAC17898.1|, |3169610|gb|AAC17897.1|, |3169608|gb|AAC17896.1|, |3169606|gb|AAC17895.1|, |3169604|gb|AAC17894.1|, |3169602|gb|AAC17893.1|, |3169599|gb|AAC17892,1|, |3169597|gb|AAC17891.1|, |3169595|gb|AAC17890.1|, |3169592|gb|AAC17889.1|, |3169590|gb|AAC17888.1|, |3169587|gb|AAC17887.1|, |3169585|gb|AAC17886.1|, |3169583|gb|AAC17885.1|, |3169581|gb|AAC17884.1|, |3169579|gb|AAC17883.1|, |3169577|gb|AAC17882.1|, |2351790|gbAAB71220.1 |2351779|gb|AAB71215.1|, |2351236|gb|AAB68447.1|, |1899080|gb|AAB68441.1|, |2194187|gb|AAB61125.1|, |1749847|gb|AAB42064.1|, |1749845|gb|AAB42063.1|, |23986259|gb|AAL12208.1|, |23986243|gb|AAL12199.1|, |23986229|gb|AAL12190.1|, |23986215|gb|AAL12181.1|, |1469864|gb|AAB05189.1|, |1469862|gb|AAB05178.1|, |18844745|dbj|BAB85467.1|, |18844735|dbj|BAB85458.1|, |18643018|gb|AAL74053.1|, |6694608|gb|AAF25321,1|, |6694606|gb|AAF25320.1|, |6694604|gb|AAF25319.1|, |6694602|gb|AAF25318.1|, |6694600|gb|AAF25317.1|, |6694598|gb|AAF25316.1|, |6694596|gb|AAF25315.1|, |6694594|gb|AAF25314.1|, |6694592|gb|AAF25313.1|, |6694590|gb|AAF25312.1|, |6694588|gb|AAF25311.1|, |6694586|gb|AAF25310.1|, |6694584|gb|AAF25309,1|, |6694582|gb|AAF25308.1|, |6694580|gb|AAF25307.1|, |6694578|gb|AAF25306.1|, |6694576|gb|AAF25305.1|, |6694574|gb|AAF25304,1|, |6694572|gb|AAF25303.1|, |6694570|gb|AAF25302.1|, |6694564|gb|AAF25299.1|, |6694560|gb|AAF25297.1|, |6694558|gb|AAF25296.1|, |6694556|gb|AAF25295.1|, |6694554|gb|AAF25294.1|, |6694552|gb|AAF25293.1|, |6694550|gb|AAF25292.1|, |6694548|gb|AAF25291.1|, |6694546|gb|AAF25290.1|, |6694544|gb|AAF25289.1|, |6694542|gb|AAF25288.1|, |6694540|gb|AAF25287.1|, |6694538|gb|AAF25286.1|, |6694536|gb|AAF25285.1|, |6694534|gb|AAF25284.1|, |6694532|gb|AAF25283.1|, |6694530|gb|AAF25282.1|, |6694528|gb|AAF25281.1|, |6694526|gb|AAF25280.1|, |6694524|gb|AAF25279.1|truncada, |6694522|gb|AAF25278.1|, |6694520|gb|AAF25277.1|, |6694518|gb|AAF25276.1|, |6694516|gb|AAF25275.1|, |6694514|gb|AAF25274.1|, |6694512|gb|AAF25273.1|, |6694510|gb|AAF25272.1|, |6694508|gb|AAF25271.1| |6694506|gb|AAF25270.1|, |6694504|gb|AAF25269.1|, |6694502|gb|AAF25268.1|, |6694500|gb|AAF25267.1|, |6694498|gb|AAF25266.1|, |6694496|gb|AAF25265.1|, |6694494|gb|AAF25264.1|, |6694492|gb|AAF25263.1|, |6694490|gb|AAF25262.1|, |6694488|gb|AAF25261.1|, |6694486|gb|AAF25260.1|, |6694484|gb|AAF25259.1|, |6694482|gb|AAF25258.1|truncada, |6694480|gb|AAF25257,1|truncada, |6694478|gb|AAF25256.1|truncada, |6694476|gb|AAF25255.1|truncada, |6694474|gb|AAF25254.1|truncada, |6694472|gb|AAF25253.1|truncada, |6694470|gb|AAF25252.1|truneated, |6694468|gb|AAF25251.1|truncada, |6694466|gb|AAF25250.1|truncada, |6694464|gb|AAF25249.1| |6694462|gb|AAF25248.1|, |6694460|gb|AAF25247.1|, |6694458|gb|AAF25246.1|, |6694456|gb|AAF25245.1|, |6694454|gb|AAF25244.1|, |6694452|gb|AAF25243.1|, |6694450|gb|AAF25242.1|, |6694448|gb|AAF25241.1|, |6694446|gb|AAF25240,1|, |6694444|gb|AAF25239,1|, |6694442|gb|AAF25238.1|, |694440|gb|AAP25237.1|truncada, |6694438|gb|AAF25236.1|truncada, |6694436|gb|AAF25235.1|, |6694434|gb|AAF25234.1|, |6694432|gb|AAF25233.1|, |6694430|gb|AAF25232.1|, |6694428|gb|AAF25231.1|, |6694426|gb|AAF25230.1|, |10880736|gb|AAG24369.1|, |16751265|gb|AAL05340.1|, |16751255|gb|AAL05331.1|, |16751247|gb|AAL05324.1|, |16751236|gb|AAL05314,1|, |15281507|gb|AAK94289.1|AF361879_9, |15281497|gb|AAK94280.1|AF361878_9, |15281487|gb|AAK94271.1|AF361877_9, |1528147|gb|AAK94263.1|AF361876_9, |15281468|gb|AAK94254.1|AF361875_9, |15281458|gb|AAK94245.1|AF361874_9, |15281448|gb|AAK94236.1|AF361873_9, |15281438|gb|AAK94227.1|AF361872_9, |15281428|gb|AAK94218.1|AF361871_9, |14530235|gb|AAK65969.1|AF286236_9, |3002848|gb|AAD03207.1|, |3002838|gb|AAD03198.1|, |5931499|dbj|BAA84676.1|, |5931490|dbj|BAA84668.1|, |13517091|dbj|BAB40429.1|, |3779267|gb|AAD03315.1|, |14530270|gb|AAK66000.1|AF316544_9, |14530261|gb|AAK65992.1|F286239_9, |14530253|gb|AAK65985.1|AF286238_9, |14530244|gb|AAK65977.1|AF286237_10, |13569336|gb|AAK31070.1|AF286235_9, |13569326|gb|AAK31061.1|AF286234_9, |13569316|gb|AAK31052.1|AF286233_9, |13569306|gb|AAK31043.1|AF286232_9, |13569296|gb|AAK31034.1|AF286231_9, |13569286|gb|AAK31025.1|AF286230_9, |13569276|gb|AAK31016.1|AF286229_9, |13569256|gb|AAK30998.1|AF286227_9, |13569246|gb|AAK30989.1|AF286226_9, |13569236|gb|AAK30980.1|AF286225_9, |13569226|gb|AAK30971.1|AF286224_9, |13569216|gb|AAK30962.1|AF286223_9, |11321029|gb|AAG34020.1|,
52
5
15
25
35
45
55
65
|82297127|sp|Q8J5A4|Q8J5A4_9HIV1, |82297126|sp|Q8J5A3|Q8J5A3_9HIV1, |82297125|sp|Q8J5A2|Q8J5A2_9HIV1, |82297124|sp|Q8J5A1|Q8J5AI_9HIV1, |82297123|sp|Q8J5A0|Q8J5A0_9HIV1, |82297122|sp|Q8J599|Q8J599_9HIV1, |82297121|sp|Q8J598|Q8J598_9HIV1, |82297120|sp|Q8J597|Q8J597_9HIV1, |82297119|sp|Q8J596|Q8J596_9HIV1, |82297118|sp|Q8J595|Q8J595_9HIV1, |82297117|sp|Q8J594|Q8J594_9HIV1, |82297116|sp|Q8J593|Q8J593_9HIV1, |82297115|sp|Q8J592|Q8J592_9HIV1, |82297114|sp|Q8J591|Q8J591_9HIV1, |82297113|sp|Q8J590|Q8J590_9HIV1, |82297112|sp|Q8J589|Q8J589_9HIV1, |82297111|sp|Q8J588|Q8J588_9HIV1, |82297110|sp|Q8J587|Q8J587_9HIV1, |82297109|sp|Q8J586|Q8J586_9HIV1, |82297108|sp|Q8J585|Q8J585_9HIV1, |82297107|sp|Q8J584|Q8J584_9HIV1, |82296833|sp|Q8J318|Q8J318_9HIV1, |82296832|sp|Q8J315|Q8J315_9HIV1, |82296831|sp|Q8J314|Q8J314_9HIV1, |82296830|sp|Q8J313|Q8J313_9HIV1, |82295871|sp|Q8ATJ8|Q8AIJ8_9HIV1truncada, |82295354|sp|Q89889Q|9889_9HIV1, |82295353|sp|Q89888|Q89888_9HIV1, |82295350|sp|Q898G6|Q89866_9HIV1, |82295349|sp|Q89851|Q89851_9HIV1, |82295348|sp|Q89844|Q89844_9HIV1, |82295346|sp|Q89821|Q89821_9HIV1, |82295345|sp|Q89778|Q89778_9HIV1, |82295343|sp|Q89758|Q89758r_9HIV1, |82295341|sp|Q89734|Q89734_9HIV1, |82295340|sp|Q89706|Q89706_9HIV1, |82295339|sp|Q89688|Q89688_9HIV1, |82295338|sp|Q89672|Q89672_9HIV1, |82295337|sp|Q89668|Q89668_9HIV1, |82295335|sp|Q89646|Q89646_9HIV1, |82295334|sp|Q89630|Q89630_9HIV1, |82295333|sp|Q89629|Q89629_9HIV1, |82295332|sp|Q89623|Q89623_9HIV1, |82295326|sp|Q89587|Q89587_9HIV1, |82295325|sp|Q89586|Q89586_9HIV1, |82295324|sp|Q89575|Q89575_9HIV1, |82295320|sp|Q89537|Q89537_9HIV1, |82295318|sp|Q89515|Q89515_9HIV1, |82295317|sp|Q89511|Q89511_9HIV1, |82295314|sp|Q89463|Q89463_9HIV1, |82295313|sp|Q89438|Q89438_9HIV1, |82295312|sp|Q89436|Q89436_9HIV1, |82295311|sp|Q89430|Q89430_9HIV1, |82291329|sp|Q79785|Q79785_9HIV1, |82291328|sp|Q79784|Q79784_9HIV1, |82291327|sp|Q79783|Q79783_9HIV1, |82291326|sp|Q79782|Q79782_9HIV1, |82291325|sp|Q79781|Q79781_9HIV1, |82291324|sp|Q79780|Q79780_9HIV1, |82291323|sp|Q79779|Q79779_9HIV1, |82291322|sp|Q79778|Q79778_9HIV1, |82291321|sp|Q79777|Q79777_9HIV1, |82291320|sp|Q79776|Q79776_9HIV 1, |82291319|sp|Q79775|Q79775_9HIV1, |82291318|sp|Q79774|Q79774_9HIV1, |82291317|sp|Q79773|Q79773_9HIV1, |82291316|sp|Q79772|Q79772_9HIV1, |82291315|sp|Q79771|Q79771_9HIV1, |82291314|sp|Q79770|Q79770_9HIV1, |82291313|sp|Q79769|Q79769_9HIV1, |82291312|sp|Q79768|Q79768_9HIV1, |82291311|sp|Q79767|Q79767_9HIV1, |82291310|sp|Q79766|Q7976G_9HIV1, |82291309|sp|Q79765|Q79765_9HIV1, |82291308|sp|Q79764|Q79764_9HIV1, |82291307|sp|Q79763|Q79763_9HIV1, |82291306|sp|Q79762|Q79762_9HIV1, |82291305|sp|Q79761|Q797G1_9HIV1, |82291304|sp|Q797G0|Q79760_9HIV1, |82291303|sp|Q79759|Q79759_9HIV1,
|82291302|sp|Q79758|Q79758_9HIV1, |82291301|sp|Q79757|Q79757_9HIV1, |82291300|sp|Q79756|Q79756_9HIV1, |82291299|sp|Q79755|Q79755_9HIV1, |82291298|sp|Q79754|Q79754_9HIV1, |82291297|sp|Q79753|Q79753_9HIV1, |82291296|sp|Q79752|Q79752_9HIV1, |82291295|sp|Q79751|Q79751_9HIV1, |82291294|sp|Q79750|Q79750_9HIV1, |82291293|sp|Q79749|Q79749_9HIV1, |82291292|sp|Q79748|Q79748_9HIV1, |82291291|sp|Q79747|Q79747_9HIV1, |82291290|sp|Q79746|Q79746_9HIV1, |82291289|sp|Q79745|Q79745_9HIV1, |82291288|sp|Q79744|Q79744_9HIV1, |82291287|sp|Q79743|Q79743_9HIV1, |82291286|sp|Q79742|Q79742_9HIV1, |82291285|sp|Q79741|Q79741_9HIV1, |82291284|sp|Q79740|Q79740_9HIV1, |82291283|sp|Q79739|Q79739_9HIV1, |82291282|sp|Q79738|Q79738_9HIV1, |82291281|sp|Q79737|Q79737_9HIV1, |82291280|sp|Q79736|Q79736_9HIV1, |82291279|sp|Q79735|Q79735_9HIV1, |82291278|sp|Q79734|Q79734_9HIV1, |82291277|sp|Q79733|Q79733_9HIV1, |82291276|sp|Q79732|Q79732_9HIV1, |82291275|sp|Q79731|Q79731_9HIV1, |82291274|sp|Q79730|Q79730_9HIV1, |82291273|sp|Q79727|Q79727_9HIV1, |82291272|sp|Q79726|Q79726 _9HIV1, |82291271|sp|Q79725|Q79725_9HIV1, |82291270|sp|Q79724|Q79724_9HIV1, |82291269|sp|Q79722|Q79722_9HIV1, |82291268|sp|Q79721|Q79721_9HIV1, |82291267|sp|Q79720|Q79720_9HIV1, |82291266|sp|Q79719|Q79719_9HIV1, |82291265|sp|Q79718|Q79718_9HIV1, |82291264|sp|Q79717|Q79717_9HIV1, |82291263|sp|Q79716|Q79716_9HIV1, |82291262|sp|Q79715|Q79715_9HIV1, |82291261|sp|Q79714|Q79714_9HIV1, |82291260|sp|Q79713|Q79713_9HIV1, |82291259|sp|Q79712|Q79712_9HIV1, |82291258|sp|Q79711|Q79711_9HIV1, |82291257|sp|Q79710|Q79710_9HIV1, |82291256|sp|Q79709|Q79709_9HIV1, |82291255|sp|Q79708|Q79708_9HIV1, |82291254|sp|Q79707|Q79707_9HIV1, |82291253|sp|Q79706|Q79706_9HIV1, |82291252|sp|Q79705|Q79705_9HIV1,
57
|22858603|gb|AAN05803.1|, |22858601|gb|AAN05802.1|, |22858599|gb|AAN05801.1|, |22858597|gb|AAN05800.1|, |22858595|gb|AAN05799.1|, |22858593|gb|AAN05798.1|, |22858591|gb|AAN05797.1|, |22858589|gb|AAN05796.1|, |22858587|gb|AAN05795.1|, |22858585|gb|AAN05794.1|, |22143038|gb|AAM10917.2|, |20142335|gb|AAM10842.2|, |20126988|gb|AAM10929.1|, |20126986|gb|AAM10928.1|, |20126984|gb|AAM10927.1|, |20126982|gb|AAM10926.1|, |20126980|gb|AAM10925.1|, |20126978|gb|AAM10924.1|, |20126975|gb|AAM10923.1|, |20126973|gb|AAM10922.1|, |20126970|gb|AAM10921.1|, |20126968|gb|AAM10920.1|, |20126965|gb|AAM10919.1|, |20126963|gb|AAM10918.1|, |20126959|gb|AAM10916.1|, |20126957|gb|AAM10915.1|, |20126954|gb|AAM10914.1|, |20126949|gb|AAM10912.1|, |20126947|gb|AAM10911.1|, |20126945|gb|AAM10910.1|, |20126943|gb|AAM10909.1|, |20126941|gb|AAM10908.1|, |20126939|gb|AAM10907.1|, |20126937|gb|AAM10906.1|, |20126935|gb|AAM10905.1|, |20126933|gb|AAM10904.1|, |20126931|gb|AAM10903.1|, |20126927|gb|AAM10901.1|, 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|45360146|gb|AAS59184.1|, |82319636|sp|Q9QBZ7|Q9QBZ7_9HIV1, |82319635|sp|Q9QBZ3|Q9QBZ3_9HIV1, |82319634|sp|Q9QBY9|Q9QBY9_9HIV1, |82319633|sp|Q9QBY5|Q9QBY5_9HIV1, |82319632|sp|Q9QBY1|Q9QBY1_9HIV1, |82319066|sp|Q9IBN2|Q9IBN2_9HIV1, |82314771|sp|Q90VS7|Q90VS7_9HIV1, |82313851|sp|Q8UTJ8|Q8UTJ8_9HIV1, |82313829|sp|Q8UT04|Q8UT04_9HN1, |82309401|sp|Q5DID4|Q5DID4_9HIV1, |82309245|sp|P90297|P90297_9HIV1, |82309222|sp|P88432|P88432_9HIV1, |82308943|sp|041884|041884_9HIV1, |82308858|sp|009529|009529_9HIV1, |82308857|sp|o09527|o09527_9HIV1, |82308265|sp|Q9YPG6|Q9YPG6_9HIV1, |82307713|sp|Q9WLX9|Q9WLX9_9HIV1, |82307712|sp|Q9WLX8|Q9WLX8_9HIV1, |82307711|sp|Q9WLX7|Q9WLX7_ 9HIV1, |82307710|sp|Q9WLX6|Q9WLX6_9HIV1, |82307709|sp|Q9WLX5|Q9WLX5_9HIV1, |82307708|sp|Q9WLX4|Q9WLX4_9HIV1, |82307707|sp|Q9WLX3|Q9WLX3_9HIV1, |82307706|sp|Q9WLX2|Q9WLX2_9HIV1, |82307705|sp|Q9WLXl|Q9WLXl_9HIV1, |82307704|sp|Q9WLX0|Q9WLX0_9HIV1, |82307703|sp|Q9WLW9|Q9WLW9_9HIV1, |82307692|sp|Q9WLL7|Q9WLL7_9HIV1, |82307691|sp|Q9WLL6|Q9WLL6_9HIV1, |82307223|sp|Q9WA35|Q9WA35_9HIV1, |82307127|sp|Q9W7X3|Q9W7X3_9HIV1, |82307126|sp|Q9W7X2|Q9W7X2_9HIV1, |82307125|sp|Q9W7X1|Q9W7X1_9HIV1, |82307124|sp|Q9W7X0|Q9W7X0 9HIV1, |82307121|sp|Q9W7U0|Q9W7U0_9HIV1, |82306895|sp|Q9QRB0|Q9QRB0_9HIV1, |82306571|sp|Q9QNZ7|Q9QNZ7_9HIV1, |82306241|sp|Q9QGW1|Q9QGWI_9HIV1, |82306240|sp|Q9QGW0|Q9QGW0_9HIV1, |82306239|sp|Q9QGV9|Q9QGV9_9HIV1, |82306238|sp|Q9QGV8|Q9QGV8_9HIV1, |82306237|sp|Q9QGV7|Q9QGV7_9HIV1, |82306236|sp|Q9QGV6|Q9QGV6_9HIV1, |82306235|sp|Q9QGV5|Q9QGV5_9HIV1, |82306234|sp|Q9QGV4|Q9QGV4_9HIV1, |82306233|sp|Q9QGV3|Q9QGV3_9HIV1, |82306232|sp|Q9QGV2|Q9QGV2_9HIV1, |82306231|sp|Q9QGV1|Q9QGV1_9HIV1, |82306230|sp|Q9QGV0|Q9QGV0_9HIV1, |82306229|sp|Q9QGU9|Q9QGU9_9HIV1, |82306228|sp|Q9QGU8|Q9QGU8_9HIV1, |82306227|sp|Q9QGU7|Q9QGU7_9HIV1, |82306226|sp|Q9QGU6|Q9QGU6_9HIV1, |82306225|sp|Q9QGU5|Q9QGU5_9HIV1, |82306224|sp|Q9QGU4|Q9QGU4_9HIV1, |82306223|sp|Q9QGU3|Q9QGU3_9HIV1, |82306222|sp|Q9QGU2|Q9QGU2_9HIV1, |82306221|sp|Q9QGU1|Q9QGU1_9HIV1, |82306220|sp|Q9QGU0|Q9QGU0_9HIV1, |82306219|sp|Q9QGT9|Q9QGT9_V9HIV1, |82306218|sp|Q9QGT8|Q9QGT8_9HIV1, |82306217|sp|Q9QGT7|Q9QGT7_9HIV1, |82306216|sp|Q9QGT6|Q9QGT6_9HIV1, |82305876|sp|Q9Q6I3|Q9Q6I3_9HN1, |82305874|sp|Q9Q6H7|Q9Q6H7_9HIV1, |82305873|sp|Q9Q6H0|Q9Q6H0_9HIV1, |82305872|sp|Q9Q6G4|Q9Q6G4_9HIV1, |82305416|sp|Q9JE93|Q9JE93_9HIV1, |82305415|sp|Q9JE92|Q9JE92_9HIV1, |82305414|sp|Q9JE91|Q9JE91_9HIV1, |82305413|sp|Q9JE90|Q9JE90_9HIV1, |82305412|sp|Q9JE89|Q9JE89_9HN1, |82305411|sp|Q9fE88|Q9JE88_9HIV1, |82305410|sp|Q9JE87|Q9JE87_9HIV1,
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67
|82308944|sp|O41886|O41886_9HIV1, |82308942|sp|O41881|O41881_9HIV1, |82308470|sp|Q9YYU9|Q9YYU9_9HIV1, |82308469|sp|Q9YYU8|Q9YYU8_9HIV1, |82308468|sp|Q9YYU7|Q9YYU7_9HIV1, |82308467|sp|Q9YYU6|Q9YYU6_9HIV1, |82308466|sp|Q9YYU5|Q9YYU5_9HIV1, |82308465|sp|Q9YYU4|Q9YYU4_9HIV1, |82308464|sp|Q9YYU3|Q9YYU3_9HIV1, |82308463|sp|VQ9YYU2lQ9YYU2_9HIV1, |82308429|sp|Q9YX74|Q9YX74_9HIV1, |82308428|sp|Q9YX73|Q9YX73_9HIV1, |82308427|sp|Q9YX72|Q9YX72_9HIV1, |82308426|sp|Q9YX71|Q9YX71_9HIV1, |82308377|sp|Q9YVE8|Q9YVE8_9HIV1, |82308355|sp|Q9YV13|Q9YV13_9HIV1, |82308353|sp|Q9YV07|Q9YV07_9HIV1, |82308351|sp|Q9YUZ9|Q9YUZ9_9HIV1, |82308278|sp|Q9YPN8|Q9YPN8_9HIV1, |82308277|sp|Q9YPN7|Q9YPN7_9HIV1, |82308276|sp|Q9YPN6|Q9YPN6_9HIV1, |82308275|sp|Q9YPN5|Q9YPN5_9HIV1,
|82308274|sp|Q9YPN4|Q9YPN4_9HIV1, |82308272|sp|Q9YPN2|Q9YPN2_9HIV1, |82308270|sp|Q9YPN0IQ9YPN0_9HIV1, |82308268|sp|Q9YPM8|Q9YPM8_9HIV1, |82308244|sp|Q9YP54|Q9YP54_9HIV1, |82308222|sp|Q9YNB9|Q9YNB9_9HIV1, |82308220|sp|Q9YNB7|Q9YNB7_9HIV1, |82307984|sp|Q9WSF2|Q9WSF2_9HIV1, |82308243|sp|Q9YP53_9HIV1, |82308273|sp|Q9YPN3|Q9YPN3_9HIV1, |82308271|sp|Q9YPN1|Q9YPN1_9HIV1, |82308269|sp|Q9YPM9|Q9YPM9_9HIV1, |82308267|sp|Q9YPM7|Q9YPM7_9HIV1, |82308223|sp|Q9YNC0|Q9YNC0_9HIV1, |82308221|sp|Q9YNB8|Q9YNB8_9HIV1, |82308219|sp|Q9YNA3|Q9YNA3_9HIV1, |82307982|sp|Q9WSE3|Q9WSE3_9HIV1, |82307973|sp|Q9WS44|Q9WS44_9HIV1, |82307899|sp|Q9WQH3|Q9WQH3_9HIV1, |82307731|sp|Q9WM29|Q9WM29_9HIV1, |82307729|sp|Q9WM27|Q9WM27_9HIV1, |82307727|sp|Q9WM25|Q9WM25_9HIV1, |82307725|sp|Q9WM23|Q9WM23_9HIV1, |82307723|sp|Q9WM21|Q9WM21_9HIV1, |82307721|sp|Q9WM19|Q9WM19_9HIV1, |82307719|sp|Q9WM17|Q9WM17_9HIV1, |82307901|sp|Q9WQI1|Q9WQI1_9HIV1, |82307732|sp|Q9WM30|Q9WM30_9HIV1, |82307730|sp|Q9WM28|Q9WM28_9HIV1, |82307728|sp|Q9WM26|Q9WM26_9HIV1, |82307726|sp|Q9WM24|Q9WM24_9HIV1, |82307724|sp|Q9WM22|Q9WM22_9HIV1 |82307722|sp|Q9WM20|Q9WM20_9HIV1, |82307720|sp|Q9WM18|Q9WM18_9HIV1, |82307718|sp|Q9WM16|Q9WM16_9HIV1, |82307696|sp|Q9WLM7|Q9WLM7_9HIV1, |82307694|sp|Q9WLM5|Q9WLM5_9HIV1, |82307687|sp|Q9WLH2|Q9WLH2_9HIV1, |82307574|sp|Q9WK41|Q9WK41_9HIV1, |82307572|sp|Q9WK39|Q9WK39_9HIV1, |82307545|sp|Q9WJR3|Q9WJR3_9HIV1, |82307539|sp|Q9WIT1|Q9WIT1_9HIV1, |82307276|sp|Q9WC70|Q9WC70_9HIV1,|82307695|sp|Q9WLM6|Q9WLM6_9HIV1, |82307693|sp|Q9WLM4|Q9WLM4_9HIV1, |82307686|sp|Q9WLG9|Q9WLG9_9HIV1, |82307573|sp|Q9WK40|Q9WK40_9HIV1, |82307571|sp|Q9WK38|Q9WK38_9HIV1, |82307542|sp|Q9WIU1|Q9WIU1_9HIV1, |82307535|sp|Q9WIS2|Q9WIS2_9HIV1, |82307274|sp|Q9WC61|Q9WC61_9HIV1, |82307187|sp|Q9W9D3|Q9W9D3_9HIV1, |82307111|sp|Q9QST2|Q9QST2_9HIV1, |82307107|sp|Q9QSR5|Q9QSR5_9HIV1, |82306567|sp|Q9QNX6|Q9QNX6_9HIV1, |82306522|sp|Q9QMK7|Q9QMK7_9HIV1, |82305929|sp|Q9Q6Y5|Q9Q6Y5_9HIV1, |82305924|sp|Q9Q6V7|Q9Q6V7_9HIV1, |82305871|sp|Q9Q5H6|Q9Q5H6_9HIV1,|82307113|sp|Q9QSU1|Q9QSU1_9HIV1, |82307109|sp|Q9QSS3|Q9QSS3_9HIV1, |82307105|sp|Q9QSQ6|Q9QSQ6_9HIV1, |82306524|sp|Q9QML5|Q9QML5_9HIV1, |82306495|sp|Q9QM82|Q9QM82_9HIV1, |82305927|sp|Q9Q6W8|Q9Q6W8_9HIV1, |82305922|sp|Q9Q6U9|Q9Q6U9_9HIV1, |82305870|sp|Q9Q5H5|Q9Q5H5_9HIV1, |82305869|sp|Q9Q5H4|Q9Q5H4_9HIV1, |82305867|sp|Q9Q5H2|Q9Q5H2_9HIV1,|82305868|sp|Q9Q5H3|Q9Q5H3_9HIV1, |82305866|sp|Q9Q5H1|Q9Q5H1_9HIV1, |82305865|sp|Q9Q5H0|Q9Q5H0_9HIV1truncada, |82305864|sp|Q9Q5G9|Q9Q5G9_9HIV1truncada, |82305863|sp|Q9Q5G8|Q9Q5G8_9HIV1, |82305862|sp|Q9Q5G7|Q9Q5G7_9HIV1, |82305861|sp|Q9Q5G6|Q9Q5G6_9HIV1, |82305860|sp|Q9Q5G5|Q9Q5G5_9HIV1, |82305859|sp|Q9Q5G4|Q9Q5G4_9HIV1, |82305858|sp|Q9Q5G3|Q9Q5G3_9HIV1, |82305857|sp|Q9Q5G2|Q9Q5G2_9HIV1 |82305856|sp|Q9Q5G1|Q9Q5G1_9HIV1, |82305855|sp|Q9Q5G0|Q9Q5G0_9HIV1, |82305854|sp|Q9Q5F9|Q9Q5F9_9HIV1, |82305853|sp|Q9Q5F8|Q9Q5F8_9HIV1, |82305852|sp|Q9Q5F7|Q9Q5F7_9HIV1, |82305851|sp|Q9Q5F6|Q9Q5F6_9HIV1 truncada, |82305850|sp|Q9Q5F5|Q9Q5F5_9HIV1 truncada, |82305849|sp|Q9Q5F4|Q9Q5F4_9HIV1 truncada, |82305848|sp|Q9Q5F3|Q9Q5F3_9HIV1 truncada, |82305847|sp|Q9Q5F2|Q9Q5F2_9HIV1, |82305845|sp|Q9Q5F0|Q9Q5F0_9HIV1, |82305843|sp|Q9Q5E8|Q9Q5E8_9HIV1, |82305841|sp|Q9Q5E6|Q9Q5E6|_9HIV1, |82305839|sp|Q9Q5E4|Q9Q5E4_9HIVI, |82305837|sp|Q9Q5E2|Q9Q5E2_9HIV1,|82305846|sp|Q9Q5F1|Q9Q5F1_9HIV1, |82305844|sp|Q9Q5E9|Q9Q5E9_9HIV1, |82305842|sp|Q9Q5E7|Q9Q5E7_9HIV1, |82305840|sp|Q9Q5E5|Q9Q5E5_9HIV1, |82305838|sp|Q9Q5E3|Q9Q5E3_9HIV1,
72
- |82296655|sp|Q8AQV6|Q8AQV6_9HIV1,
- |82296653|sp|Q8AQU7|Q8AQU7_9HIV1,
- |82296651|sp|Q8AQT8|Q8AQT8_9HIV1,
- |82296649|sp|Q8AQS9|Q8AQS9_9HIV1,
- |82296647|sp|Q8AQS0|Q8AQS0_9HIV1,
- |82296646|sp|Q8AQR9|Q8AQR9_9HIV1,
- |82296645|sp|Q8AQR8|Q8AQR8_9HIV1,
- |82296644|sp|Q8AQR7|Q8AQR7_9HIV1,
- |82296643|sp|Q8AQR6|Q8AQR6_9HIV1,
- |82296642|sp|QBAQR5|Q8AQR5_9HIV1,
- |82296641|sp|Q8AQR4|Q8AQR4_9HIV1,
- |82296640|sp|Q8AQR3|Q8AQR3_9HIV1,
- |82296639|sp|Q8AQR2|Q8AQR2_9HIV1,
- |82296638|sp|Q8AQR1|Q8AQR1_9HIV1,
- |82296637|sp|Q8AQR0|Q8AQR0_9HIV1,
- |82296636|sp|Q8AQQ9|Q8AQQ9_9HIV1,
- |82296635|sp|Q8AQQ8|Q8AQQ8_9HIV1,
- |82296634|sp|Q8AQQ7|Q8AQQ7_9HIV1,
- |82296633|sp|Q8AQQ6|Q8AQQ6_9HIV1,
- |82296632|sp|Q8AQQ5lQ8AQQ5_9HIV1,
- |82296631|sp|Q8AQQ4|Q8AQQ4_9HIV1,
- |82296630|sp|Q8AQQ3|Q8AQQ3_9HIV1,
- |82296629|sp|Q8AQQ2|Q8AQQ2_9HIV1,
- |82296628|sp|Q8AQQ1|Q8AQQ1_9HIV1,
- |82296627|sp|Q8AQQ0|Q8AQQ0_9HIV1,
- |82296626|sp|Q8AQP9|Q8AQP9_9HIV1,
- |82296625|sp|Q8AQP8|Q8AQP8_9HIV1,
- |82296623|sp|Q8AQP6|Q8AQP6_9HIV1,
- |82296622|sp|Q8AQP5|Q8AQP5_9HIV1,
- |82296621|sp|Q8AQP4|Q8AQP4_9HIV1,
- |82296620|sp|Q8AQP3|Q8AQP3_9HIV1,
- |82296619|sp|Q8AQP2|Q8AQP2_9HIV1,
- |82296618|sp|Q8AQP1|Q8AQP1_9HIV1,
- |82296617|sp|Q8AQP0|Q8AQP0_9HIV1,
- |82296616|sp|Q8AQN9|Q8AQN9_9HIV1,
- |82296615|sp|Q8AQN8|Q8AQN8_9HIV1,
- |82296613|sp|Q8AQN6|Q8AQN6_9HIV1,
- |82296612|sp|QBAQN5|Q8AQN5_9HIV1,
- |82296611|sp|Q8AQN4|Q8AQN4_9HIV1,
- |82296610|sp|Q8AQN3|Q8AQN3_9HIV1,
- |82296609|sp|Q8AQN2|Q8AQN2_9HIV1,
- |82296608|sp|Q8AQN1|Q8AQN1_9HIV1,
- |82296607|sp|Q8AQNO|Q8AQNO_9HIV1,
- |82296606|sp|Q8AQM9|Q8AQM9_9HIV1,
- |82296605|sp|Q8AQM8|Q8AQM8_9HIV1,
- |82296604|sp|Q8AQM7|Q8AQM7_9HIV1,
- |82296603|sp|Q8AQM6|Q8AQM6_9HIV1,
- |82296602|sp|QBAQM5|Q8AQM5_9HIV1,
- |82296601|sp|Q8AQM4|Q8AQM4_9HIV1,
- |82296600|sp|Q8AQM3|Q8AQM3_9HIV1,
- |82296599|sp|Q8AQM2|Q8AQM2_9HIV1,
- |82296370|sp|Q8AMH4|Q8AMH4_9HIV1,
- |82296369|sp|Q8AMH3|Q8AMH3_9HIV1,
- |82296368|sp|Q8AMH2|Q8AMH2_9HIV1,
- |82296367|sp|Q8AMH1|Q8AMH2_9HIV2,
- |82296366|sp|Q8AMH0|Q8AMH0_9HIV1,
- |82296365|sp|Q8AMG9|Q8AMG9_9HIV1,
- |82296364|sp|Q8AMG8|Q8AMG8_9HIV1,
- |82296363|sp|Q8AMG7|Q8AMG7_9HIV1,
- |82296362|sp|Q8AMG6|Q8AMG6_9HIV1,
- |82296361|sp|Q8AMG5|Q8AMG5_9HIV1,
- |82296360|sp|Q8AMG4|Q8AMG4_9HIV1,
- 82296359|sp|Q8AMG3|Q8AMG3_9HIV1,
- |82296358|sp|Q8AMG2|Q8AMG2_9HIV1,
- |82296357|sp|Q8AMG1|Q8AMG1_9HIV1,
- |82296356|sp|Q8AMG0|Q8AMG0_9HIV1,
- |82296355|sp|Q8AMF9|Q8AMF9_9HIV1,
- |82296354|spvQ8AMF8|Q8AMF8_9HIV1,
- |82296353|sp|Q8AMF7|Q8AMF7_9HIV1,
- |82296352|sp|Q8AMF6|Q8AMF6_9HIV1,
- |82296351|sp|Q8AMF5|Q8AMF5_9HIV1,
- |82296350|sp|Q8AMF4|Q8AMF4_9HIV1,
- |82296349|sp|Q8AMF3|Q8AMF3_9HIV1,
- |82296348|sp|Q8AMF2|Q8AMF2_9HIV1,
- |82296347|sp|Q8AMF1|Q8AMF1_9HIV1,
- |82296346|sp|Q8AMF0|Q8AMF0_9HIV1,
- |82296345|sp|Q8AME9|Q8AME9_9HIV1,
- |82296344|sp|Q8AME8|Q8AME8_9HIV1,
- |82296343|sp|Q8AME7|Q8AME7_9HIV1,
- |82296342|sp|Q8AME6|Q8AME6_9HIV1,
- |82296341|sp|Q8AME5|Q8AME5_9HIV1,
- |82296340|sp|Q8AMB4|Q8AMB4_9HIV1,
- |82296339|sp|Q8AME3|Q8AME3_9HIV1,
- |82296338|sp|Q8AME2|Q8AME2_9HIV1,
- |82296337|sp|Q8AME1|Q8AME1_9HIV1,
- |82296336|sp|Q8AME0|Q8AME0_9HIV1,
- |82296335|sp|Q8AMD9|Q8AMD9_9HIV1,
- |82296334|sp|Q8AMD8|Q8AMD8_9HIV1,
- |82296241|sp|Q8AK08|Q8AK08_9HIV1,
- |82296239|sp|Q8AJZ9|Q8AJZ9_9HIV1,
- |82295651|sp|Q8AF20|Q8AF20_9HIV1,
- |82295605|sp|Q8AE73|Q8AE73_9HIV1,
- |82295602|sp|Q8AE65|Q8AE65_9HIV1,
- |82295599|sp|Q8AE57|Q8AE57_9HIV1,
- |82295596|sp|Q8AE49|Q8AE49_9HIV1,
- |82295593|sp|Q8AE41|Q8AE41_9HIV1,
- |82295590|sp|Q8AE33|Q8AE33_9HIV1,
- |82295587|sp|Q8AE25|Q8AE25_9HIV1,
- |82295584|sp|Q8AE16|Q8AE16_9HIV1,
- |82295581|sp|Q8AE08|Q8AE08_9HIV1,
- |82295578|sp|Q8AE00|Q8AE00_9HIV1,
- |82295575|sp|Q8ADZ2|Q8ADZ2_9HIV1,
- |82295572|sp|Q8ADY4|Q8ADY4_9HIV1,
- |82295569|sp|Q8ADX6|Q8ADX6_9HIV1,
- |82295566|sp|Q8ADW8|Q8ADW8_9HIV1,
- |82295563|sp|QBADW0|Q8ADW0_9H1V1,
- |82295560|sp|Q8ADV2|Q8ADV2_9HIV1,
- |82295557|sp|Q8ADU4|Q8ADU4_9HIV1,
- |82295554|sp|Q8ADT6|Q8ADT6_9HIV1,
- |82295551|sp|Q8ADS8|Q8ADS8_9HIV1,
- |82295548|sp|QBADS0|Q8ADS0_9HIV1,
- |82295545|sp|Q8ADR2|Q8ADR2_9HIV1,
- |82295542|sp|Q8ADQ4|Q8ADQ4_9HIV1,
- |82295539|sp|Q8ADP6|Q8ADP6_9HIV1,
- |82295536|sp|Q8ADN8|Q8ADN8_9HIV1,
- |82295533|sp|Q8ADN0|Q8ADN0_9HIV1truncada,
- |82295531|sp|Q8ADM2|Q8ADM2_9HIV1,
- |82295528|sp|Q8ADL4|Q8ADL4_9HIV1,
- |82295523|sp|Q8ADJ8|Q8ADJ8_9HIV1,
- |82295520|sp|Q8ADJ0|Q8ADJ0_9HIV1,
- |82295514|sp|Q8ADI2|Q8ADI2_9HIV1,
- |82295511|sp|Q8ADH4|Q8ADH4_9HIV1,
- |82295508|sp|Q8ADG6|Q8ADG6_9HIV1,
- |82295505|sp|Q8ADF8|Q8ADF8_9HIV1,
- |82295502|sp|Q8ADF0|Q8ADF0_9HIV1,
- |82295499|sp|Q8ADE2|Q8ADE2_9HIV1,
- |82295496|sp|Q8ADD4|Q8ADD4_9HIV1,
- |82295493|sp|Q8ADC6|Q8ADC6_9HIV1,
- 8|2295490|sp|Q8ADB8|Q8ADB8_9HIV1,
- |82295487|sp|Q8ADB0|Q8ADB0_9HIV1,
77
|82284350|sp|Q69GP3|Q69GP3_9HIV1, |82284348|sp|Q69GN4|Q69GN4_9HIV1, |82284346|sp|Q69GM5lQ69GM5_9HIV1, |82283879|sp|Q673V6|Q673V6_9HIV1, |82283877|sp|Q673U3|Q673U3_9HIV1, |82283875|sp|Q672U2|Q672U2_9HIV1, |82283873|sp|Q672T4|Q672T4_9HIV1, |82283871|sp|Q672S7|Q672S7_9HIV1, |82283869|sp|Q672R9|Q672R9_9HIV1, |82283827|sp|Q66TT3|Q66TT3_9HIV1, |82283825|sp|Q66TS3|Q66TS3_9HIV1, |82283823|sp|Q66TR5|Q66TR5_9HIV1, |82283821|sp|Q66TQ5|Q66TQ5_9HIV1, |82283280|sp|Q5UEH3|Q5UEH3_9HIV1, |82283278|sp|Q5UEG4|Q5UEG4_9HIV1, |82283276|sp|Q5U9B8|Q5U9B8_9HIV1, |82283274|sp|Q5U9A9|Q5U9A9_9HIV1, |82283272|sp|Q5U9A1|Q5U9A1_9HIV1, |82283270|sp|Q5U992|Q5U992_9HIV1, |82283268|sp|Q5U984|Q5U984_9HIV1, |82283266|sp|Q5U977|Q5U977_9HIV1, |82283264|sp|Q5U968|Q5U968_9HIV1, |82283263|sp|Q5U967|Q5U967_9HIV1, |82283261|sp|Q5U960|Q5U960_9HIV1, |82283259|sp|Q5U944|Q5U944_9HIV1, |82283257|sp|Q5U937|Q5U937_9HIV1, |82283256|sp|Q5U8K4|Q5U8K4_9HIV1, |82283254|sp|Q5U8J5|Q5U8J5_9HIV1, |82283252|sp|Q5U8I6|Q5U8I6_9HIV1, |82283250|sp|Q5U8H7|Q5U8H7_9HIV1, |82283248|sp|Q5U8G8|Q5U8G8_9HIV1, |82283246|sp|Q5U8F9|Q5U8F9_9HIV1, |82283244|sp|Q5U8F0|Q5U8F0_9HIV1, |82283241|sp|Q5U8D2|Q5U8D2_9HIV1, |82283239|sp|Q5U8C3|Q5U8C3_9HIV1, |82283237|sp|Q5U8B4|Q5U8B4_9HIV1, |82283235|sp|Q5U8A5|Q5U8A5_9HIV1, |82283233|sp|Q5U896|Q5U896_9HIV1, |82283231|sp|Q5U887|Q5U887_9HIV1, |82283229|sp|Q5U878|Q5U878_9HIV1, |82283205|sp|Q5SFQ1|Q5SFQ1_9HIV1, |82283204|sp|Q5S3F8|Q5S3F8_9HIV1, |82283203|sp|Q5S3F7|Q5S3F7_9HIV1, |82283202|sp|Q5S3F6|Q5S3F6_9HIV1, |82283201|sp|Q5S3F7|Q5S3F7_9HIV1, |82283202|sp|Q5S3F6|Q5S3F6_9HIV1, |82283201|sp|Q5S3F5vQ5S3F5_9HIV1, |82283200|sp|Q5S3F4|Q5S3F4_9HIV1, |82283199|sp|Q5S3F3|Q5S3F3_9HIV1, |82283198|sp|Q5S3F2|Q5S3F2_9HIV1, |82283197|sp|Q5S3F1|Q5S3F1_9HIV1, |82283196|sp|Q5S3E9|Q5S3E9_9HIV1, |82283195|sp|Q5S3E8|Q5S3E8_9HIV1, |82283194|sp|Q5S3E7|Q5S3E7_9HIV1, |82283193|sp|Q5S3E6|Q5S3E6_9HIV1, |82283192|sp|Q5S3E5|QS53E5_9HIV1, |82283191|sp|Q5S3E4|Q5S3E4_9HIV1, |82283190|sp|Q5S3E2|Q5S3E2_9HIV1, |82283189|sp|Q5S3E1|Q5S3E1_9HIV1, |82283188|sp|Q5S3E0|Q5S3E0_9HIV1, |82283187|sp|Q5S3D9|Q5S3D9_9HIV1, |82283186|sp|Q5S3D8|Q5S3D8_9HIV1, |82283185|sp|Q5S3D7|Q5S3D7_9HIV1, |82283184|sp|Q5S3D6|Q5S3D6_9HIV1, |82283183|sp|Q5S3D4|Q5S3D4_9HIV1, |82283182|sp|Q5S3D2|Q5S3D2_9HIV1, |82283181|sp|Q5S3D1|Q5S3D1_9HIV1, |82283180|sp|Q5S3D0|Q5S3D0_9HIV1, |82283179|sp|Q5S3C8|Q5S3C8_9HIV1, |82283178|sp|Q5S3C7|Q5S3C7_9HIV1, |82283177|sp|Q5S3C6|Q5S3C6_9HIV1, |82283176|sp|Q5S3C5|Q5S3C5_9HIV1, |82283175|sp|Q5S3C3|Q5S3C3_9HIV1, |82283174|sp|Q5S3C2|Q5S3C2_9HIV1, |82283173|sp|Q5S3B9|Q5S3B9_9HIV1, |82283172|sp|Q5S3B7|Q5S3B7_9HIV1, |82283171|sp|Q5S3B2|Q5S3B2_9HIV1, |82283170|sp|Q5S3B0|Q5S3B0_9HIV1, |82283169|sp|Q5S3A9|Q5S3A9_9HIV1, |82283168|sp|Q5S3A8|Q5S3A8_9HIV1, |82283167|sp|Q5S3A7|Q5S3A7_9HIV1, |82283166|sp|Q5S3A6|Q5S3A6_9HIV1, |82283165|sp|Q5S3A5|Q5S3A5_9HIV1, |82283164|sp|Q5S3A3|Q5S3A3_9HIV1, |82283163|sp|Q5S3A2|Q5S3A2_9HIV1, |82283162|sp|Q5S3A1|Q5S3A1_9HIV1, |82283161|sp|Q5S3A0|Q5S3A0_9HIV1, |82283160|sp|Q5S397|Q5S397_9HIV1, |82283159|sp|Q5S396|Q5S396_9HIV1, |82283158|sp|Q5S395|Q5S395_9HIV1, |82283157|sp|Q5S394|Q5S394_9HIV1, |82283156|sp|Q5S393|Q5S393_9HIV1, |82283155|sp|Q5S392|Q5S392_9HIV1, |82283154|sp|Q5S391|Q5S391_9HIV1, |82283153|sp|Q5S389|Q5S389_9HIV1, |82283152|sp|Q5S387|Q5S387_9HIV1, |82283151|sp|Q5S385|Q5S385_9HIV1, |82283150|sp|Q5S384|Q5S384_9HIV1, |82283149|sp|Q5S383|Q5S383_9HIV1, |82283148|sp|Q5S382|Q5S382_9HIV1, |82283147|sp|Q5S380|Q5S380_9HIV1, |82283146|sp|Q5S377|Q5S377_9HIV1, |82283145|sp|Q5S374|Q5S374_9HIV1, |82283144|sp|Q5S371|Q5S371_9HIV1, |82283143|sp|Q5S370|Q5S370_9HIV1, |82283142|sp|Q5S369|Q5S369_9HIV1, |82283141|sp|Q5S367|Q5S367_9HIV1, |82283140|sp|Q5S366|Q5S366_9HIV1, |82283139|sp|Q5S365|Q5S365_9HIV1, |82283138|sp|Q5S364|Q5S364_9HIV1, |82283137|sp|Q5S363|Q5S363_9HIV1, |82283136|sp|Q5S362|Q5S362_9HIV1, |82283135|sp|Q5S360|Q5S360_9HIV1, |82283134|sp|Q5S359|Q5S359_9HIV1, |82283133|sp|Q5S358|Q5S358_9HIV1, |82283132|sp|Q5S357|Q5S357_9HIV1, |82283131|sp|Q5S356|Q5S356_9HIV1, |82283130|sp|Q5S355|Q5S355_9HIV1, |82283129|sp|Q5S354|Q5S354_9HIV1, |82283128|sp|Q5S353|Q5S353_9HIV1, |82283127|sp|Q5S352|Q5S352_9HIV1, |82283126|sp|Q5S350|Q5S350_9HIV1, |82283125|sp|Q5S349|Q5S349_9HIV1, |82283124|sp|Q5S348|Q5S348_9HIV1, |82283123|sp|Q5S346|Q5S346_9HIV1, |82283122|sp|Q5S344|Q5S344_9HIV1, |82283121|sp|Q5S342|Q5S342_9HIV1, |82283120|sp|Q5S341|Q5S341_9HIV1, |82283119|sp|Q5S338|Q5S338_9HIV1, |82283118|sp|Q5S337|Q5S337_9HIV1,
82
- |37496504|emb|CAD48460.1|,
- |37496496|emb|CAD48453.1|, |37496488|emb|CAD48446.1|,
- |32399672|emb|CAD58651.1|,
- |32399664|emb|CAD58642.1|, |18074007|emb|CAC86572,1|,
- |18073417|emb|CAC88007.1|,
- |18073407|emb|CAC87998.1|, |15209258|emb|CAC51037.1|,
- |14041644|emb|CAC38428.1|,
- |14041634|emb|CAC38437.1|, |9368387|emb|CAB98176,1|,
- |9368377|emb|CAB98194.1|,
- |7657897|emb|CAB89151,1|, |7452917|emb|CAB86382.1|,
- |7452907|emb|CAB86373.1|,
- |7321152|emb|CAB82234.1|, |7321142|emb|CAB82225.1|,
|5738574|emb|CAB53050.1|, |4539057|emb|CAB39746.1|, |4539042|emb|CAB39924.1|, |59895879|gb|AAX11319.1|, |59895877|gb|AAX11318.1|, |59895875|gb|AAX11317.1|, |59895873|gb|AAX11316.1|, |59895870|gb|AAX11315.1|, |59895868|gb|AAX11314.1|, |59895864|gb|AAX11313.1|, |59895860|gb|AAX11312.1|, |59895858|gb|AAX11311.1|, |59895856|gb|AAX11310.1|, |59895854|gb|AAX11309.1|, |59895852|gb|AAX11308.1|, |59895849|gb|AAX11307.1|, |59895847|gb|AAX11306.1|, |59895845|gb|AAX11305.1|, |59895843|gb|AAX11304.1|, |59895841|gb|AAX11303.1|, |59895838|gb|AAX11302.1|, |59895836|gb|AAX11301.1|, |59895834|gb|AAX11300.1|, |59895832|gb|AAX11299.1|, |59895829|gb|AAX11298.1|, |59895827|gb|AAX11297.1|, |59895825|gb|AAX11296.1|, |59895823|gb|AAX11295.1|, |59895821|gb|AAX11294.1|, |59895819|gb|AAX11293.1|, |59895817|gb|AAX11292.1|, |59895815|gb|AAX11291.1|, |59895813|gb|AAX11290.1|, |59895811|gb|AAX11289.1|, |59895807|gb|AAX11288.1|, |59895805|gb|AAX11287.1|, |59895803|gb|AAX11286.1|, |59895801|gb|AAX11285.1|, |59895799|gb|AAX11284.1|, |59895797|gb|AAX11283.1|, |59895795|gb|AAX11282.1|, |59895793|gb|AAX11281.1|, |59895791|gb|AAX11280.1|, |59895789|gb|AAX11279.1|, |59895787|gb|AAX11278.1|, |59895785|gb|AAX11277.1|, |59895783|gb|AAX11276.1|, |59895778|gb|AAX11275.1|, |59895776|gb|AAX11274.1|, |59895774|gb|AAX11273.1|, |59895772|gb|AAX11272.1|, |59895770|gb|AAX11271.1|, |59895768|gb|AAX11270.1|, |59895766|gb|AAX11269.1|, |59895764|gb|AAX11268.1|, |59003675|gb|AAW83670.1|, |59003665|gb|AAW83661.1|, |59003655|gb|AAW83652.1|truncada, |59003645|gb|AAW83643.1|, |59003635|gb|AAW83634.1|, |59003625|gb|AAW83625.1|, |59003616|gb|AAW83617.1|, |59003606|gb|AAW83608.1|, |59003596|gb|AAW83599.1|, |59003586|gb|AAW83590.1|, |59003576|gb|AAW83581.1|, |59003566|gb|AAW83572.1|, |59003556|gb|AAW83563.1|, |59003546|gb|AAW83554.1|, |59003536|gb|AAW83545.1|, |59003526|gb|AAW83536.1|, |59003516|gb|AAW83527.1|, |45738228|gb|AAS75886.1|, |45738218|gb|AAS75877.1|, |7904558|gb|AAW58814.1|, |57904556|gb|AAW58813.1|, |57904554|gb|AAW58812.1|, |57904552|gb|AAW58811.1|, |57904548|gb|AAW58810.1|, |57904546|gb|AAW58809.1|, |57904544|gb|AAW58808.1|, |57904542|gb|AAW58807.1|, |57904540|gb|AAW58806.1|, |57904537|gb|AAW58805.1|, |57904535|gb|AAW58804.1|, |57904533|gb|AAW58803.1|, |57904531|gb|AAW58802.1|, |57904529|gb|AAW58801.1|, |57904527|gb|AAW58800.1|, |57338570|gb|AAW49364.1|, |57338561|gb|AAW49356.1|, |57338554|gb|AAW49350.1|, |57338547|gb|AAW49344.1|, |56609039|gb|AAW03150.1|, |56609037|gb|AAW03149.1|, |56609035|gb|AAW03148.1|, |56609033)|b|AAW03147.1|, |56609031|gb|AAW03146.1|, |56609029|gb|AAW03145.1|, |56609026|gb|AAW03144.1|, |56609024|gb|AAW03143.10|, |56609022|gb|AAW03142.1|, |56609020|gb|AAW03141.1|, |56609018|gb|AAW03140.1|, |56609016|gb|AAW03139.1|, |56609014|gb|AAW03138.1|, |56609012|gb|AAW03137.1|, |56609010|gb|AAW03136.1|, |56609008|gb|AAW03135.1|, |56609006|gb|AAW03134.1|, |56609004|gb|AAW03133.1|, |56609002|gb|AAW03132.1|, |56609000|gb|AAW03131.1|, |56608998|gb|AAW03130.1|, |56608996|gb|AAW03129.1|, |56608994|gb|AAW03128.1|, |56608992|gb|AAW03127.1|, |56608990|gb|AAW03126.1|, |56608988|gb|AAW03125.1|, |56608986|gb|AAW03124.1|, |56608984|gb|AAW03123.1|, |56608982|gb|AAW03122.1|, |56608980|gb|AAW03121.1|, |56608978|gb|AAW03120.1|, |56608976|gb|AAW03119.1|, |56608974|gb|AAW03118.1|, |56608972|gb|AAW03117.1|, |56608970|gb|AAW03116.1|, |56608968|gb|AAW03115.1|, |56608966|gb|AAW03114.1|, |56608964|gb|AAW03113.1|, |56608962|gb|AAW03112,1|, |56608960|gb|AAW03111.1|, |56608958|gb|AAW03110.1|, |56608956|gb|AAW03109.1|, |56608954|gb|AAW03108.1|, |56608952|gb|AAW03107.1|, |56608950|gb|AAW03106.1|, |56608948|gb|AAW03105.1|, |56608946|gb|AAW03104.1|, |56608944|gb|AAW03103.1|, |56608942|gb|AAW03102.1|, |56608940|gb|AAW03101.1|, |56608938|gb|AAW03100.1|, |56608936|gb|AAW03099.1|, |56608934|gb|AAW03098.1|, |56608932|gb|AAW03097.1|, |56608930|gb|AAW03096.1|, |56608928|gb|AAW03095.1|, |56608926|gb|AAW03094.1|, |56608924|gb|AAW03093.1|, |56608922|gb|AAW03092.1|, |56608920|gb|AAW03091.1|, |56608918|gb|AAW03090.1|, |56608916|gb|AAW03089.1|, |56608914|gb|AAW03088.1|, |56608912|gb|AAW03087.1|, |56608910|gb|AAW03086.1|, |56608908|gb|AAW03085.1|, |56608906|gb|AAW03084.1|, |56608904|gb|AAW03083.1|, |56608902|gb|AAW03082.1|, |56608900|gb|AAW03081.1|, |56608898|gb|AAW03080.1|, |56608896|gb|AAW03079.1|, |56608894|gb|AAW03078.1|, |56608892|gb|AAW03077.1|, |56608890|gb|AAW03076.1|, |56608888|gb|AAW03075.1|, |56608886|gb|AAW03074.1|, |56608884|gb|AAW03073.1|, |56608882|gb|0AAW03072.1|, |56608880|gb|AAW03071.1|, |56608878|gb|AAW03070.1|, |56608876|gb|AAW03069.1|, |56608874|gb|AAW03068.1|, |56608872|gb|AAW03067.1|, |56608870|gb|AAW03066.1|, |56608868|gb|AAW03065.1|, |56608866|gb|AAW03064.1|, |56608864|gb|AAW03063.1|, |56608862|gb|AAW03062.1|, |56608860|gb|AAW03061.1|, |56608858|gb|AAW03060.1|, |56608856|gb|AAW03059.1|, |56608854|gb|AAW03058.1|, |56608852|gb|AAW03057.10|, |56608850|gb|AAW03056.1|, |56608848|gb|AAW03055.1|, |56608846|gb|AAW03054.1|, |56608844|gb|AAW03053.1|, |56608842|gb|AAW03052.1|, |56608840|gb|AAW03051.1|, |56608838|gb|AAW03050.1|, |56608836|gb|AAW03049.1|, |56608834|gb|AAW03048.1|, |56608832|gb|AAW03047.1|, |56608830|gb|AAW03046.1|, |56608828|gb|AAW03045.1|, |56608826|gb|AAW03044.1|, |56608824|gb|AAW03043.1|, |56608822|gb|AAW03042.1|, |56608820|gb|AAW03041.1|, |56608818|gb|AAW03040.1|, |56608816|gb|AAW03039.1|, |56608814|gb|AAW03038.1|, |56608812|gb|AAW03037.1|, |56608810|gb|AAW03036.1|, |56608808|gb|AAW03035.1|, |55925143|gb|AAV67947.1|, |55925135|gb|AAV67940.1|, |55925127|gb|AAV67933.1|, |55925119|gb|AAV67926.1|, |51572130|gb|AAU06777.1|, |51572120|gb|AAU06768.1|, |51572111|gb|AAU06760.1| |51572102|gb|AAU06752.1|, |47060062|gb|AAT09648.1|, |49472956|gb|AAT66298.1|, |49472947|gb|AAT66290.1|, |49472939|gb|AAT66283.1|, |49472930|gb|AAT66275.1|, |37682607|gb|AAQ98287.1|, |37682597|gb|AAQ98278.1|, |37682587|gb|AAQ98269.1|, |37682577|gb|AAQ98260.1|, |37682568|gb|AAQ98252.1| , |37682558|gb|AAQ98243.1|, |37682548|gb|AAQ98234.1|, |37682538|gb|AAQ98225.1|, |37682528|gb|AAQ98216.1|,
87
HAL-B
92
HLA-DRB2-9
97
IgG1 (en ratones) e IgG2b. Ambas respuestas son antagónicas con IFN-γ y IL-10 desregulando la producción de la otra.
Todos los experimentos descritos a continuación se llevaron a cabo en duplicado.
Materiales y métodos
Péptidos y proteínas recombinantes
Todos los polipéptidos utilizados en este estudio (es decir, P1: VPR aa 51 a 80 (SEQ ID 1); P2: VIF: aa 142 a 181 (SEQ ID 2); P3: REV aa 69 a 95 (SEQ ID 3); P4: NEF: aa 81 a 123 (ID SEC 4); y NRP: un polipéptido no relevante de control se sintetizaron mediante química de Fmoc y se resuspendieron en DMSO al 10% en PBS.
Las proteínas VIF recombinantes de VIH-1 (ref: EVA659), REV (fusión His-tag; ref: ARP663.2) y NEF (ref: EVA650) se obtuvieron del Depósito de reactivos de VIH (NIBSC, UK). Las preparaciones de proteína se mezclaron en cantidades equimolares en PBS a 1 mg/ml y se almacenaron a -80°C hasta uso.
Estirpes celulares
Las estirpes celulares T1 y JURKAT son estirpes linfoblastoides humanas derivadas de HLA-A*0201 que llevan y no llevan individuos respectivamente. T1 se mantuvo en medio IMDM (Invitrogen), mientras que JURKAT se mantuvo en medio RPMI-1640 (Sigma) que contenía HEPES 10 mM y piruvato de sodio 1 mM. Ambos medios se suplementaron con 50 UI/50 mg/ml de penicilina/estreptomicina (Sigma) y, como medio completo, FCS al 10%. Los cultivos de células se mantuvieron a 37°C en una atmósfera humidificada de CO2 al 5%.
Los esplenocitos primarios se mantuvieron en medio IMDM (Invitrogen) suplementado con βmercaptoetanol 0.02 mM (Sigma), 50 IU/50 mg/ml de penicilina/estreptomicina (Sigma) y FCS al 10% (Sigma) a 37°C en una atmósfera humidificada de CO2 al 5%.
Preparación de células objetivo para análisis de citoquinas
Los cultivos de células en fase exponencial se recogieron mediante centrifugación (250 g, 5 min) y se resuspendieron a una densidad de 106 células/ml en medio libre de suero. Las alícuotas de las suspensiones de células se transfectaron con una serie de antígenos de polipéptidos en una concentración de 5 µg por 106 células utilizando Lipofectina (Invitrogen) de acuerdo con las instrucciones del fabricante y se incubaron en medio completo durante 8 a 10 horas antes del tratamiento con Mitomicina C (MMC).
Para el tratamiento con MMC, las células se recogieron mediante centrifugación (250 g, 5 min) y se resuspendieron en medio IMDM libre de suero que contenía 50 µg/ml de Mitomicina C (Sigma). Después de 45 min de incubación a 37°C, las suspensiones celulares se lavaron cuatro veces en medio IMDM libre de suero (250 g, 5 min) y finalmente se resuspendieron en medio IMDM completo.
Inmunizaciones
Se inmunizaron ratones C57BL/6-Tg(HLA-A2.1)1Enge/J de siete a diez semanas de edad (HLA-A*0201 transgénico en un fondo C57/BL6, Jackson Labs) por vía intradérmica con una dosis de 100 µl (suministrada en 5 sitios a 20 µl/sitio) por ratón de la preparación de antígeno. En el grupo de prueba, cada dosis de preparación de antígeno contenía 40 nmol de una mezcla equimolar de los cuatro péptidos (VIH-V) (10 nmol de cada uno) y 0.5 nmol de Subunidad de Toxina de Cólera B (> 99% puro, BioMol) y se preparó en Lipofectina (Invitrogen) de acuerdo con las instrucciones del fabricante. En el grupo de control, cada dosis de la preparación de antígeno contenía 40 nmol del polipéptido no relevante y 0.5 nmol de Subunidad de Toxina del Cólera B (> 99% puro, BioMol) y se preparó en Lipofectina (Invitrogen) de acuerdo con las instrucciones del fabricante.
En el día 14 después de inmunización, todos los animales recibieron una inmunización de refuerzo utilizando las mismas dosis y ruta de suministro como se utilizó originalmente. Finalmente, en el día 21 o 22, todos los animales fueron sacrificados y se recolectaron sus bazos.
El protocolo de inmunización se puede representar esquemáticamente como sigue:
102
Tabla 3
- ∆ IFN-γ a Lys (pg/ml)
- NRP VIH-v
- Con A
- 2345.3 ± 45.9 2711.1 ± 44.5
- Péptido de VIH 3 (sol)
- 976.3 ± 10.5 2027.5 ± 8.0
- Pep T1-VIH 3 (pro)
- 172.2 ± 40.2 329.3 ± 10.5
- Pep Ju-VIH 3 (pro)
- < 39 <39
- Nota: “Lys” significa el fondo de control negativo sobre el que se calculan todos los valores. “Sol” significa péptido soluble presentado a la población de esplenocitos primaria. “Pro” significa que el péptido se presenta en complejo con las moléculas de células HLA luego del procesamiento interno y la carga de los epítopos resultantes sobre las moléculas de MHC. Los valores representan el promedio ± error estándar de la ∆ IFN-γ a Lys (pg/ml).
Los cultivos de esplenocitos primarios de los animales transgénicos utilizados aquí contienen diferentes poblaciones de células T (CD8+ y CD4+) capaces de responder al antígeno presentado en el contexto de moléculas MHC de ratón y humano y presentes en la población de APC de ratón también se encuentran en estos cultivos. Después de vacunación, los epítopos derivados de P3 de la Clase I y Clase II se pueden haber presentados a las células T CD8+ y CD4+. Como el número de moléculas HLA-A*0201 en los APCs de ratón sólo representan una pequeña fracción del número total de moléculas de MHC presentes (es decir, todas las moléculas de H2-D más las moléculas de HLA-A*0201), sólo una fracción del antígeno de P3 total suministrado estaría disponible a las células T CD8+ con una especificidad para HLA-A*0201. In vivo como in vitro, la intensidad de la respuesta de células T depende principalmente de la disponibilidad de antígeno. Por lo tanto, en una situación donde sería intensa competencia entre las moléculas de MHC de los epítopos P3, se deduce que aquellas moléculas que representan una pequeña fracción de la población serían responsables sólo por una pequeña fracción de la respuesta IFN-γ total.
Reactividad del péptido 4
De manera similar a P1, se puede observar el aumento de la producción de IFN-γ en el VIH-v en comparación con grupos inmunizados con NRP cuando P4 se agrega simplemente al cultivo de esplenocitos, así como cuando se presenta a través de estirpes celulares humanas transfectadas (véase la Figura 4, cuyos datos se establecen en la Tabla 4 a continuación). Como las causas de estas observaciones ya se han explicado para el caso de P1 no se desarrollarán más ampliamente aquí y uno de ellos se refiere a la sección anterior.
Tabla 4
- ∆ IFN-γ a Lys (pg/ml)
- NRP VIH-v
- Con A
- 2345.3 ± 45.9 2711.1 ± 44.5
- Péptido de VIH 4 (sol)
- 112.2 ± 2.0 141.6 ± 7.0
- Pep T1-VIH 4 (pro)
- 391.9 ± 25.7 1843.8 ± 15.5
- Pep Ju-VIH 4 (pro)
- < 39 62.5 ± 5.8
- Nota: “Lys” significa el fondo de control negativo sobre el que se calculan todos los valores. “Sol” significa péptido soluble presentado a la población de esplenocitos primaria. “Pro” significa que el péptido se presenta en complejo con las moléculas de células HLA luego del procesamiento interno y la carga de los epítopos resultantes sobre las moléculas de MHC. Los valores representan el promedio ± error estándar de la ∆ IFN-γ a Lys (pg/ml).
Reactividad a proteínas recombinantes de VIH
Hasta ahora, los experimentos aquí descritos han demostrado claramente que la inmunización con el VIH-v induce una respuesta específica de IFN-γ de células T CD8+ contra cada uno de sus componentes constituyentes. Sin embargo, es útil para establecer si los ratones vacunados con VIH-v son capaces de reconocer, y por lo tanto inducir una respuesta inmunitaria específica para los epítopos, creados en la captura y procesamiento de las proteínas de VIH completas de la que algunas de ellas se derivan. Debido a las restricciones de seguridad de la utilización del virus VIH vivo en las células humanas se decidió estudiar la respuesta de IFN-γ en el ratón vacunado con VIH-v y NRP utilizando el mismo método utilizado para P1, P2, P3 y P4, pero en este caso utilizando como antígenos de estimulación una mezcla equimolar de VIF, REV y NEF.
Una vez más, los animales con vacunación de VIH-V dieron lugar a un aumento específico en la producción
107
Claims (1)
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imagen1 imagen2
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| GB0614260A GB0614260D0 (en) | 2006-07-18 | 2006-07-18 | Peptide sequences and compositions |
| GB0614260 | 2006-07-18 | ||
| PCT/GB2007/000812 WO2007104932A2 (en) | 2006-03-10 | 2007-03-09 | Peptides of regulatory or accessory proteins of hiv, compositions and the utilization thereof |
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| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| CA2932788A1 (en) | 2013-12-08 | 2015-06-11 | Peptcell Limited | Hiv antigens and antibodies and compositions, methods and uses thereof |
| KR20220011685A (ko) | 2019-05-22 | 2022-01-28 | 길리애드 사이언시즈, 인코포레이티드 | Tlr7 조절 화합물과 hiv 백신의 조합 |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
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| EP0330359A3 (en) | 1988-02-25 | 1991-06-05 | Bio-Rad Laboratories, Inc. | Composition useful in the diagnosis and treating of hiv-1 infection |
| DE4141970C2 (de) | 1991-12-16 | 1998-02-19 | Charite Med Fakultaet | Kombinationsimpfstoff gegen AIDS, Bilharziose und Tuberkulose und Verfahren zu seiner Herstellung |
| CZ287239B6 (en) | 1993-10-14 | 2000-10-11 | Seikagaku Kogyo Co Ltd | Polypeptides exhibiting antimicrobial and antiviral activity and pharmaceutical preparations containing thereof |
| AU685521B2 (en) | 1993-10-19 | 1998-01-22 | Ajinomoto Co., Inc. | Peptide capable of inducing immune response against HIV and aids preventive or remedy containing the peptide |
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| AU7689798A (en) * | 1997-05-20 | 1998-12-11 | St. Luke's-Roosevelt Hospital | Vif-derived hiv protease inhibitors |
| PT2044950E (pt) | 1997-09-18 | 2012-09-18 | Univ Pennsylvania | Cassetes de imunização adn de vif atenuadas para vacinas genéticas |
| US6228128B1 (en) | 1997-11-10 | 2001-05-08 | Charlotte Johansen | Antimicrobial activity of laccases |
| US20020182222A1 (en) * | 1998-07-10 | 2002-12-05 | Groot Anne De | HIV vaccine candidate peptides |
| US20030180314A1 (en) | 1998-07-10 | 2003-09-25 | Degroot Anne | Immunogenic, cross-clade, HIV peptides |
| WO2000049038A2 (de) * | 1999-02-19 | 2000-08-24 | Ulrich Schubert | Synthetische peptide des regulatorischen virusproteins r (vpr) des humanen immundefizienzvirus typ 1 (hiv-1) und ihre verwendung |
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| AU1075001A (en) * | 1999-10-05 | 2001-05-10 | Epimmune, Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
| CA2397998A1 (en) | 2000-01-28 | 2001-08-02 | Statens Serum Institut | Hiv peptides and nucleic acids encoding them for diagnosis and control of hiv infection |
| NO314587B1 (no) | 2000-09-04 | 2003-04-14 | Bionor Immuno As | HIV regulatoriske- og hjelpepeptider, antigener, vaksinepreparater, immunoassay testsett og en metode for påvisning av antistoffer fremkaltav HIV |
| EP1322338A4 (en) * | 2000-10-04 | 2005-04-13 | Univ Pennsylvania | COMPOSITIONS AND METHODS OF USING A CAPSID PROTEIN FROM VARIOUS FLAVIVIRUS AND PESTIVIRUS |
| JP2004535369A (ja) * | 2001-03-01 | 2004-11-25 | アメリカ合衆国 | 試薬およびワクチンとして使用するための免疫原性ｈｉｖペプチド |
| RU2214274C2 (ru) | 2001-08-16 | 2003-10-20 | Государственное предприятие Институт иммунологии Федерального управления медико-биологических экстремальных проблем при МЗ РФ | Иммуногенная композиция, содержащая химерный полипептид вич, полипептиды и тест-система для обнаружения антител к вич |
| US6974574B2 (en) * | 2001-08-16 | 2005-12-13 | The General Hospital Corporation | Methods of inducing an HIV specific response using a Vpr-specific epitope |
| CA2357906A1 (en) | 2001-09-28 | 2003-03-28 | Institut Pasteur | Identification of new cd8 epitopes from hiv-1 proteins with therapeutical and vaccinal properties against hiv infections |
| WO2004031345A2 (en) | 2002-05-20 | 2004-04-15 | The General Hospital Corporation | Cytotoxic t-cell epitopes of hiv-1 virus |
| US20060079453A1 (en) | 2002-10-03 | 2006-04-13 | John Sidney | Hla binding peptides and their uses |
| WO2005012502A2 (en) * | 2003-03-28 | 2005-02-10 | Idm Pharma, Inc. | Methods of identifying optimal variants of peptide epitopes |
| BRPI0414443A (pt) * | 2003-09-17 | 2006-11-21 | Univ Duke | imunógenos consensuais/ancestrais |
| EP1778282B1 (en) * | 2004-08-17 | 2016-03-30 | Institut Gustave Roussy | Mutated hiv nef for modulating immunity |
| AU2006283101B2 (en) | 2005-08-23 | 2013-03-07 | Beth Israel Deaconess Medical Center | Polyvalent vaccine |
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