ES2728199T3 - Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP) - Google Patents

Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP) Download PDF

Info

Publication number: ES2728199T3
Authority: ES; Spain
Prior art keywords: inhibitors; agents; combination; aminin; cancer
Prior art date: 2007-01-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES14176452T

Other languages

English (en)

Spanish (es)

Inventor

Ontoria Jesus Maria Ontoria

Rita Scarpeli

Carsten Schultz-Fademrecht

Philip Jones

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

MSD Italia SRL

Original Assignee

MSD Italia SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-10

Filing date

2008-01-08

Publication date

2019-10-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2728199(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-01-08 Application filed by MSD Italia SRL filed Critical MSD Italia SRL

2019-10-22 Application granted granted Critical

2019-10-22 Publication of ES2728199T3 publication Critical patent/ES2728199T3/es

Status Active legal-status Critical Current

2028-01-08 Anticipated expiration legal-status Critical

Links

0 *C1=CC2=C*(c3cc(*)c(C4CNCCC4)cc3)N=C2C(*)=C1 Chemical compound *C1=CC2=C*(c3cc(*)c(C4CNCCC4)cc3)N=C2C(*)=C1 0.000 description 4

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES14176452T 2007-01-10 2008-01-08 Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP) Active ES2728199T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0700432.8A GB0700432D0 (en)	2007-01-10	2007-01-10	Therapeutic compounds
US92131007P	2007-04-02	2007-04-02

Publications (1)

Publication Number	Publication Date
ES2728199T3 true ES2728199T3 (es)	2019-10-22

Family

ID=37809722

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES14176452T Active ES2728199T3 (es)	2007-01-10	2008-01-08	Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP)
ES11157369.7T Active ES2509115T3 (es)	2007-01-10	2008-01-08	Combinaciones que contienen indazoles sustituidos con amida como inhibidores de poli(ADP-ribosa) polimerasa (PARP)
ES08702101T Active ES2362214T3 (es)	2007-01-10	2008-01-08	Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES11157369.7T Active ES2509115T3 (es)	2007-01-10	2008-01-08	Combinaciones que contienen indazoles sustituidos con amida como inhibidores de poli(ADP-ribosa) polimerasa (PARP)
ES08702101T Active ES2362214T3 (es)	2007-01-10	2008-01-08	Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).

Country Status (21)

Country	Link
CN (1)	CN101578279B (fr)
AT (1)	ATE502933T1 (fr)
CR (1)	CR10910A (fr)
DE (1)	DE602008005711D1 (fr)
DK (2)	DK2109608T3 (fr)
ES (3)	ES2728199T3 (fr)
GB (1)	GB0700432D0 (fr)
HN (1)	HN2009001260A (fr)
HU (1)	HUE044513T2 (fr)
LT (1)	LT2805945T (fr)
LU (1)	LUC00072I2 (fr)
ME (1)	ME03481B (fr)
MY (1)	MY147789A (fr)
NI (1)	NI200900135A (fr)
NZ (1)	NZ578256A (fr)
PE (1)	PE20081558A1 (fr)
PT (3)	PT2336120E (fr)
SI (2)	SI2336120T1 (fr)
TW (1)	TWI528961B (fr)
UA (1)	UA97658C2 (fr)
ZA (1)	ZA200903898B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106496187A (zh) *	2016-09-14	2017-03-15	陕西科技大学	一种制备PARP抑制剂Niraparib的合成方法
CN106432187A (zh) *	2016-09-17	2017-02-22	青岛云天生物技术有限公司	2‑[4‑(‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的手性拆分方法
CN106432188A (zh) *	2016-09-17	2017-02-22	青岛辰达生物科技有限公司	一种抗癌药2‑[4‑((3s)‑3‑哌啶基)苯基]‑2h‑吲唑‑7‑甲酰胺的制备方法
CN106467513A (zh) *	2016-09-30	2017-03-01	陕西科技大学	一种制备Niraparib的合成方法
CN106632244A (zh) *	2016-09-30	2017-05-10	陕西科技大学	一种制备抗癌药物Niraparib的新型合成方法
CN108201537A (zh) *	2016-12-16	2018-06-26	苏州苏融生物医药有限公司	一种尼拉帕尼缓控释药物组合物及其用途
KR20190130625A (ko) *	2017-03-27	2019-11-22	테사로, 인코포레이티드	니라파립 제제
CN109081828B (zh) *	2017-06-14	2021-03-26	上海时莱生物技术有限公司	聚(adp-核糖)聚合酶抑制剂、制备方法及用途
TWI843707B (zh)	2017-09-26	2024-06-01	美商提薩羅有限公司	尼拉帕尼（ｎｉｒａｐａｒｉｂ）調配物
CN108084157A (zh) *	2018-02-12	2018-05-29	安庆奇创药业有限公司	一种尼拉帕尼的合成方法
CN108203404A (zh) *	2018-03-02	2018-06-26	上海博邦医药科技有限公司	(r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法
CA3169303A1 (fr)	2020-02-24	2021-09-02	Xiaokun SHEN	Application anti-coronavirus de l'inhibiteur de la poly adp-ribose polymerase
CN115611860B (zh) *	2021-07-13	2024-06-11	上海博璞诺科技发展有限公司	合成尼拉帕尼的方法

2007
- 2007-01-10 GB GBGB0700432.8A patent/GB0700432D0/en not_active Ceased
2008
- 2008-01-08 PT PT111573697T patent/PT2336120E/pt unknown
- 2008-01-08 DE DE602008005711T patent/DE602008005711D1/de active Active
- 2008-01-08 ES ES14176452T patent/ES2728199T3/es active Active
- 2008-01-08 SI SI200831266T patent/SI2336120T1/sl unknown
- 2008-01-08 ME MEP-2019-147A patent/ME03481B/fr unknown
- 2008-01-08 ES ES11157369.7T patent/ES2509115T3/es active Active
- 2008-01-08 UA UAA200908335A patent/UA97658C2/ru unknown
- 2008-01-08 ES ES08702101T patent/ES2362214T3/es active Active
- 2008-01-08 PT PT14176452T patent/PT2805945T/pt unknown
- 2008-01-08 PT PT08702101T patent/PT2109608E/pt unknown
- 2008-01-08 PE PE2008000097A patent/PE20081558A1/es active IP Right Grant
- 2008-01-08 MY MYPI20092876A patent/MY147789A/en unknown
- 2008-01-08 HU HUE14176452 patent/HUE044513T2/hu unknown
- 2008-01-08 LT LTEP14176452.2T patent/LT2805945T/lt unknown
- 2008-01-08 SI SI200830240T patent/SI2109608T1/sl unknown
- 2008-01-08 NZ NZ578256A patent/NZ578256A/en unknown
- 2008-01-08 CN CN2008800019265A patent/CN101578279B/zh active Active
- 2008-01-08 DK DK08702101.0T patent/DK2109608T3/da active
- 2008-01-08 TW TW097100730A patent/TWI528961B/zh active
- 2008-01-08 AT AT08702101T patent/ATE502933T1/de active
- 2008-01-08 DK DK11157369.7T patent/DK2336120T3/da active
2009
- 2009-06-04 ZA ZA200903898A patent/ZA200903898B/xx unknown
- 2009-07-02 CR CR10910A patent/CR10910A/es unknown
- 2009-07-02 HN HN2009001260A patent/HN2009001260A/es unknown
- 2009-07-02 NI NI200900135A patent/NI200900135A/es unknown
2018
- 2018-05-03 LU LU00072C patent/LUC00072I2/fr unknown

Also Published As

Publication number	Publication date
LT2805945T (lt)	2019-06-25
TWI528961B (zh)	2016-04-11
GB0700432D0 (en)	2007-02-21
ES2362214T3 (es)	2011-06-29
CN101578279B (zh)	2013-07-17
PT2109608E (pt)	2011-05-30
HN2009001260A (es)	2012-03-26
PE20081558A1 (es)	2008-10-30
NZ578256A (en)	2011-12-22
DE602008005711D1 (de)	2011-05-05
MY147789A (en)	2013-01-31
LUC00072I2 (fr)	2018-07-04
CR10910A (es)	2010-01-19
DK2109608T3 (da)	2011-07-11
PT2805945T (pt)	2019-06-06
SI2336120T1 (sl)	2014-10-30
ES2509115T3 (es)	2014-10-17
ATE502933T1 (de)	2011-04-15
HUE044513T2 (hu)	2019-10-28
ME03481B (fr)	2020-01-20
UA97658C2 (ru)	2012-03-12
SI2109608T1 (sl)	2011-07-29
NI200900135A (es)	2010-08-30
PT2336120E (pt)	2014-10-01
ZA200903898B (en)	2010-04-28
CN101578279A (zh)	2009-11-11
TW200836731A (en)	2008-09-16
DK2336120T3 (da)	2014-10-06

Publication	Publication Date	Title
ES2728199T3 (es)	2019-10-22	Indazoles sustituidos con amida como inhibidores de poli (ADP-ribosa) polimerasa (PARP)
ES2548131T3 (es)	2015-10-14	Sales farmacéuticamente aceptables de 2-{4-[(3S)-piperidin-3-il]fenil}-2H-indazol-7-carboxamida
EP2805945B1 (fr)	2019-04-03	Indazoles substitués d'amide en tant qu'inhibiteurs PARP de poly(ADP-ribose)polymérase
ES2524787T3 (es)	2014-12-12	Derivados de piridazinona como inhibidores de PARP
HK40006670A (en)	2020-05-22	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
HK1154386B (en)	2015-02-06	Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
HK1131137B (en)	2011-12-09	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors