ES2625823T3 - Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo - Google Patents

Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo Download PDF

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Publication number
ES2625823T3
ES2625823T3 ES12170984T ES12170984T ES2625823T3 ES 2625823 T3 ES2625823 T3 ES 2625823T3 ES 12170984 T ES12170984 T ES 12170984T ES 12170984 T ES12170984 T ES 12170984T ES 2625823 T3 ES2625823 T3 ES 2625823T3
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amino acid
acid sequence
seq
antibody
variable region
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Yuji Yamazaki
Itaru Urakawa
Hitoshi Yoshida
Yukiko Aono
Takeyoshi Yamashita
Takashi Shimada
Hisashi Hasegawa
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Kyowa Kirin Co Ltd
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Kyowa Hakko Kirin Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)

Abstract

Anticuerpo frente a FGF23 humano o un fragmento funcional de dicho anticuerpo frente a FGF23 humano, a) en el que el anticuerpo frente a FGF23 humano o el fragmento funcional de dicho anticuerpo comprende una región variable de cadena pesada que tiene una región determinante de la complementariedad (CDR) 1 mostrada por la secuencia de aminoácidos de SEC ID Nº:40, CDR2 mostrada por la secuencia de aminoácidos de SEC ID Nº:41 y CDR3 mostrada por la secuencia de aminoácidos de SEC ID Nº:42, y una región variable de cadena ligera que tiene una región determinante de la complementariedad (CDR) 1 mostrada por la secuencia de aminoácidos de SEC ID Nº:43, CDR2 mostrada por la secuencia de aminoácidos de SEC ID Nº:44 y CDR3 mostrada por la secuencia de aminoácidos de SEC ID Nº:45, o b) en el que el anticuerpo frente a FGF23 humano se produce mediante hibridoma FERM BP-10772, o c) anticuerpo o fragmento que comprende la misma secuencia de aminoácidos que una región variable de cadena pesada y una región variable de cadena ligera de un anticuerpo producido mediante hibridoma FERM BP-10772.
ES12170984T 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo Active ES2625823T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007034018 2007-02-14

Publications (1)

Publication Number Publication Date
ES2625823T3 true ES2625823T3 (es) 2017-07-20

Family

ID=39690189

Family Applications (3)

Application Number Title Priority Date Filing Date
ES12170984T Active ES2625823T3 (es) 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo
ES17152168T Active ES2811318T3 (es) 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo
ES08711707T Active ES2530670T3 (es) 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES17152168T Active ES2811318T3 (es) 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo
ES08711707T Active ES2530670T3 (es) 2007-02-14 2008-02-14 Anticuerpo anti-FGF23 y composición farmacéutica que comprende el mismo

Country Status (22)

Country Link
US (4) US7883705B2 (es)
EP (3) EP2502996B1 (es)
JP (1) JP4800396B2 (es)
KR (1) KR101462291B1 (es)
CN (2) CN102702355B (es)
AU (1) AU2008215346B2 (es)
CA (1) CA2677782C (es)
CY (3) CY1118835T1 (es)
DK (3) DK3181691T3 (es)
ES (3) ES2625823T3 (es)
FR (1) FR18C1032I2 (es)
HR (2) HRP20170548T1 (es)
HU (3) HUE050517T2 (es)
LT (3) LT3181691T (es)
LU (2) LUC00081I2 (es)
NL (1) NL300945I2 (es)
NO (1) NO2018025I1 (es)
PL (3) PL2502996T3 (es)
PT (3) PT2128253E (es)
SI (2) SI3181691T1 (es)
TW (1) TWI422593B (es)
WO (1) WO2008099969A1 (es)

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WO2018069232A1 (en) 2016-10-10 2018-04-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of having cardiac hypertrophy
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CY2018021I2 (el) 2019-07-10
HRP20170548T1 (hr) 2017-08-25
DK2502996T3 (en) 2017-05-08
EP3181691B1 (en) 2020-07-15
SI3181691T1 (sl) 2020-09-30
SI2502996T1 (sl) 2017-08-31
HUE031728T2 (en) 2017-07-28
EP2502996A3 (en) 2013-04-10
KR101462291B1 (ko) 2014-11-14
US20110182913A1 (en) 2011-07-28
CN101652476A (zh) 2010-02-17
PL2128253T3 (pl) 2015-04-30
EP2502996A2 (en) 2012-09-26
TWI422593B (zh) 2014-01-11
HUS1800034I1 (hu) 2018-09-28
LT2502996T (lt) 2017-06-26
LT3181691T (lt) 2020-08-25
AU2008215346A1 (en) 2008-08-21
WO2008099969A1 (ja) 2008-08-21
US10202446B2 (en) 2019-02-12
EP2128253B1 (en) 2014-12-03
US20160159895A1 (en) 2016-06-09
US7883705B2 (en) 2011-02-08
LUC00081I2 (es) 2018-10-01
EP2128253A4 (en) 2010-03-10
PL3181691T3 (pl) 2020-11-02
ES2811318T3 (es) 2021-03-11
LUC00082I2 (es) 2018-10-01
JPWO2008099969A1 (ja) 2010-05-27
FR18C1032I2 (fr) 2019-08-09
NO2018025I1 (no) 2018-08-09
EP3181691A1 (en) 2017-06-21
NL300945I2 (en) 2020-05-13
PT2128253E (pt) 2015-02-04
CA2677782C (en) 2016-07-26
US20090148461A1 (en) 2009-06-11
CA2677782A1 (en) 2008-08-21
AU2008215346B2 (en) 2013-01-10
FR18C1032I1 (es) 2018-08-31
TW200902549A (en) 2009-01-16
LTC2502996I2 (lt) 2019-05-10
DK2128253T3 (en) 2015-01-05
US20190106485A1 (en) 2019-04-11
US9290569B2 (en) 2016-03-22
HUE050517T2 (hu) 2020-12-28
KR20090114452A (ko) 2009-11-03
LTPA2018508I1 (lt) 2018-09-10
PT2502996T (pt) 2017-05-10
DK3181691T3 (da) 2020-08-17
CN102702355A (zh) 2012-10-03
NL300945I1 (en) 2018-08-15
HK1140228A1 (en) 2010-10-08
ES2530670T3 (es) 2015-03-04
CN101652476B (zh) 2012-07-04
CY1123240T1 (el) 2021-10-29
PL2502996T3 (pl) 2017-07-31
JP4800396B2 (ja) 2011-10-26
CY2018021I1 (el) 2019-07-10
HK1172917A1 (en) 2013-05-03
EP2128253A1 (en) 2009-12-02
PT3181691T (pt) 2020-08-26
HRP20201266T1 (hr) 2021-02-05
CN102702355B (zh) 2014-09-24
EP2502996B1 (en) 2017-03-29
CY1118835T1 (el) 2018-01-10

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