ES2659405T3 - Composiciones que comprenden retinoide y un inhibidor de NFkB y sus métodos de uso - Google Patents
Composiciones que comprenden retinoide y un inhibidor de NFkB y sus métodos de uso Download PDFInfo
- Publication number
- ES2659405T3 ES2659405T3 ES11186402.1T ES11186402T ES2659405T3 ES 2659405 T3 ES2659405 T3 ES 2659405T3 ES 11186402 T ES11186402 T ES 11186402T ES 2659405 T3 ES2659405 T3 ES 2659405T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- retinoid
- nfkb inhibitor
- skin
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Una composición que comprende un retinoide, un inhibidor de NFkB, y un transportador tópico cosméticamente aceptable, donde la cantidad de retinoide en la composición es de 0,01% a 0,075% por peso de la composición, y donde dicho inhibidor de NFkB se selecciona del grupo consistente en resorcinoles sustituidos, (E)-3-(4- metilfenilsulfonil)-2-propenonitrilo y combinaciones de los mismos.
Description
5
15
25
35
45
55
65
aproximadamente 0,001% a aproximadamente 20% por peso de la composición, por ejemplo, desde aproximadamente 0,005% a aproximadamente 10%, como desde aproximadamente 0,01% a aproximadamente 5%.
Ejemplos de vitaminas incluyen, aunque no se limitan a, vitaminas B como vitamina B3, vitamina B5 y vitamina B12, vitamina C, vitamina K y diferentes formas de vitamina E como alfa, beta, gamma o delta tocoferoles o sus mezclas y derivados de las mismas.
Ejemplos de ácidos hidroxi incluyen, aunque no se limitan a, ácido glicólico, ácido láctico, ácido málico, ácido salicílico, ácido cítrico y ácido tartárico.
Ejemplos de antioxidantes incluyen, aunque no se limitan a, antioxidantes solubles en agua como compuestos de sulfhidrilo y sus derivados (por ejemplo, metabisulfito de sodio y N-acetil-cisteína), ácido lipoico y ácido dihidrolipoico, resveratrol, lactoferrina y ácido ascórbico y derivados de ácido ascórbico (por ejemplo, palmitato de ascorbilo y polipéptido de ascorbilo). Los antioxidantes solubles en aceite adecuados para su uso en las composiciones de esta invención incluyen, aunque no se limitan a, hidroxitolueno butilado, tocoferoles (por ejemplo, acetato de tocoferol), tocotrienoles y ubiquinona. Los extractos naturales que contienen antioxidantes adecuados para su uso en las composiciones de esta invención incluyen, aunque no se limitan a, extractos que contienen flavonoides e isoflavonoides y sus derivados (por ejemplo, genisteína y diadzeína), extractos que contienen resveratrol y similares. Ejemplos de tales extractos naturales incluyen semilla de uva, té verde, corteza de pino y propóleo.
Otros materiales
Varios otros materiales pueden también estar presentes en la composición, como se conoce en la técnica. Estos incluyen humectantes, ajustadores de pH, agentes quelantes (por ejemplo, EDTA), fragancias, tintes y conservantes (por ejemplo, parabenos), como aquellos comúnmente usados en formulaciones cosméticas.
La composición y formulaciones y productos que contienen tales composiciones de la presente invención pueden prepararse usando metodología que es bien conocida por los expertos en la técnica.
Método de uso
Las composiciones de la presente invención pueden aplicarse tópicamente a piel de mamífero que necesite tratamiento para mejorar uno o más signos de envejecimiento de la piel o acné como se ha descrito anteriormente. En una realización, las composiciones se aplican a la piel que necesite una mejora en firmeza, textura, o la aparición de línea y arrugas. Las composiciones pueden aplicarse a la piel que necesite tal tratamiento de acuerdo con un régimen adecuado de tratamiento, por ejemplo, como máximo dos veces al día y como mínimo una vez cada tres días más o menos.
En ciertas realizaciones, las composiciones de la presente invención pueden ser útiles para tratar otros estados de necesidad asociados con la piel. Por ejemplo, las composiciones de la presente invención pueden ser útiles par a tratar hiperpigmentación post-inflamatoria, para reducir el tamaño del poro, para reducir la producción de sebo o para suavizar cicatrices. En ciertas realizaciones, las composiciones de la presente invención pueden aplicarse simultáneamente o después de varias horas de un exfoliante mecánico o físico como un tratamiento de microdermoabrasión o con un exfoliante químico o agente queratolítico como ácido salicílico. En ciertas realizaciones, las composiciones de la presente invención se aplican a heridas leves o sitos pos-quirúrgicos para facilitar la curación.
Las composiciones de la presente invención pueden aplicarse tópicamente a piel de mamífero en un método cosmético de tratamiento. En una realización, las composiciones se aplican a la piel donde la piel necesita una mejora en los signos de envejecimiento, como la necesidad de mejorar en firmeza, textura, la aparición de líneas
o arrugas o la pérdida de elasticidad. En una realización adicional, las composiciones se aplican a la piel donde la piel necesita una mejora en los signos de acné, como la piel que tiene imperfecciones, lesiones o granos, granos pre-emergentes, puntos negros y/o espinillas.
Ejemplo 1: Inhibición de NFkB
El TEST DE INHBICIÓN DE NFkB descrito anteriormente en muestras de prueba de Bay 11-7082 (Sigma-Aldrich, St. Louis, MO), Tetrahidrocurcuminoides CG (Sabinsa Corporation, Piscataway, NJ), así como varias concentraciones de 4-hexilresorcinol. Los resultados se muestran en la Tabla 2, donde se presenta la activación reportera de gen NFkB (Luminiscencia, L) para las muestras de prueba y una muestra de control. También se presenta la inhibición porcentual de NFkB.
10
Claims (1)
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imagen1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/911,038 US8895628B2 (en) | 2010-10-25 | 2010-10-25 | Compositions comprising a retinoid and an NFkB-inhibitor and their methods of use |
| US911038 | 2010-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2659405T3 true ES2659405T3 (es) | 2018-03-15 |
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| ES (1) | ES2659405T3 (es) |
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| US20110081430A1 (en) | 2009-10-02 | 2011-04-07 | Simarna Kaur | COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER |
| US8084504B2 (en) | 2009-10-02 | 2011-12-27 | Johnson & Johnson Consumer Companies, Inc. | High-clarity aqueous concentrates of 4-hexylresorcinol |
| US8906432B2 (en) | 2009-10-02 | 2014-12-09 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising an NFκB-inhibitor and a non-retinoid collagen promoter |
| US8895628B2 (en) | 2010-10-25 | 2014-11-25 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising a retinoid and an NFkB-inhibitor and their methods of use |
| US9492492B2 (en) * | 2010-12-17 | 2016-11-15 | Johnson & Johnson Consumer Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
| US8293293B2 (en) | 2010-12-17 | 2012-10-23 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising Lilium martagon extracts and uses thereof |
| US8846013B2 (en) | 2012-06-29 | 2014-09-30 | Johnson & Johnson Consumer Companies, Inc. | Topical application of 1-hydroxyl-3,5-BIS(4′hydroxy styryl)benzene |
| US20140005276A1 (en) * | 2012-06-29 | 2014-01-02 | Simarna Kaur | Compositions comprising substituted phenols and topical application thereof |
| US8758731B2 (en) | 2012-06-29 | 2014-06-24 | Johnson & Johnson Consumer Companies, Inc. | Skin lightening by topical application of 1-hydroxyl 3,5-bis(4′hydroxyl styryl)benzene |
| US20140086859A1 (en) | 2012-09-24 | 2014-03-27 | Johnson & Johnson Consumer Companies, Inc. | Low oil compositions comprising a 4-substituted resorcinol and a high carbon chain ester |
| US20150272837A1 (en) * | 2014-03-27 | 2015-10-01 | Johnson & Johnson Consumer Companies, Inc. | Topical Compositions Comprising A Resorcinol and Powders |
| CA3021929A1 (en) * | 2016-05-12 | 2017-11-16 | Unilever Plc | Method for stabilizing retinoic acid precursors and a skin benefit composition with stabilized retinoic acid precursors |
| EA201991185A1 (ru) | 2016-12-21 | 2020-01-13 | Юнилевер Н.В. | Композиции для личной гигиены, содержащие цистин |
| EP3558255B1 (en) | 2016-12-21 | 2021-10-13 | Unilever IP Holdings B.V. | Topical skin lightening additive and composition with amino acids and nicotinamide compounds |
| JP7084924B2 (ja) | 2016-12-21 | 2022-06-15 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 難溶性化合物を含むパーソナルケア組成物 |
| CN110121330B (zh) | 2016-12-21 | 2022-04-29 | 联合利华知识产权控股有限公司 | 具有包含4-取代的间苯二酚和氨基酸的谷胱甘肽前体的个人护理组合物 |
| CA3069345A1 (en) * | 2017-07-12 | 2019-01-17 | Unilever Plc | Skin composition booster oil |
| WO2019224048A1 (en) | 2018-05-23 | 2019-11-28 | Unilever Plc | Nanoemulsions and a method for making the same |
| US10660866B2 (en) * | 2018-09-10 | 2020-05-26 | Johnson & Johnson Consumer Inc. | Retinol oil composition |
| CN112043820B (zh) * | 2020-09-16 | 2022-06-21 | 易舟(上海)生物医药有限公司 | 一种眼用制剂及其制备方法和应用 |
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| US4337370A (en) | 1979-11-08 | 1982-06-29 | Sumitomo Chemical Company, Limited | Process for the preparation of resorcinol derivatives |
| US4877805A (en) * | 1985-07-26 | 1989-10-31 | Kligman Albert M | Methods for treatment of sundamaged human skin with retinoids |
| US20040235950A1 (en) | 1999-05-20 | 2004-11-25 | Voorhees John J. | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes |
| KR100377397B1 (ko) * | 1999-12-23 | 2003-03-26 | 주식회사 대웅 | 레티놀 및 표피성장인자를 함유하는 피부보호 화장료 조성물 |
| US7442391B2 (en) | 2002-01-25 | 2008-10-28 | Integrated Botanical Technologies, Llc | Bioactive botanical cosmetic compositions and processes for their production |
| EP1613295A1 (en) * | 2003-04-15 | 2006-01-11 | Unilever N.V. | Use of alkyl resorcinols in the treatment of acne |
| PL1722805T3 (pl) | 2004-01-12 | 2014-08-29 | Akzo Nobel Surface Chemistry Llc | Biologicznie czynne kompozycje z roślin Theacea oraz sposoby ich wytwarzania i zastosowanie |
| US7537791B2 (en) | 2006-02-21 | 2009-05-26 | Integrated Botanical Technologies, Llc | Parthenolide free bioactive ingredients from feverfew (Tanacetum parthenium) and processes for their production |
| US20090075902A1 (en) | 2007-05-25 | 2009-03-19 | Robbins Paul D | Inhibiting the signs of aging by inhibiting nf-kappa b activation |
| US20090263513A1 (en) | 2008-04-18 | 2009-10-22 | Jan Marini | Cosmetic skin lightening formulation |
| RU2501544C2 (ru) | 2008-12-22 | 2013-12-20 | Джонсон Энд Джонсон Конзьюмер Холдингз Франс | Композиция и способ лечения патологических состояний кожи |
| US8895628B2 (en) | 2010-10-25 | 2014-11-25 | Johnson & Johnson Consumer Companies, Inc. | Compositions comprising a retinoid and an NFkB-inhibitor and their methods of use |
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| EP2572701A2 (en) | 2013-03-27 |
| BRPI1106572B1 (pt) | 2019-04-16 |
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| BRPI1106572A2 (pt) | 2015-11-10 |
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| CN102451467A (zh) | 2012-05-16 |
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| CA2755582C (en) | 2019-01-15 |
| CA2755582A1 (en) | 2012-04-25 |
| BRPI1106572B8 (pt) | 2022-08-30 |
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