ES267248A1 - Procedimiento para la obtenciën de la l-isopropilo-4-hidroxi-6-bencilo-pirazolo (3,4-d) piramidina y de sus sales - Google Patents
Procedimiento para la obtenciën de la l-isopropilo-4-hidroxi-6-bencilo-pirazolo (3,4-d) piramidina y de sus salesInfo
- Publication number
- ES267248A1 ES267248A1 ES0267248A ES267248A ES267248A1 ES 267248 A1 ES267248 A1 ES 267248A1 ES 0267248 A ES0267248 A ES 0267248A ES 267248 A ES267248 A ES 267248A ES 267248 A1 ES267248 A1 ES 267248A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrazolo
- salts
- pyrimidine
- pyrimidine ring
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- -1 oxy compound Chemical class 0.000 abstract 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 2
- 150000003230 pyrimidines Chemical group 0.000 abstract 2
- QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical group C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 abstract 1
- LPJTVPSDYDNLGE-UHFFFAOYSA-N 6-benzyl-1-propan-2-yl-5H-pyrazolo[3,4-d]pyrimidin-4-one Chemical compound N1=C2N(C(C)C)N=CC2=C(O)N=C1CC1=CC=CC=C1 LPJTVPSDYDNLGE-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229960003424 phenylacetic acid Drugs 0.000 abstract 1
- 239000003279 phenylacetic acid Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH540360A CH398626A (de) | 1960-05-11 | 1960-05-11 | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES267248A1 true ES267248A1 (es) | 1961-11-01 |
Family
ID=4292988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0267248A Expired ES267248A1 (es) | 1960-05-11 | 1961-05-09 | Procedimiento para la obtenciën de la l-isopropilo-4-hidroxi-6-bencilo-pirazolo (3,4-d) piramidina y de sus sales |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US3211731A (es) |
| CH (1) | CH398626A (es) |
| ES (1) | ES267248A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3335141A (en) * | 1964-08-17 | 1967-08-08 | Norwich Pharma Co | 4-substituted-1-alkyl-6-(5-nitro-2-furyl)-1h-pyrazolo[3, 4-d]pyrimidines |
| BE758050A (fr) * | 1969-10-28 | 1971-04-27 | Geigy Ag J R | Derives 5-nitro-furyliques et medicaments contenant de tels composes |
| MA19540A1 (fr) * | 1981-07-17 | 1983-04-01 | May & Baker Ltd | Derives du n-phenylpyrazole |
| US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| JPH11501926A (ja) * | 1995-03-10 | 1999-02-16 | サノフィ ファーマシューティカルズ インコーポレイティド | ６−アリールピラゾロ［３，４−ｄ］ピリミジン−４−オン、並びにその組成物及び使用法 |
| US5656629A (en) * | 1995-03-10 | 1997-08-12 | Sanofi Winthrop, Inc. | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
| DE19709877A1 (de) * | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
| US6531477B1 (en) * | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| US6559152B2 (en) * | 1998-10-13 | 2003-05-06 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| US7605175B2 (en) * | 2001-03-02 | 2009-10-20 | Gpc Biotech Ag | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| WO2003033499A2 (en) * | 2001-10-15 | 2003-04-24 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| EP1404670A4 (en) * | 2001-07-06 | 2004-11-24 | Bristol Myers Squibb Pharma Co | SEMICARBAZIDES AND THEIR USE |
| DE10238723A1 (de) * | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| SG173222A1 (en) * | 2003-04-07 | 2011-08-29 | Agennix Usa Inc | Aminoindeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases, useful for the treatment of alopecia, viral infections and hyperproliferative disorders, a pharmaceutical composition and uses related thereto |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| MXPA06007399A (es) | 2003-12-23 | 2007-01-26 | Gpc Biotech Inc | Inhibidores de quinasas dependientes de ciclina, composiciones y usos relacionados con ellos. |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| DE102005024493A1 (de) * | 2005-05-27 | 2006-11-30 | Bayer Healthcare Ag | Verwendung von Pyrazolopyrimidinen |
| US7777035B2 (en) | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| US20090252779A1 (en) * | 2006-06-22 | 2009-10-08 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
| US8648085B2 (en) | 2007-11-30 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders |
| UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| CN102143965A (zh) | 2008-09-08 | 2011-08-03 | 贝林格尔.英格海姆国际有限公司 | 吡唑并嘧啶酮及其在治疗中枢神经系统疾病中的用途 |
| UY32531A (es) | 2009-03-31 | 2010-10-29 | Boehringer Ingelheim Int | Nuevos compuestos para el tratamiento de trastornos del snc |
| AR077859A1 (es) * | 2009-08-12 | 2011-09-28 | Boehringer Ingelheim Int | Compuestos para el tratamiento de trastornos del snc |
| BR112013003097B1 (pt) | 2010-08-12 | 2021-03-16 | Boehringer Ingelheim International Gmbh | 6-cicloalquil-pirazolopirimidinonas e composição farmacêutica |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2016192083A1 (en) | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| WO2017000276A1 (en) | 2015-07-01 | 2017-01-05 | Merck Sharp & Dohme Corp. | Bicyclic heterocyclic compounds as pde2 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2943087A (en) * | 1960-06-28 | n naoh | ||
| US2980677A (en) * | 1961-04-18 | Certificate of correction | ||
| US2987523A (en) * | 1961-06-06 | Process for the production of j-methyl- | ||
| US2965643A (en) * | 1960-12-20 | Derivatives of pyrazolo | ||
| CA601981A (en) * | 1960-07-19 | Druey Jean | Pyrazoles and process for their manufacture | |
| US2868803A (en) * | 1956-02-10 | 1959-01-13 | Ciba Pharm Prod Inc | New pyrazoles and method of preparing same |
| DE1056613B (de) * | 1956-07-16 | 1959-05-06 | Ciba Geigy | Verfahren zur Herstellung von 1-Isopropyl-pyrazolo-[3, 4-d]-pyrimidinen |
| US3004025A (en) * | 1958-01-21 | 1961-10-10 | Richardson Merrell Inc | Oxazines |
-
1960
- 1960-05-11 CH CH540360A patent/CH398626A/de unknown
-
1961
- 1961-05-05 US US107906A patent/US3211731A/en not_active Expired - Lifetime
- 1961-05-09 ES ES0267248A patent/ES267248A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3211731A (en) | 1965-10-12 |
| CH398626A (de) | 1966-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES438946A2 (es) | Procedimiento de prreparacion de esteres cicloalquil alqui- licos de acidos que el esqueleto de eburnano | |
| ES8105682A1 (es) | Un procedimiento para preparar complejos de platino | |
| GB1324152A (en) | Process for the production of alkyl cis-chrysanthemates | |
| GB732581A (en) | Manufacture of hydrazine compounds | |
| ES264475A1 (es) | Procedimiento para la obtencion de compuestos amonicos cuaternarios | |
| ES358992A2 (es) | Procedimiento para la preparacion de acido 6-aminopenicila-nico. | |
| ES465346A1 (es) | Procedimiento para preparar imidazoles 4,5-disustituidos. | |
| ES379673A1 (es) | Procedimiento para la preparacion de colorantes basicos de oxazina. | |
| CH614940A5 (en) | Process for the preparation of new terpenoaromatic amidines | |
| ES364980A1 (es) | Un metodo para preparar nuevos derivados de adamantano. | |
| JPS51113882A (en) | Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives | |
| ES395260A1 (es) | Procedimiento para preparacion de imidazo (4,5-b) piridina. | |
| ES386294A1 (es) | Procedimiento de sintesis quimica para la preparacion de 2,6-dietanolamino 4,8-dipiperidino-pirimidino-(5,4 d)-piri- midina. | |
| GB1086666A (en) | Novel 6-p-tolyl-2,3,6,7-tetrahydro-4h-pyrimido-[1,2-c] quinazoline | |
| GB1326513A (en) | Process for the preparation of a pyrazole derivative | |
| GB740130A (en) | Derivatives of 4-cyclohexyl-cyclohexanone and process for the manufacture thereof | |
| ES302396A2 (es) | Un procedimiento para la preparacion de nuevos derivados de 6-metil y 1,6-dimetil-ergolina i. | |
| ES382147A1 (es) | Un procedimiento para preparar compuestos de morfolina n- sustituidos. | |
| ES335148A1 (es) | Un procedimiento para la preparacion de sales de cloropromazina. | |
| ES316439A1 (es) | Un procedimiento para la preparacion de una nueva sal de amina. | |
| ES409217A1 (es) | Un procedimiento para la preparacion de derivados de 5-ni- troimidazol. | |
| ES361606A1 (es) | Procedimiento para la preparacion de nuevos derivados 5-ni-trofurilicos. | |
| ES422326A1 (es) | Un procedimiento para la preparacion de pirimido (2, 1-a) isoquinoleinas. | |
| ES368590A1 (es) | Procedimiento para la preparacion de derivados tetracicli- cos. | |
| ES324386A2 (es) | Un metodo para preparar una amidina. |