ES2670444T3 - [1,2,4]Triazolo[4,3-b]piridazinas para su uso en el tratamiento de enfermedades proliferativas - Google Patents

[1,2,4]Triazolo[4,3-b]piridazinas para su uso en el tratamiento de enfermedades proliferativas Download PDF

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Publication number: ES2670444T3
Authority: ES; Spain
Prior art keywords: compound; crystal; pharmaceutically acceptable; formula; hydroxy
Prior art date: 2014-07-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES15744308.6T

Other languages

English (en)

Spanish (es)

Inventor

Robert Hugh Bradbury

Alfred Arthur Rabow

Michael James Waring

James Francis Mccabe

Steven Christopher GLOSSOP

Arshed MAHMOOD

Zoe Ann COTTER

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-07-28

Filing date

2015-07-24

Publication date

2018-05-30

2015-07-24 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2018-05-30 Application granted granted Critical

2018-05-30 Publication of ES2670444T3 publication Critical patent/ES2670444T3/es

Status Active legal-status Critical Current

2035-07-24 Anticipated expiration legal-status Critical

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
- E—FIXED CONSTRUCTIONS
- E21—EARTH OR ROCK DRILLING; MINING
- E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B7/00—Special methods or apparatus for drilling
- E21B7/04—Directional drilling
- E21B7/06—Deflecting the direction of boreholes
- E21B7/062—Deflecting the direction of boreholes the tool shaft rotating inside a non-rotating guide travelling with the shaft
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Geology (AREA)
Mining & Mineral Resources (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Environmental & Geological Engineering (AREA)
Fluid Mechanics (AREA)
General Life Sciences & Earth Sciences (AREA)
Geochemistry & Mineralogy (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES15744308.6T 2014-07-28 2015-07-24 [1,2,4]Triazolo[4,3-b]piridazinas para su uso en el tratamiento de enfermedades proliferativas Active ES2670444T3 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462029676P	2014-07-28	2014-07-28
US201462029676P		2014-07-28
PCT/GB2015/052143 WO2016016618A1 (en)	2014-07-28	2015-07-24	[1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases

Publications (1)

Publication Number	Publication Date
ES2670444T3 true ES2670444T3 (es)	2018-05-30

Family

ID=53761420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES15744308.6T Active ES2670444T3 (es)	2014-07-28	2015-07-24	[1,2,4]Triazolo[4,3-b]piridazinas para su uso en el tratamiento de enfermedades proliferativas

Country Status (37)

Country	Link
US (5)	US9944650B2 (sr)
EP (1)	EP3174881B1 (sr)
JP (1)	JP6592503B2 (sr)
KR (1)	KR20170033427A (sr)
CN (1)	CN106536524B (sr)
AP (1)	AP2017009700A0 (sr)
AU (1)	AU2015295120B2 (sr)
BR (1)	BR112017001160A2 (sr)
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TWI816880B (zh) *	2018-09-13	2023-10-01	大陸商恒翼生物醫藥（上海）股份有限公司	治療前列腺癌之組合療法
MX2022004555A (es)	2019-10-14	2022-07-21	Astrazeneca Ab	Terapia de combinacion para tratar una neoplasia maligna hematologica.
JP2023509191A (ja)	2020-01-09	2023-03-07	アストラゼネカ・アクチエボラーグ	癌を治療するための組み合わせ療法
CN113143930B (zh) *	2021-04-08	2023-05-30	深圳湾实验室	化合物在制备SARS-Cov-2 E蛋白抑制剂中的用途

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Publication number	Publication date
MY187251A (en)	2021-09-15
KR20170033427A (ko)	2017-03-24
AU2015295120A8 (en)	2017-02-09
EA032654B1 (ru)	2019-06-28
SI3174881T1 (en)	2018-06-29
EP3174881B1 (en)	2018-03-28
AP2017009700A0 (en)	2017-01-31
PH12017500159A1 (en)	2017-07-10
IL250104A0 (en)	2017-03-30
PH12017500159B1 (en)	2020-12-09
US9944650B2 (en)	2018-04-17
NI201700006A (es)	2017-08-25
HUE037571T2 (hu)	2018-09-28
NO3174881T3 (sr)	2018-08-25
PT3174881T (pt)	2018-05-25
US11407755B2 (en)	2022-08-09
JP6592503B2 (ja)	2019-10-16
JP2017522338A (ja)	2017-08-10
SMT201800260T1 (it)	2018-07-17
US20200055861A1 (en)	2020-02-20
SG11201700419SA (en)	2017-02-27
US10407432B2 (en)	2019-09-10
EA201790179A1 (ru)	2017-07-31
AU2015295120A1 (en)	2017-02-02
SV2017005368A (es)	2017-05-12
CY1120602T1 (el)	2019-12-11
CN106536524A (zh)	2017-03-22
DOP2017000018A (es)	2017-03-15
ZA201701207B (en)	2018-12-19
LT3174881T (lt)	2018-06-11
CO2017001918A2 (es)	2017-05-10
BR112017001160A2 (pt)	2017-11-14
MX374539B (es)	2025-03-06
DK3174881T3 (en)	2018-06-06
US20180230158A1 (en)	2018-08-16
WO2016016618A1 (en)	2016-02-04
GT201700016A (es)	2018-12-19
MX2017001218A (es)	2017-05-01
PE20170527A1 (es)	2017-05-24
US20170210747A1 (en)	2017-07-27
EP3174881A1 (en)	2017-06-07
IL250104B (en)	2018-10-31
EA032654B9 (ru)	2019-07-31
CL2017000223A1 (es)	2017-08-25
CA2956421C (en)	2023-03-14
CA3185741A1 (en)	2016-02-04
TN2017000018A1 (en)	2018-07-04
US10766905B2 (en)	2020-09-08
AU2015295120B2 (en)	2018-02-01
PL3174881T3 (pl)	2018-08-31
US20210107905A1 (en)	2021-04-15
RS57242B1 (sr)	2018-07-31
US20230035133A1 (en)	2023-02-02
HRP20180788T1 (hr)	2018-06-29
NO2719005T3 (sr)	2018-01-20
CA2956421A1 (en)	2016-02-04
CN106536524B (zh)	2019-11-15

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