ES2721876T3 - Formas sólidas para reparación tisular - Google Patents

Formas sólidas para reparación tisular Download PDF

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Publication number
ES2721876T3
ES2721876T3 ES10789100T ES10789100T ES2721876T3 ES 2721876 T3 ES2721876 T3 ES 2721876T3 ES 10789100 T ES10789100 T ES 10789100T ES 10789100 T ES10789100 T ES 10789100T ES 2721876 T3 ES2721876 T3 ES 2721876T3
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Spain
Prior art keywords
phase
tissue repair
solid forms
phases
framework
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ES10789100T
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English (en)
Inventor
Nir Altschuler
Razi Vago
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Cartiheal 2009 Ltd
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Cartiheal 2009 Ltd
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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Abstract

Un armazón de reparación tisular, dicho armazón consistiendo en dos fases en el que: - una primera fase de dichas dos fases comprende coral s 5 ólido, que comprende un polímero biocompatible; y - una segunda fase de dichas dos fases comprende coral sólido y dicha segunda fase comprende adicionalmente una serie de huecos a lo largo de un eje longitudinal en dicha segunda fase, que es adecuada para aumentar la vascularización o facilitar el reclutamiento de células precursoras, o una combinación de los mismos.
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Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009108760A2 (en) 2008-02-26 2009-09-03 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
ES2721876T3 (es) 2009-06-15 2019-08-06 Cartiheal 2009 Ltd Formas sólidas para reparación tisular
JP6042815B2 (ja) 2010-10-08 2016-12-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム 生物医学的応用のためのアルギン酸塩及びヒアルロン酸を用いる抗癒着性バリア膜
WO2012048283A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
US20140370094A1 (en) * 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
JP6317258B2 (ja) 2011-11-16 2018-04-25 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション コラーゲン様絹遺伝子
EP2833933B1 (en) 2012-04-05 2020-10-14 Cartiheal (2009) Ltd Multi-phasic solid implants for tissue repair
DK2854883T3 (da) 2012-05-17 2019-07-15 Cartiheal 2009 Ltd Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf
US20150289889A1 (en) 2012-11-12 2015-10-15 Cartiheal (2009) Ltd. Tools and Systems for Solid Form and Graft Implantation
EP2931327B1 (en) 2012-12-11 2019-02-13 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
DK2956183T3 (da) 2013-02-13 2021-06-14 Cartiheal 2009 Ltd Faste substrater til fremme af celle og væv vækst
JP6084884B2 (ja) * 2013-04-11 2017-02-22 日本特殊陶業株式会社 生体インプラント
WO2016179089A1 (en) 2015-05-01 2016-11-10 Rensselaer Polytechnic Institute Biomimetic nano-composite scaffold for enhanced bone healing and fracture repair
EP3291749B1 (en) 2015-05-06 2019-09-11 Cartiheal (2009) Ltd Tools for use with optimized solid substrates
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
EP3349815B1 (en) * 2015-09-14 2020-03-11 Ecole Polytechnique Federale de Lausanne (EPFL) Composition for bone regeneration
EP3380025B1 (en) 2015-11-25 2021-01-27 Subchondral Solutions, Inc. Devices for repairing anatomical joint conditions
US10485665B2 (en) 2015-12-09 2019-11-26 Reconstrata, Llc Apparatus and method for constructing implantable cartilage structures
DE102016124049B4 (de) * 2016-12-12 2018-09-27 Christoph Karl Gelenkimplantat zur Gewebeneubildung am Gelenk
CN106726014B (zh) * 2017-01-09 2018-10-19 北京积水潭医院 用于处理穹顶样髋臼骨缺损的人工骨垫块
WO2018165327A1 (en) 2017-03-08 2018-09-13 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
AU2018399962B2 (en) 2018-01-02 2024-11-14 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
US20190307928A1 (en) * 2018-04-06 2019-10-10 University Of Southern California Polymeric patch scaffolds for articular cartilage regeneration
CN108618837A (zh) * 2018-05-30 2018-10-09 上海交通大学医学院附属第九人民医院 个体化骨缺损填充用金属内固定器、其制备方法及用途
IL261820B2 (en) 2018-09-16 2024-08-01 Cartiheal 2009 Ltd Optimized cage systems promoting bone repair and fusion
US12514796B2 (en) 2019-01-15 2026-01-06 Nant Holdings Ip, Llc Aragonite compositions, methods, and uses thereof
WO2020150274A1 (en) 2019-01-15 2020-07-23 Nant Holdings Ip, Llc Aragonite compositions, methods, and uses thereof
US12600854B2 (en) 2019-08-09 2026-04-14 Nant Holdings Ip, Llc Aragonite-based polymer materials
EP4013469B1 (en) * 2019-08-16 2026-04-22 Johann Wolfgang Goethe-Universität Frankfurt am Main Mesenchymal stromal cell bone graft material
JP2021122748A (ja) * 2020-02-07 2021-08-30 マイセル・テクノロジーズ，インコーポレイテッド 生分解性層を有するステント
CN111235886A (zh) * 2020-03-23 2020-06-05 动之医学技术(上海)有限公司 壳聚糖基复合纤维的制备方法以及组织工程支架
WO2022098774A1 (en) * 2020-11-06 2022-05-12 Smith & Nephew, Inc. Graft composite for hip labrum reconstruction
CN113361182A (zh) * 2021-07-02 2021-09-07 哈尔滨理工大学 一种基于免疫系统作用的骨折愈合仿真方法
AU2022323662B2 (en) * 2021-08-03 2025-06-05 Cartiheal (2009) Ltd. Methods for promoting osteochondral cell and tissue growth including in large lesions and in populations at risk

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5858041A (ja) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 骨欠損部及び空隙部充てん材
FR2706768B1 (es) * 1993-05-13 1995-12-01 Inoteb
JP3315761B2 (ja) * 1993-06-29 2002-08-19 旭光学工業株式会社 生体吸収性高分子含有焼結型骨補填材
US8795242B2 (en) 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
FR2743496B1 (fr) 1996-01-15 1998-04-10 Univ Rennes Composite macroporeux support de substance(s) medicamenteuse(s) utilisable comme materiau de reconstitution osseuse et procede d'elaboration
IL133739A (en) 1997-07-07 2005-03-20 Australian Inst Marine Science Shaped products or structures for medical or related purposes
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
DE19926083A1 (de) * 1999-06-08 2000-12-14 Universitaetsklinikum Freiburg Biologisches Gelenkkonstrukt
US6995013B2 (en) * 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
CN1169494C (zh) * 2001-05-23 2004-10-06 中国科学院化学研究所 组织工程用复合结构细胞支架及其制法和用途
US20020183858A1 (en) * 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US6783498B2 (en) 2002-03-26 2004-08-31 Vivometrics, Inc. Method and system for extracting cardiac parameters from plethysmographic signals
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
JP4228070B2 (ja) * 2003-03-03 2009-02-25 独立行政法人産業技術総合研究所 貫通を有する多孔質リン酸カルシウム高分子ハイドロゲル複合体、その製造方法及びそれを用いた人工骨または薬剤徐放体
US20050074877A1 (en) 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
US7375077B2 (en) 2003-09-19 2008-05-20 The Board Of Trustees Of The University Of Illinois In vivo synthesis of connective tissues
FR2863172B1 (fr) * 2003-12-05 2006-07-21 Biocoral Inc Procede de purification du corail
EP1727571B1 (en) * 2004-03-22 2012-02-22 Agency for Science, Technology and Research Method for obtaining graded pore structure in scaffolds for tissues and bone
BRPI0512831A (pt) * 2004-06-30 2008-04-08 Univ Illinois construção de tecido liso, método para preparação de uma construção de tecido liso, uso da construção de tecido liso, e composição
US8796015B2 (en) * 2004-11-09 2014-08-05 Proxy Biomedical Limited Tissue scaffold
KR100720859B1 (ko) 2005-12-30 2007-05-23 한국지질자원연구원 아라고나이트 침강성탄산칼슘의 입자조절방법
WO2007078018A1 (en) 2005-12-31 2007-07-12 Korea Institute Of Geoscience And Mineral Resources Manufacture method of single phase aragonite precipitated calcium carbonate by controlling calcium ion
CA2635233C (en) 2005-12-31 2012-04-10 Korea Institute Of Geoscience And Mineral Resources Novel manufacturing method of aragonite calcium carbonate
US7824703B2 (en) * 2006-02-01 2010-11-02 Warsaw Orthopedics, Inc. Medical implants with reservoir(s), and materials preparable from same
JP2007236803A (ja) * 2006-03-10 2007-09-20 Takiron Co Ltd インプラント複合材料
WO2007131002A2 (en) * 2006-05-01 2007-11-15 Stout Medical Group, L.P. Expandable support device and method of use
US8449622B2 (en) 2006-09-11 2013-05-28 Warsaw Orthopedic, Inc. Multi-phase osteochondral implantable device
US7758643B2 (en) 2007-02-26 2010-07-20 Biomet Sports Medicine, Llc Stable cartilage defect repair plug
US20080281431A1 (en) * 2007-05-10 2008-11-13 Biomet Manufacturing Corp. Resorbable bone graft materials
ES2536633T3 (es) 2007-11-19 2015-05-27 Ben Gurion University Of The Negev Research And Development Authority Efectos mediados por calcio de corales y métodos de uso de los mismos
US9782300B2 (en) * 2008-02-01 2017-10-10 Kci Licensing, Inc. Fiber-microsphere bioresorbable composite scaffold for wound healing
US20090304654A1 (en) * 2008-04-30 2009-12-10 Regents Of The University Of California Methods for isolating adipose-derived stem cells and therapeutic use thereof
US8557288B2 (en) * 2008-08-15 2013-10-15 Washington University Hydrogel microparticle formation in aqueous solvent for biomedical applications
ES2712891T3 (es) 2008-11-20 2019-05-16 Cartiheal 2009 Ltd Formas sólidas para reparación de tejidos
ES2721876T3 (es) 2009-06-15 2019-08-06 Cartiheal 2009 Ltd Formas sólidas para reparación tisular
EP2833933B1 (en) 2012-04-05 2020-10-14 Cartiheal (2009) Ltd Multi-phasic solid implants for tissue repair
DK2854883T3 (da) 2012-05-17 2019-07-15 Cartiheal 2009 Ltd Biomatrix-hydrogeler og fremgangsmåder til anvendelse deraf
US20150289889A1 (en) 2012-11-12 2015-10-15 Cartiheal (2009) Ltd. Tools and Systems for Solid Form and Graft Implantation
DK2956183T3 (da) 2013-02-13 2021-06-14 Cartiheal 2009 Ltd Faste substrater til fremme af celle og væv vækst
US11007304B2 (en) 2015-05-06 2021-05-18 Cartiheal (2009) Ltd Optimized solid substrates, tools for use with same and uses thereof for promoting cell and tissue growth

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US20210077657A1 (en) 2021-03-18
US20160175480A1 (en) 2016-06-23
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US20190070333A1 (en) 2019-03-07
US8790681B2 (en) 2014-07-29
US10080818B2 (en) 2018-09-25
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US10702627B2 (en) 2020-07-07
US20120177702A1 (en) 2012-07-12
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CA2764881A1 (en) 2010-12-23
HUE046834T2 (hu) 2020-03-30
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US8802115B2 (en) 2014-08-12
JP2015163234A (ja) 2015-09-10
AU2010261389B2 (en) 2016-03-03
US20180339081A1 (en) 2018-11-29
EP2442749A4 (en) 2013-07-24
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DK2442749T3 (da) 2019-05-27
PT2442750T (pt) 2019-07-12
EP2442750A4 (en) 2013-07-24
WO2010146575A3 (en) 2011-02-10
US20240408268A1 (en) 2024-12-12
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US20120189669A1 (en) 2012-07-26
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