ES274572A1 - Procedimiento para la preparaciën de hidroxicobalamina a partir de cianocobalamina - Google Patents
Procedimiento para la preparaciën de hidroxicobalamina a partir de cianocobalaminaInfo
- Publication number
- ES274572A1 ES274572A1 ES0274572A ES274572A ES274572A1 ES 274572 A1 ES274572 A1 ES 274572A1 ES 0274572 A ES0274572 A ES 0274572A ES 274572 A ES274572 A ES 274572A ES 274572 A1 ES274572 A1 ES 274572A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxycobalamin
- cyanocobalamin
- solution
- preparation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 title abstract 4
- DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 title abstract 3
- 229960002104 cyanocobalamin Drugs 0.000 title abstract 2
- 235000000639 cyanocobalamin Nutrition 0.000 title abstract 2
- 239000011666 cyanocobalamin Substances 0.000 title abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- -1 hydroxyl ions Chemical class 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 238000010792 warming Methods 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3217261A GB1012360A (en) | 1961-09-07 | 1961-09-07 | A process for the preparation of hydroxycobalamin from cyanocobalamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES274572A1 true ES274572A1 (es) | 1962-05-16 |
Family
ID=10334431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0274572A Expired ES274572A1 (es) | 1961-09-07 | 1962-02-13 | Procedimiento para la preparaciën de hidroxicobalamina a partir de cianocobalamina |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT251205B (de) |
| CH (1) | CH414059A (de) |
| ES (1) | ES274572A1 (de) |
| GB (1) | GB1012360A (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3085320B2 (ja) * | 1991-09-17 | 2000-09-04 | 日石三菱株式会社 | ヒドロキソコバラミンの製造方法 |
| US11324771B2 (en) | 2020-02-12 | 2022-05-10 | RK Pharma Solutions LLC | Process for the preparation of hydroxocobalamin hydrochloride |
-
1961
- 1961-09-07 GB GB3217261A patent/GB1012360A/en not_active Expired
-
1962
- 1962-02-08 AT AT103462A patent/AT251205B/de active
- 1962-02-13 ES ES0274572A patent/ES274572A1/es not_active Expired
- 1962-06-08 CH CH695562A patent/CH414059A/de unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT251205B (de) | 1966-12-27 |
| CH414059A (de) | 1966-05-31 |
| GB1012360A (en) | 1965-12-08 |
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