ES2659421T3 - Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8 - Google Patents

Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8 Download PDF

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Publication number
ES2659421T3
ES2659421T3 ES09782234.0T ES09782234T ES2659421T3 ES 2659421 T3 ES2659421 T3 ES 2659421T3 ES 09782234 T ES09782234 T ES 09782234T ES 2659421 T3 ES2659421 T3 ES 2659421T3
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detection
molecular weight
low molecular
cold menthol
menthol receptor
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Thomas Subkowski
Claus Bollschweiler
Jens Wittenberg
Michael Krohn
Holger Zinke
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BASF SE
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BASF SE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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Abstract

Procedimiento para la modulación in vitro del receptor de mentol frío TRMP8, en donde se pone en contacto el receptor con al menos un compuesto que se selecciona de los compuestos de las fórmulas**Fórmula** los cuales, en un ensayo de actividad celular, usando células que expresan de manera recombinante el receptor de TRPM8 humano, modulan la permeabilidad de estas células para iones Ca2+.
ES09782234.0T 2008-08-26 2009-08-26 Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8 Active ES2659421T3 (es)

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EP08162997 2008-08-26
EP08162997 2008-08-26
PCT/EP2009/061019 WO2010026094A1 (de) 2008-08-26 2009-08-26 Nachweis und verwendung niedermolekularer modulatoren des kälte-menthol-rezeptors trpm8

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ES2659421T3 true ES2659421T3 (es) 2018-03-15

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ES16175305T Active ES2828974T3 (es) 2008-08-26 2009-08-26 Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8
ES16175302T Active ES2828975T3 (es) 2008-08-26 2009-08-26 Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8
ES09782234.0T Active ES2659421T3 (es) 2008-08-26 2009-08-26 Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8

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ES16175302T Active ES2828975T3 (es) 2008-08-26 2009-08-26 Detección y uso de moduladores de bajo peso molecular del receptor de mentol frío TRPM8

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EP (4) EP2349239B1 (es)
JP (3) JP5591238B2 (es)
CN (4) CN107375284B (es)
CA (4) CA2937196C (es)
ES (3) ES2828974T3 (es)
WO (1) WO2010026094A1 (es)

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JP2016029042A (ja) 2016-03-03
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CA2937196C (en) 2019-07-09
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CN111803478A (zh) 2020-10-23
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