ES2657442T3 - Método de diagnóstico para trastornos relacionados con el daño cerebral basado en la detección de DJ-1 - Google Patents
Método de diagnóstico para trastornos relacionados con el daño cerebral basado en la detección de DJ-1 Download PDFInfo
- Publication number
- ES2657442T3 ES2657442T3 ES10181193.3T ES10181193T ES2657442T3 ES 2657442 T3 ES2657442 T3 ES 2657442T3 ES 10181193 T ES10181193 T ES 10181193T ES 2657442 T3 ES2657442 T3 ES 2657442T3
- Authority
- ES
- Spain
- Prior art keywords
- brain damage
- protein
- body fluid
- stroke
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000006931 brain damage Effects 0.000 title abstract description 11
- 231100000874 brain damage Toxicity 0.000 title abstract description 11
- 208000029028 brain injury Diseases 0.000 title abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 9
- 238000001514 detection method Methods 0.000 title description 2
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 102000007659 Protein Deglycase DJ-1 Human genes 0.000 abstract description 9
- 108010032428 Protein Deglycase DJ-1 Proteins 0.000 abstract description 9
- 208000032109 Transient ischaemic attack Diseases 0.000 abstract description 5
- 201000010875 transient cerebral ischemia Diseases 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 208000016988 Hemorrhagic Stroke Diseases 0.000 abstract description 2
- 208000032382 Ischaemic stroke Diseases 0.000 abstract description 2
- 208000020658 intracerebral hemorrhage Diseases 0.000 abstract description 2
- 210000001124 body fluid Anatomy 0.000 abstract 4
- 239000010839 body fluid Substances 0.000 abstract 4
- 206010018985 Haemorrhage intracranial Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 abstract 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract 1
- 201000004810 Vascular dementia Diseases 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- 229920001184 polypeptide Polymers 0.000 description 15
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 13
- 108010062715 Fatty Acid Binding Protein 3 Proteins 0.000 description 12
- 102100037738 Fatty acid-binding protein, heart Human genes 0.000 description 12
- 208000006011 Stroke Diseases 0.000 description 11
- 238000003745 diagnosis Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 4
- 101710159080 Aconitate hydratase A Proteins 0.000 description 3
- 101710159078 Aconitate hydratase B Proteins 0.000 description 3
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 3
- 101710105008 RNA-binding protein Proteins 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004481 post-translational protein modification Effects 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 108010072220 Cyclophilin A Proteins 0.000 description 2
- 208000004552 Lacunar Stroke Diseases 0.000 description 2
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 description 2
- 102000048176 Prostaglandin-D synthases Human genes 0.000 description 2
- 108030003866 Prostaglandin-D synthases Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000000926 neurological effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- UMCMPZBLKLEWAF-BCTGSCMUSA-N 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 UMCMPZBLKLEWAF-BCTGSCMUSA-N 0.000 description 1
- 102000003908 Cathepsin D Human genes 0.000 description 1
- 108090000258 Cathepsin D Proteins 0.000 description 1
- 102000009265 Cerebrospinal Fluid Proteins Human genes 0.000 description 1
- 108010073496 Cerebrospinal Fluid Proteins Proteins 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102100030421 Fatty acid-binding protein 5 Human genes 0.000 description 1
- 101710083187 Fatty acid-binding protein 5 Proteins 0.000 description 1
- 102100030431 Fatty acid-binding protein, adipocyte Human genes 0.000 description 1
- 101710118908 Fatty acid-binding protein, adipocyte Proteins 0.000 description 1
- 102100037733 Fatty acid-binding protein, brain Human genes 0.000 description 1
- 101710098548 Fatty acid-binding protein, brain Proteins 0.000 description 1
- 101100226596 Gallus gallus FABP gene Proteins 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 1
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 108010081372 NM23 Nucleoside Diphosphate Kinases Proteins 0.000 description 1
- 102000008763 Neurofilament Proteins Human genes 0.000 description 1
- 108010088373 Neurofilament Proteins Proteins 0.000 description 1
- 102100023206 Neuromodulin Human genes 0.000 description 1
- 101710144282 Neuromodulin Proteins 0.000 description 1
- 102100023252 Nucleoside diphosphate kinase A Human genes 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- 230000004570 RNA-binding Effects 0.000 description 1
- 108010023918 S100 Calcium Binding Protein beta Subunit Proteins 0.000 description 1
- 102000011425 S100 Calcium Binding Protein beta Subunit Human genes 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 102100025038 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Human genes 0.000 description 1
- 101710186825 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Proteins 0.000 description 1
- 101710179452 Ubiquitin fusion degradation protein 1 Proteins 0.000 description 1
- 102100038833 Ubiquitin recognition factor in ER-associated degradation protein 1 Human genes 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- UDSAIICHUKSCKT-UHFFFAOYSA-N bromophenol blue Chemical compound C1=C(Br)C(O)=C(Br)C=C1C1(C=2C=C(Br)C(O)=C(Br)C=2)C2=CC=CC=C2S(=O)(=O)O1 UDSAIICHUKSCKT-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- 210000000256 facial nerve Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 238000009593 lumbar puncture Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005044 neurofilament Anatomy 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- -1 that is Proteins 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0322063.9A GB0322063D0 (en) | 2003-09-20 | 2003-09-20 | Diagnostic method for brain damage-related disorders |
| GB0322063 | 2003-09-20 | ||
| GBGB0414089.3A GB0414089D0 (en) | 2003-09-20 | 2004-06-23 | Diagnostic method for brain damage-related disorders |
| GB0414089 | 2004-06-23 | ||
| GB0419068 | 2004-08-27 | ||
| GB0419068A GB0419068D0 (en) | 2003-09-20 | 2004-08-27 | Diagnostic method for brain damage-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2657442T3 true ES2657442T3 (es) | 2018-03-05 |
Family
ID=29266361
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10181193.3T Expired - Lifetime ES2657442T3 (es) | 2003-09-20 | 2004-09-20 | Método de diagnóstico para trastornos relacionados con el daño cerebral basado en la detección de DJ-1 |
| ES10181407.7T Expired - Lifetime ES2657422T3 (es) | 2003-09-20 | 2004-09-20 | Método de diagnóstico para trastornos relacionados con el daño cerebral basado en la detección de NDKA |
| ES04787496.1T Expired - Lifetime ES2657320T3 (es) | 2003-09-20 | 2004-09-20 | Método de diagnóstico para trastornos relacionados con el daño cerebral |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10181407.7T Expired - Lifetime ES2657422T3 (es) | 2003-09-20 | 2004-09-20 | Método de diagnóstico para trastornos relacionados con el daño cerebral basado en la detección de NDKA |
| ES04787496.1T Expired - Lifetime ES2657320T3 (es) | 2003-09-20 | 2004-09-20 | Método de diagnóstico para trastornos relacionados con el daño cerebral |
Country Status (4)
| Country | Link |
|---|---|
| CA (1) | CA2932077C (fr) |
| DK (1) | DK1664795T3 (fr) |
| ES (3) | ES2657442T3 (fr) |
| GB (2) | GB0322063D0 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009282117B2 (en) * | 2008-08-11 | 2016-05-12 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| CN109696549B (zh) * | 2017-10-20 | 2022-11-01 | 成都蓝瑙生物技术有限公司 | 用于脑中风的发光elisa体外诊断试剂盒 |
-
2003
- 2003-09-20 GB GBGB0322063.9A patent/GB0322063D0/en not_active Ceased
-
2004
- 2004-06-23 GB GBGB0414089.3A patent/GB0414089D0/en not_active Ceased
- 2004-09-20 CA CA2932077A patent/CA2932077C/fr not_active Expired - Lifetime
- 2004-09-20 ES ES10181193.3T patent/ES2657442T3/es not_active Expired - Lifetime
- 2004-09-20 ES ES10181407.7T patent/ES2657422T3/es not_active Expired - Lifetime
- 2004-09-20 DK DK04787496.1T patent/DK1664795T3/en active
- 2004-09-20 ES ES04787496.1T patent/ES2657320T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2932077C (fr) | 2020-06-02 |
| ES2657422T3 (es) | 2018-03-05 |
| GB0414089D0 (en) | 2004-07-28 |
| GB0322063D0 (en) | 2003-10-22 |
| ES2657320T3 (es) | 2018-03-02 |
| DK1664795T3 (en) | 2018-02-12 |
| CA2932077A1 (fr) | 2005-03-31 |
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